Mechanisms of regulation of litter size in pigs on the genome level

Reproduction in Domestic Animals

Volumn 42, Issue SUPPL. 2, 2007, Pages 10-16

  Distl, O ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL DISEASE; CHROMOSOME; CHROMOSOME MAP; FEMALE; GENETIC MARKER; GENETIC SELECTION; GENETICS; LITTER SIZE; MALE; PHYSIOLOGY; PREGNANCY; QUANTITATIVE TRAIT LOCUS; REPRODUCTION; REVIEW; SWINE;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES; FEMALE; GENETIC MARKERS; LITTER SIZE; MALE; PREGNANCY; QUANTITATIVE TRAIT LOCI; REPRODUCTION; SELECTION (GENETICS); SWINE;

SUIDAE;

EID: 34547653460     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2007.00887.x     Document Type: Review

References (93)

1. Aldenhoven J, Spötter A, Distl O, 2007 : An insertion/deletion in the porcine FGFR2 gene. J Anim Breed Genet 124, 39 41.
2. Alfonso L, 2005 : Use of meta-analysis to combine candidate gene association to study the relationship between the ESR PvuII polymorphism and sow litter size. Genet Sel Evol 37, 417 435.
3. Almeida FR, Kirkwood RN, Aherne FX, Foxcroft GR, 2000 : Consequences of different patterns of feed intake during the estrous cycle in gilts on subsequent fertility. J Anim Sci 78, 1556 1563.
4. Borges VF, Bernardi ML, Bortolozzo FP, Wentz I, 2005 : Risk factors for stillbirth and foetal mummification in four Brazilian swine herds. Prev Vet Med 70, 165 176.
5. Buske B, Brunsch C, Zeller K, Reinecke P, Brockmann G, 2005 : Analysis of properdin (BF) genotypes associated with litter size in a commercial pig cross population. J Anim Breed Genet 122, 259 263.
6. Buske B, Sternstein I, Brockmann G, 2006 : QTL and candidate genes for fecundity in sows. Anim Reprod Sci 95, 167 183.
7. Caetano AR, Johnson RK, Pomp D, 2002 : RNA expression profiling of ovarian follicle development in swine lines selected for increased ovulation rate. Proceedings of 7th WCGALP, Montpellier. Vol. 30, pp. 657 660.
8. Campbell EMG, Nonneman D, Rohrer GA, 2003 : Fine mapping a quantitative trait locus affecting ovulation rate in pigs on chromosome 8. J Anim Sci 81, 1706 1714.
9. Canario L, Cantoni E, Le Bihan E, Caritez JC, Billon Y, Bidanel JP, Foulley JL, 2006 : Between-breed variability of stillbirth and its relationship with sow and piglet characteristics. J Anim Sci 84, 3185 3196.
10. Cassady JP, Johnson RK, Pomp D, Rohrer GA, van Vleck LD, Spiegel EK, Gilson KM, 2001 : Identification of quantitative trait loci affecting reproduction in pigs. J Anim Sci 79, 623 633.
11. Chang HS, Cheng WT, Wu KH, Choo KB, 2000 : Identification of genes expressed in the epithelium of porcine oviduct containing early embryos at various stages of development. Mol Reprod Dev 56, 331 335.
12. Chen CC, Chang T, Su HY, 2004a : Characterization of porcine leptin receptor polymorphisms and their association with reproduction and production traits. Anim Biotechnol 15, 89 102.
13. Chen CC, Chang T, Su HY, 2004b : Genetic polymorphisms in porcine leptin gene and their association with reproduction and production traits. Aust J Agric Res 54, 699 704.
14. Damgaard LH, Rydhmer L, Lovendahl P, Grandison K, 2003 : Genetic parameters for within-litter variation in piglet birth weight and change in within-lotter variation during suckling. J Anim Sci 81, 604 610.
15. De Koning DJ, Rattink AP, Harlizius B, Groenen MAM, Brascamp EW, Van Arendonk JAM, 2001 : Detection and characterization of quantitative trait loci for growth and reproduction traits in pig. Livest Prod Sci 72, 185 198.
16. Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD, 1996 : Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci USA 93, 6025 6030.
17. Du LX, Liu SF, Yan YC, Jiang YL, 2002 : Research on Alu element inserted mutation in porcine FSH beta subunit gene (in Chinese, with English abstract). Yi Chuan Xue Bao 29, 977 982.
18. Dziuk P, 1979 : Control and mechanics of parturition in the pig. Anim Reprod Sci 2, 335 342.
19. Ellegren H, Chowdhary BP, Fredholm M, Hoyheim B, Johannsson M, Brauner Nielsen PB, Thomsen PD, Andersson L, 1994a : A physically anchored linkage map of pig chromosome 1 uncovers sex-and position-specific recombination rates. Genomics 24, 342 350.
20. Ellegren H, Chowdhary BP, Johannsson M, Marklund L, Fredholm M, Gustavsson I, Andersson L, 1994b : A primary linkage map of the porcine genome reveals a low rate of genetic recombination. Genetics 137, 1089 1100.
21. Fahmy MH, Holtmann WB, MacIntyre TM, Moxley JE, 1978 : Evaluation of piglet mortality in 28 two-breed crossed among eight breeds or pig. Anim Prod 26, 277 285.
22. Fahrenkrug SC, Campbell EM, Vallet JL, Rohrer GA, 2000 : Physical assignment of the porcine erythropoietin receptor gene to SSC2. Anim Genet 31, 69 70.
23. Garlow JE, Ka H, Johnson GA, Burghardt RC, Jaeger LA, Bazer FW, 2002 : Analysis of osteopontin at the maternal-placental interface in pigs. Biol Reprod 66, 718 725.
24. Geisert RD, Yelich JV, 1997 : Regulation of conceptus development and attachment in pigs. J Reprod Fertility Suppl. 52, 133 149.
25. Gladney CD, Martinez VG, Brumbaugh KA, DeGroot BJ, Linville RC, Oommen AM, Huebinger RM, Messer L, Allan MF, Pomp D, 1999 : Mapping of the Prostaglandin-Endoperoxide Synthase 2 (PTGS2) gene to porcine chromosome 9 and bovine chromosome 16 by linkage analysis using novel PCR-RFLP. J Anim Sci 77, 787 788.
26. Goliasova E, Wolf J, 2004 : Impact of the ESR gene on litter size and production traits in Czech Large White pigs. Anim Genet 35, 293 297.
27. Green ML, Blaeser LL, Simmen FA, Simmen RCM, 1996 : Molecular cloning of spermidine/spermine N1-acetyltransferase from the periimplantation porcine uterus by messenger ribonucleic acid differential display, temporal and conceptus-modulated gene expression. Endocrinol 137, 5447 5455.
28. Green ML, Chung TE, Reed KL, Modric T, Badinga L, Yang J, Simmen FA, Simmen RCM, 1998 : Paracrine inducers of uterine endometrial spermidine/spermine N1-acetyltransferase gene expression during early pregnancy in the pig. Biol Reprod 59, 1251 1258.
29. Harney JP, Ott TL, Geisert RD, Bazer FW, 1993 : Retinol-binding protein gene expression in cyclic and pregnant endometrium of pigs, sheep and cattle. Biol Reprod 49, 1066 1073.
30. Hatey F, Milan D, 2002 : Using Genomics to Understand Genetic Variation in Reproductive Traits. Proc 7th WCGALP, Montpellier. Vol. 30, pp. 649 656.
31. Herpin P, Hulin JC, Le Dividich J, Fillaut M, 2001 : Effect of oxygen inhalation at birth on the reduction of early postnatal mortality in pigs. J Anim Sci 79, 5 10.
32. Horak P, Urban T, Dvorak J, 2005 : The FUTI and ESR genes-their variability and associations with reproduction in Prestice Black-Pied sows. J Anim Breed Genet 122, 210 213.
33. Jiang Z, Gibson JP, Archibald AL, Haley CS, 2001 : The porcine gonadotropin-releasing hormone receptor gene (GNRHR): genomic organization, polymorphisms, and association with the number of corpora lutea. Genome 44, 7 12.
