Systemic absorption of antioxidants from mulberry (Morus alba L) leaf extracts using an in situ rat intestinal preparation

Nutrition Research

Volumn 27, Issue 8, 2007, Pages 492-497

  Lee, Chooi Yeng ^a   Sim, Si Mui ^a   Cheng, Hwee Ming ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Antioxidants; Bioavailability; Intestinal absorption; Mulberry (Morus alba L); Rat; Total antioxidant activity

Indexed keywords

ALCOHOL; ANTIOXIDANT; DRUG VEHICLE; MORUS ALBA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DUODENUM; FEMALE; FOOD INTAKE; ILEUM; INTESTINE ABSORPTION; ISOLATED ORGAN; JEJUNUM; MALE; MEDICINAL PLANT; MULBERRY; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAT;

ANIMALIA; MORUS (PLANT); MORUS ALBA; RATTUS;

EID: 34547150540     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2007.06.004     Document Type: Article

References (29)

1. Asano N., Yamashita T., Yasuda K., Ikeda K., Kizu H., Kameda Y., et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 49 (2001) 4208-4213
2. Chen F., Nakashima N., Kimura I., and Kimura M. Hypoglycemic activity and mechanisms of extracts from mulberry leaves (Folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Yakugaku Zasshi 115 (1995) 476-482
3. Miyahara C., Miyazawa M., Satoh S., Sakai A., and Mizusaki S. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. J Nutr Sci Vitaminol (Tokyo) 50 (2004) 161-164
4. Hansawasdi C., and Kawabata J. α-Glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 77 (2006) 568-573
5. Lee S.H., Choi S.Y., Kim H., Hwang J.S., Lee B.G., Gao J.J., et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 25 (2002) 1045-1048
6. Kang T.H., Oh H.R., Jung S.M., Ryu J.H., Park M.W., Park Y.K., et al. Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol Pharm Bull 29 (2006) 270-274
7. Enkhmaa B., Shiwaku K., Katsube T., Kitajima K., Anuurad E., Yamasaki M., et al. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 135 (2005) 729-734
8. Katsube T., Imawaka N., Kawano Y., Yamazaki Y., Shiwaku K., and Yamane Y. Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity. Food Chem 97 (2006) 25-31
9. Huang D., Ou B., Hampsch-Woodill M., Flanagan J.A., and Prior R.L. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multi-channel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 50 (2002) 4437-4444
10. Sim S.M., and Back D.J. Intestinal absorption of oestrone, oestrone glucuronide and oestrone sulphate in rat in situ{single bond}I. Importance of hydrolytic enzymes on conjugate absorption. J Steroid Biochem 22 (1985) 781-788
11. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., and Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci 84 (1993) 407-412
12. Pellegrini N., Re R., Yang M., and Rice-Evans C.A. Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying the 2,2′-azobis(3-ethylenebenzothiazoline-6-sulfonic) acid radical cation decolorization assay. Methods Enzymol 299 (1999) 379-389
13. Gee J.M., DuPont M.S., Rhodes M.J.C., and Johnson I.T. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic Biol Med 25 (1998) 19-25
14. Brown E.D., Micozzi M.S., Craft N.E., Bieri J.G., Beecher G., Edwards B.K., et al. Plasma carotenoids in normal men after a single ingestion of vegetables or purified β-carotene. Am J Clin Nutr 49 (1989) 1258-1265
15. Micozzi M.S., Brown E.D., Edwards B.K., Bieri J.G., Taylor P.R., Khachik F., et al. Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men. Am J Clin Nutr 55 (1992) 1120-1125
16. Silberberg M., Morand C., Manach C., Scalbert A., and Remesy C. Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life Sci 77 (2005) 3156-3167
17. Hashimoto T., Ueda Y., Oi N., Sakakibara H., Piao C., Ashida H., et al. Effects of combined administration of quercetin, rutin, and extract of white radish sprout rich in kaempferol glycosides on the metabolism in rats. Biosci Biotechnol Biochem 70 (2006) 279-281
18. Spencer J.P.E., Chowrimootoo G., Choudhury R., Debnam E.S., Srai S.K., and Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett 458 (1999) 224-230
19. Sesink A.L.A., Arts I.C.W., Faassen-Peters M., and Hollman P.C.H. Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. J Nutr 133 (2003) 773-776
20. Day A.J., Gee J.M., DuPont M.S., Johnson I.T., and Williamson G. Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 65 (2003) 1199-1206
21. Hollman P.C.H., de Vries J.H.M., van Leeuwen S.D., Mengelers M.J.B., and Katan M.B. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 62 (1995) 1276-1282
22. Hollman P.C.H., Buysman M.N.C.P., van Gameren Y., Cnossen E.P.J., de Vries J.H.M., and Katan M.B. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 6 (1999) 569-573
23. Gee J.M., DuPont M.S., Day A.J., Plumb G.W., Williamson G., and Johnson I.T. Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J Nutr 130 (2000) 2765-2771
24. Wolffram S., Block M., and Ader P. Quercetin-3-glucoside is transported by the glucose carrier SGLT-1 across the brush border membrane of rat small intestine. J Nutr 132 (2002) 630-635
25. Cermak R., Landgraf S., and Wolffram S. Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum. Br J Nutr 91 (2004) 849-855
26. Halaihel N., Gerbaud D., Vasseur M., and Alvarado F. Heterogeneity of pig intestinal d-glucose transport systems. Am J Physiol 277 (1999) C1130-C1141
27. Crespy V., Morand C., Manach C., Besson C., Demigne C., and Remesy C. Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. Am J Physiol 277 (1999) G120-G126
28. Shimoi K., Yoshizumi K., Kido T., Usui Y., and Yumoto T. Absorption and urinary excretion of quercetin, rutin, and αG-rutin, a water soluble flavonoid, in rats. J Agric Food Chem 51 (2003) 2785-2789
29. Piskula M.K., and Terao J. Quercetin's solubility affects its accumulation in rat plasma after oral administration. J Agric Food Chem 46 (1998) 4313-4317