Development of numerous nerve fibers in the epidermis of hairless mice with atopic dermatitis-like pruritic skin inflammation

Journal of Pharmacological Sciences

Volumn 104, Issue 3, 2007, Pages 243-251

  Fujii, Masanori ^a   Akita, Keisuke ^a   Mizutani, Nobuaki ^a   Nabe, Takeshi ^a   Kohno, Shigekatsu ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Atopic dermatitis; Hairless mice; Itch; Nerve fiber; Protein gene product 9.5

Indexed keywords

DEXAMETHASONE; GENE PRODUCT; PROTEIN ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DIETARY INTAKE; DISEASE EXACERBATION; EPIDERMIS; EXPERIMENTAL MODEL; FEMALE; HAIRLESS MOUSE; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE FIBER; NONHUMAN; PRURITUS; SCRATCHING; SKIN INFLAMMATION; SKIN MANIFESTATION; SKIN NERVE;

EID: 34547157074     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0070436     Document Type: Article

References (31)

1. Rothman S. Physiology of itching. Physiol Rev. 1941;21:357-381.
2. Wahlgren CF. Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992;47:65-75.
3. Tucket RP. Neurophysiology and neuroanatomy of pruritus. In: Bernhard JD, editor. Itch: mechanisms and manegement of pruritus. New York: McGraw-Hill Inc; 1994. p. 1-22.
4. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92 Suppl:44-47.
5. Koblenzer CS. Itching and the atopic skin. J Allergy Clin Immunol. 1999;104:S109-S113.
6. Wahlgren CF. Itch and atopic dermatitis: an overview. J Dermatol. 1999;26:770-779.
7. Wilkinson KD, Lee K, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science. 1989;246:670-673.
8. Dalsgaard CJ, Rydh M, Haegerstrand A. Cutaneous innervation in man visualized with protein gene product 9.5 (PGP 9.5) antibodies. Histochemistry. 1989;92:385-390.
9. Wang L, Hilliges M, Jernberg T, Wiegleb-Edstrom D, Johansson O. Protein gene product 9.5-immunoreactive nerve fibers and cells in human skin. Cell Tissue Res. 1990;261:25-33.
10. Tobin D, Nabarro G, Baart de la Faille H, van Vloten WA, van der Putte SC, Schuurman HJ. Increased number of immunoreactive nerve fibers in atopic dermatitis. J Allergy Clin Immunol. 1992;90:613-622.
11. Urashima R, Mihara M. Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study. Virchows Arch. 1998;432:363-370.
12. Sugiura H, Omoto M, Hirota Y, Danno K, Uehara M. Density and fine structure of peripheral nerves in various skin lesions at atopic dermatitis. Arch Dermatol Res. 1997;289:125-131.
13. Fujii M, Tomozawa J, Mizutani N, Nabe T, Danno K, Kohno S. Atopic dermatitis-like pruritic skin inflammation caused by feeding a special diet to HR-1 hairless mice. Exp Dermatol. 2005;14:460-468.
14. Fujii M, Nabe T, Tomozawa J, Kohno S. Involvement of skin barrier dysfunction in itch-related scratching in special diet-fed hairless mice. Eur J Pharmacol. 2006;530:152-156.
15. Monroe EW. Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis. J Am Acad Dermatol. 1989;21:135-136.
16. Heyer GR, Dotzer M, Diepgen TL, Handwerker HO. Opiate and H1 antagonists effects on histamine induced pruritus and alloknesis. Pain. 1997;73:239-243.
17. Wahlgren CF, Hagermark O, Bergstrom R. The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. Br J Dermatol. 1990;122:545-551.
18. Rukwied R, Lischetzki G, McGlone F, Heyer G, Schmelz M. Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br J Dermatol. 2000;142:1114-1120.
19. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92:44-47.
20. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 2000;105:860-876.
21. Wahlgren CF, Hangermark O, Berfstrom R. Patients' perception of itch induced by histamine, compound 48/80 and wool fibres in atopic dermatitis. Acta Derm Venereol. 1991;71:488-494.
22. Werner Y, Lindberg M. Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol. 1985;65:102-105.
23. Takano N, Arai I, Kurachi M. Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol. 2003;471:223-228.
24. Bae SJ, Lee JB, Takenaka M, Tanaka Y, Shimizu K, Katayama I. Topical glucocorticoid augments scratching behavior in dinitrofluorobenzene-sensitized mice by the induction of substance P. Exp Dermatol. 2004;13:780-785.
25. Inagaki N, Shiraishi N, Igeta K, Itoh T, Chikumoto T, Nagao M, et al. Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone. Eur J Pharmacol. 2006;546:189-196.
26. Pincelli C, Yaar M. Nerve growth factor: its significance in cutaneous biology. J Invest Dermatol Symp Proc. 1997;2:31-36.
27. Toyoda M, Nakamura M, Makino T, Hino T, Kagoura M, Morohashi M. Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol. 2002;147:71-79.
28. Pincelli C, Sevignami C, Manfredini R, Grande A. Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol. 1994;103:13-18.
29. Tanaka A, Matsuda H. Expression of nerve growth factor in itchy skins of atopic NC/Nga Tnd mice. J Vet Med Sci. 2005;67:915-919.
30. Takano N, Sakurai T, Kurachi M. Effects of anti-nerve growth factor antibody on symptoms in the NC/Nga mouse, an atopic dermatitis model. J Pharmacol Sci. 2005;99:277-286.
31. Raap U, Werfel T, Goltz C, Deneka N, Langer K, Bruder M, et al. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy. 2006;61:1416-1418.