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Volumn 66, Issue 3, 1996, Pages 989-995

The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons

Author keywords

Calcium; Cortical; Glutamate; Neurons; Neuroprotection; Neurotoxicity; NMDA; Protein kinase C; Remacemide

Indexed keywords

1 METHYL 1,2 DIPHENYLETHYLAMINE; ANTICONVULSIVE AGENT; CALCIUM ION; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; REMACEMIDE;

EID: 0030064792     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66030989.x     Document Type: Article
Times cited : (12)

References (34)
  • 1
    • 0028135333 scopus 로고
    • Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat
    • Bannan P. E., Graham D. I , Lees K. R., and McCulloch J. (1994) Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat. Brain Res. 664, 271-275.
    • (1994) Brain Res. , vol.664 , pp. 271-275
    • Bannan, P.E.1    Graham, D.I.2    Lees, K.R.3    McCulloch, J.4
  • 2
    • 0028971863 scopus 로고
    • N-Methyl-D-aspartate- or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR
    • Black M. A., Tremblay R., Mealing G., Ray R., Durkin J. P., Whitfield J. F., Blosser J., and Morley P. (1995) N-Methyl-D-aspartate- or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR. J. Neurochem. 65, 2170-2177.
    • (1995) J. Neurochem. , vol.65 , pp. 2170-2177
    • Black, M.A.1    Tremblay, R.2    Mealing, G.3    Ray, R.4    Durkin, J.P.5    Whitfield, J.F.6    Blosser, J.7    Morley, P.8
  • 3
    • 0027437604 scopus 로고
    • Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat
    • Cardell M. and Weiloch T. (1993) Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat J. Neurochem. 61, 1308-1314.
    • (1993) J. Neurochem. , vol.61 , pp. 1308-1314
    • Cardell, M.1    Weiloch, T.2
  • 4
    • 0025863885 scopus 로고
    • The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate
    • Chakravarthy B. R., Bussey A., Whitfield J. F., Sikorska M., Williams R. E., and Durkin J. P. (1991) The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate. Anal. Biochem. 196, 144-150.
    • (1991) Anal. Biochem. , vol.196 , pp. 144-150
    • Chakravarthy, B.R.1    Bussey, A.2    Whitfield, J.F.3    Sikorska, M.4    Williams, R.E.5    Durkin, J.P.6
  • 5
    • 0028577806 scopus 로고
    • Inactive membrane protein kinase Cs - A possible target for receptor signalling
    • Chakravarthy B., Whitfield J. F., and Durkin J. P. (1994) Inactive membrane protein kinase Cs - A possible target for receptor signalling. Biochem. J. 304, 809-816.
    • (1994) Biochem. J. , vol.304 , pp. 809-816
    • Chakravarthy, B.1    Whitfield, J.F.2    Durkin, J.P.3
  • 6
    • 0026564448 scopus 로고
    • Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated toxicity
    • Chen H.-S. V., Pellegrini J. W., Aggarwal S. K., Lei S. Z., Warach S., Jensen F. E., and Lipton S. A. (1992) Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated toxicity. J. Neurosci. 12, 4427-4435.
    • (1992) J. Neurosci. , vol.12 , pp. 4427-4435
    • Chen, H.-S.V.1    Pellegrini, J.W.2    Aggarwal, S.K.3    Lei, S.Z.4    Warach, S.5    Jensen, F.E.6    Lipton, S.A.7
  • 8
    • 0024412962 scopus 로고
    • Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: Role of the voltage-dependent magnesium block
    • Cox J. A., Lysko P. G., and Henneberry R. C. (1989) Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: role of the voltage-dependent magnesium block. Brain Res. 499, 267-272.
    • (1989) Brain Res. , vol.499 , pp. 267-272
    • Cox, J.A.1    Lysko, P.G.2    Henneberry, R.C.3
  • 9
    • 0025612147 scopus 로고
    • Decreased protein kinase C activity during cerebral ischemia and after reperfusion in the adult rat
    • Crumrine R. C., Dubyak G., and LaManna J. C. (1990) Decreased protein kinase C activity during cerebral ischemia and after reperfusion in the adult rat. J. Neurochem. 55, 2001-2007.
