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Volumn 101, Issue 2, 2007, Pages 116-118

Old drug, new tricks: The unexpected effect of doxazosin on high-density lipoprotein

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ADAPTOR PROTEIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ANTIARRHYTHMIC AGENT; APOLIPOPROTEIN A1; CHLORTALIDONE; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; DOXAZOSIN; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; NORADRENALIN; PHOSPHATASE; PROBUCOL; PROTEIN KINASE B BETA;

EID: 34547589762     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.157404     Document Type: Editorial
Times cited : (12)

References (27)
  • 2
    • 3142709408 scopus 로고    scopus 로고
    • Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation
    • Wu CA, Tsujita M, Hayashi M, Yokoyama S. Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J Biol Chem. 2004;279:30168-30174.
    • (2004) J Biol Chem , vol.279 , pp. 30168-30174
    • Wu, C.A.1    Tsujita, M.2    Hayashi, M.3    Yokoyama, S.4
  • 3
    • 27144475012 scopus 로고    scopus 로고
    • Tangier disease: Still more questions than answers
    • Nofer JR, Remaley AT. Tangier disease: still more questions than answers. Cell Mol Life Sci. 2005;62:2150-2160.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 2150-2160
    • Nofer, J.R.1    Remaley, A.T.2
  • 5
    • 20144373625 scopus 로고    scopus 로고
    • Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner
    • Arakawa R, Tamehiro N, Nishimaki-Mogami T, Ueda K, Yokoyama S. Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005;25:1193-1197.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1193-1197
    • Arakawa, R.1    Tamehiro, N.2    Nishimaki-Mogami, T.3    Ueda, K.4    Yokoyama, S.5
  • 6
    • 34547586715 scopus 로고    scopus 로고
    • ATP binding cassette transporter A1 gene transcription is downregulated by the Activator Protein (AP) 2 α: Doxazosin inhibits AP2α and increases high-density lipoprotein biogenesis being independent of α1-adrenoreceptor blockade
    • Iwamoto N, Abe-Dohmae S, Ayaori M, Tanaka N, Kusuhara M, Ohsuzu F, Yokoyama S. ATP binding cassette transporter A1 gene transcription is downregulated by the Activator Protein (AP) 2 α: Doxazosin inhibits AP2α and increases high-density lipoprotein biogenesis being independent of α1-adrenoreceptor blockade. Circ Res. 2007;101:156-165.
    • (2007) Circ Res , vol.101 , pp. 156-165
    • Iwamoto, N.1    Abe-Dohmae, S.2    Ayaori, M.3    Tanaka, N.4    Kusuhara, M.5    Ohsuzu, F.6    Yokoyama, S.7
  • 7
    • 34249109074 scopus 로고    scopus 로고
    • Usefulness of the alpha1-blocker doxazosin as a third-line antihypertensive drug
    • Ohta Y, Tsuchihashi T, Onaka U, Eto K, Ueno M. Usefulness of the alpha1-blocker doxazosin as a third-line antihypertensive drug. Hypertens Res. 2007;30:301-306.
    • (2007) Hypertens Res , vol.30 , pp. 301-306
    • Ohta, Y.1    Tsuchihashi, T.2    Onaka, U.3    Eto, K.4    Ueno, M.5
  • 8
    • 34250867383 scopus 로고    scopus 로고
    • Finasteride and doxazosin alone or in combination for the treatment of benign prostatic hyperplasia
    • Bhardwa J, Goldstraw M, Tzortzis S, Kirby R. Finasteride and doxazosin alone or in combination for the treatment of benign prostatic hyperplasia. Expert Opin Pharmacother. 2007;8:1337-1344.
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 1337-1344
    • Bhardwa, J.1    Goldstraw, M.2    Tzortzis, S.3    Kirby, R.4
  • 9
    • 33947641548 scopus 로고    scopus 로고
    • Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: Biomolecular implications and clinical relevance
    • Alberti C. Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: biomolecular implications and clinical relevance. Eur Rev Med Pharmacol Sci. 2007;11:59-64.
    • (2007) Eur Rev Med Pharmacol Sci , vol.11 , pp. 59-64
    • Alberti, C.1
  • 10
    • 19344363324 scopus 로고    scopus 로고
    • Molecular classification of doxazosin-induced alterations in the rat prostate using gene expression profiling
    • Yono M, Foster HE, Shin D, Mane S, Latifpour J. Molecular classification of doxazosin-induced alterations in the rat prostate using gene expression profiling. Life Sci. 2005;77:470-479.
    • (2005) Life Sci , vol.77 , pp. 470-479
    • Yono, M.1    Foster, H.E.2    Shin, D.3    Mane, S.4    Latifpour, J.5
  • 11
    • 0024518052 scopus 로고
    • α-1 adrenoceptor blockade with doxazosin in hypertension: Effects on blood pressure and lipoproteins
    • Ames RP, Kiyasu JY. α-1 adrenoceptor blockade with doxazosin in hypertension: effects on blood pressure and lipoproteins. J Clin Pharmacol. 1989;29:123-127.
    • (1989) J Clin Pharmacol , vol.29 , pp. 123-127
    • Ames, R.P.1    Kiyasu, J.Y.2
  • 12
    • 0028025725 scopus 로고
    • Lipids and lipoproteins during antihypertensive drug therapy. Comparison of doxazosin and atenolol in a randomized, double-blind trial: The Alpha Beta Canada Study
    • Rabkin SW, Huff MW, Newman C, Sim D, Carruthers SG. Lipids and lipoproteins during antihypertensive drug therapy. Comparison of doxazosin and atenolol in a randomized, double-blind trial: the Alpha Beta Canada Study. Hypertension. 1994;24:241-248.
    • (1994) Hypertension , vol.24 , pp. 241-248
    • Rabkin, S.W.1    Huff, M.W.2    Newman, C.3    Sim, D.4    Carruthers, S.G.5
