메뉴 건너뛰기




Volumn 4, Issue 10, 2007, Pages 739-750

Toxicokinetics of methyl tert-butyl ether (MTBE) and tert-amyl methyl ether (TAME) in humans, and implications to their biological monitoring

Author keywords

Biological monitoring; Gasoline oxygenates; Inhalation exposure of humans; Kinetics; Methyl tert butyl ether and tert butyl alcohol; tert amyl methyl ether and tert amyl alcohol

Indexed keywords

2 METHYL 2 BUTANOL; ALCOHOL DERIVATIVE; ETHER DERIVATIVE; GASOLINE; OXYGENASE; TERT AMYL METHYL ETHER; TERT BUTYL ALCOHOL; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

EID: 34547642794     PISSN: 15459624     EISSN: 15459632     Source Type: Journal    
DOI: 10.1080/15459620701551540     Document Type: Article
Times cited : (10)

References (28)
  • 3
    • 34547645576 scopus 로고    scopus 로고
    • American Conference of Governmental Industrial Hygienists (ACGIH): tert-Amyl Methyl Ether. In Documentation of the Threshold Limit Values and Biological Exposure Indices, 7th ed. Cincinnati, Ohio: ACGIH, 2003.
    • American Conference of Governmental Industrial Hygienists (ACGIH): tert-Amyl Methyl Ether. In Documentation of the Threshold Limit Values and Biological Exposure Indices, 7th ed. Cincinnati, Ohio: ACGIH, 2003.
  • 4
    • 0028254480 scopus 로고
    • Sensory, symptomatic, inflammatory and ocular response to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment
    • Prah, J.D., G.M. Goldstein, R. Devlin, et al.: Sensory, symptomatic, inflammatory and ocular response to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment. Inhal. Toxicol. 6:521-538 (1994).
    • (1994) Inhal. Toxicol , vol.6 , pp. 521-538
    • Prah, J.D.1    Goldstein, G.M.2    Devlin, R.3
  • 5
    • 1342288984 scopus 로고    scopus 로고
    • Dermal, oral and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers
    • Prah, J., D. Ashley, B. Blount, et al.: Dermal, oral and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers. Toxicol. Sci. 77:195-205 (2004).
    • (2004) Toxicol. Sci , vol.77 , pp. 195-205
    • Prah, J.1    Ashley, D.2    Blount, B.3
  • 6
    • 0032845960 scopus 로고    scopus 로고
    • Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans
    • Amberg, A., E. Rosner, and W. Dekant: Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans. Toxicol. Sci. 51:1-8 (1999).
    • (1999) Toxicol. Sci , vol.51 , pp. 1-8
    • Amberg, A.1    Rosner, E.2    Dekant, W.3
  • 7
    • 0031194650 scopus 로고    scopus 로고
    • Body burden measurements and models to assess inhalation exposure to methyl tertiary butyl ether (MTBE)
    • Buckley, T.J., J.O. Prah, D. Ashley, R.A. Zweidinger, and L.A. Wallace: Body burden measurements and models to assess inhalation exposure to methyl tertiary butyl ether (MTBE). J. Air Waste Manage. Assoc. 47:739-752 (1997).
    • (1997) J. Air Waste Manage. Assoc , vol.47 , pp. 739-752
    • Buckley, T.J.1    Prah, J.O.2    Ashley, D.3    Zweidinger, R.A.4    Wallace, L.A.5
  • 9
    • 0034991254 scopus 로고    scopus 로고
    • Toxicokinetics of human exposure to methyl tertiary-butyl ether (MTBE) following short-term controlled exposures
    • Lee C.W., S.N. Mohr, and C.P. Weisel: Toxicokinetics of human exposure to methyl tertiary-butyl ether (MTBE) following short-term controlled exposures. J. Exp. Anal. Environ. Epidemiol. 11(2):67-78 (2001).
    • (2001) J. Exp. Anal. Environ. Epidemiol , vol.11 , Issue.2 , pp. 67-78
