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Volumn 196, Issue 4, 2007, Pages 510-521

Human T lymphotropic virus type 1 subtype C melanesian genetic variants of the Vanuatu archipelago and solomon islands share a common ancestor

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VIRUS ANTIBODY;

EID: 34547621654     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/519167     Document Type: Article
Times cited : (29)

References (50)
  • 1
    • 0019254359 scopus 로고
    • Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
    • Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980; 77:7415-9.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 7415-7419
    • Poiesz, B.J.1    Ruscetti, F.W.2    Gazdar, A.F.3    Bunn, P.A.4    Minna, J.D.5    Gallo, R.C.6
  • 2
    • 0019781211 scopus 로고
    • Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera
    • Hinuma Y, Nagata K, Hanaoka M, et al. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78:6476-80.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6476-6480
    • Hinuma, Y.1    Nagata, K.2    Hanaoka, M.3
  • 3
    • 0000904435 scopus 로고
    • Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease
    • Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 1982; 79:2031-5.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 2031-2035
    • Yoshida, M.1    Miyoshi, I.2    Hinuma, Y.3
  • 4
    • 0021995980 scopus 로고
    • Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
    • Gessain A, Barin F, Vernant JC, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 2:407-10.
    • (1985) Lancet , vol.2 , pp. 407-410
    • Gessain, A.1    Barin, F.2    Vernant, J.C.3
  • 6
    • 3042823926 scopus 로고    scopus 로고
    • Human T-cell leukaemia/lymphoma virus type 1-associated infective dermatitis in Africa: A report of five cases from Senegal
    • Mahe A, Meertens L, Ly F, et al. Human T-cell leukaemia/lymphoma virus type 1-associated infective dermatitis in Africa: a report of five cases from Senegal. Br J Dermatol 2004; 150:958-65.
    • (2004) Br J Dermatol , vol.150 , pp. 958-965
    • Mahe, A.1    Meertens, L.2    Ly, F.3
  • 7
    • 0031261067 scopus 로고    scopus 로고
    • Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding
    • Wiktor SZ, Pate EJ, Rosenberg PS, et al. Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding. J Hum Virol 1997; 1:37-44.
    • (1997) J Hum Virol , vol.1 , pp. 37-44
    • Wiktor, S.Z.1    Pate, E.J.2    Rosenberg, P.S.3
  • 8
    • 0024342411 scopus 로고
    • Sexual transmission of human T-lymphotropic virus type I (HTLV-I)
    • Murphy EL, Figueroa JP, Gibbs WN, et al. Sexual transmission of human T-lymphotropic virus type I (HTLV-I). Ann Intern Med 1989; 111:555-60.
    • (1989) Ann Intern Med , vol.111 , pp. 555-560
    • Murphy, E.L.1    Figueroa, J.P.2    Gibbs, W.N.3
  • 9
    • 0026653607 scopus 로고
    • A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion
    • Manns A, Wilks RJ, Murphy EL, et al. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int J Cancer 1992; 51:886-91.
    • (1992) Int J Cancer , vol.51 , pp. 886-891
    • Manns, A.1    Wilks, R.J.2    Murphy, E.L.3
  • 11
    • 0033526648 scopus 로고    scopus 로고
    • Human T-lymphotropic virus type I infection
    • Manns A, Hisada M, La Grenade L. Human T-lymphotropic virus type I infection. Lancet 1999; 353:1951-8.
    • (1999) Lancet , vol.353 , pp. 1951-1958
    • Manns, A.1    Hisada, M.2    La Grenade, L.3
  • 12
    • 0345711455 scopus 로고    scopus 로고
    • Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses
    • Slattery JP, Franchini G, Gessain A. Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res 1999; 9:525-40.
    • (1999) Genome Res , vol.9 , pp. 525-540
    • Slattery, J.P.1    Franchini, G.2    Gessain, A.3
  • 13
    • 0026590703 scopus 로고
    • Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations
    • Gessain A, Gallo RC, Franchini G. Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. J Virol 1992; 66:2288-95.
