Mapping quantitative trait loci for osteochondrosis in fetlock and hock joints and palmar/plantar osseus fragments in fetlock joints of South German Coldblood horses

Animal Genetics

Volumn 38, Issue 4, 2007, Pages 350-357

  Wittwer, C ^a   Lohring K ^a   Drogemuller C ^a   Hamann, H ^a   Rosenberger, E ^b   Distl, O ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b Landwirtschaftskammer Weser Ems   (Germany)

Author keywords

Horse; Microsatellite markers; Osteochondrosis; Quantitative trait loci

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTHROGRAPHY; ARTICLE; FEMALE; FORELIMB; GENETIC MARKER; GENETICS; GENOME; GENOTYPE; HINDLIMB; HORSE; HORSE DISEASE; JOINT; MALE; OSTEOCHONDRITIS; QUANTITATIVE TRAIT LOCUS; RADIOGRAPHY; TOE PHALANX;

ANIMALS; ARTHROGRAPHY; FEMALE; FORELIMB; GENETIC MARKERS; GENOME; GENOTYPE; HINDLIMB; HORSE DISEASES; HORSES; JOINTS; MALE; OSTEOCHONDRITIS; QUANTITATIVE TRAIT LOCI; TARSUS, ANIMAL; TOE PHALANGES;

ANIMALIA; EQUIDAE;

EID: 34547103729     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2007.01610.x     Document Type: Article

References (35)

