Systemic naloxone infusion may trigger spasticity in patients with spinal cord injury: Case series

Journal of Spinal Cord Medicine

Volumn 30, Issue 3, 2007, Pages 272-275

  Brackett, Nancy L ^a,b   Ibrahim, Emad ^a,b   Krassioukov, Andrei ^c   Lynne, Charles M ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Endorphins; Naloxone; Opioid; Spasticity; Spinal cord injuries

Indexed keywords

GONADOTROPIN; NALOXONE; SODIUM CHLORIDE;

ADULT; CARDIOVASCULAR PARAMETERS; CASE REPORT; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE DURATION; DRUG WITHDRAWAL; GONADOTROPIN RELEASE; HUMAN; MORBIDITY; MUSCLE INNERVATION; MUSCLE SPASM; NERVE ROOT; NEUROENDOCRINE SYSTEM; SPASTICITY; SPINAL CORD INJURY; VITAL SIGN;

EID: 34447649920     PISSN: 10790268     EISSN: None     Source Type: Journal    
DOI: 10.1080/10790268.2007.11753936     Document Type: Conference Paper

References (32)

1. Ebling FJ, Schwartz ML, Foster DL. Endogenous opioid regulation of pulsatile luteinizing hormone secretion during sexual maturation in the female sheep. Endocrinology. 1989;125:369-383.
2. Delitala G, Devilla L, Arata L. Opiate receptors and anterior pituitary hormone secretion in man. Effect of naloxone infusion. Acta Endocrinol. 1981;97:150-156.
3. Blank DM, Clark RV, Heymsfield SB, Rudman DR, Blank MS. Endogenous opioids and hypogonadism in human obesity. Brain Res Bull. 1994;34:571-574.
4. Kulkarni J, de Castella A, Smith D, et al. Gonadotropin response to naloxone challenge in female and male psychotic patients: a pilot study. Biol Psychiatry. 1995;38: 701-703.
5. Kletter GB, Padmanabhan V, Beitins IZ, et al. Acute effects of estradiol infusion and naloxone on luteinizing hormone secretion in pubertal boys. J Clin Endocrinol Metab. 1997; 82:4010-4014.
6. Adams MM, Hicks AL. Spasticity after spinal cord injury. Spinal Cord. 2005;43:577-586.
7. Boviatsis EJ, Kouyialis AT, Korfias S, Sakas DE. Functional outcome of intrathecal baclofen administration for severe spasticity. Clin Neurol Neurosurg. 2005;107:289-295.
8. Rogano LA, Greve JM, Teixeira MJ. Use of intrathecal morphine infusion for spasticity. Arq Neuropsiquiatr. 2004; 62:403-405.
9. Vidal J, Gregori P, Guevara D, Portell E, Valles M. Efficacy of intrathecal morphine in the treatment of baclofen tolerance in a patient on intrathecal baclofen therapy (ITB). Spinal Cord. 2004;42:50-51.
10. Erickson DL, Blacklock JB, Michaelson M, Sperling KB, Lo JN. Control of spasticity by implantable continuous flow morphine pump. Neurosurgery. 1985;16:215-217.
11. Soni BM, Mani RM, Oo T, Vaidyanathan S. Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance - a case report and review of literature. Spinal Cord. 2003;41:586-589.
12. Bernards CM. Recent insights into the pharmacokinetics of spinal opioids and the relevance to opioid selection. Curr Opin Anaesthesiol. 2004;17:441-447.
13. Mosby. Mosby's Drug Consult. 16th ed. St Louis, MO: Mosby; 2006.
14. Pappalardo A, Castiglione A, Restivo DA, et al. Pharmacologic management of spasticity in multiple sclerosis. Neurol Sci. 2006;27(Suppl 4):s310-315.
15. Rymer W, Katz RT. Mechanisms of spastic hypertonia. In: Katz RT, ed. Spasticity: State of the Art Review. Vol 8. Philadephia, PA: Hamley & Belfus; 1994:441-454.
16. Kakinohana M, Nakamura S, Fuchigami T, et al. Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats. Br J Anaesth. 2006;96:88-94.
17. Besse D, Lombard MC, Zajac JM, Roques BP, Besson JM. Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res. 1990;521:15-22.
18. Atweh SF, Kuhar MJ. Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res. 1977;134:393-405.
19. Seybold VS, Elde RP. Receptor autoradiography in thoracic spinal cord: correlation of neurotransmitter binding sites with sympathoadrenal neurons. J Neurosci. 1984;4:2533-2542.
20. Yaksh TL. Opioid receptor systems and the endorphins: a review of their spinal organization. J Neurosurg. 1987;67: 157-176.
21. Chen SR, Pan HL. Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids. Brain Res. 2006;1081:119-125.
22. Vaccarino AL, Kastin AJ. Endogenous opiates: 2000. Peptides. 2001;22:2257-2328.
23. Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci. 1987;7:2445-2464.
24. Reisine T. Opiate receptors. Neuropharmacology. 1995;34: 463-472.
25. Gerber HR. Intrathecal morphine for chronic benign pain. Best Pract Res Clin Anaesthesiol. 2003;17:429-442.
26. Erichsen HK, Hao JX, Xu XJ, Blackburn-Munro G. Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain. Pain. 2005;116:347-358.
27. Yaksh TL, Reddy SV. Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology. 1981;54: 451-467.
28. Chen YP, Chen SR, Pan HL. Systemic morphine inhibits dorsal horn projection neurons through spinal cholinergic system independent of descending pathways. J Pharmacol Exp Ther. 2005;314:611-617.
29. Pearson KG, Jiang W, Ramirez JM. The use of naloxone to facilitate the generation of the locomotor rhythm in spinal cats. J Neurosci Methods. 1992;42:75-81.
30. Gozariu M, Bouhassira D, Willer J, Le Bars D. Temporal summation and a C-fibre reflex in the rat: effects of morphine on facilitatory and inhibitory mechanisms. Eur J Pharmacol. 2000;394:75-84.
31. Sandrini G, Serrao M, Rossi P, et al. The lower limb flexion reflex in humans. Prog Neurobiol. 2005;77:353-395.
32. Willer JC, Bussel B. Evidence for a direct spinal mechanism in morphine-induced inhibition of nociceptive reflexes in humans. Brain Res. 1980;187:212-215.