Escitalopram ingestions reported to Texas poison control centers, 2002-2005

Human and Experimental Toxicology

Volumn 26, Issue 6, 2007, Pages 473-482

  Forrester, Mathias B ^a  

^a TEXAS DEPARTMENT OF STATE HEALTH SERVICES   (United States)

Author keywords

Adverse exposures; Escitalopram; Management; Poison control centers

Indexed keywords

ESCITALOPRAM;

ABDOMINAL PAIN; ACIDOSIS; ADOLESCENT; ADULT; AGITATION; ARTICLE; ATAXIA; BRADYCARDIA; CHILD; COMA; CONFUSION; DELUSION; DIAPHORESIS; DIARRHEA; DIZZINESS; DROWSINESS; DRUG INTOXICATION; DYSPNEA; DYSTONIA; ECG ABNORMALITY; EDEMA; EMERGENCY HEALTH SERVICE; FEMALE; FEVER; HALLUCINATION; HEADACHE; HEART MUSCLE CONDUCTION DISTURBANCE; HEMATEMESIS; HUMAN; HYPERTENSION; HYPERVENTILATION; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MUSCLE RIGIDITY; MUSCLE WEAKNESS; MYDRIASIS; NAUSEA; NYSTAGMUS; PNEUMONIA; POISON CENTER; PRIORITY JOURNAL; PRURITUS; RESPIRATION DEPRESSION; RETROSPECTIVE STUDY; SEIZURE; SLURRED SPEECH; SUICIDE ATTEMPT; SYNCOPE; TACHYCARDIA; THORAX PAIN; TINNITUS; TREMOR; UNITED STATES; URTICARIA; VOMITING;

ADOLESCENT; ADULT; AGE FACTORS; ALGORITHMS; CHILD; CHILD, PRESCHOOL; CITALOPRAM; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MEDICAL ERRORS; PATIENT-CENTERED CARE; POISON CONTROL CENTERS; PRACTICE GUIDELINES; RETROSPECTIVE STUDIES; SEROTONIN UPTAKE INHIBITORS; SEX FACTORS; SUICIDE, ATTEMPTED; TABLETS; TEXAS; TIME FACTORS;

EID: 34547665032     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327107078666     Document Type: Article

References (32)

1. Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology 2003; 167: 353-62.
2. Owens MJ, Knight DL, Nemeroff CB. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biological Psychiatry 2001; 50: 345-50.
3. Hyttel J, Bogeso KP, Perregaard J, Sanchez C. The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer. Journal of Neural Transmission General Section 1992; 88: 157-60.
4. Prescribing information. Lexapro(R) (escitalopram oxalate) tablets/oral solution. Forest Pharmaceuticals, St Louis, Missouri. February 2005. http://www.frx.com/pi/lexapro_pi.pdf.
5. Escitalopram (Lexapro) for depression. The Medical Letter 2002; 44: 83-84.
6. Burke WJ, Gergel I, Bose A. Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients. Journal of Clinical Psychiatry 2002; 63: 331-36.
7. F.D.A. clears generic version of Lexapro. New York Times, 23 May 2006.
8. von Moltke LL, Greenblatt DJ, Giancarlo GM, Granda BW, Harmatz JS, Shader RI. Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram. Drug Metabolism and Disposition 2001; 29: 1102-109.
9. Barnett AK, Brush DE, Schroeder W. The pharmacology and toxicology of escitalopram. International Journal of Medical Toxicology 2003; 6: 14.
10. Wagner KD, Jonas J, Findling RL, Ventura D, Saikali K. A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression. Journal of the American Academy of Child and Adolescent Psychiatry 2006; 45: 280-88.
11. Wiegart T, Stuart D. Serotonin syndrome following initiation of escitalopram monotherapy for depression. Journal of Toxicology-Clinical Toxicology 2003; 41: 641-42.
12. Lovecchio F, Watts D, Winched J, Knight J, McDowell T. Outcomes after supratherapeutic escitalopram ingestions. Journal of Emergency Medicine 2006; 30: 17-19.
13. Yuksel FV, Tuzer V, Goka E. Escitalopram intoxication. European Psychiatry 2005; 20: 82.
14. Olsen DG, Dart RC, Robinett M. Severe serotonin syndrome from escitalopram overdose. Journal of Toxicology-Clinical Toxicology 2004; 42: 744-45.
15. Lindgren KN, Bangh SA, Ling L, Stremski E, Mueller C. Escitalopram, a review of adverse effects in overdose reported to select regional poison centers. Journal of Toxicology-Clinical Toxicology 2003; 41: 658.
16. Seifert SA, Meissner GK. Escitalopram overdose: a case series. Journal of Toxicology-Clinical Toxicology 2004; 42: 495-96.
17. Watson WA, Litovitz TL, Klein-Schwartz W, Rodgers GC, Youniss J, Reid N, Rouse WG, Rembert RS, Borys D. 2003 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. American Journal of Emergency Medicine 2004; 22: 335-404.
18. Watson WA, Litovitz TL, Rodgers GC, Klein-Schwartz W, Reid N, Youniss J, Flanagan A, Wruk KM. 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. American Journal of Emergency Medicine 2005; 23: 589-666.
19. Fergusson D, Doucette S, Glass KC, Shapiro S, Healy D, Hebert P, Hutton B. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. British Medical Journal 2005; 330: 396.
20. Laska E, Johnson-Arbor K, McKay C, Sangalli B. A 34-month review of pediatric escitalopram ingestions. Clinical Toxicology 2006; 44: 666.
21. Ho R, Norman RF, van Veen MM, Anderson IB. A 3-year review of citalopram and escitalopram ingestions. Journal of Toxicology-Clinical Toxicology 2004; 42: 746.
22. Watts D, LoVecchio F, McDowell T. First two-year experience with escitalopram exposures. Journal of Toxicology-Clinical Toxicology 2004; 42: 820.
23. Dart RC, Erdman AR, Olson KR, Christianson G, Manoguerra AS, Chyka PA, Caravati EM, Wax PM, Keyes DC, Woolf AD, Scharman EJ, Booze LL, Troutman WG; American Association of Poison Control Centers. Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 2006; 44: 1-18.
24. Manoguerra AS, Erdman AR, Booze LL, Christianson G, Wax PM, Scharman EJ, Woolf AD, Chyka PA, Keyes DC, Olson KR, Caravati EM, Troutman WG. Iron ingestion: an evidence-based consensus guideline for outof-hospital management. Clinical Toxicology 2005; 43: 553-70.
25. Manoguerra AS, Erdman AR, Wax PM, Nelson LS, Caravati EM, Cobaugh DJ, Chyka PA, Olson KR, Booze LL, Woolf AD, Keyes DC, Christianson G, Scharman EJ, Troutman WG; American Association of Poison Control Centers. Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management. Clinical Toxicology 2006; 44: 357-70.
26. Scharman EJ, Erdman AR, Wax PM, Chyka PA, Caravati EM, Nelson LS, Manoguerra AS, Christianson G, Olson KR, Woolf AD, Keyes DC, Booze LL, Troutman WG. Diphenhydramine and dimenhydrinate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 2006; 44: 205-23.
27. Caravati EM, Erdman AR, Christianson G, Manoguerra AS, Booze LL, Woolf AD, Olson KR, Chyka PA, Scharman EJ, Wax PM, Keyes DC, Troutman WG. Ethylene glycol exposure: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 2005; 43: 327-45.
28. Olson KR, Erdman AR, Woolf AD, Scharman EJ, Christianson G, Caravati EM, Wax PM, Booze LL, Manoguerra AS, Keyes DC, Chyka PA, Troutman WG. Calcium channel blocker ingestion: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 2005; 43: 797-822.
29. Wax PM, Erdman AR, Chyka PA, Keyes DC, Caravati EM, Booze L, Christianson G, Woolf A, Olson KR, Manoguerra AS, Scharman EJ, Troutman WG. Beta-blocker ingestion: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 2005; 43: 131-46.
30. Grunebaum MF, Ellis SP, Li S, Oquendo MA, Mann JJ. Antidepressants and suicide risk in the United States, 1985-1999. Journal of Clinical Psychiatry 2004; 65: 1456-62.
31. Paulose-Ram R, Jonas BS, Orwig D, Safran MA. Prescription psychotropic medication use among the U.S. adult population: results from the third National Health and Nutrition Examination Survey, 1988-1994. Journal of Clinical Epidemiology 2004; 57: 309-17.
32. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. Journal of the American Medical Association 2002; 287: 337-44.