Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: Case-control study in a young Mexican population

Annals of Surgical Oncology

Volumn 14, Issue 8, 2007, Pages 2246-2249

  Medina Franco, Heriberto ^a   Medina, Antonio Ramos De La ^a   Vizcaino, Gloria ^b   Medina Franco, Jose Luis ^c  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b Hospital Regional   (Mexico)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cadherin; CDH1; Gastric cancer; Polymorphism

Indexed keywords

UVOMORULIN;

ADULT; ALLELE; ARTICLE; BLOOD SAMPLING; CANCER RISK; CASE CONTROL STUDY; CHI SQUARE TEST; CLINICAL ARTICLE; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; FAMILY HISTORY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; MALE; MEXICO; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PROMOTER REGION; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM; STATISTICAL SIGNIFICANCE; STOMACH CANCER;

ADULT; ALLELES; CADHERINS; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MEXICO; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; STOMACH NEOPLASMS;

EID: 34547445530     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-006-9054-4     Document Type: Article

References (17)

1. Medina-Franco H, Heslin MJ, Cortés-González R. Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol 2000; 7:515-9
2. Ramos-De la Medina A, Salgado-Nesme N, Torres-Villalobos G, Medina-Franco H. Clinicopathological characteristics of gastric cancer in a young patient population. J Gastrointest Surg 2004; 8:240-4
3. Pignatelli M, Vessey CJ. Adhesion molecules: novel molecular tools in tumor pathology. Hum Pathol 1994; 25:849-56
4. Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 1988; 102:639-55
5. Behrens J, Mareel MM, Von Roy FM, Birchmeier W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989; 108:2435-47
6. Medina-Franco H, Gamboa-Dominguez A, Torres-Villalobos G, et al. Altered expression of E-cadherin predicts survival in young patients with poorly differentiated gastric adenocarcinoma. Proc Am Soc Clin Oncol 2003; 22:351
7. Berx G, Becker KF, Hofler H, van Roy F. Mutation of the human E-cadherin (CDH1) gene. Hum Mutat 1998; 12:226-37
8. Guilford P, Hopkins J, Harraway J, et al. E-cadherin germline mutations in familial gastric cancer. Nature 1998; 392:402-5
9. Li LC, Chui RM, Sasaki M, et al. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res 2000; 60:873-6
10. Humar B, Graziano F, Cascinu S, et al. Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene 2002; 21:8192-5
11. Ramos-De la Medina, More H, Medina-Franco H, et al. Single nucleotide polymorphisms (SNPs) in the promoter region of CDH1 in familial gastric cancer. Rev Esp Enferm Dig 2006; 98:36-41
12. Wu MS, Huang SP, Chang YT, et al. Association of the -160 C→A promoter polymorphism of E-cadherin gene with gastric carcinoma risk. Cancer 2002; 94:1443-8
13. Park WS, Cho YG, Park JY, et al. A single nucleotide polymorphism in the E-cadherin gene promoter -160 is not associated with risk of Korean gastric cancer. J Korean Med Sci 2003; 18:501-4
14. Pharoah PD, Oliveira C, Machado JC, et al. CDH1 c-160a promoter polymorphism is not associated with the risk of stomach cancer. Int J Cancer 2002; 101:196-7
15. Perera FP, Weinstein IB. Molecular epidemiology: recent advances and future directions. Carcinogenesis 2000; 21:517-24
16. Lei H, Sjoberg-Margolin S, Salahsor S, et al. CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variations show no detectable breast cancer risk. Int J Cancer 2002; 98:199-204
17. Porter TR, Richards FM, Houlston RS, et al. Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. Oncogene 2002; 21:1928-33