메뉴 건너뛰기




Volumn 30, Issue 4 SUPPL. 1, 2007, Pages

Targeting the epidermal growth factor receptor in colorectal carcinoma

Author keywords

Acneiform rash; Adverse effects, diarrhea; Adverse effects, skin; Cetuximab; Colorectal cancer; Epidermal growth factor receptor inhibitor; Erlotinib; Gefitinib; Interstitial lung disease; Panitumumab

Indexed keywords

6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; BEVACIZUMAB; CANERTINIB; CAPECITABINE; CETUXIMAB; CLINDAMYCIN; EKI 569; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; ERYTHROMYCIN; EVEROLIMUS; FLUOROPYRIMIDINE; FLUOROURACIL; FLUTICASONE PROPIONATE; FOLINIC ACID; GEFITINIB; HYDROCORTISONE; IRINOTECAN; LAPATINIB; LIDOCAINE; MATUZUMAB; METRONIDAZOLE; OXALIPLATIN; PANITUMUMAB; PIMECROLIMUS; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; TACROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 34547557983     PISSN: 0162220X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.NCC.0000281757.78081.74     Document Type: Review
Times cited : (6)

References (56)
  • 1
    • 17644427902 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta, Ga: American Cancer Society;, Available at:, Accessed December 7
    • American Cancer Society. Cancer Facts and Figures 2006. Atlanta, Ga: American Cancer Society; 2006. Available at: http://www.cancer.org/ downloads/STT/CAFF2006PWSecured.pdf. Accessed December 7, 2006.
    • (2006) Cancer Facts and Figures 2006
  • 2
    • 34547596609 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. Colon and rectal cancer - chemotherapy for advanced or metastatic colon cancer. From NCCN treatment guidelines. Available at: http://www.nccn.org/patients/patient_gls/asp/ ASP_Script_showTree/SVGAframeset.asp_pg=colon&idChart=8&bkG=. Accessed December 7, 2006.
    • National Comprehensive Cancer Network. Colon and rectal cancer - chemotherapy for advanced or metastatic colon cancer. From NCCN treatment guidelines. Available at: http://www.nccn.org/patients/patient_gls/asp/ ASP_Script_showTree/SVGAframeset.asp_pg=colon&idChart=8&bkG=. Accessed December 7, 2006.
  • 3
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351:337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 4
    • 15844371598 scopus 로고    scopus 로고
    • Therapeutic options in the management of colon cancer: 2005 update
    • Wilkes GM. Therapeutic options in the management of colon cancer: 2005 update. Clin J Oncol Nurs. 2005;9(1):31-44.
    • (2005) Clin J Oncol Nurs , vol.9 , Issue.1 , pp. 31-44
    • Wilkes, G.M.1
  • 5
    • 17644382288 scopus 로고    scopus 로고
    • Critical evaluation of current treatments in metastatic colorectal cancer
    • Venook A. Critical evaluation of current treatments in metastatic colorectal cancer. Oncologist. 2005;10:250-261.
    • (2005) Oncologist , vol.10 , pp. 250-261
    • Venook, A.1
  • 6
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • for the Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, et al, for the Irinotecan Study Group. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med. 2000;343:905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 7
    • 34547594317 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, Available at:, Accessed December 7
    • Center for Drug Evaluation and Research. Eloxatin information. Available at: http://www.fda.gov/cder/drug/infopage/eloxatin/default.htm. Accessed December 7, 2006.
    • (2006) Eloxatin information
  • 8
    • 34547557757 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, Available at:, Accessed January 22
    • Center for Drug Evaluation and Research. FDA approves Vectibix (panitumumab) to treat metastatic colorectal cancer. Available at: www.fda.gov/cder/offices/OODP/whatsnew/panitumumab.htm. Accessed January 22, 2007.
    • (2007) FDA approves Vectibix (panitumumab) to treat metastatic colorectal cancer
  • 9
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM, Schmoll H-J. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol. 2004;22:1209-1214.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.-J.4
  • 10
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22:23-30.