    • (1990) J. Neurochem. , vol.55 , pp. 2001-2007
    • Crumrine, R.C.1    Dubyak, G.2    Lamanna, J.C.3
  • 10
    • 0018102835 scopus 로고
    • Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation
    • Dichter M. A. (1973) Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation. Brain Res. 149, 279-293.
    • (1973) Brain Res. , vol.149 , pp. 279-293
    • Dichter, M.A.1
  • 11
    • 0026529437 scopus 로고
    • Effect of brain ischemia on protein kinase C
    • Domańska-Janik K. and Zalewska T. (1992) Effect of brain ischemia on protein kinase C. J. Neurochem. 58, 1432-1439.
    • (1992) J. Neurochem. , vol.58 , pp. 1432-1439
    • Domańska-Janik, K.1    Zalewska, T.2
  • 12
    • 0026093663 scopus 로고
    • Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury
    • Dubinsky J. M. and Rothman S. M. (1991) Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury. J. Neurosci. 11, 2545-2551.
    • (1991) J. Neurosci. , vol.11 , pp. 2545-2551
    • Dubinsky, J.M.1    Rothman, S.M.2
  • 13
    • 0030045253 scopus 로고    scopus 로고
    • An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons
    • Durkin J. P., Tremblay R., Buchan A. M., Blosser J., Chakravarthy B., Mealing G., Morley P., and Song D. (1996) An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 66, 951-962.
    • (1996) J. Neurochem. , vol.66 , pp. 951-962
    • Durkin, J.P.1    Tremblay, R.2    Buchan, A.M.3    Blosser, J.4    Chakravarthy, B.5    Mealing, G.6    Morley, P.7    Song, D.8
  • 14
    • 0027293257 scopus 로고
    • Secobarbital attenuates excitotoxicity but potentiates oxygen-glucose deprivation neuronal injury in cortical cell culture
    • Giffard R. G., Weiss J. H., Swanson R. A., and Choi D. W. (1993) Secobarbital attenuates excitotoxicity but potentiates oxygen-glucose deprivation neuronal injury in cortical cell culture. J. Cereb. Blood Flow Metab. 13, 803-810.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 803-810
    • Giffard, R.G.1    Weiss, J.H.2    Swanson, R.A.3    Choi, D.W.4
  • 17
    • 0024431210 scopus 로고
    • Delayed rescue of N-methyl-D-aspartate receptor mediated neuronal injury in cortical culture
    • Hartley D M. and Choi D. W. (1989) Delayed rescue of N-methyl-D-aspartate receptor mediated neuronal injury in cortical culture. J. Pharmacol. Exp. Ther. 250, 752-758.
    • (1989) J. Pharmacol. Exp. Ther. , vol.250 , pp. 752-758
    • Hartley, D.M.1    Choi, D.W.2
  • 18
    • 0002084728 scopus 로고
    • MK-801 (dizocilpine maleate) - NMDA receptor antagonist
    • Iversen L. L. (1994) MK-801 (dizocilpine maleate) - NMDA receptor antagonist. Neurotransmissions 10, 1-4.
    • (1994) Neurotransmissions , vol.10 , pp. 1-4
    • Iversen, L.L.1
  • 19
    • 0023219059 scopus 로고
    • Non-competitive antagonists of excitatory amino acid receptors
    • Kemp J. A., Foster A. C., and Wong E. H. F. (1987) Non-competitive antagonists of excitatory amino acid receptors. Trends Neurosci. 10, 294-298.
    • (1987) Trends Neurosci. , vol.10 , pp. 294-298
    • Kemp, J.A.1    Foster, A.C.2    Wong, E.H.F.3
  • 20
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S. A. and Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 21
    • 0024357646 scopus 로고
    • Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: Pharmacological characterization
    • Lysko P. G., Cox J A., Vigano M. A., and Henneberry R. C. (1989) Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: pharmacological characterization. Brain Res. 499, 258-266.
    • (1989) Brain Res. , vol.499 , pp. 258-266
    • Lysko, P.G.1    Cox, J.A.2    Vigano, M.A.3    Henneberry, R.C.4
  • 23
    • 0025166328 scopus 로고
    • Glutamate neurotoxicity in vitro: Antagonist pharmacology and intracellular calcium concentrations
    • Michaels R. L. and Rothman S. M. (1990) Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10, 283-292.
    • (1990) J. Neurosci. , vol.10 , pp. 283-292
