Bioactive compounds from the sea

Marine and Freshwater Products Handbook

Volumn , Issue , 2000, Pages 641-661

  Ireland, Chris M ^a   Copp, Brent R ^a   Foster, Mark P ^a   McDonald, Leonard A ^a   Radisky, Derek C ^a   Christopher Swersey, J ^a  

^a UNIVERSITY OF UTAH   (United States)

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EID: 34547519268     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (245)

1. Abraham, S., G.N. Beatch, B.A. MacLeod, and M.J. Walker Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effect of ventricular sodium channel blockade. J. Pharmacol. Exp. Ther. 251:1166–1173.
2. Abramson, S.N., P. Culver, T. Cline, Y. Li, P. Guest, L. Gutman, and P. Taylor. 1988. Lophotoxin and related coral toxins covalently label the α-subunit of the nicotinic acetylcholine receptor. J. Biol. Chem. 263:18568–18573.
3. Abramson, S.N., Y. Li, P. Culver, and P. Taylor. 1989. An analog of lophotoxin reacts covalently with Tyr190 in the α-subunit of the nicotinic acetylcholine receptor. J. Biol. Chem. 264:12666–12672.
4. Abramson, S.N., Z. Radic, D. Manker, D.J. Faulkner, and P. Taylor. 1989. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Mol. Pharmacol. 36 349-354.
5. Albizati, K F., T. Holman, D.J. Faulkner, K.B. Glaser, and R.S. Jacobs. 1987. Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella sp. Experientia. 43:949–950.
6. Albizati, K.F., V.A. Martin, M.R. Agharahimi, and D.A. Stolze. 1990. Synthesis of Marine Natural Products. In Bioorganic Marine Chemistry, Volume 5, P.J. Scheuer (ed.). Springer-Verlag. Berlin, Heidelberg.
7. Baba, M., R. Snoeck, R. Pauwels, and E. de Clerq. 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including Herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antimicrobial Agents and Chemotherapy. 32(11):1742- 1745.
8. Baden, D. G. 1989. Brevetoxins: Unique polyether di- noflagellate toxins. FASEB journal. 3:1807–1817.
9. Bai, R., G.R. Pettit, and E. Hamel. 1990a. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid domain. Biochem Pharmacol. 39:1941–1949.
10. Bai, R., G. R. Pettit, and E. Hamel. 1990b. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J. Biol. Chem. 265:17141–17149.
11. Baird-Lambert, J., J. F. Marwood, L. P. Davies, and L. Taylor. 1980. 1-methylisoguanosine: an orally active marine natural product with skeletal muscle and cardiovascular effects. Life Sci. 26:1069–1077.
12. Ballesta, J. J., M. Palmero, M. J. Hidalgo, L. M. Gutierrez, J. Reig, S. Viniegra, and A.G. Garcia. 1989. Separate binding and functional sites for ω-conotoxin and nitrendipine suggest two types of calcium channels in bovine chromaffin cells. J. Neurochem. 53:1050–1056.
13. Barzaghi, G., H. M. Sarace, and S. Mong. 1989. Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture. J. Pharm. Exp. Ther. 248:559–566.
14. Benjamin, D., D.P. Hartmann, L.S. Bazar, and R.J. Jacobsen. Burkitt’s cells can be triggered by teleocidin to secrete interferon-gamma. Am. J. Hematology. 22:169–177. ‘
15. Benjamin, D., S. Hooker, and J. Miller. 1990. Differential effects of teleocidin on TNF-alpha receptor regulation in human B cell lines: relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion. Cellular Immunology. 125:480–497.
16. Bergmann, W. and D. C. Burke. 1955. Contributions to the study of marine products, XXXIX. The nucleosides of sponges, III: Spongothymidine and spongouridine. J. Org. Chem. 20:1501–1507.
17. Bergmann, W. and R. J. Feeney. 1951. Contributions to the study of marine products. XXXII. The nucleosides of sponges, I. J. Org. Chem. 16:981–987.
18. Berkow, R. L. and A. S. Kraft. 1985. Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor. Biochem. Biophys. Res. Comm. 131:1109–1116.
19. Bialojan, C. and A. Takai. 1988. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256:283–290.
20. Bialojan, C., J.C. Riiegg, and A. Takai. 1988. Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea-pig tenia coli. J. Physiology. 398:81–95.
21. Billiar, R.B., J. Kalash, V. Romita, K. Tsuji, and T. Kosuge. Neosurugatoxin: CNS acetylcholine receptors and leutinizing hormone secretion in ovariectomized rats. Brain Res. Bull. 20: 315–322.
22. Biskupiak, J.E. and C.M. Ireland. 1984. Revised absolute configuration of dysidenin and isodysidenin. Tetrahedron Lett. 25:2935–2936.
23. Boldt, J., A.M. Howe, J.B. Parkerson, L.E. Gunter, and E. Kuehn. 1989. Carbohydrate involvement in sperm-egg fusion in mice. Biol. Reprod. 40(4): 887–896.
24. Bontemps, F. and G. van den Berghe. 1989. Mechanism of adenosine triphosphate catabolism induced by deoxyadenosine and by nucleoside analogs in adenosine deaminase-inhibited human erythrocytes. Cancer Res. 49:4983–4989.
25. Bourke, J.E., S.J. Bunn, P.D. Marley, and B.G. Livett. 1988. The effects of neosurugatoxin on evoked catecholamine secretion from bovine adrenal chromaffin cells. Br. J. Pharmacol. 93:275–280.
26. Bouvier, M. 1990. Cross-talk between secondary messengers. Ann. N. Y. Acad. Sci. 594:120–129.
27. Brandley, B.K., T.S. Ross, and R.L. Schnaar. 1987. Multiple carbohydrate receptors on lymphocytes revealed by adhesion to immobilized polysaccharides. J. Cell. Biol. 105(2):991–997.
28. Bruno, I., L. Minale, and R. Riccio. 1990. Starfish Saponins, Part 43. J. Nat. Products. 53:366–374 and references therein.
29. Bryant, R.W., C.A. Granzow, M.I. Siegel, R.W. Egan, and M.M. Billah. 1990. Phorbol esters increase synthesis of decay-accelerating factor, a phosphatidylinositol- anchored surface protein, in human endothelial cells. J. Immunol. 144:593–598.
30. Burres, N.S. and J.J. Clement. 1989. Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide. Cancer Res. 49:2935–2940.
31. Burres, N.S., S. Sazesh, G.P. Gunawardana, and J.J Clement. 1989. Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge. Cancer Res. 49:5267–5274.
32. Cai, M. and PC. Jordan. 1990. How does vestibule surface charge affect ion conduction and toxin binding in a sodium channel? Biophys. J. 57:883–891.
33. Canonico, P.G., W.L. Pannier, J.W. Huggins, and K.L. Rinehart. 1982. Inhibition of RNA viruses in vitro and in rift valley fever-infected mice by didemnins A and Antimicro. Ag. Chemother. 22:696–697.