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 11
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 12
    • 0344870269 scopus 로고    scopus 로고
    • Irinotecan improves the activity of the AIO regimen in metastatic colorectal cancer: Results of EORTC GI Group Study 40986
    • abstr
    • Kohne C, Van Cutsem E, Wils J, et al. Irinotecan improves the activity of the AIO regimen in metastatic colorectal cancer: results of EORTC GI Group Study 40986. Proc Am Soc Clin Oncol. 2003;22:1018. [abstr].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1018
    • Kohne, C.1    Van Cutsem, E.2    Wils, J.3
  • 13
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment of metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment of metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000;355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 14
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2004;22:229-237.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 15
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004;22:1201-1208.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 16
    • 34547609402 scopus 로고    scopus 로고
    • Peeters M, Van Cutsem E, Siena S, et al, The Panitumumab Study Team. A phase 3, multicenter, randomized controlled (RCT) of panitumumab plus best supportive care (BSC) vs BSC alone in patients (pts) with metastatic colorectal cancer (mCRC). Presented at: 97th American Association for Cancer Research Annual Meeting; April 1-5, 2006; Washington, DC. Abstract CP-1. Available at: http://app2.capitalreach.com/esp1204/servlet/tc?cn=aacr&c=10165&s= 20323&e=5641&&autoRegRBI=1&m=1&espbr=95. Accessed January 25, 2007.
    • Peeters M, Van Cutsem E, Siena S, et al, The Panitumumab Study Team. A phase 3, multicenter, randomized controlled (RCT) of panitumumab plus best supportive care (BSC) vs BSC alone in patients (pts) with metastatic colorectal cancer (mCRC). Presented at: 97th American Association for Cancer Research Annual Meeting; April 1-5, 2006; Washington, DC. Abstract CP-1. Available at: http://app2.capitalreach.com/esp1204/servlet/tc?cn=aacr&c=10165&s= 20323&e=5641&&autoRegRBI=1&m=1&espbr=95. Accessed January 25, 2007.
  • 17
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst RS, Shin DM. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer. 2002;94:1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 18
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture ME. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer. 2006;6:803-812.
    • (2006) Nat Rev Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 19
    • 0033970141 scopus 로고    scopus 로고
    • Modulation of molecular targets to enhance radiation
    • Harari PM, Huang S-M. Modulation of molecular targets to enhance radiation. Clin Cancer Res. 2000;6:2323-2325.
    • (2000) Clin Cancer Res , vol.6 , pp. 2323-2325
    • Harari, P.M.1    Huang, S.-M.2
  • 21
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
    • Ciardiello F, Tortora G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res. 2001;7:2958-2970.
    • (2001) Clin Cancer Res , vol.7 , pp. 2958-2970
    • Ciardiello, F.1    Tortora, G.2
  • 22
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • Arteaga CL. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol. 2001;19(18 Suppl):32S-40S.
    • (2001) J Clin Oncol , vol.19 , Issue.18 SUPPL.
    • Arteaga, C.L.1
  • 23
    • 34547610022 scopus 로고    scopus 로고
    • FDA approves Erbitux for colorectal cancer
    • and Drug Administration, Available at:, Accessed January 22, 2007
    • US Food and Drug Administration. FDA News: FDA approves Erbitux for colorectal cancer. Available at: http://www.fda.gov/bbs/topics/NEWS/2004/ NEW01024.html. Accessed January 22, 2007.
    • FDA News
    • Food, U.S.1
  • 24
    • 34547573429 scopus 로고    scopus 로고
    • ClinicalTrials.gov Web site. Effects of matuzumab in combination with pemetrexed for the treatment of advanced lung cancer. Available at: http://www.clinicaltrials.gov/show/NCT00111839. Accessed December 8, 2006.
    • ClinicalTrials.gov Web site. Effects of matuzumab in combination with pemetrexed for the treatment of advanced lung cancer. Available at: http://www.clinicaltrials.gov/show/NCT00111839. Accessed December 8, 2006.
  • 25
    • 33847157166 scopus 로고    scopus 로고
    • Antitumour activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models
    • Chen J, Smith M, Kolinsky K, et al. Antitumour activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models. Cancer Chemother Pharmacol. 2007;59(5):651-659.