    • (1992) J Virol , vol.66 , pp. 2288-2295
    • Gessain, A.1    Gallo, R.C.2    Franchini, G.3
  • 14
    • 0025816552 scopus 로고
    • In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies
    • Komurian F, Pelloquin F, de Thé G. In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. J Virol 1991; 65:3770-8.
    • (1991) J Virol , vol.65 , pp. 3770-3778
    • Komurian, F.1    Pelloquin, F.2    de Thé, G.3
  • 15
    • 0028147681 scopus 로고
    • Phylogenetic subtypes of human T-lymphotropic virus type I and their relations to the anthropological background
    • Miura T, Fukunaga T, Igarashi T, et al. Phylogenetic subtypes of human T-lymphotropic virus type I and their relations to the anthropological background. Proc Natl Acad Sci USA 1994; 91:1124-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1124-1127
    • Miura, T.1    Fukunaga, T.2    Igarashi, T.3
  • 16
    • 0031023572 scopus 로고    scopus 로고
    • Molecular epidemiology of 58 new African human T-cell leukemia virus type 1 (HTLV-1) strains: Identification of a new and distinct HTLV-1 molecular subtype in Central Africa and in Pygmies
    • Mahieux R, Ibrahim F, Mauclere P, et al. Molecular epidemiology of 58 new African human T-cell leukemia virus type 1 (HTLV-1) strains: identification of a new and distinct HTLV-1 molecular subtype in Central Africa and in Pygmies. J Virol 1997; 71:1317-33.
    • (1997) J Virol , vol.71 , pp. 1317-1333
    • Mahieux, R.1    Ibrahim, F.2    Mauclere, P.3
  • 17
    • 0027949796 scopus 로고
    • Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations
    • Yanagihara R. Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations. Adv Virus Res 1994; 43:147-86.
    • (1994) Adv Virus Res , vol.43 , pp. 147-186
    • Yanagihara, R.1
  • 18
    • 0026653475 scopus 로고
    • LTR sequence and phylogenetic analyses of a newly discovered variant of HTLV-I isolated from the Hagahai of Papua New Guinea
    • Saksena NK, Sherman MP, Yanagihara R, Dube DK, Poiesz BJ. LTR sequence and phylogenetic analyses of a newly discovered variant of HTLV-I isolated from the Hagahai of Papua New Guinea. Virology 1992; 189:1-9.
    • (1992) Virology , vol.189 , pp. 1-9
    • Saksena, N.K.1    Sherman, M.P.2    Yanagihara, R.3    Dube, D.K.4    Poiesz, B.J.5
  • 19
    • 0025143949 scopus 로고
    • Human T lymphotropic virus type I infection in Papua New Guinea: High prevalence among the Hagahai confirmed by Western analysis
    • Yanagihara R, Jenkins CL, Alexander SS, Mora CA, Garruto RM. Human T lymphotropic virus type I infection in Papua New Guinea: high prevalence among the Hagahai confirmed by Western analysis. J Infect Dis 1990; 162:649-54.
    • (1990) J Infect Dis , vol.162 , pp. 649-654
    • Yanagihara, R.1    Jenkins, C.L.2    Alexander, S.S.3    Mora, C.A.4    Garruto, R.M.5
  • 20
    • 0027428330 scopus 로고
    • Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon Islands
    • Nerurkar VR, Song KJ, Saitou N, Melland RR, Yanagihara R. Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon Islands. Virology 1993; 196:506-13.
    • (1993) Virology , vol.196 , pp. 506-513
    • Nerurkar, V.R.1    Song, K.J.2    Saitou, N.3    Melland, R.R.4    Yanagihara, R.5
  • 21
    • 0025764098 scopus 로고
    • Human T-lymphotropic virus type I infection in the Solomon Islands
    • Yanagihara R, Ajdukiewicz AB, Garruto RM, et al. Human T-lymphotropic virus type I infection in the Solomon Islands. Am J Trop Med Hyg 1991; 44:122-30.
