Divalproex sodium for the treatment of PTSD and conduct disordered youth: A pilot randomized controlled clinical trial

Child Psychiatry and Human Development

Volumn 38, Issue 3, 2007, Pages 183-193

  Steiner, Hans ^a   Saxena, Kirti S ^a   Carrion, Victor ^a   Khanzode, Leena A ^a   Silverman, Melissa ^a   Chang, Kiki ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clinical trial; Conduct disorder; Divalproex sodium; PTSD

Indexed keywords

VALPROATE SEMISODIUM;

ADOLESCENT; AROUSAL; ARTICLE; AVOIDANCE BEHAVIOR; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; CONDUCT DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; GASTROINTESTINAL SYMPTOM; HUMAN; IMPULSIVENESS; LOW DRUG DOSE; MALE; OUTCOME ASSESSMENT; PARALLEL DESIGN; PILOT STUDY; POSTTRAUMATIC STRESS DISORDER; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SOMNOLENCE; SYMPTOM;

ADOLESCENT; ANTICONVULSANTS; COMORBIDITY; CONDUCT DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; INTERNAL-EXTERNAL CONTROL; MALE; PERSONALITY ASSESSMENT; PILOT PROJECTS; PSYCHOPATHOLOGY; STRESS DISORDERS, POST-TRAUMATIC; VALPROIC ACID;

EID: 34447536305     PISSN: 0009398X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10578-007-0055-8     Document Type: Article

References (35)