    • (2007) Cancer Chemother Pharmacol , vol.59 , Issue.5 , pp. 651-659
    • Chen, J.1    Smith, M.2    Kolinsky, K.3
  • 26
    • 34547580606 scopus 로고    scopus 로고
    • erlotinib) tablets [prescribing information]. Melville
    • NY: OSI Pharmaceuticals Inc; and San Francisco, Calif: Genentech, Inc;
    • Tarceva® (erlotinib) tablets [prescribing information]. Melville, NY: OSI Pharmaceuticals Inc; and San Francisco, Calif: Genentech, Inc; 2005.
    • (2005)
    • Tarceva®1
  • 27
    • 33750155908 scopus 로고    scopus 로고
    • Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer
    • Wolpin BM, Clark JW, Meyerhardt JA, et al. Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2006;6:208-213.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 208-213
    • Wolpin, B.M.1    Clark, J.W.2    Meyerhardt, J.A.3
  • 28
    • 34547556261 scopus 로고    scopus 로고
    • gefitinib) tablets [prescribing information
    • Wilmington, Del: AstraZeneca Pharmaceuticals LP;
    • Iressa® (gefitinib) tablets [prescribing information]. Wilmington, Del: AstraZeneca Pharmaceuticals LP; 2005.
    • (2005)
    • Iressa®1
  • 29
    • 26444610104 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hoekstra R, Dumez H, Eskens FA, et al. Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. Clin Cancer Res. 2005;11:6908-6915.
    • (2005) Clin Cancer Res , vol.11 , pp. 6908-6915
    • Hoekstra, R.1    Dumez, H.2    Eskens, F.A.3
  • 30
    • 33744824672 scopus 로고    scopus 로고
    • Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors
    • Erlichman C, Hidalgo M, Boni JP, et al. Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J Clin Oncol. 2006;24:2252-2260.
    • (2006) J Clin Oncol , vol.24 , pp. 2252-2260
    • Erlichman, C.1    Hidalgo, M.2    Boni, J.P.3
  • 31
    • 21044439024 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer
    • Nemunaitis J, Eiseman I, Cunningham C, et al. Phase I clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2005;11:3846-3853.
    • (2005) Clin Cancer Res , vol.11 , pp. 3846-3853
    • Nemunaitis, J.1    Eiseman, I.2    Cunningham, C.3
  • 32
    • 34547611089 scopus 로고    scopus 로고
    • cetuximab) [prescribing information]. Branchburg
    • NJ: ImClone Systems Incorporated; and Princeton, NJ: Bristol-Myers Squibb Company;
    • Erbitux® (cetuximab) [prescribing information]. Branchburg, NJ: ImClone Systems Incorporated; and Princeton, NJ: Bristol-Myers Squibb Company; 2006.
    • (2006)
    • Erbitux®1
  • 33
    • 34547571289 scopus 로고    scopus 로고
    • ClinicalTrials.gov Web site. Information on clinical trials and human research studies: trial list for colorectal cancer and EGFR therapy. Available at: http://www.clinicaltrials.gov/ct/search;jsessionid= 253ED68908F9EB4CF6FDDBB3D5029FB6?term=egfr+colorectal+cancer. Accessed December 8, 2006.
    • ClinicalTrials.gov Web site. Information on clinical trials and human research studies: trial list for colorectal cancer and EGFR therapy. Available at: http://www.clinicaltrials.gov/ct/search;jsessionid= 253ED68908F9EB4CF6FDDBB3D5029FB6?term=egfr+colorectal+cancer. Accessed December 8, 2006.
  • 34
    • 33644822287 scopus 로고    scopus 로고
    • Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
    • Rothenberg ML, LaFleur B, Levy DE, et al. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol. 2005;23:9265-9274.
    • (2005) J Clin Oncol , vol.23 , pp. 9265-9274
    • Rothenberg, M.L.1    LaFleur, B.2    Levy, D.E.3
  • 35
    • 20144366145 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 (Iressa) 750 mg per day, an oral epidermal growth factor receptor-tyrosine kinase inhibitor, in patients with metastatic colorectal cancer
    • Mackenzie MJ, Hirte HW, Glenwood G, et al. A phase II trial of ZD1839 (Iressa) 750 mg per day, an oral epidermal growth factor receptor-tyrosine kinase inhibitor, in patients with metastatic colorectal cancer. Invest New Drugs. 2005;23:165-170.
