PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure

Environmental Health Perspectives

Volumn 104, Issue 8, 1996, Pages 858-865

  Thomas, Russell S ^a   Yang, Raymond S H ^a   Morgan, Daniel G ^b   Moorman, Michael P ^c   Kermani, Hamid R S ^c   Sloane, Richard A ^c   O'Connor, Robert W ^d   Adkins Jr , Bernard ^d   Gargas, Michael L ^e   Andersen, Melvin E ^f  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b GLAXOSMITHKLINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d ALION SCIENCE AND TECHNOLOGY   (United States)

^e ChemRisk A Div of McLaren/Hart   (United States)

^f ICF Kaiser   (United States)

Author keywords

Bootstrap resampling; Glutathione S transferase; Methylene chloride; Monte Carlo simulation; Physiologically based pharmacokinetic modeling; Risk assessment

Indexed keywords

DICHLOROMETHANE; GLUTATHIONE TRANSFERASE; MIXED FUNCTION OXIDASE;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENVIRONMENTAL HEALTH; ENZYME INDUCTION; ENZYME INHIBITION; EXPOSURE; FEMALE; INHALATION; LIVER LEVEL; LONG TERM EXPOSURE; LUNG; METABOLISM; MOUSE; MUSCLE LEVEL; NONHUMAN; PARTITION COEFFICIENT; PHARMACOKINETICS; PRIORITY JOURNAL; RISK ASSESSMENT; TISSUE LEVEL;

EID: 16044365170     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104858     Document Type: Article

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