Analysis of chromosomal damage after in vivo exposure to 56 Fe ions by means of mFISH and micronucleus methods

Advances in Space Research

Volumn 40, Issue 4, 2007, Pages 491-500

  Rithidech, Kanokporn Noy ^a   Supanpaiboon, Wisa ^a   Honikel, Louise ^a   Whorton, Elbert B ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

56 Fe ions; Blood erythrocytes; Bone marrow cells; Chromosome aberrations; In vivo; mFISH; Micronucleus assay; Mouse; Rays

Indexed keywords

CELL CULTURE; CHROMOSOMES; GAMMA RAYS; MICROSTRUCTURE; RADIATION DAMAGE;

BONE MARROW CELLS; CHROMOSOME ABERRATIONS; MICRONUCLEUS ASSAY;

HEAVY IONS;

EID: 34547408328     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2007.03.097     Document Type: Article

References (37)

1. Abramsson-Zetterberg L., Zetterberg G., and Grawe J. The time-course of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood. Mutat. Res. 350 (1996) 349-358
2. Brooks A., Bao S., Rithidech K., Couch L.A., and Braby L.A. Relative effectiveness of HZE iron-56 particles for the induction of cytogenetic damage in vivo. Radiat. Res. 155 (2001) 353-359
3. Brooks A.L. Biomarkers of exposure, sensitivity and disease. Int. J. Radiat. Biol. 75 (1999) 1481-1503
4. Chang P.Y., Torous D., Lutze-Mann L., and Winegar R. Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes. Mutat. Res. 466 (2000) 87-96
5. Cornforth M.N. Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res. 155 (2001) 643-659
6. Cucinotta F.A., Schimmerling W., Wilson J.W., Peterson L.E., Badhwar G.D., Saganti P.B., and Dicello J.F. Space radiation cancer risks and uncertainties for Mars missions. Radiat. Res. 156 (2001) 682-688
7. Durante M., Ando K., Furusawa Y., Obe G., George K., and Cucinotta F.A. Complex chromosomal rearrangements induced in vivo by heavy ions. Cytogenet. Genome Res. 104 (2004) 240-244
8. Durante M., Bonassi S., George K., and Cucinotta F.A. Risk estimation based on chromosomal aberrations induced by radiation. Radiat. Res. 156 (2001) 662-667
9. Durante M., George K., Wu H., and Cucinotta F.A. Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 158 (2002) 581-590
10. Fenech M. The advantages and disadvantages of the cytokinesis-block micronucleus method. Mutat. Res. 392 (1997) 11-18
11. Fenech M., Denham J., Francis W., and Morley A. Micronuclei in cytokinesis-blocked lymphocytes of cancer patients following fractionated partial-body radiotherapy. Int. J. Radiat. Biol. 57 (1990) 373-383
12. George K., Durante M., Willingham V., Wu H., Yang T.C., and Cucinotta F.A. Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes. Radiat. Res. 160 (2003) 425-435
13. George K., Durante M., Wu H., Willingham V., Badhwar G., and Cucinotta F.A. Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res. 156 (2001) 731-738
14. Hagmar L., Bonassi S., Stromberg U., Brogger A., Knudsen L.E., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58 (1998) 4117-4121
15. Hande M.P., Azizova T.V., Burak L.E., Khokhryakov V.F., Geard C.R., and Brenner D.J. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44 (2005) 1-9
16. Hayashi M., Sofuni T., and Ishidate Jr. M. An application of acridine orange fluorescent staining to the micronucleus test. Mutat. Res. 120 (1983) 241-247
17. Heddle J.A., Hite M., Kirkhart B., Mavournin K., MacGregor J.T., Newell G.W., and Salamone M.F. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 123 (1983) 61-118
