Attenuation of hypertriglyceridemia-induced pressor effect in rats with fructose-induced insulin resistance

Chinese Journal of Physiology

Volumn 50, Issue 1, 2007, Pages 16-21

  Lin, Hung Jung ^a   Loh, Ching Hui ^b   Liao, Min Tser ^c   Liu, Tse Tsung ^d   Hsieh, Po Shiuan ^b  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c TAO YUAN GENERAL HOSPITAL   (Taiwan)

^d HUALIEN ARMED FORCES GENERAL HOSPITAL   (Taiwan)

Author keywords

Fructose fed rats; Hyperlipidemia; Hypertriglyceridemia; Insulin resistance; Pressor response

Indexed keywords

FRUCTOSE; GLUCOSE; INSULIN; LIPOFUNDIN; SODIUM CHLORIDE; SOMATOSTATIN; TRIACYLGLYCEROL; PHOSPHOLIPID; SORBITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLAMP; CONTROLLED STUDY; EMULSION; GLUCOSE BLOOD LEVEL; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOGENESIS; PRESSOR RESPONSE; RAT; SPRAGUE DAWLEY RAT; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; DIET; DRUG COMBINATION; DRUG EFFECT; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; OSMOLARITY; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; DIET; DRUG COMBINATIONS; FRUCTOSE; HEART RATE; HYPERTRIGLYCERIDEMIA; INFUSIONS, INTRAVENOUS; INSULIN; INSULIN RESISTANCE; MALE; OSMOLAR CONCENTRATION; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SORBITOL; TRIGLYCERIDES;

