Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell

Protein Science

Volumn 16, Issue 8, 2007, Pages 1641-1658

  Manning, Lois R ^a   Russell, J Eric ^b   Padovan, Julio C ^c   Chait, Brian T ^c   Popowicz, Anthony ^c   Manning, Robert S ^d   Manning, James M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d HAVERFORD COLLEGE   (United States)

Author keywords

Adult human hemoglobins; Embryonic; Fetal; Hemoglobin; Subunit competition; Subunit exchange; Subunit interfaces

Indexed keywords

DIMER; HEMOGLOBIN CHAIN; HEMOGLOBIN F; HEMOGLOBIN H; TETRAMER;

ALPHA CHAIN; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE LIFESPAN; HEMOGLOBIN ANALYSIS; HEMOGLOBINOPATHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN QUALITY; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE;

ANIMALS; DIMERIZATION; EMBRYO; ERYTHROCYTES; FETAL HEMOGLOBIN; HEMOGLOBIN A2; HEMOGLOBINS; HEMOGLOBINS, ABNORMAL; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SPECIES SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34547591811     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.072891007     Document Type: Article

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