18. Horstmann M., Durante M., Johannes C., Pieper R., and Obe G. Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts' lymphocytes. Radiat. Environ. Biophys. 44 (2005) 219-224
19. Kawata T., Ito H., Motoori K., Ueda T., Shigematsu N., Furusawa Y., Durante M., George K., Wu H., and Cucinotta F.A. Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions. J. Radiat. Res. 43 Suppl. (2002) S169-S173
20. Loucas B.D., Eberle R.L., Durante M., and Cornforth M.N. Complex chromatid-isochromatid exchanges following irradiation with heavy ions?. Cytogenet. Genome Res. 104 (2004) 206-210
21. MacGregor J.T., Wehr C.M., and Gould D.H. Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test. Environ. Mutagen. 2 (1980) 509-514
22. Moore F.D. Radiation burdens for humans on prolonged exomagnetospheric voyages. FASEB J. 6 (1992) 2338-2343
23. Obe G., Johannes I., Johannes C., Hallman K., Reitz G., and Facius R. Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int. J. Radiat. Biol. 72 (1997) 727-734
24. Pinkel D., Landegent J., Collins C., Fuscoe J., Segraves R., Lucas J., and Gray J. Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA 85 (1988) 9138-9142
25. Rithidech K., Au W.W., Ramanujam V.M., Whorton Jr. E.B., and Legator M.S. Persistence of micronuclei in peripheral blood normochromatic erythrocytes of subchronically benzene-treated male mice. Environ. Mol. Mutagen. 12 (1988) 319-329
26. Rithidech K., Bond V.P., Cronkite E.P., Thompson M.H., and Bullis J.E. Hypermutability of mouse chromosome 2 during the development of X-ray-induced murine myeloid leukemia. Proc. Natl. Acad. Sci. USA 92 (1995) 1152-1156
27. Rithidech K.N., Tungjai M., Arbab E., and Simon S.R. Activation of NF-kappaB in bone marrow cells of BALB/cJ mice following exposure in vivo to low doses of (137)Cs gamma-rays. Radiat. Environ. Biophys. 44 (2005) 139-143
28. Rowley J.D., and Potter D. Chromosomal banding patterns in acute nonlymphocytic leukemia. Blood 47 (1976) 705-721
29. Schlegel R., and MacGregor J.T. The persistence of micronucleated erythrocytes in the peripheral circulation of normal and splenectomized Fischer 344 rats: implications for cytogenetic screening. Mutat. Res. 127 (1984) 169-174
30. Schmid W. The micronucleus test. Mutat. Res. 31 (1975) 9-15
31. Testard I., Ricoul M., Hoffschir F., Flury-Herard A., Dutrillaux B., Fedorenko B., Gerasimenko V., and Sabatier L. Radiation-induced chromosome damage in astronauts' lymphocytes. Int. J. Radiat. Biol. 70 (1996) 403-411
32. Tsoupas, N., Bellavia, S., Bonati, R., Brown, K., Chaing, I.H., Gardner, C.J., Jao, S., Marneris, I.A.M., Phillips, D., Pile, P., Prigl, P., Rusek, A., Snydsrup, L. Results from the commissioning of the NSRL beam transfer line at BNL. Proceedings of EPAC: Lucerne, Switzerland, 2004.
33. Tucker J.D. Radiation cytogenetics: from chromosomes to single nucleotides and from metaphase cells to tissues. Cancer Metastasis Rev. 23 (2004) 341-349
34. Tucker J.D., Marples B., Ramsey M.J., and Lutze-Mann L.H. Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions. Radiat. Res. 161 (2004) 648-655
35. Whorton E.B. Some experimental design and analysis considerations for cytogenetics studies. Environ. Mutagen. 7 Suppl. 4 (1985) 9-15
36. Wu H., Durante M., Furusawa Y., George K., Kawata T., and Cucinotta F.A. M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro. Adv. Space Res. 31 (2003) 1537-1542
37. Wu H., Durante M., George K., and Yang T.C. Induction of chromosome aberrations in human cells by charged particles. Radiat. Res. 148 (1997) S102-S107