Migraine and ischaemic heart disease and stroke: Potential mechanisms and treatment implications

Cephalalgia

Volumn 27, Issue 8, 2007, Pages 981-987

  Tietjen, Gretchen E ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Ischaemia; Migraine; Stroke

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERGOTAMINE; PROPRANOLOL; SEROTONIN AGONIST; TRIPTAN DERIVATIVE;

ARTERY DISSECTION; BRAIN VASOSPASM; DISEASE ASSOCIATION; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; HEART INFARCTION; HUMAN; HYPERCOAGULABILITY; ISCHEMIC HEART DISEASE; MIGRAINE; OXIDATIVE STRESS; PROPHYLAXIS; REVIEW; RISK FACTOR; SPREADING CORTICAL DEPRESSION; STROKE; THROMBOCYTE; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; TREATMENT OUTCOME;

ANIMALS; CEREBRAL INFARCTION; CEREBROVASCULAR ACCIDENT; HUMANS; MIGRAINE DISORDERS; MYOCARDIAL ISCHEMIA; RISK FACTORS;

EID: 34547171574     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2007.01407.x     Document Type: Review

References (115)

1. Moskowitz MA. Pathophysiology of headache - past and present. Headache 2007 47 (Suppl. 1): S58 63.
2. Leao APP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 1944 7 : 359 90.
3. Cao Y, Welch KM, Aurora S, Vikingstad EM. Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999 56 : 548 54.
4. Friberg L, Olesen J, Lassen NA, Olsen TS, Karle A. Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine. Stroke 1994 25 : 974 9.
5. Woods RP, Iacoboni M, Mazziotta JC. Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994 331 : 1689 92.
6. Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE. Migraine and risk of cardiovascular disease in women. JAMA 2006 296 : 283 91.
7. Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE. Migraine and risk of cardiovascular disease in men. Arch Intern Med 2007 167 : 795 801.
8. Oral contraceptives and stroke in young women. Associated risk factors. JAMA 1975 231 : 718 22.
9. Tzourio C, Iglesias S, Hubert JB, Visy JM, Alperovitch A, Tehindrazanarivelo A et al. Migraine and risk of ischaemic stroke: a case-control study. BMJ 1993 307 : 289 92.
10. Tzourio C, Tehindrazanarivelo A, Iglesias S, Alperovitch A, Chedru F, d'Anglejan-Chatillon J et al. Case-control study of migraine and risk of ischaemic stroke in young women. BMJ 1995 310 : 830 3.
11. Lidegaard O. Oral contraceptives, pregnancy and the risk of cerebral thromboembolism: the influence of diabetes, hypertension, migraine and previous thrombotic disease. Br J Obstet Gynaecol 1995 102 : 153 9.
12. Buring JE, Hebert P, Romero J, Kittross A, Cook N, Manson J et al. Migraine and subsequent risk of stroke in the Physicians' Health Study. Arch Neurol 1995 52 : 129 34.
13. Carolei A, Marini C, De Matteis G. History of migraine and risk of cerebral ischaemia in young adults. The Italian National Research Council Study Group on Stroke in the Young. Lancet 1996 347 : 1503 6.
14. Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N. Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 1997 54 : 362 8.
15. Chang CL, Donaghy M, Poulter N. Migraine and stroke in young women: case-control study. The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. BMJ 1999 318 : 13 8.
16. Milhaud D, Bogousslavsky J, Van Melle G, Liot P. Ischemic stroke and active migraine. Neurology 2001 57 : 1805 11.
17. Schwaag S, Nabavi DG, Frese A, Husstedt IW, Evers S. The association between migraine and juvenile stroke: a case-control study. Headache 2003 43 : 90 5.
18. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders, 2nd edn. Cephalalgia 2004 24 : 9 160.
19. Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994 117 : 199 210.
