The role of ventromedial prefrontal cortex in decision making: Judgment under uncertainty or judgment per se?

Cerebral Cortex

Volumn 17, Issue 11, 2007, Pages 2669-2674

  Fellows, Lesley K ^a,b   Farah, Martha J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Executive functions; Frontal lobes; Human; Lesion; Orbitofrontal cortex; Reward

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BRAIN CORTEX LESION; BRAIN DAMAGE; BRAIN FUNCTION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DECISION MAKING; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POST HOC ANALYSIS; PREFRONTAL CORTEX; PREFRONTAL VENTROMEDIAL CORTEX; PRIORITY JOURNAL; TASK PERFORMANCE;

BRAIN INJURIES; DECISION MAKING; FEMALE; HUMANS; JUDGMENT; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PROBLEM SOLVING; TASK PERFORMANCE AND ANALYSIS;

EID: 34547674826     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhl176     Document Type: Article

References (43)

1. Ackerly S. Prefrontal lobes and social development. 1950/2000. Yale J Biol Med. 73:211-219.
2. Arana FS, Parkinson JA, Hinton E, Holland AJ, Owen AM, Roberts AC. 2003. Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection. J Neurosci. 23:9632-9638.
3. Baylis LL, Gaffan D. 1991. Amygdalectomy and ventromedial prefrontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward. Exp Brain Res. 86:617-622.
4. Bechara A, Damasio H, Damasio AR, Lee GP. 1999. Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci. 19:5473-5481.
5. Bechara A, Damasio H, Tranel D, Damasio AR. 1997. Deciding advantageously before knowing the advantageous strategy. Science. 275:1293-1295.
6. Camille N, Coricelli G, Sallet J, Pradat-Diehl P, Duhamel JR, Sirigu A. 2004. The involvement of the orbitofrontal cortex in the experience of regret. Science. 304:1167-1170.
7. Cunningham WA, Johnson MK, Gatenby JC, Gore JC, Banaji MR. 2003. Neural components of social evaluation. J Pers Soc Psychol. 85:639-649.
8. Eslinger PJ, Damasio AR. 1985. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology. 35:1731-1741.
9. Fellows LK. 2006. Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision making. Brain. 129:944-952.
10. Fellows LK, Farah MJ. 2003. Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain. 126:1830-1837.
11. Fellows LK, Farah MJ. 2005. Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans. Cereb Cortex. 15:58-63.
12. Harlow JM. 1848/1999. Passage of an iron rod through the head. J Neuropsychiatry Clin Neurosci. 11:281-283.
13. Heekeren HR, Marrett S, Bandettini PA, Ungerleider LG. 2004. A general mechanism for perceptual decision-making in the human brain. Nature. 431:859-862.
14. Heekeren HR, Marrett S, Ruff DA, Bandettini PA, Ungerleider LG. 2006. Involvement of human left dorsolateral prefrontal cortex in perceptual decision making is independent of response modality. Proc Natl Acad Sci USA. 103:10023-10028.
15. Hornak J, O'Doherty J, Bramham J, Rolls ET, Morris RG, Bullock PR, Polkey CE. 2004. Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci. 16:463-478.
16. Hsu M, Bhatt M, Adolphs R, Tranel D, Camerer CF. 2005. Neural systems responding to degrees of uncertainty in human decision-making. Science. 310:1680-1683.
17. Izquierdo A, Suda RK, Murray EA. 2004. Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J Neurosci. 24:7540-7548.
18. Johnson SC, Schmitz TW, Kawahara-Baccus TN, Rowley HA, Alexander AL, Lee J, Davidson RJ. 2005. The cerebral response during subjective choice with and without self-reference. J Cogn Neurosci. 17:1897-1906.
19. Jones B, Mishkin M. 1972. Limbic lesions and the problem of stimulus - reinforcement associations. Exp Neurol. 36:362-377.
20. Manes F, Sahakian B, Clark L, Rogers R, Antoun N, Aitken M, Robbins T. 2002. Decision-making processes following damage to the prefrontal cortex. Brain. 125:624-639.
21. McClure SM, Li J, Tomlin D, Cypert KS, Montague LM, Montague PR. 2004. Neural correlates of behavioral preference for culturally familiar drinks. Neuron. 44:379-387.
22. Montague PR, King-Casas B, Cohen JD. 2006. Imaging valuation models in human choice. Annu Rev Neurosci. 29:417-448.
23. O'Doherty JP. 2004. Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol. 14:769-776.
24. O'Doherty JP, Buchanan TW, Seymour B, Dolan RJ. 2006. Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum. Neuron. 49:157-166.
25. Padoa-Schioppa C, Assad JA. 2006. Neurons in the orbitofrontal cortex encode economic value. Nature. 441:223-226.
26. Paulus MP, Frank LR. 2003. Ventromedial prefrontal cortex activation is critical for preference judgments. Neuroreport. 14:1311-1315.
27. Pears A, Parkinson JA, Hopewell L, Everitt BJ, Roberts AC. 2003. Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates. J Neurosci. 23:11189-11201.
28. Roberts AC. 2006. Primate orbitofrontal cortex and adaptive behaviour. Trends Cogn Sci. 10:83-90.
29. Roesch MR, Olson CR. 2004. Neuronal activity related to reward value and motivation in primate frontal cortex. Science. 304:307-310.
30. Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, et al. 1999. Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology. 20: 322-339.
31. Rolls ET. 2000. The orbitofrontal cortex and reward. Cereb Cortex. 10:284-294.
32. Sanfey AG, Hastie R, Colvin MK, Grafman J. 2003. Phineas gauged: decision-making and the human prefrontal cortex. Neuropsychologia. 41:1218-1229.
33. Schultz W. 2000. Multiple reward signals in the brain. Nat Rev Neurosci. 1:199-207.
34. Schultz W, Tremblay L, Hollerman JR. 2000. Reward processing in primate orbitofrontal cortex and basal ganglia. Cereb Cortex. 10:272-284.
35. Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG. 1992. Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 4:134-139.
36. Stuss DT, Levine B. 2002. Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annu Rev Psychol. 53:401-433.
37. Sugrue LP, Corrado GS, Newsome WT. 2005. Choosing the greater of two goods: neural currencies for valuation and decision making. Nat Rev Neurosci. 6:363-375.
38. Tremblay L, Schultz W. 1999. Relative reward preference in primate orbitofrontal cortex. Nature. 398:704-708.
39. Turk DJ, Banfield JF, Walling BR, Heatherton TF, Grafton ST, Handy TC, Gazzaniga MS, Macrae CN. 2004. From facial cue to dinner for two: the neural substrates of personal choice. Neuroimage. 22: 1281-1290.
40. Tversky A. 1969. Intransitivity of preferences. Psychol Rev. 76:31-48.
41. Volz KG, Schubotz RI, von Cramon DY. 2006. Decision-making and the frontal lobes. Curr Opin Neurol. 19:401-406.
42. Wallis JD, Miller EK. 2003. Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task. Eur J Neurosci. 18:2069-2081.
43. Zysset S, Huber O, Ferstl E, von Cramon DY. 2002. The anterior frontomedian cortex and evaluative judgment: an fMRI study. Neuroimage. 15:983-991.