    • (1991) Am J Trop Med Hyg , vol.44 , pp. 122-130
    • Yanagihara, R.1    Ajdukiewicz, A.B.2    Garruto, R.M.3
  • 23
    • 0028421373 scopus 로고
    • Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I variants from Melanesians with and without spastic myelopathy
    • Nerurkar VR, Song KJ, Melland RR, Yanagihara R. Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I variants from Melanesians with and without spastic myelopathy. Mol Neurobiol 1994; 8:155-73.
    • (1994) Mol Neurobiol , vol.8 , pp. 155-173
    • Nerurkar, V.R.1    Song, K.J.2    Melland, R.R.3    Yanagihara, R.4
  • 24
    • 0028057876 scopus 로고
    • HTLV-I and clinical disease correlates in central Australian aborigines
    • Mollison LC. HTLV-I and clinical disease correlates in central Australian aborigines. Med J Aust 1994; 160:238.
    • (1994) Med J Aust , vol.160 , pp. 238
    • Mollison, L.C.1
  • 25
    • 0027497738 scopus 로고
    • Isolation of a human T-lymphotropic virus type I strain from Australian aboriginals
    • Bastian I, Gardner J, Webb D, Gardner I. Isolation of a human T-lymphotropic virus type I strain from Australian aboriginals. J Virol 1993; 67:843-51.
    • (1993) J Virol , vol.67 , pp. 843-851
    • Bastian, I.1    Gardner, J.2    Webb, D.3    Gardner, I.4
  • 26
    • 0027195149 scopus 로고
    • HTLV-I and scabies in Australian aborigines
    • Mollison LC, Lo ST, Marning G. HTLV-I and scabies in Australian aborigines. Lancet 1993; 341:1281-2.
    • (1993) Lancet , vol.341 , pp. 1281-1282
    • Mollison, L.C.1    Lo, S.T.2    Marning, G.3
  • 27
    • 0027396050 scopus 로고
    • Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: Genetic and phylogenetic relationship to HTLV-I strains from other geographical regions
    • Gessain A, Boeri E, Yanagihara R, Gallo RC, Franchini G. Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions. J Virol 1993; 67:1015-23.
    • (1993) J Virol , vol.67 , pp. 1015-1023
    • Gessain, A.1    Boeri, E.2    Yanagihara, R.3    Gallo, R.C.4    Franchini, G.5
  • 28
    • 0025868266 scopus 로고
    • Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands
    • Gessain A, Yanagihara R, Franchini G, et al. Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands. Proc Natl Acad Sci USA 1991; 88:7694-8.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7694-7698
    • Gessain, A.1    Yanagihara, R.2    Franchini, G.3
  • 29
  • 30
    • 0034460084 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1 gag indeterminate western blot patterns in Central Africa: Relationship to Plasmodium falciparum infection
    • Mahieux R, Horal P, Mauclere P, et al. Human T-cell lymphotropic virus type 1 gag indeterminate western blot patterns in Central Africa: relationship to Plasmodium falciparum infection. J Clin Microbiol 2000; 38:4049-57.
    • (2000) J Clin Microbiol , vol.38 , pp. 4049-4057
    • Mahieux, R.1    Horal, P.2    Mauclere, P.3
  • 31
    • 0029334377 scopus 로고    scopus 로고
    • Gessain A, Mathieux R. HTLV-I indeterminate western blot patterns observed in sera from tropical regions: the situation revisited. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 9:316-9.
    • Gessain A, Mathieux R. HTLV-I "indeterminate" western blot patterns observed in sera from tropical regions: the situation revisited. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 9:316-9.