20. Woods RP, Iacoboni M, Mazziotta JC. Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994 331 : 1689 92.
21. Sanin LC, Mathew NT. Severe diffuse intracranial vasospasm as a cause of extensive migrainous cerebral infarction. Cephalalgia 1993 13 : 289 92.
22. Cutrer FM, Sorensen AG, Weisskoff RM, Ostergaard L, Sanchez DR, Lee EJ et al. Perfusion-weighted imaging defects during spontaneous migrainous aura. Ann Neurol 1998 43 : 25 31.
23. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004 113 : 1447 55.
24. Meschia JF, Malkoff MD, Biller J. Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. Arch Neurol 1998 55 : 712 4.
25. Marshall N, Maclaurin WA, Koulouris G. MRA captures vasospasm in fatal migrainous infarction. Headache 2007 47 : 280 3.
26. Rose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR et al. Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 2004 63 : 2233 9.
27. Sarchielli P, Alberti A, Coppola F, Baldi A, Gallai B, Floridi A et al. Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. Cephalalgia 2004 24 : 623 30.
28. McCrary JK, Nolasco LH, Hellums JD, Kroll MH, Turner NA, Moake JL. Direct demonstration of radiolabeled von Willebrand factor binding to platelet glycoprotein Ib and IIb-IIIa in the presence of shear stress. Ann Biomed Eng 1995 23 : 787 93.
29. Manotti C, Quintavalla R, Manzoni GC. Platelet activation in migraine. Thromb Haemost 1983 50 : 758.
30. Kovacs K, Herman F, Filep J, Jelencsik I, Magyar K, Csanda E. Platelet aggregation of migraineurs during and between attacks. Cephalalgia 1990 10 : 161 5.
31. Hilton BP, Cumings JN. 5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache. J Neurol Neurosurg Psychiatry 1972 35 : 505 9.
32. Kozubski W, Stanczyk L. Platelet aggregation in patients with migraine during the pain attack and in the pain-free period. Neurol Neurochir Pol 1985 19 : 302 7.
33. Cesar JM, Garcia-Avello A, Vecino AM, Sastre JL, Alvarez-Cermeno JC. Increased levels of plasma von Willebrand factor in migraine crisis. Acta Neurol Scand 1995 91 : 412 3.
34. Takano K, Latour LL, Formato JE, Carano RA, Helmer KG, Hasegawa Y et al. The role of spreading depression in focal ischemia evaluated by diffusion mapping. Ann Neurol 1996 39 : 308 18.
35. Dreier JP, Kleeberg J, Alam M, Major S, Kohl-Bareis M, Petzold GC et al. Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Exp Biol Med (Maywood) 2007 232 : 204 13.
36. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 2006 140 : 723 30.
37. Koh KK, Cho SK, Kim SS, Oh BH, Lee YW. Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis. Int J Cardiol 1993 41 : 168 70.
38. Michiels JJ, Berneman Z, Schroyens W, Koudstaal PJ, Lindemans J, Neumann HA et al. Platelet-mediated erythromelalgic, cerebral, ocular and coronary microvascular ischemic and thrombotic manifestations in patients with essential thrombocythemia and polycythemia vera: a distinct aspirin-responsive and coumadin-resistant arterial thrombophilia. Platelets 2006 17 : 528 44.
39. Matijevic N, Wu KK. Hypercoagulable states and strokes. Curr Atheroscler Rep 2006 8 : 324 9.
40. Tatlisumak T, Fisher M. Hematologic disorders associated with ischemic stroke. J Neurol Sci 1996 140 : 1 11.
41. McIntyre KJ, Hoagland HC, Silverstein MN, Petitt RM. Essential thrombocythemia in young adults. Mayo Clin Proc 1991 66 : 149 54.
42. Newton LK. Neurologic complications of polycythemia and their impact on therapy. Oncology, 1990 4 : 59 64.
43. Iniesta JA, Corral J, Gonzalez-Conejero R, Rivera J, Vicente V. Prothrombotic genetic risk factors in patients with coexisting migraine and ischemic cerebrovascular disease. Headache 1999 39 : 486 9.
