Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures

Journal of Clinical Epidemiology

Volumn 60, Issue 9, 2007, Pages 911-918

  Hennessy, Sean ^a   Bilker, Warren B ^a   Leonard, Charles E ^a   Chittams, Jesse ^a   Palumbo, Cristin M ^a   Karlawish, Jason H ^a   Yang, Yu Xiao ^a   Lautenbach, Ebbing ^a   Baine, William B ^b   Metlay, Joshua P ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b AGENCY FOR HEALTHCARE RESEARCH AND QUALITY   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Aged; Antidepressive agents; Confounding factors; Pharmacoepidemiology; Pneumonia; Pneumonia, aspiration

Indexed keywords

AMITRIPTYLINE; AMOXAPINE; ANTIDEPRESSANT AGENT; BUTRIPTYLINE; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; DIBENZEPIN; DOSULEPIN; DOXEPIN; DULOXETINE; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; IPRINDOLE; LOFEPRAMINE; MAPROTILINE; MIANSERIN; MIRTAZAPINE; NORTRIPTYLINE; OPIPRAMOL; PAROXETINE; PROTRIPTYLINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRIMIPRAMINE; UNINDEXED DRUG; VENLAFAXINE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; ASPIRATION PNEUMONIA; COMORBIDITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEPRESSION; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; RISK FACTOR; SEX RATIO; STATISTICAL ANALYSIS;

AGE FACTORS; AGED; ANTIDEPRESSIVE AGENTS; CASE-CONTROL STUDIES; COMORBIDITY; CONFOUNDING FACTORS (EPIDEMIOLOGY); FEMALE; GREAT BRITAIN; HOSPITALIZATION; HUMANS; MALE; MEDICAL RECORDS SYSTEMS, COMPUTERIZED; ODDS RATIO; PNEUMONIA; RISK ASSESSMENT; SEX FACTORS;

EID: 34547568964     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2006.11.022     Document Type: Article

References (17)

1. Gorina Y., Hoyert D., Lentzner H., and Goulding M. Trends in causes of death among older persons in the United States. Aging Trends, No 6 (2006), National Center for Health Statistics, Hyattsville, MD
2. Fry A.M., Shay D.K., Holman R.C., Curns A.T., Anderson L.J., Fry A.M., et al. Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002. JAMA 294 (2005) 2712-2719
3. Yamaya M., Yanai M., Ohrui T., Arai H., Sasaki H., Yamaya M., et al. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 49 (2001) 85-90
4. Marik P.E., and Kaplan D. Aspiration pneumonia and dysphagia in the elderly. Chest 124 (2003) 328-336
5. Marik P.E. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 344 (2001) 665-671
6. Baine W.B., Yu W., and Summe J.P. Epidemiologic trends in the hospitalization of elderly Medicare patients for pneumonia, 1991-1998. Am J Public Health 91 (2001) 1121-1123
7. Baine W.B., and Kazakova S.V. An analysis of administrative data found that proximate clinical event ratios provided a systematic approach to identifying possible iatrogenic risk factors or complications. J Clin Epidemiol 58 (2005) 162-170
8. Garcia Rodriguez L.A., and Perez G.S. Use of the UK General Practice Research Database for pharmacoepidemiology. Br J Clin Pharmacol 45 (1998) 419-425
9. Flanders W.D., and Louv W.C. The exposure odds ratio in nested case-control studies with competing risks. Am J Epidemiol 124 (1986) 684-692
10. Mickey R.M., and Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol 129 (1989) 125-137
11. Edwards J.H. The recognition and estimation of cyclic trends. Ann Hum Genet 25 (1961) 83-86
12. Dupont W.D., and Plummer Jr. W.D. Power and sample size calculations. A review and computer program. Control Clin Trials 11 (1990) 116-128
13. Almirall J., Bolibar I., Balanzo X., Gonzalez C.A., Almirall J., Bolibar I., et al. Risk factors for community-acquired pneumonia in adults: a population-based case-control study. Eur Respir J 13 (1999) 349-355
14. Farr B.M., Bartlett C.L., Wadsworth J., Miller D.L., Farr B.M., Bartlett C.L., et al. Risk factors for community-acquired pneumonia diagnosed upon hospital admission. British Thoracic Society Pneumonia Study Group. Respir Med 94 (2000) 954-963
15. Farr B.M., Woodhead M.A., Macfarlane J.T., Bartlett C.L., McCraken J.S., Wadsworth J., et al. Risk factors for community-acquired pneumonia diagnosed by general practitioners in the community. Respir Med 94 (2000) 422-427
16. Laheij R.J., Sturkenboom M.C., Hassing R.J., Dieleman J., Stricker B.H., Jansen J.B., et al. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. Chest 292 (2004) 1955-1960
17. Langmore S.E., Skarupski K.A., Park P.S., Fries B.E., Langmore S.E., Skarupski K.A., et al. Predictors of aspiration pneumonia in nursing home residents. Dysphagia 17 (2002) 298-307