EID: 34447629217     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Anderson, R.A., Evans, M.L., Ellis, G.R., Graham, J., Morris, K., Jackson, S.K., Lewis, M.J., Rees, A. and Frenneaux, M.P. The relationship between postprandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes. Atherosclerosis 154: 435448, 2001.
2. Bae, J.H., Bassenge, E., Kim, K.B., Kim, Y.N., Kim, K.S., Lee, H.J., Moon, K.C., Lee, M.S., Park, K.Y. and Schwemmer, M. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis 155: 517-523, 2001.
3. Banos, G., Carvajal, K., Cardoso, G., Zamora, J. and Franco, M. Vascular reactivity and effect of serum in a rat model of hypertriglyceridemia and hypertension. Am. J. Hypertens. 10: 379-388, 1997.
4. Ceriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R. and Motz, E. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation 106:1211-1218, 2002.
5. Cruzado, M., Risler, N., Castro, C., Ortiz, A. and Ruttler, M.E. Proliferative effect of insulin on cultured smooth muscle cells from rats mesenteric resistance vessels. Am. J. Hypertens. 11: 54-58, 1998.
6. Edwards, J.G. and Tipton, C.M. Influences of exogenous insulin on arterial blood pressure measurements of the rats. J. Appl. Physiol. 67: 2335-2342, 1989.
7. Faxon, D.P., Sanborn, T.A., Weber, V.J., Handenschild, C., Gottsman, S.B., McGovern, W.A. and Ryan, TJ. Restenosis following transluminal angioplasty in experimental atherosclerosis. Arteriosclerosis 4: 189-195, 1984.
8. Finch, D., Davis, G., Bower, H. and Kirchner, K. Effect of insulin on renal sodium handling in hypertensive rats. Hypertension 15: 514-518, 1990.
9. Hwang, I.S., Ho, H., Hoffman, B.B. and Reaven, G.M. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10: 512-516, 1987.
10. Haastrup, A.T., Stepniakowski, K.T., Goodfriend, T.L. and Egan, B.M. Intralipid enhances alpha 1-adrenergic receptor mediated pressor sensitivity. Hypertension 32: 693-698, 1998.
11. Halperin, R.O., Sesso, H.D., Ma, J., Buring, J.E., Stampfer, M.J. and Gaziano, M. Dyslipidemia and the risk of incident hypertension in men. Hypertension47: 45-50, 2006.
12. Hossam, A.S. and Abdel-Rahman, A.A. Mechanism of fatty acids induced suppression of cardiovascular reflexes in rats. J. Pharmacol. Exp. Ther. 314: 1328-1337, 2005.
13. Hsieh, P.S. Attenuation of insulin-mediated pressor effect and nitric oxide release in rats with fructose-induced insulin resistance. Am. J. Hypertens. 17: 707-711, 2004.
14. Hsieh, P.S. and Huang, W.C. Neonatal chemical sympathectomy attenuates fructose-induced hypertriglyceridemia and hypertension in rats. Chinese J. Physiol. 44: 25-31, 2001.
15. Hwang, I.S., Huang, W.C., Wu, J.N., Shieh, L.R. and Reaven, G.M. Effect of fructose-induced hypertension on the rennin-angiotension-aldosterone system and atrial natriuretic factor. Am. J. Hypertens. 2: 424-427, 1989.
16. Jonkers, I.J., de Man, F.H., van der Laarse, A., Frolich, M., Gevers Leuven, J.A., Kamper, A.M., Blauw, G.J. and Smelt, A.H. Bezafibrate reduces heart rates and blood pressure in patients with hypertriglyceridemia. J. Hypertens. 19: 749-755, 2001.
17. Klimes, I. and Sebokova, E. Hypertension and the insulin resistance syndrome of rats. Are they related? Ann. NY Acad. Sci. 827:13-34, 1997.
18. King, G.L., Goodman, A.D., Buzney, S., Moses, A. and Kahn, C.R. Receptors and growth-promoting effects of insulin and insulin-like growth factors on cells from bovine retinal capillaries and aorta. J. Clin. Invest. 75: 1028-1036, 1985.
19. Kunes, H., Dobesova, Z. and Zicha, J. Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hygertriglyceridemia. Clin. Sci. 102: 269-277, 2002.
20. Lee, M.K., Miles, P.D., Khoursheed, M., Gao, K.M., Moosa, A.R., and Olefsky, J.M. Metabolic effects of troglitazone on fructose-induced insulin resistance in rats. Diabetes 43: 1435-1439, 1994.
21. Lopes, H.F., Stojiljikovic, M.P., Zhang, D., Goodfriend, T.L. and Egan, B.M. The pressor response to acute hyperlipidemia is enhanced in lean normotensive offspring of hypertensive parents. Am. J. Hypertens. 14: 1032-1037, 2001.
22. Misra, A., Cherukupalli, R., Reddy, K.S., Mohan, A. and Bajaj, J.S. Hyperinsulinemia and dyslipidemia in non-obese, normotensive offspring of hypertensive parents in northern India. Blood Press. 7: 286-290, 1998.
23. Moreau, P., Lamarche, L., Laflamme, A.K., Calderone, A., Yamaguchi, N. and de Champlain, J. Chronic hyperinsulinemia and hypertension: the role of the sympathetic nervous system. J. Hypertens. 13: 333-340, 1995.
24. Piatti, P., Monti, L.D., Confi, M., Baruffaldi, L., Galli, L., Phan, C.V., Guazzini, B., Ponfiroli, A.E. and Pozza, G. Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans. Diabetes 45: 316-321, 1996.
25. Rao, R.H. Changes in insulin sensitivity due to stress during repetive sampling in anesthetized rats. Am. Physiol. 262: R1033-R1039, 1992.
26. Si, X., Webb, R.C. and Richey, J.M. Bezabibrate, an antihypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats. Can. J. Physiol. Pharmacol. 77: 755-762, 1999.
27. Smiseth, O.A. and Mjos, O.D. Haemodynamic and metabolic consequences of elevated plasma free fatty acids during acute ischaemic left ventricular failure in dogs. Scand. J. Clin. Lab. Invest. 45: 515-520, 1985.
28. Stanley, W.C., Lopaschunk, G.D. and McCormack, J.G. Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc. Res. 34: 25-33, 1997.
29. Williams, R.R., Hunt, S.C., Hopkins, P.N., Stults, B.M., Wu, L.L., Hasstedt, S.J., Barlow, G.K. and Stephenson, S.H. Familial dyslipidemic hypertension: Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. J.A.M.A. 259: 2579-3586, 1998.