1. Abecasis G.R., Cherny S.S., Cookson W.O. Cardon L.R. (2002) Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics 30, 97 101.
2. Andersson-Eklund L., Uhlhorn H., Lundeheim N., Dalin G. Andersson L. (2000) Mapping quantitative trait loci for principal components of bone measurements and osteochondrosis scores in a wild boar x large white intercross. Genetical Research 75, 223 30.
3. Arnan P. Hertsch B. (2005) OCD des Fessel-, Sprung- und Kniegelenks im Vergleich vom Fohlen zum Zweijährigen. Pferdeheilkunde 21, 322 6.
4. Carlsten J., Sandgren B. Dalin G. (1993) Development of osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints of Standardbred trotters. I. A radiological survey. Equine Veterinary Journal Supplement 16, 42 7.
5. Chowdhary B.P., Raudsepp T., Kata S.R. et al. (2003) The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes. Genome Research 13, 742 51.
6. Dik K.J., Enzerink E. Van Weeren P.R. (1999) Radiographic development of osteochondral abnormalities, in the hock and stifle of Dutch Warmblood foals, from age 1 to 11 months. Equine Veterinary Journal Supplement 31, 9 15.
7. Grøndahl A.M. (1991) The incidence of osteochondrosis in the tibiotarsal joint of Norwegian Standardbred trotters. Journal of Equine Veterinary Science 11, 272 74.
8. Grøndahl A.M. Dolvik N.J. (1993) Heritability estimations of osteochondrosis in the tibiotarsal joint and of bone fragments in the palmar/plantar portion of the metacarpo- and metatarsophalangeal joints of horses. Journal of the American Veterinary Medical Association 203, 101 4.
9. Hoppe F. (1984a) Radiological investigations of osteochondrosis dissecans in Standardbred trotters and Swedish Warmblood horses. Equine Veterinary Journal Supplement 16, 425 9.
10. Hoppe F. (1984b) An epidemiologic and radiologic investigation of osteochondrosis in a collection of normal young Standardbred trotters and Swedish Warmblood horses. In : Osteochondrosis in Swedish horses. A radiological and epidemiological study with special reference to frequency and heredity, Chapter II, 1 11. Thesis, University of Agricultural Sciences, Uppsala, Sweden.
11. Jeffcott L.B. (1991) Osteochondrosis in the horse - searching for the key to pathogenesis. Equine Veterinary Journal 23, 331 8.
12. Jeffcott L.B. Henson F.M.D. (1998) Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (osteochondrosis). The Veterinary Journal 156, 177 92.
13. Kong A. Cox J. (1997) Allele-sharing models: LOD scores and accurate linkage tests. American Journal of Human Genetics 61, 1179 88.
14. Kroll A., Hertsch B. Höppner S. (2001) Entwicklung osteochondraler Veränderungen in den Fessel- und Talokruralgelenken im Röntgenbild beim Fohlen. Pferdeheilkunde 17, 489 500.
15. Lander E.S. Schork N.J. (1994) Genetic dissection of complex traits. Science 265, 2037 48.
16. Lee G.J., Archibald A.L., Garth G.B., Law A.S., Nicholsen D., Barr A. Haley C.S. (2003) Detection of quantitative trait loci for locomotion and osteochondrosis-related traits in Large White X Meishan pigs. Animal Science 76, 155 65.
17. Leppävuori J., Kujala U., Kinnunen J., Kaprio J., Nissilä M., Heliövaara M., Klinger N., Partanen J., Terwilliger J. D. Peltonen L. (1999) Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q. American Journal of Human Genetics 65, 1060 7.
18. Loughlin J., Dowling B., Chapman K., Marcelline L., Mustafa Z., Southam L., Ferreira A., Ciesielski C., Carson D.A. Corr M. (2004) Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Medical Science 101, 9757 62.
19. Michalickova K., Susic M., Willing M.C., Wenstrup R.J. Cole W.G. (1998) Mutations of the alpha-2(V) chain of type V collagen impair matrix assembly and produce Ehlers-Danlos syndrome type I. Human Molecular Genetics 7, 249 55.
20. Ohshima S., Kuchen S., Seemayer C.A. et al. (2003) Galectin 3 and its binding protein in rheumatoid arthritis. Arthritis Rheumatology 48, 2788 95.
21. Penedo M.C.T., Millon L.V., Bernoco D. et al. (2005) International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources. Cytogenetic and Genome Research 111, 5 15.
22. Perrocheau M., Boutreux V., Chadi S. et al. (2006) Construction of a medium-density horse gene map. Animal Genetics 37, 145 55.
23. Philipsson J., Andreasson E., Sandgren B., Dalin G. Carlsten J. (1993) Osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints in Standardbred Trotters. II. Heritability. Equine Veterinary Journal Supplement 16, 38 41.
24. Raimond J., Zimonjic D.B., Mignon C., Mattei M.-G., Popescu N.C., Monsigny M. Legrand A. (1997 Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21-22. Mammalian Genome 8, 706 7.
25. Roodman G.D., Kurihara N., Ohsaki Y., Kukita A., Hosking D., Demulder A., Smith J.F. Singer F.R. (1992) Interleukin 6: a potential autocrine/paracrine factor in Paget's disease of bone. The Journal of Clinical Investigation 89, 46 52.
26. Schober M. (2003) Schätzung von genetischen Effekten beim Auftreten von Osteochondrosis dissecans beim Warmblutpferd. Dissertation, Georg-August-Universität Göttingen.
27. Schougaard H., Ronne J.F. Philipsson J. (1990) A radiological survey of tibiotarsal osteochondrosis in a selected population of trotting horses in Denmark and its possible genetic significance. Equine Veterinary Journal 22, 288 9.
28. Stock K.F., Hamann H. Distl O. (2005a) Prevalence of osseous fragments in limb joints of Hanoverian Warmblood horses. Journal of Veterinary Medicine A 52, 388 94.
29. Stock K.F., Hamann H. Distl O. (2005b) Estimation of genetic parameters for the prevalence of osseous fragments in limb joints of Hanoverian Warmblood horses. Journal of Animal Breeding and Genetics 122, 271 80.
30. Swinburne J.E., Gerstenberg C., Breen M. et al. (2000) First comprehensive low-density horse linkage map based on two, three-generation, full-sibling, cross-bred horse reference families. Genomics 66, 123 34.
31. Swinburne J.E., Boursnell M., Hill G. et al. (2006) Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. Genomics 87, 1 29.
32. Trotter G.W. McIlwraith C.W. (1981) Osteochondrosis in horses: pathogenesis and clinical syndromes. American Association of Equine Practitioners 27, 141 60.
33. Willms F., Röhe R. Kalm E. (1999) Genetische Analyse von Merkmalskomplexen in der Reitpferdezucht unter Berücksichtigung von Gliedmaßenveränderungen. Züchtungskunde 71, 330 45.
34. Winter D., Bruns E., Glodek P. Hertsch B. (1996) Genetische Disposition von Gliedmaßenerkrankungen beim Reitpferd. Züchtungskunde 68, 92 108.
35. Wittwer C., Hamann H., Rosenberger E. Distl O. (2006) Prevalence of osteochondrosis in the limb joints of South German Coldblood horses. Journal of Veterinary Medicine A 53, 531 9.