34. Carmichael, W. W., N. A. Mahmood, and E. G. Hyde. 1990. Natural toxins from cyanobacteria (blue-green algae). In Marine Toxins, ACS Symposium Series 418, S. Hall and G. Strichartz (eds.), pp. 87–106. American Chemical Society, Washington, DC.
35. Carte, B., S. Mong, B. Poehland, H. Sarau, J.W. Westley, and D.J. Faulkner. 1989. 15-Acetylthioxy-furodysinin lactone, a potent LTB4 receptor partial agonist from a marine sponge of the eenus. Dusidea, Tetrahedron Lett. 30:2725–2726.
36. Catterall, W.A. 1980. Neurotoxins that act on voltage- sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxicol. 20:15–43.
37. Charles, C., J.C. Braekman, D. Dalose, and B. Tursch. 1980. The relative and absolute configuration of dysidenin. Tetrahedron. 36:2133–2135.
38. Charles, C., J. C. Braekman, D. Daloze, B. Tursch, and R. Karlson. 1978. Isodysidenin, a further hexachlorinatedmetabolite from the sponge. Dysidca herbacea, Tetrahedron Lett. 17:1519–1520.
39. Chida, K. and I. Yamamoto. 1987. Antitumor activity of a crude fucoidan fraction prepared from the roots of kelp (Laminaria species). Kitasato Arch. Exp. Med. 60(1-2):33–39.
40. Chun, H.G., B. Davies, D. Hoth, M. Suffness, J. Plowman, K. Flora, C. Grieshaber, and B. Leyland-Jones. 1986. Didemnin B: the first marine compound entering clinical trials as an antineoplastic agent. Invest. New Drugs. 4:279–284.
41. Church, F. C., J. B. Meade, R. E. Treanor, and H. C. Whinna. 1989. Antithrombin activity of fucoidin. The interaction of fucoidin with heparin cofactor II, antithrombin III, and thrombin. J. Biol. Chem. 264(6):3618–3623.
42. Cohen, P. 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58:453–508.
43. Cohen, P., C.F.B. Holmes, and Y. Tsukitani. 1990. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15:98–102.
44. Cohen, P., S. Klumpp, and D.L. Schelling. 1989a. An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues. FEBS Lett. 250:596–600.
45. Cohen, P., D.L. Schelling, and M.J.R. Stark. 1989b. Remarkable similarities between yeast and mammalian protein phosphatases. FEBS Lett. 250:601–606.
46. Cohen, S.S. 1977. The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA). Cancer. 40:509–518.
47. Crampton, S.L., E.G. Adams, S.L. Kuentzel, L.H. Li, G. Badiner, and B.K. Bhuyan. 1984. Biochemical and cellular effects of didemnins A and B. Cancer Res. 44:1796–1801.
48. Cruz, L.J., G. Kupryszewski, G.W. LeCheminant, W.R. Gray, B.M. Olivera, and J. Rivier. 1989. μ-Conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabelling and receptor characterization. Biochemistry 28:3437–3442.
49. Culver, P. and R.S. Jacobs. 1981. Lophotoxin: a neuromuscular acting toxin from the sea whip (Lophogorgia rigida). Toxicol. 19:825–830.
50. Culver, P., M. Bursch, C. Potenza, L. Wasserman, W. Fenical, and P. Taylor. 1985. Structure-activity relationships for the irreversible blockade of nicotinic receptor agonist sites by lophotoxin and congeneric diterpene lactones. Mol. Pharm. 28:436–444.
51. Culver, P., W. Fenical, and P. Taylor. 1984. Lophotoxin irreversibly inactivates the nicotinic acetylcholine receptor by preferential association at one of the two primary agonist sites. J. Biol. Chem. 259:3763–3770.
52. Das, D.K. and H. Steinberg. 1988. Adenosine transport in the lung. J. Appl. Physiol. 65:297–305.
53. Davies, L.P., D.D. Jamieson, J.A. Baird-Lambert, and R. Kaslauskas. 1984. Halogenated pyrrolopyrimidine analogues of adenosine from marine organisms: pharmacological activities and potent inhibition of adenosine kinase. Biochem. Pharmacol. 33:347–355.
54. Dawicki, D.D., K.C. Agarwal, and R.E. Parks Jr. 1988. Adenosine metabolism in human whole blood. Biochem. Pharmacol. 37:621–626.
55. de Andrea, M.L., B. de Camargo, and R. Melaragno. 1990. A new treatment protocol for childhood non- Hodgkin’s lymphoma: preliminary evaluation. J.Clin. Oncol. 8:666–671.
56. de Oliveira, C.A. and B. Mantovani. 1988. Latrunculin A is a potent Inhibitor of Phagocytosis by Macrophages. Tetrahedron Lett. 43:1825–1830.
57. de Silva, E.D. and P.J. Scheuer. 1980. Manoalide, an antibiotic sesterterpenoid from the marine sponge Luffariella variabilis (Polejaeff). Tetrahedron Lett. 21:1611–1614.
58. de Vries, G.W., L. Amdahl, A. Mobasser, M. Wenzel, and L.A. Wheeler. 1988. Preferential inhibition of 5- lipoxygenase activity by manoalide. Biochem. Pharmacol. 37: 2899–2905.
59. Degnan, B.M., C.J. Hawkins, M.F. Lavin, E.J. McCaffrey, D.L. Parry, and D.J. Watters. 1989. Novel cytotoxic compounds from the ascidian Lissoclinum bistratum. J. Med. Chem. 32:1355–1359.
60. Dorr, A., R. Schwartz, J. Kuhn, J. Bayne, and D.A. Von Hoff. 1986. Phase I clinical trial of didemnin B (Abstract). Proc. Am. Assoc. Cancer Res. 5:39.
61. Dorr, F.A., J.G. Kuhn, J. Phillips, and D.D. Von Hoff. 1988. Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic depsipeptide. Eur. J. Cancer Clin. Oncol. 24:1699–1706.
62. Dowding, A.J. and Z.W. Hall. 1987. Monoclonal antibodies specific for each of the two toxin-binding sites of Torpedo acetylcholine receptor. Biochemistry. 26:6372–6381.
63. Dutar, P., O. Rascol, and Y. Lamour. 1989. ω-Conotoxin GVIA blocks synaptic transmission in the CA1 field of the hippocampus. J. Pharmacol. 174:261–6.
64. Edwards, R.A., P.L. Lutz, and D.G. Baden. 1989. Relationship between energy expenditure and ion channel density in the turtle and rat brain. Am. J Physiol. 257:R1354-358.
65. Evans, J.S., E.A. Musser, L. Bostwick, and G.D. Mengel. 1964. The effect of 1-b-D-arabinofuranosylcytosine hydrochloride on murine neoplasms. Cancer Res.24:1285–1293.
66. Evans, J.S., E.A. Musser, G.D. Mengel, K.R. Forsblad, and J.H. Hunter. 1961. Antitumor activity of 1-b-D- arabinofuranosylcytosine hydrochloride. Proc. Soc. Exp. Biol. Med. 106:350–353.
