Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays

Journal of Endotoxin Research

Volumn 13, Issue 2, 2007, Pages 126-132

  Heine, Holger ^a   Gronow, Sabine ^a   Zamyatina, Alla ^b   Kosma, Paul ^b   Brade, Helmut ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Chlamydia; Lipid A; Penta acyl lipid A; Synthetic; Tetra acyl lipid A

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 8; LIPID A; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; 3 DEOXY D MANNO OCTULOSONATE TRANSFERASE; 3-DEOXY-D-MANNO-OCTULOSONATE TRANSFERASE; CD14 ANTIGEN; DRUG DERIVATIVE; GLYCOLIPID; IL8 PROTEIN, HUMAN; LIPID A PRECURSORS, BACTERIAL; LY96 PROTEIN, HUMAN; PROTEIN MD 2; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HEK293; CHLAMYDIA; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PSITTACI; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ASSAY; ESCHERICHIA COLI; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; SALMONELLA ENTERICA; THIN LAYER CHROMATOGRAPHY; CELL LINE; CHEMISTRY; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM;

CHLAMYDIA; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PSITTACI; ESCHERICHIA COLI; SALMONELLA ENTERICA; TETRA;

ANTIGENS, CD14; CELL LINE; CHLAMYDIA; GLYCOLIPIDS; HUMANS; INTERLEUKIN-8; LIPID A; LYMPHOCYTE ANTIGEN 96; RECOMBINANT PROTEINS; TOLL-LIKE RECEPTORS; TRANSFECTION; TRANSFERASES;

EID: 34547612277     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/0968051907079122     Document Type: Article

References (28)

1. Stephens RS Chlamydia. Washington, DC: ASM Press, 1999.
2. Moulder JW Interaction of Chlamydiae and host cells in vitro. Microbiol Rev 1991; 55: 143-190.
3. Everett KD Chlamydia and Chlamydiales: More than meets the eye. Vet Microbiol 2000; 75: 109-126.
4. Brade H., Brabetz W., Brade L. et al. Chlamydial lipopolysaccharide. J Endotoxin Res 1997; 4: 67-84.
5. Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annu Rev Biochem 2002; 71: 635-700.
6. Alexander C., Rietschel ET Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001; 7: 167-202.
7. Loppnow H, Rietschel ETH, Brade H et al. Lipid A precursor Ia (compound 406) and Rhodobacter capsulatus lipopolysaccharide: Potent endotoxin antagonists in the human system in vitro. In: Levin J, Alving CR, Munford RS, Stütz PL. (eds) Bacterial endotoxin: Recognition and effector mechanisms. Amsterdam: Elsevier Science, 1993; 337 - 348.
8. Heine H., Muller-Loennies S., Brade L., Lindner B., Brade H. Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC. Eur J Biochem 2003; 270: 440-450.
9. Ingalls RR, Rice PA, Qureshi N., Takayama K., Lin JS, Golenbock DT The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun 1995; 63: 3125-3130.
10. Rund S., Lindner B., Brade H., Holst O. Structural analysis of the lipopolysaccharide from Chlamydia trachomatis serotype L2. J Biol Chem 1999; 274: 16819-16824.
11. Rund S., Lindner B., Brade H., Holst O. Structural analysis of the lipopolysaccharide from Chlamydophila psittaci strain 6BC. Eur J Biochem 2000; 267: 5717-5726.
12. Qureshi N., Kaltashov I., Walker K. et al. Structure of the mono-phosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem 1997; 272:10594-10600.
13. Galanos C., Lüderitz O., Westphal O. Preparation and properties of a standardized lipopolysaccharide from Salmonella abortus equi. Zbl Bakt Hyg I Abt Orig 1979; 243: 226-244.
14. Imoto M., Yoshimura H., Yamamoto M., Shimamoto T., Kusumoto S., Shiba T. Chemical synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor of lipid A. Tetrahedr Lett 1985; 25: 2667.
15. Imoto M., Yoshimura H., Shimamoto S., Sakaguchi N., Kusumoto S., Shiba T. Total synthesis of Escherichia coli lipid A, the endotoxically active principle of cell-surface lipopolysaccharide. Bull Chem Soc Jpn 1987; 60: 2205-2214.
16. Zamyatina A., Sekljic H., Brade H., Kosma P. Synthesis and purity assessment of tetra-and pentaacyl lipid A of Chlamydia containing (R)-3-hydroxyicosanoic acid. Tetrahedron 2004; 60: 12113-12137.
17. Brabetz W., Lindner B., Brade H. Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12. Eur J Biochem 2000; 267: 5458-5465.
18. Bode CE, Brabetz W., Brade H. Cloning and characterization of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase genes (kdtA) from Acinetobacter baumannii and Acinetobacter haemolyticus. Eur J Biochem 1998; 254: 404-412.
19. Gronow S., Brabetz W., Brade H. Comparative functional characterization in vitro of heptosyltransferase I (WaaC) and II (WaaF) from Escherichia coli. Eur J Biochem 2000; 267: 6602-6611.
20. Hirschfeld M., Weis JJ, Toshchakov V. et al. Signaling by Toll-Like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001; 69: 1477-1482.
21. Werts C., Tapping RI, Mathison JC et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2001; 2: 346-352.
22. Girard R., Pedron T., Uematsu S. et al. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 2003; 116: 293-302.
23. Takada H., Kotani S., Tsujimoto M. et al. Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule and of its analogs. Infect Immun 1985; 48: 219-227.
24. Belunis CJ, Raetz CRH. Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. J Biol Chem 1992; 267: 9988-9997.
25. Stephens RS The cellular paradigm of chlamydial pathogenesis. Trends Microbiol 2003; 11: 44-51.
26. Campbell LA, Kuo CC Chlamydia pneumoniae - an infectious risk factor for atherosclerosis? Nat Rev Microbiol 2004; 2: 23-32.
27. Hahn DL Chlamydia pneumoniae and asthma: More than just exacerbations. J Allergy Clin Immunol 2004; 113: 568.
28. Hammerschlag MR Chlamydia pneumoniae and asthma in children: Diagnostic issues. Clin Infect Dis 2004; 39: 1251-1252.