    • (2005) Invest New Drugs , vol.23 , pp. 165-170
    • Mackenzie, M.J.1    Hirte, H.W.2    Glenwood, G.3
  • 36
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris HA III, Hurwitz HI, Dees EC, et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol. 2005;23:5305-5313.
    • (2005) J Clin Oncol , vol.23 , pp. 5305-5313
    • Burris III, H.A.1    Hurwitz, H.I.2    Dees, E.C.3
  • 37
    • 34547574441 scopus 로고    scopus 로고
    • Vectibix™ (panitumumab) [prescribing information]. Thousand Oaks, Calif: Amgen Inc; 2006.
    • Vectibix™ (panitumumab) [prescribing information]. Thousand Oaks, Calif: Amgen Inc; 2006.
  • 38
    • 3543053772 scopus 로고    scopus 로고
    • Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
    • 14S:3510, Abstract
    • Lenz HJ, Mayer RJ, Gold PJ, et al. Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. J Clin Oncol. 2004;24(14S):3510. [Abstract].
    • (2004) J Clin Oncol , pp. 24
    • Lenz, H.J.1    Mayer, R.J.2    Gold, P.J.3
  • 39
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol. 2005;23:1803-1810.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 40
    • 34547560525 scopus 로고    scopus 로고
    • Tabernero JM, Van Cutsem E, Sastre J, et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results. J Clin Oncol. 2004;22(14S):3512. [Abstract].
    • Tabernero JM, Van Cutsem E, Sastre J, et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results. J Clin Oncol. 2004;22(14S):3512. [Abstract].
  • 41
    • 34547598064 scopus 로고    scopus 로고
    • Venook A, Niedzwiecki D, Holis D, et al. Phase III study of irinotecan/5FU/LV (FOLFIRI) or oxaliplatin/5FU/LV (FOLFOX) ± cetuximab for patients (pts) with untreated metastatic adenocarcinoma of the colon or rectum (MCRC): CALGB 80203 preliminary results. J Clin Oncol. 2006;24(18S part 1):3509. [Abstract].
    • Venook A, Niedzwiecki D, Holis D, et al. Phase III study of irinotecan/5FU/LV (FOLFIRI) or oxaliplatin/5FU/LV (FOLFOX) ± cetuximab for patients (pts) with untreated metastatic adenocarcinoma of the colon or rectum (MCRC): CALGB 80203 preliminary results. J Clin Oncol. 2006;24(18S part 1):3509. [Abstract].
  • 42
    • 5144223438 scopus 로고    scopus 로고
    • Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): Early termination due to increased toxicities
    • Messersmith WA, Laheru DA, Senzer NN, et al. Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): early termination due to increased toxicities. Clin Cancer Res. 2004;10:6522-6527.
    • (2004) Clin Cancer Res , vol.10 , pp. 6522-6527
    • Messersmith, W.A.1    Laheru, D.A.2    Senzer, N.N.3
  • 43
    • 33644848522 scopus 로고    scopus 로고
    • Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: Phase I trial results
    • Czito BG, Willett CG, Bendell JC, et al. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. J Clin Oncol. 2006;24:656-662.
    • (2006) J Clin Oncol , vol.24 , pp. 656-662
    • Czito, B.G.1    Willett, C.G.2    Bendell, J.C.3
  • 44
    • 33745911892 scopus 로고    scopus 로고
    • Efficacy of cetuximab after treatment with oral epidermal growth factor receptor tyrosine kinase inhibitor-based chemotherapy in metastatic colorectal cancer
    • Meyerhardt JA, Heseltine D, Oginao S, et al. Efficacy of cetuximab after treatment with oral epidermal growth factor receptor tyrosine kinase inhibitor-based chemotherapy in metastatic colorectal cancer. Clin Colorectal Cancer. 2006;6:59-65.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 59-65
    • Meyerhardt, J.A.1    Heseltine, D.2    Oginao, S.3
  • 45
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
    • Matar P, Rojo F, Cassia R, et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res. 2004;10:6487-6501.