67. Famiani, V. 1987. In vivo effect of didemnin B on two tumors of the rat. Oncology. 44:42–46.
68. Farago, A. and Y. Nishizuka. 1990. Protein kinase C in transmembrane signalling. FEBS Lett 2 68:350–354.
69. S. Fattorusso, L. Minale, and G. Sodano. 1970. Aeroplysinin-1, a new bromo-compound from Aplysina aerophoba. J. Chem. Soc. Perkin 1,12:751–752.
70. Faulkner, D.J. 1984. Natural Products Reports. 1: 551–98 and subsequent volumes.
71. Fautin, D.G. (ed.). 1988. Biomedical Importance of Marine Organisms. Memoirs of the California Academy of Sciences Number 13. California Academy of Sciences, San Francisco.
72. Fenical, W., R.K. Okuda, M.M. Banduraga, R Culver, and R.S. Jacobs. 1981. Lophotoxin: a novel neuromuscular toxin from pacific sea whips of the genus Lopltogorgia. Science. 212:1512–1514.
73. Felix, M., P. Cohen, and E. Karsenti. 1990. Cdc2 HI kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid. EMBO J. 9:675–683.
74. Foster, M. P., C. L. Mayne, R. Dunkel, R. J. Pugmire, D. M. Grant, J. M. Kornprobst, J. F. Verbist, J. F. Biard, and C. M. Ireland. 1992. The revised structure of Bistramide A (Bistratene A): Application of a new program for the automated analysis of 2D INADEQUATE Spectra. J. Amer. Chem. Soc. 114:1110.
75. Fredholm, B.B. 1990. Differential sensitivity to blockade by 4-aminopyridine of presynaptic receptors regulating [3H]acetylcholine release from rat hippocampus. J. Neurochem. 54:1386–1390.
76. Fujiki, H. and T. Sugimura. 1987. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. Adv. Cancer Res. 59:223–264.
77. Fujiki, H., M. Suganuma, M. Nakayasu, H. Hakii, T. Horiuchi, S. Takayama, and T. Sugimura. 1986. Palytoxin is a non-12-O-tetradecanoylphorbol-13- acetate type tumor promoter in two-stage mouse skin carcinogenesis. Carcinogenesis. 7:707–710.
78. Fujiki, H., M. Suganuma, H. Suguri, S. Yoshizawa, K. Takagi, and M. Kobayashi. 1989b. Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin. J Cancer Res. Clin. Oncol. 115:25–28.
79. Fujiki, H., M. Suganuma, H. Suguri, S. Yoshizawa, K. Takagi, T. Sassa, N. Uda, K. Wakamatsu, K. Yamada, T. Yasumoto, Y. Kato, N. Fusetani, K. Hashimoto, and T. Sugimura. 1989a. New tumor promoters from marine sources: the okadaic acid class. In Mycotoxins and Phycotoxins. S. Natori, K. Hashimoto and Y. Ueno (eds.), pp. 453–460. Elsevier Science Publishers. B.V., Amsterdam.
80. Fujiki, H., M. Suganuma, H. Suguri, S. Yoshizawa, K. Takagi, N. Uda, K. Wakamatsu, K. Yamada, M. Murata, T. Yasumoto, and T. Sugimura. 1988.Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin, Japan. J. Cancer Res. (Gann) 79:1089–1093.
81. Fulmor, W., G. E. Van Lear, G. P. Morton, and R. D. Mills. 1970. Isolation and absolute configuration of the aeroplysinin 1 enantiomorphic pair from lanthella ardis. Tetrahedron Lett. 52:4551–4552.
82. Gaveriaux, C. and F. Loor. Proliferation of interleukin 2 dependent cytotoxic T cell line cells. Int. Arch. Allergy Appl. Immunol. 88:294–6.
83. Geller, R. B., R. Saral, J. E. Karp, G. W. Santos, and P. J. Burke. 1990. Cure of acute myelocytic leukemia in adults: a reality. Leukemia. 4:313–315.
84. Glaser, K. B. and R. S. Jacobs. 1986. Molecular pharmacology of manoalide. Biochem. Pharmacol. 35:449–453.
85. Glaser, K. B., M. S. de Carvalho, R. S. Jacobs, M. R. Kernan, and D. J. Faulkner. 1989. Manoalide: structure activity studies and definition of the pharmacophore for phospholipase A2 inactivation. Mol. Pharmacol. 36:782–788.
86. Glaser, K. B., T. S. Vedvivk, and R. S. Jacobs. 1988. Inactivation of phospholipase A2 by manoalide. Localization of the manoalide binding site on bee venom phospholipase A, Biochem. Pharmacol. 37:3639–3646.
87. Goris, J., J. Hermann, P. Hendrix, R. Ozon, and W. Merlevede. 1989. Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes. FEBS Lett. 245:9194.
88. Gouiffes, D., M. Juge, N. Grimaud, L. Welin, M.P. Sauviat, Y. Barbin, D. Laurent, C. Roussakis, J.P. Henichart, and J.F. Verbist. 1988a. Bistratamide A, a new toxin from the urochordata Lissoclinum bistratum sluiter: isolation and preliminary characterization. Toxicol. 26:1129–1136.
89. Gouiffes, D., S. Moreau, N. Helbecque, J.L. Bernier, J.P. Henichart, Y. Barbin, D. Laurent, and J.F. Verbist. 1988b. Proton nuclear magnetic study of bistratamide A, a new cytotoxic drug isolated from Lissoclinum bistratum sluiter. Tetrahedron. 44:451–459.
90. Gschwendt, M., W. Kittstein, and F. Marks. 1987. Didemnin B inhibits biological effects of tumor promoting phorbol esters on mouse skin, as well as phosphorylation of a 100 kD protein in mouse epidermis cytosol. Cancer Lett. 34:187–191.
91. Gunawardana, G.P., S. Kohmoto, S.P. Gunasekera, O.J. McConnell, and F.E. Koehn. 1988. Dercitin, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp. J. Am. Chem. Soc. 110:4856–4858.
92. Gusovsky, F. and J.W. Daly. 1990. Maitotoxin: A unique pharmacological tool for research on calcium- dependent mechanisms- Biochem. Pharmacology. 39:1633–1639.
93. Gustafson, K.R., J.H. Cardellina, R.W. Fuller, O.S. Weislow, R.F. Kiser, K.M. Snader, G.M. Patterson, and M.R. Boyd. 1989. AIDS-antiviral sulfolipids from cyanobacteria (blue-green algae). J. Natl. Cane. Inst. 81(16):1254–1258.
94. Hall, S., F. Strichartz, E. Moczydlowski, A. Ravindran, and P.B. Reichardt. 1990. The saxitoxins: sources, chemistry and pharmacology. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 29–65. American Chemical Society. Washington, DC.
95. Hannun, Y. A. and R.A. Bell. 1989. Regulation of protein kinase C by sphingosine and lysophingolipids. Clin. Chem. Acta. 185:333–345.