    • Lee, C.W.1    Mohr, S.N.2    Weisel, C.P.3
  • 10
    • 0032007257 scopus 로고    scopus 로고
    • Experimental exposure to methyl tertiary-butyl ether. I. Toxicokinetics in humans
    • Nihlén, A., A. Löf, and G. Johanson: Experimental exposure to methyl tertiary-butyl ether. I. Toxicokinetics in humans. Toxicol. Appl. Pharmacol. 148:274-280 (1998).
    • (1998) Toxicol. Appl. Pharmacol , vol.148 , pp. 274-280
    • Nihlén, A.1    Löf, A.2    Johanson, G.3
  • 12
    • 0031726967 scopus 로고    scopus 로고
    • Exposure to MTBE and TAME in gasoline during tank lorry loading and its measurement using biological monitoring
    • Vainiotalo, S., K. Pekari, and A. Aitio: Exposure to MTBE and TAME in gasoline during tank lorry loading and its measurement using biological monitoring. Int. Arch. Occup. Environ. Health 71:391-396 (1998).
    • (1998) Int. Arch. Occup. Environ. Health , vol.71 , pp. 391-396
    • Vainiotalo, S.1    Pekari, K.2    Aitio, A.3
  • 14
    • 0018693845 scopus 로고
    • Partition coefficients of some aromatic hydrocarbons and ketones inwater, blood and oil
    • Sato, A., and T. Nakajima: Partition coefficients of some aromatic hydrocarbons and ketones inwater, blood and oil. Br. J. Ind. Med. 36:231-234 (1979).
    • (1979) Br. J. Ind. Med , vol.36 , pp. 231-234
    • Sato, A.1    Nakajima, T.2
  • 15
    • 0033400825 scopus 로고    scopus 로고
    • Principles for the assessment of risks to human health from exposure to chemicals
    • World Health Organization WHO, Geneva: WHO
    • World Health Organization (WHO): Principles for the assessment of risks to human health from exposure to chemicals. Environmental Health Criteria 210. Geneva: WHO, 1999.
    • (1999) Environmental Health Criteria 210
  • 16
    • 84930316126 scopus 로고
    • Determination of rate constants
    • Hamilton, Ontario: Hamilton Press
    • Ritschel, W.A.: Determination of rate constants. In Handbook of Basic Pharmacokinetics. Hamilton, Ontario: Hamilton Press, 1977. pp. 187-188.
    • (1977) Handbook of Basic Pharmacokinetics , pp. 187-188
    • Ritschel, W.A.1
  • 17
    • 0034121895 scopus 로고    scopus 로고
    • Biotransformation and kinetics of excretion of tert.-amyl methyl ether in humans and rats after inhalation exposure
    • Amberg, A., E. Rosner, and W. Dekant: Biotransformation and kinetics of excretion of tert.-amyl methyl ether in humans and rats after inhalation exposure. Toxicol. Sci. 55:279-283 (2000).
    • (2000) Toxicol. Sci , vol.55 , pp. 279-283
    • Amberg, A.1    Rosner, E.2    Dekant, W.3
  • 18
    • 0035883501 scopus 로고    scopus 로고
    • Toxicology and human health effects following exposure to oxygenated or reformulated gasoline
    • Ahmed, F.E.: Toxicology and human health effects following exposure to oxygenated or reformulated gasoline. Toxicol. Lett. 123(2-3):89-113 (2001).
    • (2001) Toxicol. Lett , vol.123 , Issue.2-3 , pp. 89-113
    • Ahmed, F.E.1
  • 19
    • 0029609948 scopus 로고
    • Liquid/air partition coefficients of methyl and ethyl t-butylethers, t-amyl methyl ether and t-butyl alcohol
    • Nihlén, A., A. Löf, and G. Johanson: Liquid/air partition coefficients of methyl and ethyl t-butylethers, t-amyl methyl ether and t-butyl alcohol. J. Expos. Anal. Environ. Epidemiol. 5:573-582 (1995).
    • (1995) J. Expos. Anal. Environ. Epidemiol , vol.5 , pp. 573-582
    • Nihlén, A.1    Löf, A.2    Johanson, G.3
