Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE

Molecular Biology Reports

Volumn 34, Issue 3, 2007, Pages 137-144

  Guo, Zekun ^a,b   Yuan, Jian ^a   Tang, Wenwen ^a   Chen, Xinya ^a   Gu, Xiuting ^a   Luo, Kuntian ^a   Wang, Yingli ^a   Wan, Bo ^a   Yu, Long ^a  

^a FUDAN UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

RAP2C; SRE; Transcription

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; GUANOSINE TRIPHOSPHATASE; RAP PROTEIN; RAP2C PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLADDER; BONE MARROW; BRAIN; CELL FUNCTION; CELL GROWTH; CELL LINE; CHROMOSOME XQ; CYTOPLASM; DATA BASE; DNA LIBRARY; GENE ACTIVATION; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LIVER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PANCREAS; PROSTATE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; RECTUM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM RESPONSIVE ELEMENT; SKELETAL MUSCLE; STOMACH; TESTIS; TRANSCRIPTION REGULATION; UTERUS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; CYTOSOL; HUMANS; MOLECULAR SEQUENCE DATA; PHYLOGENY; RAS PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERUM RESPONSE ELEMENT; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS);

EID: 34547192730     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-006-9023-9     Document Type: Article

References (26)

1. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ (1998) Increasing complexity of Ras signaling. Oncogene 17:1395-1413
2. Kaibuchi K, Kuroda S, Amano M (1999) Regulation of cytoskeletons and cell adhesions by the Rho-family GTPases. Annu Rev Biochem 68:459-486
3. Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L (2005) Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-κB. Mol Biol Rep 32:205-214
4. Pizon V, Lerosey I, Chardin P, Tavitian A (1988) Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B). Nucleic Acids Res 16:7719
5. Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (1988) Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene 3:201-204
6. Ohmstede CA, Farrel FX, Reep BR, Clemetson KJ. Lapetina EG (1990) RAP2B: a RAS-related GTP-binding protein from platelets. Proc Natl Acad Sci USA 87:6527-6531
7. Rodriguez-Viviana P, Warne P, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532
8. Wolthuis RMF, Bauer B, van't Veer LJ, de Vries-Smits AMM, Cool R, Spaargaren M, Wittinghofer A, Burgering BMT, Bos JL (1996) RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Oncogene 13:353-362
9. Herrmann C, Horn G, Spaargaren M, Wittinghofer A (1996) Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J Biol Chem 271:6794-6800
10. Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (1999) Identification and Characterization of Potential Effector Molecules of the Ras-related GTPase Rap2. J Biol Chem 274(13):8737-8745
11. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556
12. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156-160
13. Han J, Lee JD, Ribbs L, Ulevitch RJ (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811
14. Pearson EJ, Wilsbacher G, Swantek J, Karandikar J, Xu M, Cobb MH (1999) New insights into the control of MAP kinase pathways. Exp Cell Res 253:255-270
15. Tang WW, Yuan J, Chen XY, Shan YX, Luo KT, Guo ZK, Zhang Y, Wan B, Yu L (2005) Cloning and characterization of the CDZFP gene which encodes a putative zinc finger protein. DNA Seq 16:391-196
16. Wickens M (1990) How the messenger got its tail: Addition of poly(A) in the nucleus. Trends Biochem Sci 15:277-281
17. Lowy DR, Willumsen BM (1993) Function and regulation of Ras. Annu Rev Biochem 62:851-891
18. Fu HW, Casey PJ (1999) Enzymology and biology of CaaX protein prenylation. Recent Prog Horm Res 54:315-42
19. Moores SL, Scholber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JM (1991) J Biol Chem 266:14603-14610
20. Cox AD, Der CJ (1992) The ras/cholesterol connection: implications for ras oncogenicity. Crit Rev Oncog 3:365-400
21. Farrell F, Torti M, Lapetina EG (1992) Rap proteins: investigating their role in cell function. J Lab Clin Med 120:533-537
22. Kawata M, Farnsworth CC, Yoshida Y, Gelb MH, Glomset JA, Takai Y (1990) Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. Proc Natl Acad Sci USA 87:8960-8964
23. Winegar DA, Molina Y, Vedia L, Lapetina EG (1991) Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. J Biol Chem 266:4381-4386
24. Herrera RE, Shaw PE, Nordheim A (1989) Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature 340:68-70
25. Li SJ, Wang DZ, Wang ZG, Richardson JA, Olson EN (2003) The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci USA 100(16):9366-9370
26. Christian SL, Lee RL, McLeod SJ, Burgess AE, Li AH, Dang-Lawson M, Lin KB, Gold MR (2003) Activation of the Rap GTPases in B lymphocytes modulates B Cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem 278:41756-41767