The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: Determination of a novel susceptible haplotype

Diabetes and Vascular Disease Research

Volumn 4, Issue 2, 2007, Pages 124-129

  Singh, Puneetpal ^a   Singh, Monica ^a   Gaur, Sunil ^b   Kaur, Taranpal ^c  

^a PUNJABI UNIVERSITY   (India)

^b Sai Cardio Clinic   (India)

^c City Medsave Hospital   (India)

Author keywords

ApoA I gene; ApoA IV gene; ApoC III gene; Coronary heart disease; Haplotypes; Linkage disequilibrium; Punjab; Type 2 diabetes

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; APOLIPOPROTEIN A4; APOLIPOPROTEIN C3; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DNA FLANKING REGION; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INSULIN TREATMENT; INTRON; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

3' FLANKING REGION; 3' UNTRANSLATED REGIONS; ADULT; AGED; APOLIPOPROTEIN A-I; APOLIPOPROTEIN C-III; APOLIPOPROTEINS A; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INDIA; INTRONS; LINKAGE DISEQUILIBRIUM; LIPIDS; MALE; MIDDLE AGED; MULTIGENE FAMILY; ODDS RATIO; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RISK ASSESSMENT; RISK FACTORS;

EID: 34547424788     PISSN: 14791641     EISSN: None     Source Type: Journal    
DOI: 10.3132/dvdr.2007.030     Document Type: Article

References (27)

1. Ford ES, Stefano F. Risk factors for mortality from all causes and from coronary heart disease among persons with diabetes. Findings from the National Health and Nutrition Examination Survey Epidemiologic Follow-up study. Am J Epidemiol 1991;133:1220-30.
2. Bierman EL. Atherogenesis in diabetes. Atherosclerosis Thromb 1991;12:647-50.
3. Stern MP. Do non-insulin dependent diabetes mellitus and cardiovascular disease share common antecedents? Ann Int Med 1996;124:110-16.
4. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229-34.
5. Trembath RC, Thomas DJ, Hendra TJ, Yudkin JS, Galton DJ. Deoxyribonucleic acid polymorphism of the apoprotein AI-CIII-AIV gene cluster and coronary heart disease in non-insulin-dependent diabetes. Br Med J 1987;294: 1577-88.
6. Rigoli L, Cucinotta D, Cocozza S et al. A genetic polymorphism of the apolipoprotein AI-CIII gene cluster is associated with coronary heart disease in non insulin dependent diabetes mellitus. Diabetes Nutr Metab 1994;7:71-5.
7. Rigoli L, Raimondo C, Di Benedetto A et al. Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus. Acta Diabetol 1995;4:251-6.
8. Karathanasis SK, McPheroson J, Zannis VI, Breslow JL. Linkage of human Apolipoprotein AI, CIII and AIV genes. Nature 1983;304:371-3.
9. Groenendijk M, Cantor RM, de Bruin TW, Dallinga-Thie CM. The ApoAI-CIII-AIV gene cluster. Atherosclerosis 2001;157:1-11.
10. Mooradian AD, Haas MJ, Wong NC. Transcriptional control of apolipoprotein A-I gene expression in diabetes. Diabetes 2004;53:513-20.
11. Gao J, Wei Y, Huang Y et al. The expression of intact and mutant human apoAI/CIII/AIV/AV gene cluster in transgenic mice. J Biol Chem 2005;13:12559-66.
12. Ordovas JM, Civeira F, Genest J Jr et al. Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis 1991;87:75-86.
13. Tybjaerg-Hansen A, Nordestgaard BG, Gerdes LU, Faergeman O, Humphries SE. Genetic markers in the apo AI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis. Atherosclerosis 1993;100:157-69.
14. Paul-Hayase H, Rosseneu M, Robinson D, Van Bervliet JP, Deslypere JP, Humphries SE. Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apo AIV concentrations. Hum Genet 1992;88:439-46.
15. Kee F, Amouyel R Fumeron F. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Atherosclerosis 1999;145:187-95.
16. Vavatsi NA, Kouidou SA, Geleris PN. Increased frequency of the rare PstI allele (P2) in a population of CAD patients in northern Greece. Clin Genet 1995;47:22-6.
17. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
18. Haviland MB, Kessling AM, Davignon J, Singh CF Estimation of Hardy-Weinberg and pairwise disequilibrium in the apolipoprotein AI-CIII-AIV gene cluster. Am J Hum Genet 1991;49:350-65.
19. Epstein MP, Satten GA. Inference on haplotype effects in case-control studies using unphased genotype data. Am J Hum Genet 2003;73:1316- 29.
20. Akaike H. Factor analysis and AIC. Psychometrika 1987;52:317-32.
21. Excoffier L, Laval C, Schneider S. Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005;1:47-50.
22. Botstein D, White RL, Skolnick M, Davis RW Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 1980;32:314-31.
23. Russo GT, Meigs JB, Cupples LA et al. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study. Atherosclerosis 2001;158:173-81.
24. Rodrigo E, Gonzalez-Lamuno D, Ruiz JC. Apolipoprotein C-III and E polymorphisms and cardiovascular syndrome, hyperlipidemia, and insulin resistance in renal transplantation. Am J Transplant 2002;2:343-8.
25. Wile DB, Barbir M, Gallagher J. Apolipoprotein A-I gene polymorphisms: frequency in patients with coronary artery disease and healthy controls and association with serum apo A-I and HDL-cholesterol concentration. Atherosclerosis 1989;78:9-18.
26. Paulweber B, Friedl W, Krempler F, Humphries SE, Sandhofer F. Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease. Atherosclerosis 1988;73:125-33.
27. Simons LA, Balasubramaniam S, Szanto A et al. High density lipoproteins, genetic polymorphism for apoA-I and coronary artery disease Aus N Z J Med 1991;21:330-4.