Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4987-4990

  Drewe, John ^a   Kasibhatla, Shailaja ^a   Tseng, Ben ^a   Shelton, Emma ^b   Sperandio, David ^b   Yee, Robert M ^b   Litvak, Joane ^b   Sendzik, Martin ^b   Spencer, Jeffrey R ^b   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

^b CELERA   (United States)

Author keywords

Apoptosis inducer; HTS assay; Tubulin inhibitor

Indexed keywords

5(4 HYDROXY 6 METHYL 2 OXO 2H PYRAN 3 YL) 7 (2 METHOXY 4 (METHYLTHIO)PHENYL) (E) 2,3,6,7 TETRAHYDRO 1,4 THIAZEPINE; 5(4 HYDROXY 6 METHYL 2 OXO 2H PYRAN 3 YL) 7 (4 METHYLPHENYL) (E) 2,3,6,7 TETRAHYDRO 1,4 THIAZEPINE; 5(4 HYDROXY 6 METHYL 2 OXO 2H PYRAN 3 YL) 7 PHENYL (E) 2,3,6,7 TETRAHYDRO 1,4 THIAZEPINE; CASPASE; THIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, CHEMICAL; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES; TUBULIN;

EID: 34547498132     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.098     Document Type: Article

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