34. Jiang Z, Robinson JAB, Verrinder Gibbins AM, Gibson JP, Archibald AL, Haley CS, 2002 : Mapping of QTLs for prolificacy traits on SSC8 using a candidate gene approach. Proc 7th WCGALP, Montpellier. Vol. 30, pp. 633 636.
35. Kerr JC, Cameron ND, 1995 : Reproductive performance of pigs selected for components of efficient lean growth. Anim Sci 60, 281 290.
36. Kim JG, Vallet JL, Christenson RK, 2001 : Characterization of uterine epidermal growth factor during early pregnancy in pigs. Domest Anim Endocrinol 20, 253 265.
37. Kim JG, Vallet JL, Rohrer GA, Christenson RK, 2002 : Characterization of porcine uterine estrogen sulfotransferase. Domest Anim Endocrinol 23, 493 506.
38. King AH, Jiang Z, Gibson JP, Haley CS, Archibald AL, 2003 : Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biol Reprod 68, 2172 2179.
39. Klemcke HG, Lunstra DD, Brown-Borg HM, Borg KE, Christenson RK, 1993 : Association between low birth weight and increased adrenocortical function in neonatal pigs. J Anim Sci 71, 1010 1018.
40. Knol EF, 2001 : Genetic Aspects of Piglet Survival. PhD dissertation, Wageningen University, Wageningen, The Netherlands.
41. Knol EF, Leenhouwers JI, van der Lende T, 2002 : Genetic aspects of piglet survival. Livest Prod Sci 78, 47 55.
42. Korwin-Kossakowska A, Kamyczek M, Cieslak D, Pierzchala M, Kuryl J, 2002 : The effect of the polymorphism of leptin (LEP), leptin receptor (LEPR) and osteopontin (OPN) genes on selected reproduction traits of synthetic Line 990 sows. Anim Sci Papers Rep 20, 159 168.
43. La Bonnardiere C, 1993 : Nature and possible functions of interferous secreted by the preimplantation pig blastocyst. J Reprod Fertil Suppl 48, 157 170.
44. Lay DC, Matteri RL, Carroll JA, Fangman TJ, Safranski TJ, 2002 : Preweaning survival in swine. J Anim Sci 89, E74 E86.
45. Leenhouwers JI, van der Lende T, Knol EF, 1999 : Analysis of stillbirth in different lines of pig. Livest Prod Sci 57, 243 253.
46. Leenhouwers JI, Knol EF, van der Lende T, 2002 : Differences in late prenatal development as an explanation for genetic differences in piglet survival. Livest Prod Sci 78, 57 62.
47. Leenhouwers JI, Wissink P, van der Lende T, Paridaans H, Knol EF, 2003 : Stillbirth in the pig in relation to genetic merit for farrowing survival. J Anim Sci 81, 2419 2424.
48. Legault C, Gruand J, 1976 : Improvement of prolificacy of sows by the formation of a hyperprolific line and its use in artificial insemination. J Rech Porc France 8, 201 206.
49. Li N, Zhoa YF, Xiao L, Zang FJ, Chen YZ, Dai RJ, Zang JS, Shen SQ, Chen YF, Wu CX, 1998 : Candidate gene analysis for identification of genetic loci controlling litter size in swine. Proc 6th WCGALP, Armidale. Vol. 26, pp. 183 186.
50. Liang P, Pardee AB, 1992 : Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967 971.
51. Linville RC, Pomp D, Johnson RK, Rothschild MF, 2001 : Candidate gene analysis for loci affecting litter size and ovulation rate in swine. J Anim Sci 79, 60 67.
52. Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J, 1995 : PCR amplification, cloning and localization of the genes for pig FSHB and LHB. Cytogenet Cell Genet 70, 224.
53. Mendez EA, Messer LA, Larsen NJ, Robic A, Rothschild MF, 1999 : Epidermal growth factor maps to pig chromosome 8. J Anim Sci 77, 494 495.
54. Munoz G, Ovilo C, Amillis M, Rodriguez C, 2004 : Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs. Anim Genet 35, 242 244.
55. Pomp D, Caetano AR, Bertani GR, Gladney CD, Johnson RK, 2001 : Applying functional genomics research to the study of pig reproduction. Reprod Suppl. 58, 277 292.
