Aminopenicillin-induced exanthema allows treatment with certain cephalosporins or phenoxymethyl penicillin

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 1, 2007, Pages 107-111

  Trcka, Jiri ^a,b   Seitz, Cornelia S ^a   Bröcker, Eva B ^a   Gross, Gerd E ^b   Trautmann, Axel ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Drug challenge; Drug provocation; Non IgE mediated allergic hypersensitivity; Skin tests

Indexed keywords

AMINOPENICILLIN; AMOXICILLIN; AMPICILLIN; ANTIHISTAMINIC AGENT; BETA LACTAM ANTIBIOTIC; CEFIXIME; CEFPODOXIME; CEPHALOSPORIN DERIVATIVE; GLUCOCORTICOID; PENICILLIN G; PENICILLIN V;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CROSS REACTION; DELAYED HYPERSENSITIVITY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROVOCATION TEST; SKIN TEST;

ADOLESCENT; ADULT; AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CEFIXIME; CEFTIZOXIME; CEPHALOSPORINS; CROSS REACTIONS; DRUG HYPERSENSITIVITY; EXANTHEMA; FEMALE; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; PENICILLIN V; SINGLE-BLIND METHOD; SKIN TESTS; TREATMENT OUTCOME;

EID: 34447565037     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm146     Document Type: Article

References (37)

1. Bigby M, Jick S, Jick H et al. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256: 3358-63.
2. Romano A. Delayed hypersensitivity to aminopenicillins. Clin Exp Allergy 1998; 28 Suppl 4: 29-32.
3. Shepherd GM. Hypersensitivity reactions to drugs: Evaluation and management. Mt Sinai J Med 2003; 70: 113-25.
4. Lin RY. A perspective on penicillin allergy. Arch Intern Med 1992; 152: 930-7.
5. Yawalkar N, Hari Y, Frutig K et al. T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic. J Invest Dermatol 2000; 115: 647-52.
6. Schnyder B, Pichler WJ. Skin and laboratory tests in amoxicillin-and penicillin-induced morbilliform skin eruption. Clin Exp Allergy 2000; 30: 590-5.
7. Aihara M, Ikezawa Z. Evaluation of the skin test reactions in patients with delayed type rash induced by penicillins and cephalosporins. J Dermatol 1987; 14: 440-8.
8. Osawa J, Naito S, Aihara M et al. Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J Dermatol 1990; 17: 235-9.
9. Romano A, Di Fonso M, Papa G et al. Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy 1995; 50: 113-8.
10. Torres MJ, Sanchez-Sabate E, Alvarez J et al. Skin test evaluation in nonimmediate allergic reactions to penicillins. Allergy 2004; 59: 219-24.
11. Romano A, Viola M, Mondino C et al. Diagnosing nonimmediate reactions to penicillins by in vivo tests. Int Arch Allergy Immunol 2002; 129: 169-74.
12. Romano A, Quaratino D, Di Fonso M et al. A diagnostic protocol for evaluating nonimmediate reactions to aminopenicillins. J Allergy Clin Immunol 1999; 103: 1186-90.
13. Patriarca G, D'Ambrosio C, Schiavino D et al. Clinical usefulness of patch and challenge tests in the diagnosis of cell-mediated allergy to β-lactams. Ann Allergy Asthma Immunol 1999; 83: 257-66.
14. Blanca M, Mayorga C, Torres MJ et al. Side-chain-specific reactions to β-lactams: 14 years later. Clin Exp Allergy 2002; 32: 192-7.
15. Baldo BA. Penicillins and cephalosporins as allergens - structural aspects of recognition and cross-reactions. Clin Exp Allergy 1999; 29: 744-9.
16. Blanca M, Mayorga C, Torres MJ et al. Clinical evaluation of Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001; 56: 862-70.
17. Pham NH, Baldo BA. β-Lactam drug allergens: Fine structural recognition patterns of cephalosporin-reactive IgE antibodies. J Mol Recognit 1996; 9: 287-96.
18. Brockow K, Romano A, Blanca M et al. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002; 57: 45-51.
19. Aberer W, Bircher A, Romano A et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: General considerations. Allergy 2003; 58: 854-63.
20. Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet 2001; 357: 1851-3.
21. Vega JM, Blanca M, Carmona MJ et al. Delayed allergic reactions to β-lactams. Four cases with intolerance to amoxicillin or ampicillin and good tolerance to penicillin G and V. Allergy 1991; 46: 154-7.
22. Lisi P, Lapomarda V, Stingeni L et al. Skin tests in the diagnosis of eruptions caused by β-lactams. Contact Dermatitis 1997; 37 151-4.
23. Lopez SC, Villas F, Cabanas R et al. Delayed hypersensitivity to β-lactams. J Investig Allergol Clin Immunol 1994; 4: 315-9.
24. Barbaud A, Reichert-Penetrat S, Trechot P et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998; 139: 49-58.
25. Romano A, Blanca M, Torres MJ et al. Diagnosis of nonimmediate reactions to β-lactam antibiotics. Allergy 2004; 59: 1153-60.
26. Beeler A, Engler O, Gerber BO et al. Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 2006; 117 455-62.
27. Arroliga ME, Pien L. Penicillin allergy: Consider trying penicillin again. Cleve Clin J Med 2003; 70: 313-8.
28. Salkind AR, Cuddy PG, Foxworth JW. The rational clinical examination. Is this patient allergic to penicillin? An evidence-based analysis of the likelihood of penicillin allergy. JAMA 2001; 285: 2498-505.
29. Surtees SJ, Stockton MG, Gietzen TW. Allergy to penicillin: Fable or fact? BMJ 1991; 302: 1051-2.
30. Romano A, Quaratino D, Papa G et al. Aminopenicillin allergy. Arch Dis Child 1997; 76: 513-7.
31. Romano A, De Santis A, Romito A et al. Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes. Ann Allergy Asthma Immunol 1998; 80: 433-7.
32. Sastre J, Quijano LD, Novalbos A et al. Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin. Allergy 1996; 51: 383-6.
33. Miranda A, Blanca M, Vega JM et al. Cross-reactivity between a penicillin and a cephalosporin with the same side chain. J Allergy Clin Immunol 1996; 98: 671-7.
34. Perez-Inestrosa E, Suau R, Montanez MI et al. Cephalosporin chemical reactivity and its immunological implications. Curr Opin Allergy Clin Immunol 2005; 5: 323-30.
35. Phillips E, Knowles SR, Weber EA et al. Cephalexin tolerated despite delayed aminopenicillin reactions. Allergy 2001; 56: 790.
36. Novalbos A, Sastre J, Cuesta J et al. Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins. Clin Exp Allergy 2001; 31: 438-43.
37. Terrados S, Blanca M, Garcia J et al. Nonimmediate reactions to β-lactams: Prevalence and role of the different penicillins. Allergy 1995; 50: 563-7.