Development of a validated method for the simultaneous determination of amphetamine, methamphetamine and methylenedioxyamphetamines (MDA, MDMA, MDEA) in serum by GC-MS after derivatisation with perfluorooctanoyl chloride

Accreditation and Quality Assurance

Volumn 12, Issue 7, 2007, Pages 335-342

  Westphal, Folker ^a   Franzelius, Cornelia ^a   Schäfer, Jon ^a   Schütz, Hans Werner ^a   Rochholz, Gertrud ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Amphetamines; GC MS; Methylenedioxyamphetamines; PFOC derivatisation after LLE; Quantitation

Indexed keywords

EID: 34547150519     PISSN: 09491775     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00769-007-0280-7     Document Type: Article

References (37)

1. Fineschi V, Masti A (1996) Fatal poisoning by MDMA (ecstasy) and MDEA: a case report. Int J Leg Med 108:272-275
2. Iwersen S, Schmoldt A (1996) Two very different fatal cases associated with the use of methylenedioxyethylamphetamine (MDEA): Eve as deadly as Adam. Clin Toxicol 34(2):241-244
3. Lora-Tamayo C, Tena T, Rodríguez A (1997) Amphetamine derivative related deaths. Forensic Sci Int 85:149-157
4. Henry JA, Hill IR (1998) Fatal interaction between ritonavir and MDMA. Lancet 352:1751-1752
5. Burges C, O'Donohoe A, Gill M (2000) Agony and ecstasy: a review of MDMA effects and toxicity. Eur Psychiatry 15:287-294
6. Gill JR, Hayes JA, deSouza IS, Marker E, Stajic M (2002) Ecstasy (MDMA) deaths in New York City: a case series and review of the literature. J Forensic Sci 47:121-126
7. De Letter EA, Clauwaert KM, Lambert WE, van Bocxlaer JF, De Leenheer AP, Piette MHA (2002) Distribution study of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in a fatal overdose. J Anal Toxicol 26:113-118
8. Sticht G, Pluisch F, Bierhoff E, Käferstein H (2003) Todesfall nach Ecstasy-Überdosierung. Arch Krim 211:73-80
9. Crifasi J, Long C (1996) Traffic fatality related to the use of methylenedioxymethamphetamine. J Forensic Sci Int 41:1082-1084
10. Möller et al. (1998) Drogenerkennung im Straßenverkehr. Berichte der Bundesanstalt für Straßenwesen, Mensch und Sicherheit, Wirtschaftsverlag NW, Bremerhaven, Heft M 96
11. Schulz E, Vollrath M, Klimesch C, Szegedi A (1997) Fahruntüchtigkeit durch Cannabis, Amphetamine und Cocain. In: Berichte der Bundesanstalt für Straßenwesen, Mensch und Sicherheit, Wirtschaftsverlag NW, Bremerhaven, Heft M 81
12. Samyn N, van Haeren C (2000) On-site testing of saliva and sweat with Drugwipe and determination of concentrations of drugs of abuse in saliva, plasma and urine of suspected users. Int J Legal Med 113:150-154
13. Rodgers J (2000) Cognitive performance amongst recreational users of "ecstasy". Psychopharmacology (Berl) 151:19-24
14. Kraemer T, Maurer HH (1998) Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine. J Chromatogr B Biomed Sci Appl 713:163-187
15. Helmlin H-J, Bracher K, Bourquin D, Vonlanthen D, Brenneisen R, Styk J (1996) Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. J Anal Toxicol 20:432-440
16. Bogusz MJ, Kala M, Maier RD (1997) Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biological fluids by HPLC-APCI-MS or DAD. J Anal Toxicol 21:59-69
17. Sadeghipour F, Veuthey JL (1997) Sensitive and selective determination of methylenedioxylated amphetamines by high-performance liquid chromatography with fluorimetric detection. J Chromatogr A 787:137-143
18. Clauwaert KM, Van Bocxlaer JF, De Letter EA, Van Calenbergh S, Lambert WE, De Leenheer AP (2000) Determination of the designer drugs 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4-methylenedioxyamphetamine with HPLC and fluorescence detection in whole blood, serum, vitreous humor, and urine. Clin Chem 46(12):1968-1977
19. Al-Dirbashi OY, Kuroda N, Wada M, Takahashi M, Nakashima K (2000) Quantification of methamphetamine, amphetamine and enantiomers by semi-micro column HPLC with fluorescence detection; applications on abusers' single hair analyses. Biomed Chromatogr 14(5):293-300
