Simultaneous assessment of the effects of L-type current modulators on sensory and motor pathways of the mouse spinal cord in vitro

Neuropharmacology

Volumn 53, Issue 3, 2007, Pages 464-471

  Martinez Gomez, J ^a   Lopez Garcia, J A ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Benzothiazepines; Dihydropyridines; Phenylalkylamines; Spinal nociceptive pathways; Wind up

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; DILTIAZEM; NIMODIPINE; VERAPAMIL;

ANALGESIA; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DORSAL ROOT; DRUG EFFECT; LUMBAR SPINAL CORD; MOTONEURON; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SPINAL CORD;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; EFFERENT PATHWAYS; MICE; PHYSICAL STIMULATION; SPINAL CORD;

EID: 34547657186     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.06.007     Document Type: Article

References (25)

1. Catterall W.A. Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium 24 (2000) 307-323
2. Cervero F., and Laird J.M. Mechanisms of touch-evoked pain (allodynia): a new model. Pain 68 (1996) 13-23
3. Chaplan S.R., Pogrel J.W., and Yaksh T.L. Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J. Pharmacol. Exp. Ther. 269 (1994) 1117-1123
4. Diaz A., and Dickenson A.H. Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation. Pain 69 (1997) 93-100
5. Diochot S., Richard S., Baldy-Moulinier M., Nargeot J., and Valmier J. Dihydropyridines, phenylalkylamines and benzothiazepines block N-, P/Q- and R-type calcium currents. Pflugers Arch. 431 (1995) 10-19
6. Dobremez E., Bouali-Benazzouz R., Fossat P., Monteils L., Dulluc J., Nagy F., and Landry M. Distribution and regulation of L-type calcium channels in deep dorsal horn neurons after sciatic nerve injury in rats. Eur. J. Neurosci. 21 (2005) 3321-3333
7. Dobrev D., Milde A.S., Andreas K., and Ravens U. The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum. Br. J. Pharmacol. 127 (1999) 576-582
8. Ertel E.A., Campbell K.P., Harpold M.M., Hofmann F., Mori Y., Perez-Reyes E., Schwartz A., Snutch T.P., Tanabe T., Birnbaumer L., Tsien R.W., and Catterall W.A. Nomenclature of voltage-gated calcium channels. Neuron 25 (2000) 533-535
9. Fossat P., Sibon I., Le Masson G., Landry M., and Nagy F. L-type calcium channels and NMDA receptors: a determinant duo for short-term nociceptive plasticity. Eur. J. Neurosci. 25 (2007) 127-135
10. Hara K., Saito Y., Kirihara Y., Sakura S., and Kosaka Y. Antinociceptive effects of intrathecal L-type calcium channel blockers on visceral and somatic stimuli in the rat. Anesth. Analg. 87 (1998) 382-387
11. Hedo G., and Lopez-Garcia J.A. Alpha-1A adrenoceptors modulate potentiation of spinal nociceptive pathways in the rat spinal cord in vitro. Neuropharmacology 41 (2001) 862-869
12. Herrero J.F., Laird J.M., and Lopez-Garcia J.A. Wind-up of spinal cord neurones and pain sensation: much ado about something?. Prog. Neurobiol. 61 (2000) 169-203
13. Jiang Z., Rempel J., Li J., Sawchuk M.A., Carlin K.P., and Brownstone R.M. Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur. J. Neurosci. 11 (1999) 3481-3487
14. Lipscombe D., Helton T.D., and Xu W. L-type calcium channels: the low down. J. Neurophysiol. 92 (2004) 2633-2641
15. Malmberg A.B., and Yaksh T.L. Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. J. Neurosci. 14 (1994) 4882-4890
16. Martinez-Gomez J., and Lopez-Garcia J.A. Electrophysiological and pharmacological characterisation of ascending anterolateral axons in the in vitro mouse spinal cord. J. Neurosci. Methods 146 (2005) 84-90
17. McCarthy R.T., and TanPiengco P.E. Multiple types of high-threshold calcium channels in rabbit sensory neurons: high-affinity block of neuronal L-type by nimodipine. J. Neurosci. 12 (1992) 2225-2234
18. Morisset V., and Nagy F. Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons. Eur. J. Neurosci. 12 (2000) 3087-3095
19. Neugebauer V., Vanegas H., Nebe J., Rumenapp P., and Schaible H.G. Effects of N- and L-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to mechanical stimulation of the normal and the inflamed knee joint. J. Neurophysiol. 76 (1996) 3740-3749
20. Perrier J.F., Alaburda A., and Hounsgaard J. Spinal plasticity mediated by postsynaptic L-type Ca2+ channels. Rev. Brain Res. Brain Res. 40 (2002) 223-229
21. Perz-Trepichio A.D., and Jones S.C. Evaluation of a novel nimodipine delivery system in conscious rats that allows sustained release for 24 h. J. Neurosci. Methods 68 (1996) 297-301
22. Schnee M.E., and Ricci A.J. Biophysical and pharmacological characterization of voltage-gated calcium currents in turtle auditory hair cells. J. Physiol. 549 (2003) 697-717
23. Striessnig J., Grabner M., Mitterdorfer J., Hering S., Sinnegger M.J., and Glossmann H. Structural basis of drug binding to L Ca2+ channels. Trends Pharmacol. Sci. 19 (1998) 108-115
24. Vanegas H., and Schaible H. Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain 85 (2000) 9-18
25. Xiao H.S., Huang Q.H., Zhang F.X., Bao L., Lu Y.J., Guo C., Yang L., Huang W.J., Fu G., Xu S.H., Cheng X.P., Yan Q., Zhu Z.D., Zhang X., Chen Z., and Han Z.G. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 8360-8365