Ovarian toxicity in rats caused by methidathion and ameliorating effect of vitamins E and C

Human and Experimental Toxicology

Volumn 26, Issue 6, 2007, Pages 491-498

  Güney, Mehmet ^a,b   Demirin, Hilmi ^a   Oral, Baha ^a   Özgüner, Meltem ^a   Bayhan, Gökhan ^a   Altuntas, Irfan ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b Modernevler Mahallesi   (Turkey)

Author keywords

Lipid peroxidation; Methidathion; Ovarian toxicant; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CHOLINESTERASE; CORN OIL; MALONALDEHYDE; METHIDATHION;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; INTOXICATION; LIPID PEROXIDATION; NONHUMAN; OVARY DISEASE; OVARY FOLLICLE; OVARY FOLLICLE ATRESIA; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ALPHA-TOCOPHEROL; ANIMALS; ASCORBIC ACID; CHOLINESTERASES; CORPUS LUTEUM; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ESTROUS CYCLE; FATIGUE; FEMALE; INJECTIONS, INTRAPERITONEAL; INSECTICIDES; INTUBATION, GASTROINTESTINAL; MALONDIALDEHYDE; ORGANOTHIOPHOSPHORUS COMPOUNDS; OVARIAN DISEASES; OVARIAN FOLLICLE; RATS; RATS, WISTAR; VITAMINS; WEIGHT GAIN; WEIGHT LOSS;

RATTUS; ZEA MAYS;

EID: 34547700333     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106077505     Document Type: Article

References (39)

