Effects of standard and low dose 17beta-estradiol plus norethisterone acetate on body composition and leptin in postmenopausal women at risk of body mass index and waist girth related cardiovascular and metabolic disease

Saudi Medical Journal

Volumn 28, Issue 6, 2007, Pages 855-861

  Odabasi, Ali R ^a   Yuksel, Hasan ^a   Karul, Aslihan ^a   Kozaci, Didem ^a   Sezer, Selda D ^a   Onur, Ergun ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL PLUS NORETHISTERONE ACETATE; LEPTIN; DRUG DERIVATIVE; ESTRADIOL; NORETHISTERONE; NORETHISTERONE ACETATE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; FEMALE; HIGH RISK POPULATION; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; METABOLIC DISORDER; OBESITY; POSTMENOPAUSE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SAUDI ARABIA; SINGLE BLIND PROCEDURE; UNIVERSITY HOSPITAL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; DRUG EFFECT; HORMONE SUBSTITUTION; MIDDLE AGED;

BODY COMPOSITION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; ESTRADIOL; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; LEPTIN; METABOLIC DISEASES; MIDDLE AGED; NORETHINDRONE; POSTMENOPAUSE; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; WAIST-HIP RATIO;

EID: 34547119057     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: Prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 2003; 163: 427-436.
2. Guthrie JR, Dennerstein L, Taffe JR, Lehert P, Burger HG. The menopausal transition: A 9-year prospective population-based study. The Melbourne Women's Midlife Health Project. Climacteric 2004; 7: 375-389.
3. Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 1996; 335: 453-461.
4. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Writing Group for the Women>s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-333.
5. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
6. Seidell JC, Kahn HS, Williamson DF, Lissner L, Valdez R. Report from a Centers for Disease Control and Prevention Workshop on use of adult anthropometry for public health and primary health care. Am J Clin Nutr 2001; 73: 123-126.
7. Onat A, Sansoy V, Uysal O. Waist circumference and waist-to-hip ratio in Turkish adults: Interrelation with other risk factors and association with cardiovascular disease. Int J Cardiol 1999; 70: 43-50.
8. Wauters M, Mertens I, Considine R, De Leeuw I, Van Gaal L. Are leptin levels dependent on body fat distribution in obese men and women? Eat Weight Disord 1998; 3: 124-130.
9. Samaras K, Hayward CS, Sullivan D, Kelly RP, Campbell LV. Effects of postmenopausal hormone replacement therapy on central abdominal fat, glycemic control, lipid metabolism, and vascular factors in type 2 diabetes: A prospective study. Diabetes Care 1999; 22: 1401-1407.
10. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults-The Evidence Report. National Institutes of Health. Obes Res 1998; 6 (Suppl 2): 51S-209S.
11. Willett WC, Manson JE, Stampfer MJ, Colditz GA, Rosner B, Speizer FE, et al. Weight, weight change, and coronary heart disease in women. Risk within the normal weight range. JAMA 1995; 273: 461-465.
12. World Health Organization. Obesity, preventing and managing the global epidemic: Report of a WHO consultation on obesity. Geneva: World Health Organization; 1997.
13. Despres JP, Lemieux I, Prud'homme D. Treatment of obesity: Need to focus on high-risk abdominally obese patients. BMJ 2001; 322: 716-720.
14. Zhu S, Heshka S, Wang Z, Shen W, Allison DB, Ross R, et al. Combination of BMI and Waist Circumference for Identifying Cardiovascular Risk Factors in Whites. Obes Res 2004; 12: 633-645.
15. Espeland MA, Stefanick ML, Kritz-Silverstein D, Fineberg SE, Waclawiw MA, James MK, et al. Effect of postmenopausal hormone therapy on body weight and waist and hip girths. Postmenopausal Estrogen-Progestin Interventions Study Investigators. J Clin Endocrinol Metab 1997; 82: 1549-1556.
16. Arabi A, Garnero P, Porcher R, Pelissier C, Benhamou CL, Roux C. Changes in body composition during post-menopausal hormone therapy: A 2 year prospective study. Hum Reprod 2003; 18: 1747-1752.
17. Kristensen K, Pedersen SB, Vestergaard P, Mosekilde L, Richelsen B. Hormone replacement therapy affects body composition and leptin differently in obese and non-obese postmenopausal women. J Endocrinol 1999; 163: 55-62.
18. Laivuori H, Koistinen HA, Karonen SL, Cacciatore B, Ylikorkala O. Comparison between 1 year oral and transdermal oestradiol and sequential norethisterone acetate on circulating concentrations of leptin in postmenopausal women. Hum Reprod 2001; 16: 1632-1635.
19. Walker RJ, Lewis-Barned NJ, Sutherland WH, Goulding A, Edwards EA, de Jong SA, et al. The effects of sequential combined oral 17beta-estradiol norethisterone acetate on insulin sensitivity and body composition in healthy postmenopausal women: A randomized single blind placebo-controlled study. Menopause 2001; 8: 27-32.
20. Norman RJ, Flight IH, Rees MC. Oestrogen and progestogen hormone replacement therapy for peri-menopausal and post-menopausal women: weight and body fat distribution. Cochrane Database Syst Rev 2000; 2: CD001018.
21. Tufano A, Marzo P, Enrini R, Morricone L, Caviezel F, Ambrosi B. Anthropometric, hormonal and biochemical differences in lean and obese women before and after menopause. J Endocrinol Invest 2004; 27: 648-653.
22. Martinez-Carpio PA, Fiol C, Hurtado I, Arias C, Ruiz E, Orozco P, et al. Relation between leptin and body fat distribution in menopausal status. J Physiol Biochem 2003; 59: 301-307.
23. Lofgren I, Herron K, Zern T, West K, Patalay M, Shachter NS, et al. Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. J Nutr 2004; 134: 1071-1076.
24. Perrone G, Liu Y, Capri O, Critelli C, Barillaro F, Galoppi P, et al. Evaluation of the body composition and fat distribution in long-term users of hormone replacement therapy. Gynecol Obstet Invest 1999; 48: 52-55.
25. Ozbey N, Sencer E, Molvalilar S, Orhan Y. Body fat distribution and cardiovascular disease risk factors in pre- and postmenopausal obese women with similar BMI. Endocr J 2002; 49: 503-509.
26. O'Sullivan AJ, Crampton LJ, Freund J, Ho KK. The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest 1998; 102: 1035-1040.