8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 29, Issue 4, 2007, Pages 269-272

  Ebenezer, I S ^a   Arkle, M J ^a   Tite, R M ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

5 HT1A receptor; 8 OH DPAT; Food intake; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; FOOD INTAKE; HYPOPHAGIA; MALE; NONHUMAN; RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; APPETITE DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FASTING; FOOD DEPRIVATION; INJECTIONS, SUBCUTANEOUS; MALE; PIPERAZINES; PYRIDINES; RATS; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TIME FACTORS;

EID: 34547617377     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2007.29.4.1075362     Document Type: Article

References (23)

1. Hoyer, D., Hannon, J.P., Martin, G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002, 71: 533-54.
2. Blundell, J.E. Serotonin and appetite. Neuropharmacology 1984, 23: 1537-51.
3. Simansky, K.J. Serotonergic control of the organization of feeding and satiety. Behav Brain Res 1996, 73: 37-42.
4. Dourish, C.T., Hutson, P.H., Curzon, G. Characteristics of feeding induced by the serotonin agonist 2-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res Bull 1985, 15: 377-84.
5. 1A agonist 8-OH-DPAT on operant food intake in non-deprived rats. NeuroReport 1992, 3: 62-4.
6. Gilbert, F., Dourish, C.T. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology (Berl) 1987, 93: 349-52.
7. Fletcher, P.J., Davis, M. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. Br J Pharmacol 1990, 99: 519-25.
8. Ebenezer, I.S. Effects of gepirone and buspirone on operant food intake in non-deprived rats. Br J Pharmacol 1993, 110: 98P.
9. 1A agonist 8-OH-DPAT and gepirone. Meth Find Exp Clin Pharmacol 1994, 16: 91-6.
10. Bendotti, C., Samanin, R. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free feeding rats by acting on central serotonin neurons. Eur J Pharmacol 1986, 121: 147-50.
11. 1B agonists. Synapse 1987, 1: 3-9.
12. 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rats brain in vivo. Naunyn Schmied Arch Pharmacol 1988, 338: 463-71.
13. 1A agonist 8-OH-DPAT on food intake in food deprived rats. NeuroReport 1992, 3: 1019-22.
14. 1A receptor antagonist. Behav Brain Res 1996, 73: 337-53.
15. Ebenezer, I.S. The effect of intracerebroventricular administration of baclofen on food intake in rats. NeuroReport 1990. 1: 73-6.
16. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino) tetralin in the rats. Eur J Pharmacol 1984, 105: 271-82.
17. 1A receptor agonist 8-OH-DPAT on food intake in food-deprived pigs. Physiol Behav 1999, 67: 213-17.
18. 1A receptor agonist 8-OH-DPAT on food and water intake in chickens. Physiol Behav 2002, 75: 271-5.
19. 1A receptors. Eur J Pharmacol 2000, 408: 273-6.
20. Ebenezer, I.S. Effects of buspirone on operant and non-operant food intake in food-deprived rats. Methods Find Exp Clin Pharmacol 1996, 18: 475-80.
21. 1A receptors. Med Chem Res 1994, 4: 161-9.
22. 1A antagonists MM-77 and WAY 100635 on the mouse isolated vasa deferentia. Autonom Autocoid Pharmacol 2005, 25: 121-7.
23. 1A agonist MM-77 on feeding in rats. Proc Brit Pharmacol Soc 2004, 2(1): abstract no. 017P (available at http://www.pa2online.org).