96. Hatanaka, Y., E. Yoshida, H. Nakayama, and Y. Kanaoka. 1990. Synthesis of m-conotoxin GIIIA: A chemical probe for sodium channels. Chem. Pharm. Bull. Tokyo 38:236–8.
97. Hayashi, E. and S. Yamada. 1975. Pharmacological studies on surugatoxin, the toxin principle from Japanese ivory mollusk (Babylonia japonica). Br. J. Pharmacol. 53:207–251.
98. Hayashi, E., M. Isogui, Y. Kagawa, N. Takayanagi, and S. Tamada, 1984. Neosurugatoxin, a specific antagonist of nicotinic acetylcholine receptors. J. Neurochem. 42:1491–1494.
99. Haystead, T.A.J., A.T.R. Sim, D. Carling, R.C. Honnor, Y. Tsukitani, P. Cohen, and D.G. Hardie. 1989. Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337:78–81.
100. Hennings, H., P.M. Blumberg, G.R. Pettit, C.L. Herald, R. Shores, and S.H. Yuspa. 1987. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis. 8:1343–1346.
101. Herdon, H. and S.R. Nahorski. 1989. Investigations of the roles of dihydropyridine- and ω-conotoxin-sensitive calcium channels in mediating depolarization-evoked endogenous dopamine release from striatal slices. Naunyn-Schmiedebergs Arch. Pharmacol. 340:36–40.
102. Hescheler, J., G. Mieskes, J.C. Riiegg, A. Takai, and W. Trautwein. 1988. Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes. Pfliigers Arch. 412:248–252.
103. Hirata, Y. and D. Uemura. 1986. Halichondrins: antitumor polyether macrolides from a marine sponge. Pure Appl. Chem. 58:701–710.
104. Hong, S.J. and C.C. Chang. 1989. Use of geographutoxin II (μ-conotoxin) for the study of neuromuscular transmission in mice. Br. J. Pharmacol. 97:934–940.
105. Huang, T.T.F. and R. Yanagimachi. 1984. Fucoidin inhibits attachment of guinea pig spermatazoa to the zona pellucida through binding to the inner acrosomal membrane and equatorial domains. Exp. Cell. Res. 153:363–373.
106. Hudson, J.B., H. Saboune, Z. Abramowski, G.H. Towers, and K.L. Rinehart. 1988. The photoactive antimicrobial properties of eudistomins from the Caribbean tunicate Eudistoma olivaceum. Photochem. Photobiol. 47(3):377–381.
107. Ireland, C.M. and Maiese, W.M. 1992. Unpublished results.
108. Ireland, C. M., T.F. Molinski, D.M. Roll, T.M. Zabriskie, T.C. McKee, J.C. Swersey, and M.P. Foster. 1989. Natural Product Peptides from Marine Organisms. In Bioorganic Marine Chemistry, Volume 3. P. J. Scheuer (ed.), pp. 1–46. Springer-Verlag. Berlin, Heidelberg.
109. Ireland, C.M., D.M. Roll, T.F. Molinski, T.C. McKee, T.M. Zabriskie, and J.C. Swersey. 1988. Uniqueness of the Marine Chemical Environment: Categories of Marine Natural Products from Invertebrates, Biomedical Importance of Marine Organisms, Memoirs of the California Academy of Sciences Number 13. D.G. Fautin (ed.), pp. 41–57. California Academy of Sciences. San Francisco.
110. Ireland, C. and D. J. Faulkner. 1978. The defensive secretion of the opithobranch mollusk Onchidella binneyi. Bioorg. Chem. 7:125–130.
111. Irie, K., N. Hagiwara, H. Tokuda, and K. Koshimizu. 1987. Structure-activity studies of the indole alkaloid tumor promoter teleocidins. Carcinogenesis. 8:547–552.
112. Ishihara, H., B.L. Martin, D.L. Brautigan, H. Karaki, H. Ozaki, Y. Kato, N. Fusetani, S. Watabe, K. Hashimoto, D. Uemura, and D.J. Hartshorne. 1989. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun. 159:871–877.
113. Issinger, O., T. Martin, W.W. Richter, M. Olson, and H. Fujiki. 1988. Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumor-promoter treatment. EMBO J. 7:1621–1626.
114. Itai, A., Y. Kato, N. Tomioka, Y. Iitaka, Y. Endo, M. Hasegawa, K. Shudo, H. Fujiki, and S. Sakai. 1988. A receptor model for tumor promoters: rational superposition of teleocidins and phorbol esters. Proc. Natl. Acad. Sci. USA. 85:3688–3692.
115. Jacobs, R.S., P. Culver, R. Langdon, T. O’Brien, and S. White. 1985. Some pharmacological observations on marine natural products. Tetrahedron. 41:981–984.
116. Jacobson, P.B., L.A. Marshall, A. Sunf, and R.S. Jacobs. Inactivation of human sinovial fluid phospholipase A2 by the marine natural product manoalide. Biochem. Pharmacol. 39:1557–1564.
117. Jaken, S. 1990. Protein kinase C and tumor promoters. Curr. Opin. Cell. Biol. 2:192–197.
118. Jan, C. R., M. Titeler, and A. S. Schneider. 1990. Identification of ω-conotoxin binding sites on adrenal medullary membranes: possiblility of multiple calcium channels in chromaffin cells. J. Neurochem. 54:355–358.
119. Jeffrey, A. M., R. M. L. Liskamp. 1986. Computer assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin. Proc. Natl. Acad. Sci. USA. 83:241–245.
120. Jiang, T. L., R. H. Liu, and S. E. Salmon. 1983. Antitumor activity of didemnin B in the human tumor stem cell assay. Cancer Chemother. Pharmacol. 11:1–4.
121. Kao, C.Y. 1966. Tetrodotoxin, saxitoxin, and their significance in the study of excitation phenomena. Pharmacol. Rev. 18:997–1049.
122. Kao, C. Y. 1986. Structure-activity relations of tetrodotoxin, saxitoxin and analogues. In Tetrodotoxin, Saxitoxin and the Molecular Biology of the Sodium Channel. C.Y. Kao and S.R. Levinson (eds.), pp. 52–67. Annals of the New York Academy of Science Volume 479. New York.
123. Karschin, A. and S. A. Lipton. 1989. Calcium channels in solitary retinal ganglion cells from post-natal rat.J. Physiol. 418:379–396.
124. Kaslauskas, R., P.T. Murphy, R.J. Wells, J.A. Baird-Lambert, and D.D. Jamieson. 1983. Halogenated pyrrolo [2,3-d] pyrimidine nucleosides from marine organisms. Aust. J. Chem. 36:165–170.
125. Kather, H. 1990. Pathways of purine metabolism in human adipocytes. J. Biol. Chem. 265:96–102.
126. Kato, Y., N. Fusetani, S. Matsunaga, and K. Hashimoto. Calyculin A, a novel antitumor metabolite from the marine sponge Discodermia calyx. J. Am. Chem. Soc. 108:2780–2781.