20. Weinmann W, Svoboda M (1998) Fast screening for drugs of abuse by solid-phase extraction combined with flow-injection ionspray-tandem mass spectrometry. J Anal Toxicol 22:319-328
21. Garofano L, Santoro M, Patri P, Guidugli F, Bollani T, Favretto D, Traldi P (1998) Ion trap mass spectrometry for the characterization of N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine and N-ethyl-3,4- methylenedioxyamphetamine, two widely distributed street drugs. Rapid Commun Mass Spectrom 12:779-782
22. Hensley D, Cody JT (1999) Simultaneous determination of amphetamine, methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) enantiomers by GC-MS. J Anal Toxicol 23:518-523
23. Stout PR, Horn CK, Klette KL (2002) Rapid simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by solid-phase extraction and GC-MS: a method optimized for high-volume laboratories. J Anal Toxicol 26:253-261
24. Gentili S, Torresi A, Marsili R, Chiarotti M, Macchia T (2002) Simultaneous detection of amphetamine-like drugs with headspace solid-phase microextraction and gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 780(1):183-192
25. Kronstrand R, Ahlner J, Dizdar N, Larson G (2003) Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication. J Anal Toxicol 27(3):135-141
26. Bogusz MJ, Krüger KD, Maier RD (2000) Analysis of underivatized amphetamines and related phenethylamines with high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Anal Toxicol 24:77-84
27. Wood M, De Boeck G, Samyn N, Morris M, Cooper DP, Maes RAA, De Bruijn EA (2003) Development of a rapid and sensitive method for the quantitation of amphetamines in human plasma and oral fluid by LC-MS-MS. J Anal Toxicol 27:78-87
28. Tagliaro F, Turrina S, Pisi P, Smith FP, Marigo M (1998) Determination of illicit and/or abused drugs and compounds of forensic interest in biosamples by capillary electrophoretic/electrokinetic methods. J Chromatogr B Biomed Sci Appl 713:27-49
29. Iwata YT, Garcia A, Kanamori T, Inoue H, Kishi T, Lurie IS (2002) The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis. Electrophoresis 23(9):1328-1334
30. Geiser L, Cherkaoui S, Veuthey JL (2000) Simultaneous analysis of some amphetamine derivatives in urine by nonaqueous capillary electrophoresis coupled to electrospray ionization mass spectrometry. J Chromatogr A 895(1-2):111-121
31. McCooeye MA, Mester Z, Ells B, Barnett DA, Purves RW, Guevremont R (2002) Quantitation of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by solid-phase microextraction coupled with electrospray ionization-high-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal Chem 74(13):3071-3075
32. Mußhoff F, Daldrup T, Aderjan R, v. Meyer L (2002) Anlage zu den Richtlinien der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen - Anhang B2. Toxichem Krimtech 69(1):32-34
33. Gjerde H, Hasvold I, Pettersen G, Christophersen AS (1993) Determination of amphetamine and methamphetamine in blood by derivatization with perfluorooctanoyl chloride and gas chromatography/mass spectrometry. J Anal Toxicol 17:65-68
34. Aderjan R, Babel B, Briellmann T, Daldrup T, Demme U, Hallbach J, Hartung M, Harzer K, Herbold M, von Meyer L, Möller M, Mußhoff F, Schmitt G, Weinmann W (2000) Anlagen zu den Richtlinien der GTFCh zur Qualitä tssicherung bei forensisch-toxikologischen Untersuchungen - Anhang A. Toxichem Krimtech 67(1):13-16
35. Peters F, Hartung M, Herbold M, Schmitt G, Daldrup T, Mußhoff F (2004) Anlage zu den Richtlinien der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen - Anhang C: Anforderungen an die Durchführung von Analysen. Toxichem Krimtech 71(3):146-154
36. Benutzeranleitung Valistat, Version 1.0, Arvecon GmbH, Walldorf, Germany
37. Peters FT, Maurer HH (2002) Bioanalytical method validation and its implications for forensic and clinical toxicology - a review. Accred Qual Assur 7:441-449