Dissolution of the inorganic phase of bone leading to release of calcium regulates osteoclast survival

Biochemical and Biophysical Research Communications

Volumn 360, Issue 4, 2007, Pages 834-839

  Nielsen, Rasmus H ^a   Karsdal, Morten A ^a   Sørensen, Mette G ^a   Dziegiel, Morten H ^b   Henriksen, Kim ^a  

^a NORDIC BIOSCIENCE A S   (Denmark)

^b Mental Health Services CPH   (Denmark)

Author keywords

Acidification; Bone resorption; Calcium; ClC 7; Osteoclast survival

Indexed keywords

BAFILOMYCIN; CALCIUM; RYANODINE;

ARTICLE; BONE MATRIX; CALCIUM TRANSPORT; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

APOPTOSIS; BONE AND BONES; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; HUMANS; HYDROGEN-ION CONCENTRATION; OSTEOCLASTS;

EID: 34447561567     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.145     Document Type: Article

References (25)

1. Vaananen H.K., Zhao H., Mulari M., and Halleen J.M. The cell biology of osteoclast function. J. Cell Sci. 113 Pt 3 (2000) 377-381
2. Baron R., Neff L., Louvard D., and Courtoy P.J. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kDa lysosomal membrane protein at the osteoclast ruffled border. J. Cell Biol. 101 (1985) 2210-2222
3. Li Y.P., Chen W., Liang Y., Li E., and Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat. Genet. 23 (1999) 447-451
4. Kornak U., Kasper D., Bosl M.R., Kaiser E., Schweizer M., Schulz A., Friedrich W., Delling G., Jentsch T.J., et al. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104 (2001) 205-215
5. Henriksen K., Gram J., Schaller S., Dahl B.H., Dziegiel M.H., Bollerslev J., Karsdal M.A., et al. Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II. Am. J. Pathol. 164 (2004) 1537-1545
6. Frattini A., Orchard P.J., Sobacchi C., Giliani S., Abinun M., Mattsson J.P., Keeling D.J., Andersson A.K., Wallbrandt P., Zecca L., et al. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat. Genet. 25 (2000) 343-346
7. Bollerslev J., Thomas S., Grodum E., Brixen K., and Djoseland O. Collagen metabolism in two types of autosomal dominant osteopetrosis during stimulation with thyroid hormones. Eur. J. Endocrinol. 133 (1995) 557-563
8. Del Fattore A., Peruzzi B., Rucci N., Recchia I., Cappariello A., Longo M., Fortunati D., Ballanti P., Iacobini M., Luciani M., et al. Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment. J. Med. Genet. 43 (2006) 315-325
9. Karsdal M.A., Henriksen K., Sorensen M.G., Gram J., Schaller S., Dziegiel M.H., Heegaard A.M., Christophersen P., Martin T.J., Christiansen C., et al. Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption. Am. J. Pathol. 166 (2005) 467-476
10. Silver I.A., Murrills R.J., and Etherington D.J. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp. Cell Res. 175 (1988) 266-276
11. Ritchie C.K., Maercklein P.B., and Fitzpatrick L.A. Direct effect of calcium channel antagonists on osteoclast function: alterations in bone resorption and intracellular calcium concentrations. Endocrinology 135 (1994) 996-1003
12. Zaidi M., Shankar V.S., Tunwell R., Adebanjo O.A., Mackrill J., Pazianas M., O'Connell D., Simon B.J., Rifkin B.R., Venkitaraman A.R., et al. A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing. J. Clin. Invest. 96 (1995) 1582-1590
13. Bennett B.D., Alvarez U., and Hruska K.A. Receptor-operated osteoclast calcium sensing. Endocrinology 142 (2001) 1968-1974
14. Datta H.K., MacIntyre I., and Zaidi M. The effect of extracellular calcium elevation on morphology and function of isolated rat osteoclasts. Biosci. Rep. 9 (1989) 747-751
15. Lorget F., Kamel S., Mentaverri R., Wattel A., Naassila M., Maamer M., Brazier M., et al. High extracellular calcium concentrations directly stimulate osteoclast apoptosis. Biochem. Biophys. Res. Commun. 268 (2000) 899-903
16. Iwamoto J., Takeda T., Sato Y., and Yeh J.K. Response of cortical and cancellous bones to mild calcium deficiency in young growing female rats: a bone histomorphometry study. Exp. Anim. 53 (2004) 347-354
17. C. Gaudin, H. Liboudan, M. Moreau, M.F. Basle, M. Audran, D. Chappard, Increased osteoclast number and size in C57bl mice with calcium deprivation and treatment with a single dose of zoledronic acid, J. Bone Miner. Res. 19 (Suppl. 1) (Abstract M421).
18. Karsdal M.A., Hjorth P., Henriksen K., Kirkegaard T., Nielsen K.L., Lou H., Delaisse J.M., Foged N.T., et al. TGF-beta controls human osteoclastogenesis through the p38 MAP kinase and regulation of RANK expression. J. Biol. Chem. 278 (2003) 44975-44987
19. Henriksen K., Sorensen M.G., Nielsen R.h., Gram J., Schaller S., Dziegiel M.H., Everts V., Bollerslev J., Karsdal M.A., et al. Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification. J. Bone Miner. Res. 21 (2006) 58-66
20. Bollerslev J., Marks Jr. S.C., Pockwinse S., Kassem M., Brixen K., Steiniche T., Mosekilde L., et al. Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteopetrosis. Bone 14 (1993) 865-869
21. Schaller S., Henriksen K., Sveigaard C., Heegaard A.M., Helix N., Stahlhut M., Ovejero M.C., Johansen J.V., Solberg H., Andersen T.L., et al. The chloride channel inhibitor n53736 prevents bone resorption in ovariectomized rats without changing bone formation. J. Bone Miner. Res. 19 (2004) 1144-1153
22. Helfrich M.H. Osteoclast diseases. Microsc. Res. Tech. 61 (2003) 514-532
23. Zaidi M., Datta H.K., Patchell A., Moonga B., and MacIntyre I. 'Calcium-activated' intracellular calcium elevation: a novel mechanism of osteoclast regulation. Biochem. Biophys. Res. Commun. 163 (1989) 1461-1465
24. Moonga B.S., Li S., Iqbal J., Davidson R., Shankar V.S., Bevis P.J., Inzerillo A., Abe E., Huang C.L., Zaidi M., et al. Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor. Am. J. Physiol. Renal Physiol. 282 (2002) F921-F932
25. Berger C.E., Rathod H., Gillespie J.I., Horrocks B.R., and Datta H.K. Scanning electrochemical microscopy at the surface of bone-resorbing osteoclasts: evidence for steady-state disposal and intracellular functional compartmentalization of calcium. J. Bone Miner. Res. 16 (2001) 2092-2102