127. Keith, R.A., T.J. Mangano, and A.I. Salama. 1989. Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by ω-conotoxin GVIA. Br. J. Pharmacol. 98:767–772.
128. Kipreos, E.T. and J.Y.T. Wang. 1990. Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science 248:217–220.
129. Kobayashi, M.J. Kobayashi, and Y. Ohizumi. 1989. Cone shell toxins and the mechanisms of their pharmacological action. In Bioorganic Marine Chemistry, Volume 3 P.J. Scheuer (ed.), pp. 71–84. Springer-Verlag. Berlin, Heidelberg.
130. Kobayashi, M., T. Nakagawa, and H. Mitsuhashi. 1979. Marine terpenes and terpenoids. I. Structures of four cembrane-type diterpenes: sarcophytol-A, sarcophytol-A acetate, sarcophytol-B, and sarcophytonin-A, from the soft coral, Sarcophyton glaucum. Chem Pharm. Bull. (Tokyo) 27:2382–2387.
131. Kodama, I., N. Kondo, and S. Shibata. 1986. Electrochemical effects of okadaic acid isolated from black sponge in guinea-pig ventricular muscles. J. Physiol. 378:359–373.
132. Kosuge, T., K. Tsuji, and K. Hirai. 1981. Isolation and structure determination of a new marine toxin, neosurugatoxin, from the Japanese ivory shell, Babylonia japonica. Tetrahedron Lett. 22:3417–3420.
133. Kreuter, M. H., A. Bernd, H. Holzmann, W. Miiller-Klieser, A. Maidhof, N. Weibmann, Z. Kljajic, R. Batel, H.C. Schroder and W.E.G. Muller. 1989. Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells. Z. Naturforsch. 44c:680–688.
134. Kume, H., A. Takai, H. Tokuno, and T. Tomita. 1989. Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Nature. 341:152–154.
135. Laporte, D.C., B. M. Wierman, et al. 1980. Calcium- induced exposure of a hydrophobic surface on Calmodulin. Biochem. 19:3814–3819.
136. Levine, L. and H. Fujiki. 1985. Stimulation of arachidonic metabolism by different types of tumor promoters. Carcinogenesis. 6:1631–1634.
137. Levine, L., D. Xiao, and H. Fujiki. 1986. A combination of palytoxin with 1-oleoyl-2-acety 1-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combination of 12- O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters with OAG does not. Carcinogenesis. 7:99–103.
138. Li, L. H., L. G. Timmins, T. L. Wallace, W. C. Krueger, M. D. Prairie, and W. B. Im. 1984. Mechanism of action of didemnin B, a depsipeptide from the sea. Cancer Lett. 23:279–288.
139. Lin, Y. Y., M. Risk, S. M. Ray, D. van Engen, J. C. Clardy, J. Golik, J. C. James, and K. Nakanishi. 1981. Isolation and structure of brevetoxin-B from the “red tide” dinoflagellate Ptychodiscus brevis (Gymnodinium breve). J. Am. Chem. Soc. 103:6773–6775.
140. Lister, M. D., K. B. Glaser, R. J. Ulevitch, and E. A. Dennis. 1989. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388Dt cell. J. Biol. Chem. 264:8520–8528.
141. Look, S. A., W. Fenical, R. S. Jacobs, and J. Clardy. 1986 The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae. Proc. Nat. Acad. Sci. USA. 83:6238–6240.
142. Loya, S., and A. Hizi. 1990. The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives. FEBS. 269:131–134.
143. Luedke, E. S. 1990. The identification and characterization of the pseudopterosins: anti-inflammatory agents isolated from the gorgonian coral Pseudopterogorgia elizabethae, Ph.D. Thesis, University of California. Santa Barbara.
144. Luetje, C. W., K. Wada, S. Rogers, S. N. Abramson, K. Tsuji, S. Heinemann, and J. Patrick. 1990. Neurotoxins distiguish between different neuronal nicotinic acetylcholine receptor subunit combinations. J. Neurochem. 55:632–639.
145. MacKintosh, C. and P. Cohen. 1989 Identification of high levels of type 1 and type 2A protein phosphatases in higher plants. Biochem. J 262:335–339.
146. Maeda, N., K. Wada, M. Yuzaki, and K. Mikoshiba. 1989. Autoradiographic visualisation of a calcium channel antagonist, [125I]ω-conotoxin GVIA, binding site in the brains of normal and cerebellar mutant mice (pcd and weaver). Brain Res. 489:21–30.
147. Maldonado, E., J. A. Lavergne, and E. Kraiselburd. 1982. Didemnin A inhibits the in vitro replication of dengue virus types 1, 2 and 3. Puerto Rico Health Science Journal. 1:22–25.
148. Mangano, T. J., J. Patel, A. I. Salama, and R. A. Keith. 1990. Glycine-evoked neurotransmitter release from rat hippocampal brain slices: evidence for the involvement of glutaminergic transmission. J. Pharm. Experi. Ther. 252:574–80.
149. Marshall, I. G. and A. L. Harvey. 1990. Selective neuromuscular blocking properties of α-conotoxin in vivo. Toxicon. 28:231–234.
150. Maruyama, H, J. Nakajima, and I. Yamamoto. 1987. A study on the anticoagulant and fibrinolytic activities of a crude fucoidan from the edible brown seaweed laminaria religiosa, with special reference to its inhibitory effect on the growth of sarcoma-180 ascites cells subcutaneously implanted in mice. Kitasato Arch. Exp. Med. 60(3): 105–121.
151. Mayer, A. M. S., K. B. Glaser, and R. S. Jacobs. 1988. Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases. J Pharm. Exp. Ther. 244:871–878.
152. Mayer, A. M. and Jacobs, R. S. 1988. Manoalide: an antiinflammatory and analgesic marine natural product. In Biomedical Importance of Marine Organisms, Memoirs of the California Academy of Sciences Number 13. D.G. Fautin (ed.), pp. 133–1142. California Academy of Sciences. San Francisco.
153. Minigo, H., D. Nemet, A. Planinc-Peraica, V. Bogdanic, B. Labar, B. Jaksic, and E. Hauptmann. 1990. High dose ara-C as induction therapy of acute myeloid leukemia. Folia Haematol. 117:135–140.
154. Mong, S., B. Votta, H.M. Sarau, J.J. Foley, D. Schmidt, B.K. Carte, B. Poehland, and J. Westley. 1990.15-Acetylthioxy-furodysinin lactone, isolated from a marine sponge, Dysidea sp., is a potent agonist to human leukotriene B4 receptor. Prostaglandins. 39:89–97.
155. Montgomery, D.W. and C.F. Zukoski. 1985. Didemnin B: a new immunosuppressive cyclic peptide with potent activity in vitro and in vivo. Transplantation Proc. 40:49–56.
156. Montgomery, D.W., A. Celniker, and C.F. Zukoski. 1987. Didemnin B: a new immunosuppressive cyclic peptide that stimulates murine antibody responses in vitro and in vivo. Transplantation Proc. 19:1295–1296.
