Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14α-demethylase (CYP51)

Chemistry and Biodiversity

Volumn 4, Issue 7, 2007, Pages 1472-1479

  Zhao, Qing Jie ^a   Hu, Hong Gang ^a   Li, Yao Wu ^a   Song, Yan ^a   Cai, Ling Zhi ^a   Wu, Qiu Ye ^a   Jiang, Yuan Ying ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 BROMOBENZYL) (CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [(2 CHLOROBENZYL) (CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [(4 BROMOBENZYL) (CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [(4 CHLOROBENZYL) (CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [(4 TERT BUTYLBENZYL) (CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [BENZYL(CYCLOPROPYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [CYCLOPROPYL(2 FLUOROBENZYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [CYCLOPROPYL(2 METHYLBENZYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [CYCLOPROPYL(2,4 DIFLUOROBENZYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRAIZOL 1 YL)PROPAN 2 OL; 1 [CYCLOPROPYL(4 FLUOROBENZYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [CYCLOPROPYL(4 METHYLBENZYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA TROPICALIS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL STRAIN; MICROSPORUM CANIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TRICHOPHYTON RUBRUM;

ANTIFUNGAL AGENTS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HYDROGEN; MICROBIAL SENSITIVITY TESTS; OXIDOREDUCTASES; TRIAZOLES;

CANDIDA ALBICANS; CANDIDA TROPICALIS; FILOBASIDIELLA NEOFORMANS; FUNGI; MICROSPORUM CANIS; TRICHOPHYTON RUBRUM;

EID: 34547536299     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200790125     Document Type: Article

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