44. Tietjen GE, Day M, Norris L, Aurora S, Halvorsen A, Schultz LR et al. Role of anticardiolipin antibodies in young persons with migraine and transient focal neurologic events: a prospective study. Neurology 1998 50 : 1433 40.
45. Whitty CW, Hockaday JM, Whitty MM. The effect of oral contraceptives on migraine. Lancet 1966 1 : 856 9.
46. Conard J, Samama MM. Oral contraceptives, hormone replacement therapy and haemostasis. Cephalalgia 2000 20 : 175 82.
47. Tzourio C, Benslamia L, Guillon B, Aidi S, Bertrand M, Berthet K et al. Migraine and the risk of cervical artery dissection: a case-control study. Neurology 2002 59 : 435 7.
48. Tzourio C, El Amrani M, Robert L, Alperovitch A. Serum elastase activity is elevated in migraine. Ann Neurol 2000 47 : 648 51.
49. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003 23 : 168 75.
50. Vischer UM. von Willebrand factor, endothelial dysfunction, and cardiovascular disease. J Thromb Haemost 2006 4 : 1186 93.
51. Tietjen GE, Al Qasmi MM, Athanas K, Dafer RM, Khuder SA. Increased von Willebrand factor in migraine. Neurology 2001 57 : 334 6.
52. Tietjen GE, Al Qasmi MM, Athanas K, Utley C, Herial NA. Altered hemostasis in migraineurs studied with a dynamic flow system. Thromb Res 2007 119 : 217 22.
53. Tietjen GE, Gottwald L, Al Qasmi MM, Gunda P, Khuder SA. Migraine is associated with livedo reticularis: a prospective study. Headache 2002 42 : 263 7.
54. Tietjen GE, Al Qasmi MM, Shukairy MS. Livedo reticularis and migraine: a marker for stroke risk? Headache 2002 42 : 352 5.
55. Totaro R, Marini C, De Matteis G, Di Napoli M, Carolei A. Cerebrovascular reactivity in migraine during headache-free intervals. Cephalalgia 1997 17 : 191 4.
56. de Hoon JN, Willigers JM, Troost J, Struijker-Boudier HA, van Bortel LM. Cranial and peripheral interictal vascular changes in migraine patients. Cephalalgia 2003 23 : 96 104.
57. Gobron C, Vahedi K, Vicaut E, Stucker O, Laemmel E, Baudry N et al. Characteristic features of in vivo skin microvascular reactivity in CADASIL. J Cereb Blood Flow Metab 2007 27 : 250 7.
58. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD et al. Migraine as a risk factor for subclinical brain lesions. JAMA 2004 291 : 427 34.
59. D'Andrea G, Toldo M, Cortelazzo S, Milone FF. Platelet activity in migraine. Headache 1982 22 : 207 12.
60. Gawel M, Burkitt M, Rose FC. The platelet release reaction during migraine attacks. Headache 1979 19 : 323 7.
61. Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia 2001 21 : 137 9.
62. Brey RL, Stallworth CL, McGlasson DL, Wozniak MA, Wityk RJ, Stern BJ et al. Antiphospholipid antibodies and stroke in young women. Stroke 2002 33 : 2396 400.
63. Moskowitz MA. Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 1993 43 (Suppl. 3 S16 20.
64. Brandes JL, Welch KM, Salerno J, Brandes AW. C-Reactive protein increased in migraine. Headache 2004 44 : 489.
65. Andersson PG, Hinge HH, Johansen O, Andersen CU, Lademann A, Gotzsche PC. Double-blind study of naproxen vs placebo in the treatment of acute migraine attacks. Cephalalgia 1989 9 : 29 32.
66. Rasmussen MK, Binzer M. Non-steroidal anti-inflammatory drugs in the treatment of migraine. Curr Med Res Opin 2001 17 (Suppl. 1 s26 9.
67. Kudrow D, Thomas HM, Ruoff G, Ishkanian G, Sands G, Le VH et al. Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. Headache 2005 45 : 1151 62.
68. Goldstein J, Silberstein SD, Saper JR, Ryan RE Jr., Lipton RB. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 2006 46 : 444 53.
69. Rozen TD. Migraine headache: immunosuppressant therapy. Curr Treat Options Neurol 2002 4 : 395 401.
70. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C, Marini C, Carolei A. Urinary nitric oxide metabolites and lipid peroxidation by-products in migraine. Cephalalgia 2003 23 : 39 42.
71. Kario K, Matsuo T, Kobayashi H, Kanai N, Hoshide S, Mitsuhashi T et al. Endothelial cell damage and angiotensin-converting enzyme insertion/deletion genotype in elderly hypertensive patients. J Am Coll Cardiol 1998 32 : 444 50.
72. Makris TK, Stavroulakis GA, Dafni UG, Gialeraki AE, Krespi PG, Hatzizacharias AN et al. ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial dysfunction in patients with untreated hypertension. Am Heart J 2000 140 : 760 5.
73. Butler R, Morris AD, Burchell B, Struthers AD. DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans. Hypertension 1999 33 : 1164 8.
74. von Depka M, Czwalinna A, Wermes C, Eisert R, Scharrer I, Ganser A et al. The deletion polymorphism in the angiotensin-converting enzyme gene is a moderate risk factor for venous thromboembolism. Thromb Haemost 2003 89 : 847 52.
75. Margaglione M, Celentano E, Grandone E, Vecchione G, Cappucci G, Giuliani N et al. Deletion polymorphism in the angiotensin-converting enzyme gene in patients with a history of ischemic stroke. Arterioscler Thromb Vasc Biol 1996 16 : 304 9.
76. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995 332 : 706 11.
77. Sharma P. Meta-analysis of the ACE gene in ischaemic stroke. J Neurol Neurosurg Psychiatry 1998 64 : 227 30.
78. Holmer SR, Bickeboller H, Hengstenberg C, Rohlmann F, Engel S, Lowel H et al. Angiotensin converting enzyme gene polymorphism and myocardial infarction: a large association and linkage study. Int J Biochem Cell Biol 2003 35 : 955 62.
79. Zhang JH, Kohara K, Yamamoto Y, Nakura J, Tabara Y, Fujisawa M et al. Genetic predisposition to neurological symptoms in lacunar infarction. Cerebrovasc Dis 2004 17 : 273 9.
80. Markus HS, Barley J, Lunt R, Bland JM, Jeffery S, Carter ND et al. Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma. Stroke 1995 26 : 1329 33.
81. Hassan A, Hunt BJ, O'Sullivan M, Parmar K, Bamford JM, Briley D et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003 126 : 424 32.
82. Purandare N, Oude Voshaar RC, Davidson Y, Gibbons L, Hardicre J, Byrne J et al. Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: a pilot study. J Am Geriatr Soc 2006 54 : 1395 400.
83. Kowa H, Fusayasu E, Ijiri T, Ishizaki K, Yasui K, Nakaso K et al. Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura. Neurosci Lett 2005 374 : 129 31.
84. Paterna S, Di Pasquale P, D'Angelo A, Seidita G, Tuttolomondo A, Cardinale A et al. Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura. Eur Neurol 2000 43 : 133 6.
85. Lea RA, Ovcaric M, Sundholm J, Solyom L, Macmillan J, Griffiths LR. Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. Brain Res Mol Brain Res 2005 136 : 112 7.
86. Cronin S, Furie KL, Kelly PJ. Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005 36 : 1581 7.
87. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H et al. Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 2006 59 : 372 5.
88. Overell JR, Bone I, Lees KR. Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies. Neurology 2000 55 : 1172 9.
89. Lamy C, Giannesini C, Zuber M, Arquizan C, Meder JF, Trystram D et al. Clinical and imaging findings in cryptogenic stroke patients with and without patent foramen ovale: the PFO-ASA Study. Atrial Septal Aneurysm Stroke 2002 33 : 706 11.
90. Del Sette M, Angeli S, Leandri M, Ferriero G, Bruzzone GL, Finocchi C et al. Migraine with aura and right-to-left shunt on transcranial Doppler: a case-control study. Cerebrovasc Dis 1998 8 : 327 30.