157. Moore, R.E. and G. Bartolini. 1981. Structure of paly toxin. J. Am. Chem. Soc. 103:2491–2494.
158. Nakadate, T. 1989. The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems, Japan J. Pharmacol. 49:1–9.
159. Nakamura, H., H. Wu, J. Kobayashi, Y. Nakamura, Y. Ohizumi, and Y. Hirata. 1985. Purealin, a novel enzyme activator from the okinawan marine sponge Psammaplysilla purea. Tetrahedron Lett. 26(37):4517- 4520.
160. Nakamura, H., K. Yoshito, M.A. Pajares, and R.R. Rando. Structural basis of protein kinase C activation by tumor promoters. Proc. Natl. Acad. Sci. USA. 86:9672–9676.
161. Nakamura, Y., M. Kobayashi, H. Nakamura, H. Wu, J. Kobayashi, and Y. Ohizumi. 1987. Purealin, a novel activator of skeletal muscle actomyosin ATPase and myosin EDTA-ATPase that enhanced the superprecipitation of actomyosin. Eur. J. Biochem. 167:1–6.
162. Narahashi, T. 1974. Chemical tools in the study of excitable membranes. Physiol. Rev. 54: 813–889.
163. Narahashi, T. 1988. Mechanism of tetrodotoxin and saxitoxin action. In Handbook of Natural Toxins, Volume 3: Marine Toxins and Venoms. A.T. Tu (ed.), pp. 185–210. Mercel Dekker Inc. New York.
164. Narisawa, T., M. Takahashi, M. Niwa, Y. Fukaura, and H. Fujiki. 1989. Inhibition of methylnitrosourea-induced large bowel cancer development in rats by sarcophytol A, a product from a marine soft coral, Sarcophyton glaucum. Cancer Res. 49:3287–3289.
165. Nishizuka, Y. 1988. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 334:661–5.
166. Nishizuka, Y. 1989. The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction. JAMA. 262:1826–32.
167. Obara, K., A. Takai, J.C. Riiegg, and P. de Lanerolle. 1989. Okadaic acid, a phosphatase inhibitor, produces a Ca2+ and calmodulin-independent contraction of smooth muscle. Phliigers Arch. 414:134–138.
168. Oehninger, S., A. Acosta, and G.D. Hodgen. 1990. Antagonistic and agonistic properties of saccharide moieties in the hemizona assay. Fertil. Steril. 53(1):143–149.
169. Ohizumi, Y. and M. Kobayashi. 1990. Ca-dependent excitatory effects of maitotoxin on smooth and cardiac muscle. In Marine Toxins. ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 233–143. American Chemical Society, Washington, DC.
170. Olivera, B. M., W.R. Gray, and Cruz, L. J. 1988. Marine snail venoms. In Handbook of Natural Toxins. Volume 3: Marine Toxins and Venoms. A. T. Tu (ed.), pp. 327–354. Mercel Dekker Inc. New York.
171. Olivera, B.M., W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. deSantos, and L.J. Cruz. 1985. Peptide neurotoxins from fish-hunting cone snails. Science. 230:1338–1343.
172. Olivera, B.M., D.R. Hillyard, J. Rivier, S. Woodward, W.R. Gray, G. Corpuz, and L.J. Cruz. 1990a. Conotoxins: targeted peptide ligands from snail venoms. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 256–278. American Chemical Society. Washington, DC.
173. Olivera, B.M., J. Rivier, C. Clark, C.A. Ramilo, G.P. Corpuz, F.C. Abogadie, E.E. Mena, S.R. Woodward, D.R. Hillyard, and L.J. Cruz. 1990b. Diversity of Conus neurotoxins. Science. 249:257–263.
174. Palczewski, K., J.H. McDowell, S. Jakes, T.S. Ingebritsen, and P.A. Hargrave. 1989. Regulation of rhodopsin dephosphorylation by arrestin. J. Biol. Chem. 264:15770–15773.
175. Pardi, A., A. Galdes, J. Florance, and D. Maniconte. 1989. Solution structures of a-cono-toxin G1 determined by two-dimensional NMR spectroscopy. Biochemistry. 28:5494–5501.
176. Perry, N.B., J.W. Blunt, M.H.G. Munro, and L.K. Pannell. Mycalamide A, an antiviral compound from a New Zealand sponge of the genus Mycale. J. Am. Chem. Soc. 110:4850–4851.
177. Pettit, G. R., Y. Kamano, C. L. Herald, A. A. Tuinman, F. E. Boettner, H. Kizu, J. M. Schmidt, L. Baczynskyj, K. B. Tomer, and R. J. Bontems. 1987. The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10. J. Am. Chem. Soc. 109:6883–6885.
178. Pettit, G. R., S. B. Singh, F. Hogan, P. Lloyd-Williams, D. L. Herald, D. D. Burkett, and P. J. Clewlow. 1989. The absolute configuration and synthesis of natural(-)- olastatin 10. J.Am. Chem. Soc. 111:5463–5465.
179. Pettit, G. R., C. L. Herald, D. L. Doubek, and D. L. Herald. 1982. Isolation and structure of Bryostatin 1. J. Am. Chem. Soc. 104:6846–6848.
180. Pinchuk, L. N. and G. V. Pinchuk. 1990. Monoclonal antibody to brain cytoplasmic tetrodotoxin-sensitive protein detects an epitope associated with lymphocytes and involved in lymphocyte activation (Med Line Abstract). J. Neuroimmunol. 27:71–78.
181. Plummer, M. R., D. E. Logothetis, and P. Hess. 1989. Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron. 2:1453–63.
182. Rapier, C., G. G. Lunt, and S. Wonnacott. 1990. Nicotinic modulation of [3H]-dopamine release from striatal synaptosomes: pharmacological characterization. J. Neurochem. 54:937–945.
183. Redpath, N.T. and C.G. Proud. 1989. The tumor promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2. Biochem. J 262:69–75.
184. Rinehart, K.L., T.G. Holt, N.L. Fregeau, J.G. Stroh, P.A. Keifer, F. Sun, L.H. Li, and D.G. Martin. 1990. Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem. 55:4512–4515.
185. Rinehart, K.L., J.B. Gloer, J.C. Cook, S. A. Mizsak, and T.A. Scahill. 1981a, Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate J. Am. Chem. Soc. 103:1857–1859.
186. Rinehart, K.L., J.B. Gloer, R.G. Hughes, H.E. Renis, J.P. McGovren, E.B. Swynenberg, D.A. Stringfellow, S.L. Kuentzel, and H. Li. 1981b. Didemnins: antiviral and antitumor depsipeptides from a Caribbean tunicate. Science. 212:933–935.
187. Rinehart, K.L., J.B. Gloer, G.R. Wilson, R.G. Hughes, L.H. Li, H.E. Renis, and J.P. McGovren. 1983. Antiviral and antitumor compounds from tunicates. Fed. Proc. 42:87–90.