1. Feron VJ, Groten JP. Toxicology evaluation of chemical mixtures. Food Chem Toxicol 2002; 40: 825-39.
2. Gomes J, Dawodu AH, Lioyd O, Revitt DM, Aniall SV. Hepatic injury and distubed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides. Hum Exp Toxicol 1999; 18: 33-37.
3. Kossmann S, Magner-Krezel Z, Sobieraj R, Szwed Z. The assesment of nephrotoxic effect based on the determination of the activity of some selected enzymes in urine. Przegel Lek 1997; 54: 707-11.
4. Aly NM, El-Gend KS. Effects of dimethoate on the immune system of the female mice. J Environ Sci Health 2000; 35: 77-86.
5. Hagar HH, Fahmy AH. A biochemical, and ultrastructural evaluation of the effect of dimethioate intoxication on rat pancreas. Toxicol Lett 2002; 133: 161-70.
6. Yavuz T, Altuntas I, Delibas N, Yildirim B, Candir O, Cora A, Karahan N, Ibrisim E, Kutsal A. Cardiotoxicity in rats induced by methidathion ameliorating effect of vitamins E and C. Hum Exp Toxicol 2004; 23: 323-29.
7. Yavuz T, Delibas N, Yildirim B, Altuntas I, Candir O, Cora A, Karaman N, Ibrisim E, Kutsal A. Vascular wall damage in rats induced by methadion and ameliorating effect of vitamin E and C. Arch Toxicol 2004; 78: 655-59.
8. Mattison DR, Thomford PJ. The mechanisms of action of reproductive toxicants. Toxicol Pathol 1989; 17: 364-76.
9. Kasagami T, Miyamoto T, Yamamoto I. Activated transformations of organophosphorus insecticides in the case of non-ChE inhibitory oxons. Pest Manag Sci 2002; 58: 1107-17.
10. Kousba AA, Poet TS, Timchalk C. Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. Toxicology 2003; 188: 219-32.
11. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. In vitro and in vivo generation of reactive oxygen species. DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 1995; 104: 129-40.
12. Gultekin F, Ozturk M, Akdogan M. The effects of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch Toxicol 2000; 74: 533-38.
13. Aslan R, Sekeroglu MR, Gultekin F, Bayiroglu F. Blood lipoperoxidation and antioxidant anzymes in healty individuals: relation to age, sex, habits, life style and environment. J Environ Sci Health A 1997; 32: 2102-109.
14. Bachowski S, Kolaja KL, Xu Y, Ketcham CA, Stevenson DE, Walborg Jr EF, Klaunig JE. Role of oxidative stress in the mechanism of dieldrin's hepatotoxicity. Ann Clin Lab Sci 1997; 27: 196-209.
15. Gupta Dasgupta J, Datta J, Sarkar A, Sengupta D. Effect of malathion on antioxidant defence system in human fetus-an in vitro study. Indian J Exp Biol 1992; 30: 352-54.
16. Altuntas I, Delibas N, Sutcu R. The effects of organophosphate insecticide methidation on lipid peroxidation and antioxidant enzymes in rat erythrocytes: role of Vitamins E and C. Hum Exp Toxicol 2002; 21: 681-85.
17. Altuntas I, Delibas N, Demirci M, Kilinc I, Tamer N. The effects of methidation on lipid peroxidation and some liver enzymes: role of Vitamins E and C. Arch Toxicol 2002; 76: 470-73.
18. Gaines TB, Linder RE. Acute toxicity of pesticide in adult and weanling rats. Fundam Appl Toxicol 1986; 7: 299-308.
19. Gullinaz A, Mehtap C, Cenk C, Gülriz M et al. The effects of vitamin E on catalase activities in various rat tissues. Turk J Med Sci 1998: 127-31.
20. Rocha NP. Vitamin E stimulates endotoxin-inhibited monocyte migration and phagocytosis in vivo. Braz J Med Biol Res 1989; 22: 1401-403.
21. Khan PK, Sihna SP Antimutagenic efficacy of higher doses of vitamin C. Mutat Res 1993; 298: 157-61.
22. Zarrow MX, Yochia Jm, McCarthy JJ. Experimental endocrinology: a source book of basic tecniques. Academic Press, 1964: 36-39.
23. Pedersen T, Peters H. Proposal for classification of oocytes and follicles in the mouse ovary. J Reprod Fertil 1968; 17: 208-12.
24. Plowchalk DR, Smith BJ, Mattison DR. Assesment of toxicity to the ovary using follicle quantitation and morphometries. In Female reproductive toxicology (Vol. 3). Academic Press, 1993: 57-68.
25. Smith CG. Reproductive toxicity: hypothalamic pituatary mechanisms. Am J Ind Med 1983; 4: 107-12.
26. Binder N, Landon EJ, Weeker L, Dettbarn WD. Effect of parathion and its metabolites on Ca uptake activity of rat skeletal muscle sarcoplasmic reticulum in vitro. Biochem Pharmacol 1976; 25: 835-39.
27. Rosenstock L, Daniell W, Barnhart S, Schwartz D, Demers PA. Chronic neurophysiological sequelae of occupational exposure to organophosphate insecticides. Am J Ind Med 1990; 18: 321-25.
28. Schneider RP. Mechanism of inhibition of rat brain (Na + K)-adenosine triphosphatase by 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT). Biochem Pharmacol 1975; 24: 939-46.
29. Gultekin F, Delibas N, Yasar S, Kiling I. In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Arch Toxicol 2001; 75: 88-96.
30. Gultekin F, Ozturk M, Akdogan M. The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch Toxicol 2000; 74: 533-38.
31. Sagsöz N, Kisa Ü, Apan A. Ischaemia-reperfusion injury of rat ovary and effects of vitamin C, mannitol and verapamil. Human Reproduction 2002; 17: 2972-76.
32. Mahadevaswami MP, Jadaramkunti AC, Hiremath MB, Kaliwal BB. Effect of mancozeb on ovarian compensatory hypertrophy and biochemical constituents in hemicastrated albino rats. Reprod Toxicol 2000; 14: 127-34.
33. Nugent D, Newton H, Gallivan L, Gosden, RG. Protective effect of vitamin E on ischaemia-reperfusion injury in ovarian grafts. J Reprod Fertil 1998; 114: 341-46.
34. Matkovics B, Szabo L, Ivan J, Gaal I. Some further data on the effects of two organophosphate pesticides on the oxidative metabolism in the liver. Gen Pharmacol 1983; 14: 689-91.
35. Goel A, Dani V, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chemico-Biological Interactions 2005; 156: 131-40.
36. Knuth UA, Friesen HG. Starvation induced anoestreus: Effect of chronic food restriction on body weight, its influence on estrous cycle and gonadotropin secretion in rats. Acta Endocrinol 1983; 103: 402-409.
37. Cooper RL, Goldman JM, Vandenbergh JG. Monitoring of the estrous cycle in the laboratory rodent by vaginal lavage. In Female reproductive toxicology (Vol. 3). Academic Press, 1983: 45-46.
38. Hiremath MB, Kaliwal BB. Effect of endosulfan on ovarian compensatory hypertrophy in hemicas-trated albino mice. Reprod Toxicol 2002; 16: 783-90.
39. Hooser SB, Douds DP, DeMerell DG, Hoyer PB, Sipes IG. Long-term ovarian and gonadotropin changes in mice exposed to 4-vinylcyclohexene. Reprod Toxicol 1994; 8: 315-23.