Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity

Toxicon

Volumn 50, Issue 3, 2007, Pages 438-441

  Ho, Lionel ^a   Gaudieux, Anne Laure ^b   Fanok, Stella ^a   Newcombe, Gayle ^a   Humpage, Andrew R ^a  

^a South Australian Water Corporation ^*  (Australia)

^b UNIVERSITÉ DE POITIERS   (France)

Author keywords

Biodegradation; Cytotoxicity; Microcystin; MTT; Protein phosphatase 2A (PP2A); Sphingopyxis; VERO

Indexed keywords

CYANOGINOSIN; CYANOGINOSIN LA; CYANOGINOSIN LR; DRINKING WATER; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIUM; BIODEGRADATION; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; CYTOTOXICITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROBIAL DEGRADATION; NONHUMAN; PRIORITY JOURNAL; SPHINGPOYXIS; WATER SUPPLY;

ALPHAPROTEOBACTERIA; ANIMALS; BIODEGRADATION, ENVIRONMENTAL; CERCOPITHECUS AETHIOPS; MICROCYSTINS; VERO CELLS; WATER;

BACTERIA (MICROORGANISMS); SPHINGOPYXIS;

EID: 34447639593     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.03.021     Document Type: Article

References (19)

1. Bourne D.G., Jones G.J., Blakeley R.L., Jones A., Negri A.P., and Riddles P. Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR. Appl. Environ. Microbiol. 62 11 (1996) 4086-4094
2. Bourne D.G., Riddles P., Jones G.J., Smith W., and Blakeley R.L. Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR. Environ. Toxicol. 16 6 (2001) 523-534
3. Brooke S., Newcombe G., Nicholson B., and Klass G. Decrease in toxicity of microcystins LA and LR in drinking water by ozonation. Toxicon 48 8 (2006) 1054-1059
4. Carmichael W.W. Toxins of freshwater algae. In: Tu A.T.T. (Ed). Handbook of Natural Toxins, Marine Toxins and Venoms (1988), Marcel Dekker, Inc., New York, USA 121-147
5. Carmichael W.W. Cyanobacteria secondary metabolites-the cyanotoxins. J. Appl. Bacteriol. 72 6 (1992) 445-459
6. Codd G.A. Cyanobacterial toxins: occurrence, properties and biological significance. Water Sci. Technol. 32 4 (1995) 149-156
7. Fanok, S., Froscio, S., Humpage, A. Improved cytotoxicity testing of products in contact with drinking water. Water (in press).
8. Harada K.-I., Imanishi S., Kato H., Masayoshi M., Ito E., and Tsuji K. Isolation of Adda from microcystin-LR by microbial degradation. Toxicon 44 1 (2004) 107-109
9. Heresztyn T., and Nicholson B.C. Determination of cyanobacterial hepatotoxins directly in water using a protein phosphatase inhibition assay. Water Res. 35 13 (2001) 3049-3056
10. Ho, L., Hoefel, D., Saint, C.P., Newcombe, G. Isolation and identification of a novel microcystin-degrading bacterium from a biological sand filter. Water Res., submitted.
11. Ho L., Meyn T., Keegan A., Hoefel D., Brookes J., Saint C.P., and Newcombe G. Bacterial degradation of microcystin toxins within a biologically active sand filter. Water Res. 40 (2006) 768-774
12. Hoefel D., Grooby W.L., Monis P.T., Andrews S., and Saint C.P. Enumeration of water-borne bacteria using viability assays and flow cytometry: a comparison to culture-based techniques. J. Microbiol. Methods 55 (2003) 585-597
13. Ishii H., Nishijima M., and Abe T. Characterization of degradation process of cyanobacterial hepatotoxins by a Gram-negative aerobic bacterium. Water Res. 38 11 (2004) 2667-2676
14. Keil C., Forchert A., Fastner J., Szewzyk U., Rotard W., Chorus I., and Krätke R. Toxicity and microcystin content of extracts from a Planktothrix bloom and two laboratory strains. Water Res. 36 8 (2002) 2133-2139
15. Nicholson B.C., Rositano J., and Burch M.D. Destruction of cyanobacterial peptide hepatotoxins by chlorine and chloramine. Water Res. 28 6 (1994) 1297-1303
16. Park H.-D., Sasaki Y., Maruyama T., Yanagisawa E., Hiraishi A., and Kato K. Degradation of cyanobacterial hepatotoxin microcystin by a new bacterium isolated from a hypertrophic lake. Environ. Toxicol. 16 4 (2001) 337-343
17. Saito T., Okana K., Park H.-D., Itayama T., Inamori Y., Neilan B.A., Burns B.P., and Sugiura N. Detection and sequencing of the microcystin LR-degrading gene, mlrA, from new bacteria isolated from Japanese lakes. FEMS Microbiol. Lett. 229 2 (2003) 271-276
18. Standards Australia, 2005. Testing of products for use in contact with drinking water. Australian/New Zealand Standard AS/NZS 4020:2005, pp. 42-50.
19. Valeria A.M., Ricardo E.J., Stephan P., and Alberto W.D. Degradation of microcystin-RR by Sphingomonas sp. CBA4 isolated from San Roque reservoir (Córdoba-Argentina). Biodegradation 17 (2006) 447-455