188. Rinehart, K.L., P.D. Shaw, L.S. Shield, J.B. Gloer, G.C. Harbour, M.E.S. Koker, D. Samain, R.E. Schwartz, A.A. Tymiak, D.L. Weller, G.T. Carter, M.H.G. Munro, R.G. Hughes, H.E. Renis, E.B. Swyneberg, D.A. Stringfellow, J.J. Vavra, J.H. Coats, G.E. Zurenko, S.L. Kuentzel, L.H. Li, G.J. Bakus, R.C. Brusca, L.L. Craft, D.N. Young, and J.L. Connor. 1981c. Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents. Pure Appl. Chem. 53:795–817.
189. Rossof, A.H., RA. Johnson, B.D. Kimmell, J.E. Graham, and D.L. Roseman. 1983. In vitro phase II study of didemin B in human cancer (Abstract,). Proc. Am. Assoc. Cancer Res. 24:315.
190. Sakai, R., I. Ikeda, H. Kitani, H. Fujiki, E Takaku, U. Rapp, T. Sugimura, and M. Nagao. 1989. Flat reversion by okadaic acid of raf and ret-II transformants. Proc. Natl. Acad. Sci. USA. 86:9946–9950.
191. Santostasi, G., R.K. Kutty, A.L. Bartorelli, T. Yasumoto, and G. Krishna. 1990. Maitotoxin-induced myocardial cell injury: calcium accumulation followed by ATP depletion precedes cell death. Toxicol. Appl. Pharmacol. 102:164–173.
192. Sassa, T.; W.W. Richter, N. Uda, M. Suganuma, H. Suguri, S. Yoshizawa, M. Horita, and H. Fujiki. 1989. Apparent “activation” of protein kinases by okadaic acid class tumor promoters. Biochem. Biophys. Res. Commun. 159:939–944.
193. Sawyer, P.J., J.H. Gentile, and J.J. Sasuer Jr. 1968. Demonstration of a toxin from Aphanizomenon flos-aque (L.) Ralfs. Can J. Microbiol. 14:1199–1204.
194. Schatten, G., H. Schatten, H. Spector, C. Cline, N. Paweletz, C. Simerly, and C. Petzelt. 1986. Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice. Exp. Cell Res. 166:191–208.
195. Schatten, H. and G. Schatten. 1986. Motility and centrosomal organization during sea urchin and mouse fertilization. Cell Motil. Cytoskel. 6:163–175.
196. Schmitz, F.J., R.S. Prasad, Y. Gopichand, M.G. Hossain, and D. van der Helm. 1981. Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium J Am. Chem. Soc. 103:2467–2469.
197. Schneider, H.R., M. Mieskes, and O. Issinger. 1989. Specific dephosphorylation by phosphatases 1 and 2A of a nuclear protein structurally and immunologically related to nucleolin. Eur. J. Biochem. 180:449–455.
198. Shibata, S., Y. Ishida, H. Kitano, Y. Ohizumi, J. Habon, Y. Tsukitani, and H. Kikuchi. 1982. Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency. J. Pharmacol. Exp. Ther. 223:135–143.
199. Shimizu, Y., H. Bando, H. N. Chou, G. van Duyne, and J.C. Clardy. 1986b. Absolute configuration of brevetoxins. J Chem. Soc., Chem. Commun, pp. 1656–1658.
200. Shimizu, Y., H.-N. Chou, H. Bando, G. van Duyne, J.C. Clardy. 1986a
201. Sorenson, E. M., P. Culver, and V.A. Chiappinelli. 1987. Lophotoxin: selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin. Neuroscience. 20:875–884.
202. Spector, I. and N.R. Shochet. 1983. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science. 219:493–495.
203. Spector, I., N.R. Shochet, D. Blasberger, and Y. Kashman.1989 Latrunculins — novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. Cell Motil. Cytoskel. 13:127–144.
204. Stewart, J.A., W.P. Tong, J.N. Hartshorn, and J.J. McCormack. 1986. Phase I evaluation of didemnin B (NSC 325319) (Abstract). Proc. Am. Soc. Clin. Oncol. 5:33.
205. Strichartz, G. and N. Castle. 1990. Pharmacology of marine toxins: effects on membrane channels. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 2–20. American Chemical Society, Washington, DC.
206. Strichartz, G., T. Rando, S. Hall, J. Gitscher, L. Hall, B. Magnani, and B. Hansen Bay. 1986. On the mechanism by which saxitoxin binds to and blocks sodium channels. In Tetrodotoxin, saxitoxin and the molecular biology of the sodium channel. C. Y. Kao and S. R. Levinson (eds.), pp. 96–112. New York Academy of Science.
207. Stroud, R.M., M.R. McCarthy, and M. Shuster. 1990. Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels. Biochemistry. 29:11009–11023.
208. Structure of brevetoxin A (GB-1 Toxin), the most potent toxin in the florida Red Tide organism Gymnodinium breve (Ptychodiscus brevis). J. Am. Chem. Soc. 108:514–515.
209. Stryer, L. 1981. –Biochemistry.— Biochemistry 2 ed., W. H. Freeman and Co., New York.
210. Suganuma, M., H. Fujiki, H. Furuya-Suguri, S. Yoshizawa, S. Yasumoto, Y. Kato, N. Fusetani, and T. Sugimura. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-I mouse skin. Cancer Res. 50:3521–3525.
211. Suganuma, M., H. Fujiki, H. Suguri, S. Yoshizawa, M. Hirota, M. Nakayasu, M. Ojika, K. Wakamatsu, K. Yamada, and T. Sugimura. 1988. Okadaic acid: an additional non-phorbal-12-tetradecanoate-13-acetate- type tumor promoter. Proc. Natl. Acad. Sci. USA. 85:1768–1771.
212. Suganuma, M., M. Suttajit, H. Suguri, M. Ojika, K. Yamada, and H. Fujiki. 1989. Specific binding of okadaic acid, a new tumor promoter in mouse skin. FEBS Lett. 250:615–618.
213. Sugawara, I., W. Itoh, S. Kimura, S. Mori, and K. Shimada. Further characterization of sulfated homopoiysaccharides as anti-HIV agents. Experientia. 45(10):996–998.
214. Tachibana, K., P.J. Scheuer, Y. Tsukitani, H. Kikuchi, D. Van Engen, J. Clardy, Y. Gopichand, and F.J. Schmitz. 1981. Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. J. Am. Chem. Soc. 103:2469–2471.
215. Takai, A., C. Bialojan, M. Troschka, and J.C. Riiegg. 1987. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEBS Lett. 217:81–84.
216. Takai, A., M. Troschka, G. Mieskes, and A.V. Somlyo. 1989. Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2. Biochem. J. 262:617–623.
217. Takemura, M., J. Kishino, A. Yamatodani, and H. Wada. 1989a. Inhibition of histamine release from rat hypothalamic slices by ω-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative. Brain Res. 496:351–6.
218. Takemura, M., H. Kiyama, H. Fukui, M. Tohyama, and H. Wada. 1989b. Distribution of the ω-conotoxin receptor in rat brain. An autoradiographic mapping. Neurosci. 32:405–416.