1. Kessler RC, Sonnega A, Bromet, E (1999) Risk factors for posttraumatic stress disorder. In: Yehuda R (ed) American Psychiatric Association, Washington, DC, US, pp 23-59
2. Giaconia RM, Reinherz HZ, Silverman AB (1995) Traumas and posttraumatic stress disorder in a community population of older adolescents. J Am Acad Child Adolesc Psychiatry 34(10):1369-1380
3. Berman SL, Kurtines WM, Silverman WK (1996) The impact of exposure to crime and violence on urban youth. Am J Orthopsychiatry 3(66):329-336
4. Cauffman E, Feldman SS, Waterman J, Steiner H (1998) Posttraumatic stress disorder among incarcerated females. J Am Acad Child Adolesc Psychiatry 37(11):1209-1216
5. Steiner H, Garcia IG, Matthews Z (1997) Posttraumatic stress disorder in incarcerated juvenile delinquents. J Am Acad Child Adolesc Psychiatry 36(3):357-365
6. McLeer SV, Deblinger EB, Henry D (1992) Sexually abused children at high risk for post-traumatic stress disorder. J Am Acad Child Adolesc Psychiatry 31(5):875-879
7. Famularo R, Fenton Terence, Augustyn M (1996) Persistence of pediatric posttraumatic stress disorder after 2 years. Child Abuse & Neglect 20(12):1245-1248
8. Pfefferbaum B (1997) Posttraumatic stress disorder in children: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 36(11):1503-1511
9. Donnelly CL, Amaya JL, March JS (1999) Psychopharmacology of pediatric posttraumatic stress disorder. J Child Adolesc Psychopharmacol Ann 9(3):203-220
10. RUPP STUDY GROUP (2001) Fluvoxamine for the treatment of anxiety disorders in children and adolescents. New England Journal of Medicine 1279-1285
11. Famularo R, Kinscherff R, Fenton T (1988) Propranolol treatment for childhood posttraumatic stress disorder, acute type. A pilot study. Am J Dis Child 142(11):1244-1247
12. Harmon RJ, Riggs PD (1996) Clonidine for posttraumatic stress disorder in preschool children. J Am Acad Child Adolesc Psychiatry 35(9):1247-1249
13. Nader KO, Pynoos RS, Fairbanks LA, Al-Ajeel M, Al-Asfour A (1993) A preliminary study of PTSD and grief among the children of Kuwait following the Gulf crisis. Br J Clin Psychol 32(Pt 4):407-416
14. Post RM, Weiss SRB, Smith M, Li H, McCann U (1997) Kindling vs. quenching: implications for the evolution and treatment of PTSD. Ann NY Acad Sci 821:285-295
15. Wilcox J (1994) Divalproex sodium in the treatment of aggressive behavior. Ann Clin Psychiatry 6(1):17-20
16. Donovan SJ, Susser ES, Nunes EV, Stewart JW, Quitkin FM, Klein DF (1997) Divalproex treatment of disruptive adolescents: a report of 10 cases. J Clin Psychiatry 58:12-15
17. Loof D, Grimley P, Kuller F (1995) Carbamazepine found efficacious for some children, adolescents with PTSD. Special Report: Anxiety Disorders. Psychiatric Times 23
18. Fesler FA (1991) Valproate in combat related posttraumatic stress disorder. J Clin Psychiatry 52: 361-364
19. Rana M, Khanzode LA, Karnik N, Saxena K, Chang K, Steiner H (2005) Divalproex sodium in the treatment of pediatric psychiatric disorders. Expert Rev Neurother 5(2):165-176
20. Steiner H, Petersen M, Saxena K, Ford S, Matthews Z (2003) Divalproex Sodium for the treatment of Severe Conduct Disorder: a randomized controlled clinical trial. J of Clinical Psychiatry 64:1183-1191
21. Othmer E, Penick EC, Powell BJ, Read MR, Othmer SC (1981) Psychiatric Diagnostic Interview- Revised (PDI-R). Los Angeles, Western Psychological Services
22. Achenbach TM (1991) Manual for Youth Self-Report and 1991 Profile. Burlington, VT, University of Vermont Dept. of Psychiatry
23. Weinberger D (1997) Distress and self-restraint as measures of adjustment across the life Span: confirmatory factor analysis in clinical and nonclinical samples. Psychol Assess 9(2):132-135
24. Guy W (1976) ECDEU Assessment Manual for Psychopharmacology, 2nd ed. Washington DC, US Government Printing Office
25. Deltito JA, Levitan J, Damore J, Hajal F, Zambenedetti M (1998) Naturalistic experience with the use of divalproex sodium on an in-patient unit for adolescent psychiatric patients. Acta Pschiatr Scand 97: 236-240
26. Feldman SS, Weinberger DA (1995) Self-restraint as a mediator of family influences on boys' delinquent behavior: a longitudinal study. Child Dev 65: 195-121, 1994.
27. Weinberger DA, Gomes ME: Changes in daily mood and self-restraint among under controlled preadolescents: a time series analysis of "acting out". J Am Acad Child Adolesc Psychiatry 34(11):1473-1482
28. Lasko NB, Gurvits TV, Kuhne AA, Orr SP, Pitman RK (1994) Aggression and its correlates in Vietnam veterans with and without chronic posttraumatic stress disorder. Compr Psychiatry 35(5):373-381
29. Begic D, Jokie BN (2001) Aggressive behavior in combat veterans with post-traumatic stress disorder. Mil Med 166(8):671-676
30. Donovan SJ, Stewart JW, Nunes EV, Quitkin FM, Parides M, Daniel W (2000) Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Am J Psychiatry 157(5):818-820
31. Donovan SJ, Nunes EV, Stewart JW, Ross D, Quitkin FM, Jensen PS et al (2003) "Outer-Directed Irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder? J Clin Psychiatry 64(6):698-701
32. Steiner H, Saxena K, Chang K (2003) Psychopharmacological Strategies for the treatment of Aggression in Juveniles. CNS Spectrum 8(4):298-308
33. Wagner K (2002) An Open-label trial of divalproex in children & adolescents with Bipolar disorder. J Am Acad Child Adolesc Psychiatry 41(10):1224-1230
34. Ohtsuka Y, Amano R, Mizukawa M, Oka E, Ohtahara S (1992) Treatment of intractable childhood epilepsy with high-dose valproate. Epilepsia 33(1):158-164
35. Steiner H, and AAACAP Work Group on Quality Issues (1997) Practice parameters for the assessment and treatment of children and adolescents with conduct disorder. J Am Acad Child Adolesc Psychiatry 36(10):122S-19S