    • Michaels, R.L.1    Rothman, S.M.2
  • 24
    • 0028067770 scopus 로고
    • Rapid desensitization determines the pharmacology of glutamate neurotoxicity
    • Moudy A. M., Yamada K. A., and Rothman S. M. (1994) Rapid desensitization determines the pharmacology of glutamate neurotoxicity. Neuropharmacology 33, 953-962
    • (1994) Neuropharmacology , vol.33 , pp. 953-962
    • Moudy, A.M.1    Yamada, K.A.2    Rothman, S.M.3
  • 25
    • 0023485902 scopus 로고
    • The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
    • Murphy S. N., Thayer S. A., and Miller R. J (1987) The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro. J. Neurosci. 7, 4145-4158.
    • (1987) J. Neurosci. , vol.7 , pp. 4145-4158
    • Murphy, S.N.1    Thayer, S.A.2    Miller, R.J.3
  • 26
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli A., Reilly J. A., Lysko P. G., and Henneberry R. C. (1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451, 205-212.
    • (1988) Brain Res. , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 27
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney J. W., Labruyere J., and Price M. T. (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244, 1360-1362.
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 28
    • 0002689576 scopus 로고
    • Pharmacological effects of remacemide and MK-801 on memory and hippocampal CA1 damage in the rat four-vessel occlusion (4-VO) model of global ischemia
    • Globus M. and Dietrich W. D., eds Plenum Press, New York
    • Ordy J. M., Volpe B , Murray R , Thomas G., Bialobok P., Wengenack T. M., and Dunlap W. (1992) Pharmacological effects of remacemide and MK-801 on memory and hippocampal CA1 damage in the rat four-vessel occlusion (4-VO) model of global ischemia, in The Role of Neurotransmitters in Brain Injury (Globus M. and Dietrich W. D., eds), pp. 83-92. Plenum Press, New York.
    • (1992) The Role of Neurotransmitters in Brain Injury , pp. 83-92
    • Ordy, J.M.1    Volpe, B.2    Murray, R.3    Thomas, G.4    Bialobok, P.5    Wengenack, T.M.6    Dunlap, W.7
  • 30
    • 0027749328 scopus 로고
    • Antiepileptic and neuroprotective potential of remacemide hydrochloride
    • Palmer G. C., Clark B., and Hutchison J. B. (1993) Antiepileptic and neuroprotective potential of remacemide hydrochloride. Drugs Future 18, 1021-1042.
    • (1993) Drugs Future , vol.18 , pp. 1021-1042
    • Palmer, G.C.1    Clark, B.2    Hutchison, J.B.3
  • 31
    • 0027176541 scopus 로고
    • Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
    • Rogawski M. A. (1993) Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. Sci. 14, 325-331.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 325-331
    • Rogawski, M.A.1
  • 32
    • 0021743001 scopus 로고
    • Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain
    • Simon R. P., Swan J. H., Griffiths T., and Meldrum B. S. (1984) Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226, 850-852.
    • (1984) Science , vol.226 , pp. 850-852
    • Simon, R.P.1    Swan, J.H.2    Griffiths, T.3    Meldrum, B.S.4
  • 33
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski M., Charlton M. P., Carlen P. L., and Tator C. H. (1993) Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J. Neurosci. 13, 2085-2104.
    • (1993) J. Neurosci. , vol.13 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 34
    • 13344251281 scopus 로고
    • Remacemide HCl and its metabolite, FPL 12495AA, limit action potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture
    • in press
    • Wamil A. W., Cheung H., Harris E. W., and McLean M. J. (1995) Remacemide HCl and its metabolite, FPL 12495AA, limit action potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture. Epilepsy Res. (in press).
    • (1995) Epilepsy Res.
    • Wamil, A.W.1    Cheung, H.2    Harris, E.W.3    McLean, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.