219. Takito, J., H. Nakamura, J. Kobayasi, and Y. Ohizumi. 1987a. Enhancement of the actin-activated ATPase activity of myosin from canine cardiac ventricle by purealin. Biochim. Biophys. Acta. 912:404–407.
220. Takito, J., H. Nakamura, J. Kobayasi, Y. Ohizumi, K. Ebisawa, and Y. Nonomura. 1986. Purealin, a novel stabilizer of smooth muscle myosin filaments that modulates ATPase activity of dephosphorylated myosin. J Biol. Chem. 261(29):13861–13865.
221. Takito, J., Y. Ohizumi, J. Kobayasi, K. Ebisawa, and Y. Nonomura. 1987b. The mechanism of inhibition of light-chain phosphorylation by purealin in chicken gizzard myosin. Eur. J. Pharmacol. 142:189–195.
222. Tamplin, M.L. 1990. Abacterial source of tetrodotoxins and saxitoxins. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 78–86. American Chemical Society, Washington, DC.
223. Taylor, P., P. Culver, S. Abramson, L. Wasserman, T. Kline, and W. Fenical. 1988. Use of selective toxins to examine acetylcholine receptor structure. In Biomedical Importance of Marine Organisms. Memoirs of the California Academy of Sciences Number 13. D.G. Fautin (ed.), pp. 109–114. California Academy of Sciences. San Francisco.
224. Thomson, C. and J. Wilkie. 1989. The conformations and electrostatic potential maps of phorbol esters, teleocidins and ingenols. Carcinogenesis. 10:531–540.
225. Trainer, V. L., R.A. Edwards, A.M. Szmant, A.M. Stuart, T.J. Mende, and D.G. Baden. 1990. Brevetoxins: unique activators of voltage-sensitive sodium channels. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 166–175. American Chemical Society. Washington, DC.
226. Uemura, D., K. Ueda, and Y. 1981. Further studies of palytoxin. II. Structure of palytoxin. Tetrahedron Lett. 22:2781–2784.
227. Ulevitch, R.J., Y. Watanabe, M. Sano, M.D. Lister, R.A. Deems, and E.A. Dennis. 1988. Solubilization, purification, and characterization of membrane- bound phospholipase A, from the P388D1 macrophage-like cell line. J.Biol. Chem. 263:3079–3085.
228. van Duyne, G.D. 1990. X-ray crystallographic studies of marine toxins. In Marine Toxins, ACS Symposium Series 418. S. Hall and G. Strichartz (eds.), pp. 144165. American Chemical Society. Washington, DC.
229. van Sande, J., F. Deneubourg, R. Beauivens, J.C. Breakman, D. Daloze, and J.E. Dumont. 1990. Inhibition of iodide transport in thyroid cells by dysidenin, a marine toxin, and some of its analogs. Mol. Pharmacol. 37:583–589.
230. Wada, A., Y. Uezono, M. Arita, K. Tsuji, N. Yanagihara, H. Kobayashi, and F. Izumi, 1989. High affinity and selectivity of neosurugatoxin for the inhibition of 22Na influx via nicotinic receptor-ion channel in cultured bovine adrenal medullary cells: comparative study with histrionicotoxin. Neuroscience. 33:333–339.
231. Wattenberg, E.V., K.L. Byron, M.L. Villereal, H. Fujiki, and M.R. Rosner. 1989a. Sodium as a mediator of non- phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. J. Biol. Chem. 264:14668–14673.
232. Wattenberg, E.V., H. Fujiki, and M.R. Rosner. 1987. Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O- tetradecanoylphorbol-13-acetate-type tumor promoter. Cancer Res. 47:4618–4622.
233. Wattenberg, E.V., P.L. McNeil, H. Fujiki, and M.R. Rosner. 1989b. Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. J. Biol. Chem. 264:213–219.
234. Watters, D., K. Marshall, S. Hamilton, J. Michael, M. McArthur, G. Seymour, C. Hawkins, R. Gardiner, and M. Lavin. 1990. The bistratenes: new cytotoxic marine macrolides which induce some properties indicative of differentiation in HL-60 cells. Biochem. Pharmacol. 39:1609–1614.
235. Weinberg, J.M., J.A. Davis, A. Lawton, and M. Abarzua. 1988. Modulation of cell nucleotide levels in isolated kidney tubules. Am. J Physiol. 254:F311-F322.
236. Wender, P.A., K.F. Koehler, N.A. Sharkey, M.L. Dell’Aquila, and P.M. Blumberg. 1986. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proc. Natl. Acad. Sci. USA. 83:4214–8.
237. Wessler, I., D.J. Dooley, H. Osswald, and F. Schlemmer. Differential blockade by nifedipine and ω-conotoxin GVIA of a1 and b1-adrenoceptor-controlled calcium channel motor nerve terminals of the rat. Neurosci. Lett. 108:173–178.
238. Wheeler, L.A., G. Sachs, D. Goodrum, L. Amdahl, N. Horowitz, and W. de Vries. 1988. Importance of marine natural products in the study of inflammation and calcium channels. In Biomedical Importance of Marine Organisms, Memoirs of the California Academy of Sciences Number 13. D.G. Fautin (ed.), pp. 11125–132. California Academy of Sciences. San Francisco.
239. Williams, M., M. Abreu, M.F. Jarvis, and L. Noronha-Blob. Characterization of adenosine receptors in the PC12 pheochromocytoma cell line using radioligand binding: evidence for A-2 selectivity. J. Neurochem. 48:498–502.
240. Wollner, D.A., R. Scheinman, and W.A. Catterall. 1988. Sodium channel expression and assembly during development of retinal ganglion cells. Neuron. 1:727–739.
241. Wright, A.E., D.A. Forleo, G.P. Gunawardana, S.P. Gunasekera, F.E. Koehn, and O.J. McConnell. 1990. Antitumor Tetrahydroisoquinoline Alkaloids from the Colonial Ascidian Ectinascidia turbinata. J. Org. Chem. 55:4508–4512.
242. Wu, C.H. and T. Narahashi. 1988. Mechanism of action of novel marine neurotoxins on ion channels. Ann. Rev. Pharmacol. Toxicol. 28:141–161.
243. Yoshikami, D., Z. Bagabaldo, and B.M. Olivera. 1989. The inhibitory effects of ω-conotoxins on Ca channel and synapses. Ann. N. Y. Acad. Sci. 560:230–248.
244. Zabriskie, T.M., C.L. Mayne, and C.M. Ireland. 1988. Patellazole C: A Novel Cytotoxic Macrolide from Lissoclinum patella. J. Amer. Chem. Soc. 110:7919–7920.
245. Zafaralla, G.C., C. Ramilo, W.R. Gray, R. Karlstrom, B.M. Olivera, and L.J. Cruz. 1988. Phylogenetic specificity of cholinergic ligands: α-conotoxin SI. Biochemistry. 27:7102–7105