  • 20
    • 0034057426 scopus 로고    scopus 로고
    • Partition coefficients for gasoline additives and their metabolites
    • Kaneko, T., P.-Y. Wang, and A. Sato: Partition coefficients for gasoline additives and their metabolites. J. Occup. Health 42:86-87 (2000).
    • (2000) J. Occup. Health , vol.42 , pp. 86-87
    • Kaneko, T.1    Wang, P.-Y.2    Sato, A.3
  • 21
    • 0032586283 scopus 로고    scopus 로고
    • Biotransformation of [12C]- and [13C]-tert-amyl methyl ether and tert amyl alcohol
    • Amberg, A., U. Bernauer, D. Scheutzow, and W. Dekant: Biotransformation of [12C]- and [13C]-tert-amyl methyl ether and tert amyl alcohol. Chem. Res. Toxicol. 12:958-964 (1999).
    • (1999) Chem. Res. Toxicol , vol.12 , pp. 958-964
    • Amberg, A.1    Bernauer, U.2    Scheutzow, D.3    Dekant, W.4
  • 23
    • 0019134294 scopus 로고
    • Oxidative demethylation of t-butyl alcohol by rat liver microsomes
    • Cederbaum, A.I., and G. Cohen: Oxidative demethylation of t-butyl alcohol by rat liver microsomes. Biochem. Biophys. Res. Commun. 97:730-736 (1980).
    • (1980) Biochem. Biophys. Res. Commun , vol.97 , pp. 730-736
    • Cederbaum, A.I.1    Cohen, G.2
  • 24
    • 0021049516 scopus 로고
    • Production of formaldehyde and acetone by hydroxyl-radical generating systems during the metabolism of tertiary butyl alcohol
    • Cederbaum, A.I., A. Qureshi, and G. Cohen: Production of formaldehyde and acetone by hydroxyl-radical generating systems during the metabolism of tertiary butyl alcohol. Biochem. Pharmacol. 32:3517-3524 (1983).
    • (1983) Biochem. Pharmacol , vol.32 , pp. 3517-3524
    • Cederbaum, A.I.1    Qureshi, A.2    Cohen, G.3
  • 25
    • 0033215097 scopus 로고    scopus 로고
    • Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: Identification of CYP2A6 as a major catalyst
    • Hong J.Y., Y.Y. Wang, F.Y. Bondoc, et al.: Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: Identification of CYP2A6 as a major catalyst. Toxicol. Appl. Pharmacol. 160:43-48 (1999).
    • (1999) Toxicol. Appl. Pharmacol , vol.160 , pp. 43-48
    • Hong, J.Y.1    Wang, Y.Y.2    Bondoc, F.Y.3
  • 26
    • 0035887386 scopus 로고    scopus 로고
    • Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels
    • Le Gal, A., Y. Dréano, P.G. Gervasi, and F. Berthou: Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels. Toxicol. Lett. 124:47-58 (2001).
    • (2001) Toxicol. Lett , vol.124 , pp. 47-58
    • Le Gal, A.1    Dréano, Y.2    Gervasi, P.G.3    Berthou, F.4
  • 27
    • 0043161937 scopus 로고    scopus 로고
    • Diversity of selective environmental substrates for human cytochrome P450 2A6: Alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine
    • Le Gal A., Y. Dréano, D. Lucas, and F. Berthou: Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine. Toxicol. Lett. 144:77-91 (2003).
    • (2003) Toxicol. Lett , vol.144 , pp. 77-91
    • Le Gal, A.1    Dréano, Y.2    Lucas, D.3    Berthou, F.4
  • 28
    • 0037607104 scopus 로고    scopus 로고
    • Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels
    • Kawai, T., Z.W. Zwang, A. Takeuchi, et al.: Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. Int. Arch. Occup. Environ. Health 76:17-23 (2003).
    • (2003) Int. Arch. Occup. Environ. Health , vol.76 , pp. 17-23
    • Kawai, T.1    Zwang, Z.W.2    Takeuchi, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.