Synthesis and anticonvulsant activity of novel 2-amino-5-[4-chloro-2-(2- chlorophenoxy) phenyl]-1,3,4-thiadiazole derivatives

Daru

Volumn 15, Issue 2, 2007, Pages 89-93

  Foroumadi, A ^a,b   Sheibani, V ^b   Sakhteman, A ^a   Rameshk, M ^b   Abbasi, M ^a   Farazifard, R ^b   Tabatabai, S A ^c   Shafiee, A ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,3,4 thiadiazole; Anticonvulsant activity; Maximal electroshock

Indexed keywords

2 AMINO 5 [4 CHLORO 2 (2 CHLOROPHENOXY)PHENYL] 1,3,4 THIADIAZOLE; 5 [4 CHLORO 2 (2 CHLOROPHENOXY)PHENYL] N ETHYL 1,3,4 THIADIAZOL 2 AMINE; 5 [4 CHLORO 2 (2 CHLOROPHENOXY)PHENYL] N METHYL 1,3,4 THIADIAZOL 2 AMINE; 5 [4 CHLORO 2 (2 CHLOROPHENOXY)PHENYL] N PHENYL 1,3,4 THIADIAZOL 2 AMINE; DIAZEPAM; FLUMAZENIL; PENTETRAZOLE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; MOUSE; NONHUMAN;

EID: 34447563859     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Löscher W. New visions in the pharmacology of anticonvulsion. Eur J Pharm 1998; 342: 1-13.
2. Gringauz A. Introduction to Medicinal Chemistry; 1st ed. Wiley-VCH: New York, 1997; 589-593.
3. Brodie M. Monotherapy trials: prerequisite data. J Epilepsy Res 2001; 45:61-64.
4. Mattson. Antiepileptic drug monitoring: a reappraisal R H Epilepsia (Suppl. 2) 1995; 36:S-13
5. Chapleo CB, Mayers M, Myers PL, Saville JF, Smith ACB, Stillings MR, Tulloch IF, Walter DS and Welbourn AP. Substituted 1,3,4-thiadiazole with anticonvulsant activity. 1. Hydrazines. J Med Chem 1986; 29: 2273-2280.
6. Shafiee A, Rastkari N, Sharifzadeh M. Anticonvulsant Activities of New 1,4-dihydropyridine Derivatives Containing 4-nitroimidazolyl Substituents. Daru 2004; 12: 81-86.
7. Bineshmarvasti M, Sharifzadeh M, Jalilian R, Soltaninejad K and Shafiee A. Syntheses and Anticonvulsant Activity of N4-Substituted Triazolylthiazoles. Daru 2003; 11: 74-78.
8. Dogan HN, Duran A, Rollas S, Sener G, Uysal MK and Gulen D. Synthesis of new 2,5-disubstituted1-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities. Bioorg Med Chem 2002; 10: 2893-2898.
9. Almasirad A, Tabatabai SA, Faizi M, Kebriaeezadeh A, Mehrabi N, Dalvandi A and Shafiee A. Synthesis and anti convulsant activity of new 2-substututed 5-[2-(2-flurophenoxy)phenyl]-1,3,4-oxadiazole and 1,2,4-triazoles. Bioorg Med Chem Lett 2004; 14: 6057-6059.
10. Akbarzadeh T, Tabatabai SA, Khoshnoud MJ, Shafaghi B, Shafiee A. Design and synthesis of 4H-3-(2-Phenoxy) phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem 2003; 11: 769-773.
11. Foroumadi A, Tabatabai SA, Gitinezhad G, Zarrindast MR and Shafiee A. Synthesis and anticonvulsant activity of 5-aryl-1,3,4-thiadiazole derivatives. Pharm Pharmacol Commun 2000; 6:31-33.
12. Woodley HF, Lewis T and Jones I. Method of antagonizing herbicides on soy bean and cotton, US Pat. 4,242,121, 30 Dec 1980; ref. Chem. Abstr 1981; 95: 19713t.
13. Detar DF and Hlynsky A. The thermal decomposition of 2-phenoxybenzoyl peroxide. J Am Chem Soc 1955; 77: 4411-4412.
14. Jackson HC, Hansen HC, Kristiansen M, Suzdak PD, Klitgaard H, Judge ME and Swedberg MDB. Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice. Eur J Pharmacol 1996; 306: 21-30.
15. Turner S, Myers M, Gadie B, Nelson AJ, Pape R, Saville JF, Doxey JC and Berrridge TL. Antihypertensive Thiadiazoles. 1. Synthesis of some 2-Aryl-5-hydrazino-1,3,4-thiadiazoles with vasodilator activity. J Med Chem 1998; 31: 902-905.