Detection, enumeration and characterization of T helper cells secreting type 1 and type 2 cytokines in patients with recurrent aphthous stomatitis

Tohoku Journal of Experimental Medicine

Volumn 212, Issue 2, 2007, Pages 101-105

  Albanidou Farmaki, Eleni ^a   Markopoulos, Anastasios K ^a   Kalogerakou, Filanthi ^a   Antoniades, Demetrios Z ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Immunopathogenesis of recurrent aphthous stomatitis; Peripheral blood mononuclear cells; Type 1 and 2 T helper cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APHTHOUS STOMATITIS; ARTICLE; CELL COUNT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSPOT ASSAY; EPIGENETICS; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; T LYMPHOCYTE;

ADULT; CASE-CONTROL STUDIES; CELL COUNT; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; RECURRENCE; STOMATITIS, APHTHOUS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 34447542063     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.212.101     Document Type: Article

References (10)

1. Albanidou-Farmaki, E., Kayavis, I.G., Polymenidis, Z. & Papanayotou, P. (1988) HLA-A,B,C and DR Antigens n Recurrent Oral Ulcer. Ann. Dent., 479, 5-8.
2. Borra, R.C., Andrade, P.M., Silva, I.D.C.G., Morgun, A., Weckx, L.L.M., Smirnova, A.S. & Franco, M. (2004) The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by CDNA microarray. J. Oral. Pathol. Med., 33, 140-146.
3. Buno, I.J., Huff, J.C., Weston, W.L., Cook, D.T. & Brice, S.L. (1998) Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2,4 and 5, but not interleukin-10, are present in recurrent aphthous stomatitis. Arch. Dermatol., 134, 827-831.
4. Hasan, A., Shinnick, T., Mizushima, V., Van der Zee, R. & Lehner, T. (2002) Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis. Clin. Exp. Immunol., 128, 318-325.
5. Mackay, I.R. & Rosen, F.S. (2001) Tolerance and autoimmunity. N. Engl. J. Med., 344, 655-664.
6. Natah, S., Haytinen-Immoren, R., Heitanen, J., Malstrom, M. & Konttinen, Y. (2000) Immunolocalization of tumour necrosis factor-alpha expressing cells in recurrent aphthous ulcers lesions (RAU). J. Oral. Pathol. Med., 29, 19-25.
7. Scully, C., Gorsky, M. & Lozada-Nur, F. (2003) The diagnosis and management of recurrent aphthous stomatitis; a consensus approach. J. Am. Dent. Assoc., 134, 200-207.
8. Sun, A., Chia, J.S., Chang, Y.F. & Chiang, C.P. (2003) Levamisole and Chinese medicinal herbs can modulate the serum interleukin-6 level in patients with recurrent aphthous ulceration. J. Oral. Pathol. Med., 32, 2006-2014.
9. Sun, A., Chang, Y.F., Chia, J.S. & Chiang, C.P. (2004) Serum interleukin-8 level is a more sensitive marker than serum interleukin-6 level in monitoring the disease activity of recurrent aphthous ulceration. J. Oral. Pathol. Med., 33, 133-139.
10. Taylor, L.J., Bagg, J. & Walker, D.M. (1992) Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. J. Oral. Pathol. Med., 21, 21-25.