56. Pope WF, 1994 : Embryonic mortality in swine. In : Zavy MT, Geisert RD (eds Embryonic Mortality in Domestic Species. CRC Press, Boca Raton, pp. 53 77.
57. Quiniou N, Dagorn J, Gaudre D, 2002 : Variation of piglets' birth weight and consequences on subsequent performance. Livest Prod Sci 78, 63 70.
58. Rathje TA, Rohrer GA, Johnson RK, 1997 : Evidence for quantitative trait loci affecting ovulation rate in pigs. J Anim Sci 75, 1486 1494.
59. Roberts RM, Xie S, Trout WE, 1993 : Embryo-uterine interactions in pigs during week 2 of pregnancy. J Reprod Fertil Suppl. 48, 171 186.
60. Roehe R, Kalm E, 2000 : Estimation of genetic and environmental risk factors associated with pre-weaning mortality in piglets using generalized linear mixed models. Anim Sci 70, 227 240.
61. Rohrer GA, Ford JJ, Wise TH, Vallet JL, Christenson RK, 1999 : Identification of quantitative trait loci affecting female reproductive traits in a multigeneration Meishan-White Composite swine population. J Anim Sci 77, 1385 1391.
62. Ross JW, Ashworth MD, Hurst AG, Malayer JR, Geisert RD, 2003 : Analysis and characterization of differential gene expression during rapid trophoblastic elongation in the pig using suppression subtractive hybridization. Reprod Biol Endocrinol 1, 23.
63. Rothschild MF, Jacobson C, Vaske D, Tuggle CK, Wang L, Short T, Eckardt G, Sasaki S, Vincent A, McLaren D, Southwood O, van der Stehen A, Mileham A, Plastow GS, 1996 : The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Natl Acad Sci USA 93, 201 205.
64. Rothschild MF, Messer L, Day A, Wales R, Short T, Southwood O, Plastow G, 2000 : Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mamm Genome 11, 75 77.
65. Short TH, Rothschild MF, McLaren DG, Southwood OI, Devries AG, van der Steen A, Tuggle CK, Helm J, Vaske DA, Mileham AJ, Plastow GS, 1997a : Effect of the estrogen receptor locus on reproduction and production traits in four commercial pig lines. J Anim Sci 75, 3138 3142.
66. Short TH, Southwood OI, Devries AG, McLaren DG, Evans GJ, Mileham AJ, Plastow GS, 1997b : Evidence of a new genetic marker for litter size in pigs. J Anim Sci 75 Suppl., 29.
67. Siewerdt F, Cardellino RA, 1996 : Genetic parameters of piglet mortality from birth to 21 days of age in the Landrace breed. Revista Soc Brasileira Zoot 25, 902 909.
68. Simmen RCM, Simmen FA, 1990 : Regulation of uterine and conceptus secretory activity in the pig. J Reprod Fertil Suppl. 40, 279 292.
69. Spötter A, Distl O, 2006 : Genetic approaches to the improvement of fertility traits in the pig. Vet J 172, 234 247.
70. Spötter A, Drögemuller C, Hamann H, Distl O, 2005 : Evidence of a new LIF associated genetic marker for litter size in synthetic pig line. J Anim Sci 83, 2264 2270.
71. Spötter A, Drögemuller C, Kuiper H, Brenig B, Leed T, Distl O, 2003 : Mapping and microsatellite marker development for the porcine leukemia inhibitory factor receptor (LIFR) and epidermal growth factor receptor (EGFR) genes. Cytogenetic Genome Res 98, 216 220.
72. Spötter A, Drögemuller C, Kuiper H, Brenig B, Leeb T, Distl O, 2001a : Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21→q22 and SSC10q11→q12. Cytogenet Cell Genet 95, 92 96.
73. Spötter A, Kuiper H, Drögemuller C, Brenig B, Leeb T, Distl O, 2001b : Assignment of the porcine epidermal growth factor (EGF) gene to SSC8q2.3→q2.4 by fluorescence in situ hybridization and radiation hybrid mapping. Anim Genet 33, 166 167.