  • 32
    • 0030855431 scopus 로고    scopus 로고
    • Demographic, ethnic, and geographic differences between human T cell lymphotropic virus (HTLV) type I-seropositive carriers and persons with HTLV-I Gag-indeterminate Western blots in Central Africa
    • Mauclere P, Le Hesran JY, Mahieux R, et al. Demographic, ethnic, and geographic differences between human T cell lymphotropic virus (HTLV) type I-seropositive carriers and persons with HTLV-I Gag-indeterminate Western blots in Central Africa. J Infect Dis 1997; 176:505-9.
    • (1997) J Infect Dis , vol.176 , pp. 505-509
    • Mauclere, P.1    Le Hesran, J.Y.2    Mahieux, R.3
  • 33
    • 17944364370 scopus 로고    scopus 로고
    • Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: Close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-1 subtype B strains
    • Meertens L, Rigoulet J, Mauclere P, et al. Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-1 subtype B strains. Virology 2001; 287:275-85.
    • (2001) Virology , vol.287 , pp. 275-285
    • Meertens, L.1    Rigoulet, J.2    Mauclere, P.3
  • 34
    • 0034848170 scopus 로고    scopus 로고
    • DAMBE: Software package for data analysis in molecular biology and evolution
    • Xia X, Xie Z. DAMBE: software package for data analysis in molecular biology and evolution. J Hered 2001; 92:371-3.
    • (2001) J Hered , vol.92 , pp. 371-373
    • Xia, X.1    Xie, Z.2
  • 36
    • 13144260648 scopus 로고    scopus 로고
    • New insights in HTLV-I phylogeny by sequencing and analyzing the entire envelope gene
    • Capdepont S, Londos-Gagliardi D, Joubert M, et al. New insights in HTLV-I phylogeny by sequencing and analyzing the entire envelope gene. AIDS Res Hum Retroviruses 2005; 21:28-42.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 28-42
    • Capdepont, S.1    Londos-Gagliardi, D.2    Joubert, M.3
  • 37
    • 0035062563 scopus 로고    scopus 로고
    • Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes
    • Van Dooren S, Salemi M, Vandamme AM. Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes. Mol Biol Evol 2001; 18:661-71.
    • (2001) Mol Biol Evol , vol.18 , pp. 661-671
    • Van Dooren, S.1    Salemi, M.2    Vandamme, A.M.3
  • 38
    • 0028031617 scopus 로고    scopus 로고
    • Yamaguchi K. Human T-lymphotropic virus type I in Japan. Lancet 1994; 343:213-6.
    • Yamaguchi K. Human T-lymphotropic virus type I in Japan. Lancet 1994; 343:213-6.
  • 39
    • 0026240333 scopus 로고
    • Adult T-cell leukaemia lymphoma in an aborigine
    • Kirkland MA, Frasca J, Bastian I. Adult T-cell leukaemia lymphoma in an aborigine. Aust N Z J Med 1991; 21:739-41.
    • (1991) Aust N Z J Med , vol.21 , pp. 739-741
    • Kirkland, M.A.1    Frasca, J.2    Bastian, I.3
  • 40
    • 0034059957 scopus 로고    scopus 로고
    • Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different western blot criteria
    • Takao S, Ishida T, Bhatia KK, Saha N, Soemantri A, Kayame OW. Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different western blot criteria. J Clin Virol 2000; 16:129-33.
    • (2000) J Clin Virol , vol.16 , pp. 129-133
    • Takao, S.1    Ishida, T.2    Bhatia, K.K.3    Saha, N.4    Soemantri, A.5    Kayame, O.W.6
  • 41
    • 0028002995 scopus 로고
    • Evidence for anti-Plasmodium falciparum antibodies that cross-react with human T-lymphotropic virus type I proteins in a population in Irian Jaya, Indonesia
    • Porter KR, Liang L, Long GW et al. Evidence for anti-Plasmodium falciparum antibodies that cross-react with human T-lymphotropic virus type I proteins in a population in Irian Jaya, Indonesia. Clin Diagn Lab Immunol 1994; 1:11-5.