91. Anzola GP, Magoni M, Guindani M, Rozzini L, Dalla VG. Potential source of cerebral embolism in migraine with aura: a transcranial Doppler study. Neurology 1999 52 : 1622 5.
92. Wilmshurst P, Nightingale S. Relationship between migraine and cardiac and pulmonary right-to-left shunts. Clin Sci (Lond) 2001 100 : 215 20.
93. Carerj S, Narbone MC, Zito C, Serra S, Coglitore S, Pugliatti P et al. Prevalence of atrial septal aneurysm in patients with migraine: an echocardiographic study. Headache 2003 43 : 725 8.
94. Arquizan C, Coste J, Touboul PJ, Mas JL. Is patent foramen ovale a family trait? A transcranial Doppler sonographic study. Stroke 2001 32 : 1563 6.
95. Wilmshurst PT, Nightingale S, Walsh KP, Morrison WL. Effect on migraine of closure of cardiac right-to-left shunts to prevent recurrence of decompression illness or stroke or for haemodynamic reasons. Lancet 2000 356 : 1648 51.
96. Post MC, Thijs V, Herroelen L, Budts WI. Closure of a patent foramen ovale is associated with a decrease in prevalence of migraine. Neurology 2004 62 : 1439 40.
97. Schwerzmann M, Wiher S, Nedeltchev K, Mattle HP, Wahl A, Sieler C et al. Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks. Neurology 2004 62 : 1399 401.
98. Adami A. Right-to-left shunt does not affect white matter lesion load in migraine patients. Stroke, 2007 38 : 459.
99. Bousser MG, Conard J, de Kittner S, Lignieres B, MacGregor EA, Massiou H et al. Recommendations on the risk of ischaemic stroke associated with use of combined oral contraceptives and hormone replacement therapy in women with migraine. The International Headache Society Task Force on Combined Oral Contraceptives & Hormone Replacement Therapy. Cephalalgia 2000 20 : 155 6.
100. Goadsby PJ. The pharmacology of headache. Prog Neurobiol 2000 62 : 509 25.
101. Parsons AA, Whalley ET, Feniuk W, Connor HE, Humphrey PP. 5-HT1-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery. Br J Pharmacol 1989 96 : 434 40.
102. Papademetriou V. Cardiovascular risk assessment and triptans. Headache 2004 44 (Suppl. 1 S31 9.
103. Velentgas P, Cole JA, Mo J, Sikes CR, Walker AM. Severe vascular events in migraine patients. Headache 2004 44 : 642 51.
104. Lindboe CF, Dahl T, Rostad B. Fatal stroke in migraine: a case report with autopsy findings. Cephalalgia 1989 9:277 80.
105. Lipton RB. Ergotamine tartrate and dihydroergotamine mesylate: safety profiles. Headache 1997 37 (Suppl. 1 S33 41.
106. Sharpe CJ. Letter: Propranolol in the treatment of migraine. Br Med J 1974 3 : 522.
107. Prendes JL. Considerations on the use of propranolol in complicated migraine. Headache 1980 20 : 93 5.
108. Gilbert GJ. An occurrence of complicated migraine during propranolol therapy. Headache 1982 22 : 81 3.
109. Katz B. Migrainous central retinal artery occlusion. J Clin Neuroophthalmol 1986 6 : 69 75.
110. Bardwell A, Trott JA. Stroke in migraine as a consequence of propranolol. Headache 1987 27 : 381 3.
111. Alvarez SJ, Molins A, Turon A, Titus F, Codina A. Migraine-infarct in patients treated with beta-blockers. Rev Clin Esp 1993 192 : 228 30.
112. Evans RW, Lipton RB. Topics in migraine management: a survey of headache specialists highlights some controversies. Neurol Clin 2001 19 : 1 21.
113. Schrader H, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study. BMJ 2001 322 : 19 22.
114. Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA 2003 289 : 65 9.
115. Ito A, Egashira K, Narishige T, Muramatsu K, Takeshita A. Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension. Jpn Circ J 2001 65 : 775 8.