74. Spötter A, Drögemuller C, Kuiper H, Brenig B, Leeb T, Distl O, 2001c : Molecular characterization and chromosomal assignment of the porcine gene for leukemia inhibitory factor LIF. Cytogenet Cell Genet 93, 87 90.
75. Steinheuer R, Drögemüller C, Hamann H, Distl O, 2003 : Einsatzmöglichkeiten genetischer Marker zur Steigerung der Fruchtbarkeit und Gesundheit in der Schweineproduktion. Dtsch tierärztl Wschr 110, 255 265.
76. Tess MW, Bennett GL, Dickerson GE, 1983 : Simulation of genetic changes in life cycle efficiency of pork production I. A bioeconomic model. J Anim Sci 56, 336 353.
77. Town SC, Putman CT, Turchinsky NJ, Dixon WT, Foxcroft GR, 2004 : Number of conceptuses in utero affects porcine fetal muscle development. Reprod 128, 443 454.
78. Vallée M, Beaudry D, Roberge C, Matte JJ, Blouin R, Palin MF, 2002 : Identification by subtractive hybridization of the most promising genes related to embryo survival in early gestating sows. Proceedings of 7th WCGALP, Montpellier. Vol. 30, pp. 661 664.
79. Vallet JL, Leymaster KA, Christenson RK, 2002 : The influence of uterine function on embryonic and fetal survival. J Anim Sci 80, E115 E125.
80. Vallet JL, Freking BA, Leymaster KA, Christenson RK, 2005a : Allelic variation in the erythropoietin receptor gene is associated with uterine capacity and litter size in swine. Anim Genet 36, 97 103.
81. Vallet JL, Freking BA, Leymaster KA, Christenson RK, 2005b : Allelic variation in the secreted folate binding protein gene is associated with uterine capacity in swine. J Anim Sci 83, 1860 1867.
82. Van Rens BTTM, de Groot PN, van der Lende T, 2002 : The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts. Theriogenol 57, 1635 1649.
83. Van Rens BTTM, Evans GJ, Van der Lende T, 2003 : Components of litter size in gilts with different prolactin receptor genotypes. Theriogenol 59, 915 926.
84. Vincent A, Wang L, Tuggle CK, Robic A, Rothschild MF, 1997 : Prolactin receptor maps to pig chromosome 16. Mamm Genome 8, 793 794.
85. Vonnahme KA, Wilson ME, Foxcroft GR, Ford SP, 2002 : Impacts on conceptus survival in a commercial swine herd. J Anim Sci 80, 553 559.
86. Webb AJ, 1998 : Objectives and strategies in pig improvement: an applied perspective. J Dairy Sci 81, 36 46.
87. Wilkie PJ, Paszek AA, Beattie CW, Alexander LJ, Wheeler MB, Schook LB, 1999 : A genomic scan of porcine reproductive traits reveals possible quantitative trait loci (QTLs) for number of corpora lutea. Mamm Genome 10, 573 578.
88. Wilson ME, Fahrenkrug SC, Smith TP, Rohrer GA, Ford SP, 2002 : Differential expression of cyclooxygenase-2 around the time of elongation in the pig conceptus. Anim Reprod Sci 71, 229 237.
89. Yelich JV, Pomp D, Geisert RD, 1997a : Detection of transcripts for retinoic acid receptors, retinol binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus. Biol Reprod 57, 286 294.
90. Ying C, Yang YC, Hong WF, Cheng WTK, Hsu WL, 2000 : Progesterone receptor gene expression in preimplantation pig embryos. Eur J Endocrinol 143, 697 703.
91. Zaleski HM, Hacker RR, 1993 : Effect of oxygen and neostigmine on stillbirth and pig viability. J Anim Sci 7, 298 305.
92. Zhang Z, Krause M, Davis DL, 1992a : Epidermal growth factor receptors in porcine endometrium: binding characteristics and the regulation of prostaglandin E and F2α production. Biol Reprod 46, 932 936.
93. Zhang Y, Paria BC, Dey SK, Davis DL, 1992b : Characterization of the epidermal growth factor receptor in preimplantation pig conceptuses. Dev Biol 151, 617 621.