    • (1994) Clin Diagn Lab Immunol , vol.1 , pp. 11-15
    • Porter, K.R.1    Liang, L.2    Long, G.W.3
  • 42
    • 0026686859 scopus 로고
    • Failure to isolate human T cell lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate western immunoblot
    • Nerurkar VR, Miller MA, Leon-Monzon ME, et al. Failure to isolate human T cell lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate western immunoblot. J Gen Virol 1992; 73:1805-10.
    • (1992) J Gen Virol , vol.73 , pp. 1805-1810
    • Nerurkar, V.R.1    Miller, M.A.2    Leon-Monzon, M.E.3
  • 43
    • 24944493978 scopus 로고    scopus 로고
    • Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana
    • Tortevoye P, Tuppin P, Carles G, Peneau C, Gessain A. Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana. Am J Trop Med Hyg 2005; 73:560-5.
    • (2005) Am J Trop Med Hyg , vol.73 , pp. 560-565
    • Tortevoye, P.1    Tuppin, P.2    Carles, G.3    Peneau, C.4    Gessain, A.5
  • 44
    • 0036374983 scopus 로고    scopus 로고
    • Envelope sequence variation and phylogenetic relations of human T cell lymphotropic virus type 1 from endemic areas of Colombia
    • Dominguez MC, Castillo A, Cabrera J, Eizuru Y, Garcia-Vallejo F. Envelope sequence variation and phylogenetic relations of human T cell lymphotropic virus type 1 from endemic areas of Colombia. AIDS Res Hum Retroviruses 2002; 18:887-90.
    • (2002) AIDS Res Hum Retroviruses , vol.18 , pp. 887-890
    • Dominguez, M.C.1    Castillo, A.2    Cabrera, J.3    Eizuru, Y.4    Garcia-Vallejo, F.5
  • 45
    • 1542744620 scopus 로고    scopus 로고
    • Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon: A prospective follow-up of 4 years
    • Nyambi PN, Ville Y, Louwagie J, et al. Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon: a prospective follow-up of 4 years. J Acquir Immune Defic Syndr Hum Retrovirol 1996; 12:187-92.
    • (1996) J Acquir Immune Defic Syndr Hum Retrovirol , vol.12 , pp. 187-192
    • Nyambi, P.N.1    Ville, Y.2    Louwagie, J.3
  • 46
    • 33645952982 scopus 로고    scopus 로고
    • Seroprevalence and molecular epidemiology of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 in blood donors from Dakar, Senegal
    • Diop S, Calattini S, Abah-Dakou J, Thiam D, Diakhate L, Gessain A. Seroprevalence and molecular epidemiology of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 in blood donors from Dakar, Senegal. J Clin Microbiol 2006; 44:1550-4.
    • (2006) J Clin Microbiol , vol.44 , pp. 1550-1554
    • Diop, S.1    Calattini, S.2    Abah-Dakou, J.3    Thiam, D.4    Diakhate, L.5    Gessain, A.6
  • 49
    • 33748143448 scopus 로고    scopus 로고
    • Molecular epidemiology of the HHV-8 K1 gene from Moroccan patients with Kaposi's sarcoma
    • Duprez R, Hbid O, Afonso P, et al. Molecular epidemiology of the HHV-8 K1 gene from Moroccan patients with Kaposi's sarcoma. Virology 2006; 353:121-32.
    • (2006) Virology , vol.353 , pp. 121-132
    • Duprez, R.1    Hbid, O.2    Afonso, P.3
  • 50
    • 0038391040 scopus 로고    scopus 로고
    • Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs
    • Alcantara LC, Shindo N, Van Dooren S, et al. Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. AIDS Res Hum Retroviruses 2003; 19:519-23.
    • (2003) AIDS Res Hum Retroviruses , vol.19 , pp. 519-523
    • Alcantara, L.C.1    Shindo, N.2    Van Dooren, S.3


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