Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4729-4732

  Takayama, Hiromitsu ^a   Yaegashi, Yuichi ^a   Kitajima, Mariko ^a   Han, Xia ^a   Nishimura, Kazuhiro ^a   Okuyama, Shigeru ^b   Igarashi, Kazuei ^a  

^a CHIBA UNIVERSITY   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Channel blocker; Dementia; Nitrogenous heterocycle; NMDA receptor; Polyamine

Indexed keywords

AQ 343; AQ 444; BENZAZEPINE DERIVATIVE; DIHYDRODIBENZAZEPINE TETRAAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; NONHUMAN; XENOPUS LAEVIS;

AMINES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 34547509320     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.069     Document Type: Article

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