  • 13
    • 0029991306 scopus 로고    scopus 로고
    • Principal results of the Hypertension and Lipid Trial (HALT): A multicenter study of doxazosin in patients with hypertension
    • Levy D, Walmsley P, Levenstein M. Principal results of the Hypertension and Lipid Trial (HALT): a multicenter study of doxazosin in patients with hypertension. Am Heart J. 1996;131:966-973.
    • (1996) Am Heart J , vol.131 , pp. 966-973
    • Levy, D.1    Walmsley, P.2    Levenstein, M.3
  • 15
    • 0034828280 scopus 로고    scopus 로고
    • Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients
    • Hirano T, Yoshino G, Kashiwazaki K, Adachi M. Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients. Am J Hypertens. 2001;14:908-913.
    • (2001) Am J Hypertens , vol.14 , pp. 908-913
    • Hirano, T.1    Yoshino, G.2    Kashiwazaki, K.3    Adachi, M.4
  • 18
    • 0028331994 scopus 로고
    • Changes in glucose, insulin, lipid, lipoprotein, and apoprotein concentrations and insulin action in doxazosin-treated patients with hypertension. Comparison between nondiabetic individuals and patients with non-insulin-dependent diabetes mellitus
    • Maheux P, Facchini F, Jeppesen J, Greenfield MS, Clinkingbeard C, Chen YD, Reaven GM. Changes in glucose, insulin, lipid, lipoprotein, and apoprotein concentrations and insulin action in doxazosin-treated patients with hypertension. Comparison between nondiabetic individuals and patients with non-insulin-dependent diabetes mellitus. Am J Hypertens. 1994;7:416-424.
    • (1994) Am J Hypertens , vol.7 , pp. 416-424
    • Maheux, P.1    Facchini, F.2    Jeppesen, J.3    Greenfield, M.S.4    Clinkingbeard, C.5    Chen, Y.D.6    Reaven, G.M.7
  • 19
    • 0031950817 scopus 로고    scopus 로고
    • A 5-year comparison of doxazosin and atenolol in patients with mild-to-moderate hypertension: Effects on blood pressure, serum lipids, and coronary heart disease risk
    • Daae LN, Westlie L. A 5-year comparison of doxazosin and atenolol in patients with mild-to-moderate hypertension: effects on blood pressure, serum lipids, and coronary heart disease risk. Blood Press. 1998;7:39-45.
    • (1998) Blood Press , vol.7 , pp. 39-45
    • Daae, L.N.1    Westlie, L.2
  • 20
    • 0030037824 scopus 로고    scopus 로고
    • Effects of doxazosin on functional alterations of isolated coronary arteries from cholesterol-fed rabbits
    • Simonsen U, Prieto D, Nyborg NC, Mulvany MJ. Effects of doxazosin on functional alterations of isolated coronary arteries from cholesterol-fed rabbits. J Pharm Pharmacol. 1996;48:607-614.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 607-614
    • Simonsen, U.1    Prieto, D.2    Nyborg, N.C.3    Mulvany, M.J.4
  • 21
    • 3042754728 scopus 로고    scopus 로고
    • Pharmacological exploitation of the α1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation
    • Shaw YJ, Yang YT, Garrison JB, Kyprianou N, Chen CS. Pharmacological exploitation of the α1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation. J Med Chem. 2004;47:4453-4462.
    • (2004) J Med Chem , vol.47 , pp. 4453-4462
    • Shaw, Y.J.1    Yang, Y.T.2    Garrison, J.B.3    Kyprianou, N.4    Chen, C.S.5
  • 22
    • 34250159840 scopus 로고    scopus 로고
    • Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?
    • Schaefer EJ, Asztalos BF. Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction? Curr Opin Cardiol. 2007;22:373-378.
    • (2007) Curr Opin Cardiol , vol.22 , pp. 373-378
    • Schaefer, E.J.1    Asztalos, B.F.2
  • 23
    • 33645422718 scopus 로고    scopus 로고
    • Zannis VI, Chroni A, Krieger M. Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. J Mol Med. 2006;84:276-294.
    • Zannis VI, Chroni A, Krieger M. Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. J Mol Med. 2006;84:276-294.
  • 24
    • 0033997752 scopus 로고    scopus 로고
    • Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
    • Luo Y, Tall AR. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest. 2000;105:513-520.
    • (2000) J Clin Invest , vol.105 , pp. 513-520
    • Luo, Y.1    Tall, A.R.2
  • 26
    • 0034685403 scopus 로고    scopus 로고
    • Major cardiovascular events in hypertensive paitents randomized to doxazosin vs chlorthalidone: the hypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Group. J Am Med Assoc. 2000:283:1967-1975.
    • Major cardiovascular events in hypertensive paitents randomized to doxazosin vs chlorthalidone: the hypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Group. J Am Med Assoc. 2000:283:1967-1975.
  • 27
    • 34547572786 scopus 로고    scopus 로고
    • SREBP-2- and LXR-driven dual promoter regulation of hepatic ABCA1 gene expression: Mechanism underlying the unique response to cellular cholesterol status
    • In press
    • Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira KI, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T. SREBP-2- and LXR-driven dual promoter regulation of hepatic ABCA1 gene expression: mechanism underlying the unique response to cellular cholesterol status. J Biol Chem. 2007. In press.
    • (2007) J Biol Chem
    • Tamehiro, N.1    Shigemoto-Mogami, Y.2    Kakeya, T.3    Okuhira, K.I.4    Suzuki, K.5    Sato, R.6    Nagao, T.7    Nishimaki-Mogami, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.