    • (2004) Clin Cancer Res , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3
  • 46
    • 33646576196 scopus 로고    scopus 로고
    • Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors
    • Calvo E, Baselga J. Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors. J Clin Oncol. 2006;24:2158-2163.
    • (2006) J Clin Oncol , vol.24 , pp. 2158-2163
    • Calvo, E.1    Baselga, J.2
  • 47
    • 4544328968 scopus 로고    scopus 로고
    • Greater risks of chemotherapy toxicity in elderly patients with cancer
    • Repetto L. Greater risks of chemotherapy toxicity in elderly patients with cancer. J Support Oncol. 2003;1:18-24.
    • (2003) J Support Oncol , vol.1 , pp. 18-24
    • Repetto, L.1
  • 49
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005;97:339-346.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 50
    • 33645785347 scopus 로고    scopus 로고
    • Clinical experience with anti-EGFR therapy
    • Fish-Steagall A, Searcy P, Sipples R. Clinical experience with anti-EGFR therapy. Semin Oncol Nurs. 2006;22(1 Suppl 1):10-19.
    • (2006) Semin Oncol Nurs , vol.22 , Issue.1 SUPPL. 1 , pp. 10-19
    • Fish-Steagall, A.1    Searcy, P.2    Sipples, R.3
  • 51
    • 33645776493 scopus 로고    scopus 로고
    • Administration of anti-EGFR therapy: A practical review
    • Khoukaz T. Administration of anti-EGFR therapy: a practical review. Semin Oncol Nurs. 2006;22(1 Suppl 1):20-27.
    • (2006) Semin Oncol Nurs , vol.22 , Issue.1 SUPPL. 1 , pp. 20-27
    • Khoukaz, T.1
  • 52
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
    • Perez-Soler R, Chachoua A, Hammond LA, et al. Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol. 2004;22:3238-3247.
    • (2004) J Clin Oncol , vol.22 , pp. 3238-3247
    • Perez-Soler, R.1    Chachoua, A.2    Hammond, L.A.3
  • 53
    • 0347426783 scopus 로고    scopus 로고
    • Multicenter study of ABX-EGF monotherapy in patients with metastatic colorectal cancer
    • abstr
    • Meropol NJ, Berlin J, Hecht JR, et al. Multicenter study of ABX-EGF monotherapy in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol. 2003:256. [abstr].
    • (2003) Proc Am Soc Clin Oncol , pp. 256
    • Meropol, N.J.1    Berlin, J.2    Hecht, J.R.3
  • 54
    • 34547602126 scopus 로고    scopus 로고
    • Toxicity of targeted therapy: Focus on rash and other dermatologic side effects
    • O'Keeffe P, Parrilli M, Lacouture ME. Toxicity of targeted therapy: focus on rash and other dermatologic side effects. Oncol Nurs Educ. 2006;20(103 Suppl 12):1-6.
    • (2006) Oncol Nurs Educ , vol.20 , Issue.103 SUPPL. 12 , pp. 1-6
    • O'Keeffe, P.1    Parrilli, M.2    Lacouture, M.E.3
  • 55
    • 21344462378 scopus 로고    scopus 로고
    • Cutaneous side-effects of kinase inhibitors and blocking antibodies
    • Robert C, Soria J-C, Spatz A, et al. Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol. 2005;6:491-500.
    • (2005) Lancet Oncol , vol.6 , pp. 491-500
    • Robert, C.1    Soria, J.-C.2    Spatz, A.3
  • 56
    • 33644899420 scopus 로고    scopus 로고
    • Doxycycline for the treatment of paronychia induced by the epidermal growth factor receptor inhibitor cetuximab
    • Suh K-Y, Kindler HL, Medenica M, Lacouture M. Doxycycline for the treatment of paronychia induced by the epidermal growth factor receptor inhibitor cetuximab. Br J Dermatol. 2006;154:191-192.
    • (2006) Br J Dermatol , vol.154 , pp. 191-192
    • Suh, K.-Y.1    Kindler, H.L.2    Medenica, M.3    Lacouture, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.