Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation

Cornea

Volumn 26, Issue 6, 2007, Pages 665-669

  Trattler, William ^a   McDonald, Marguerite ^a  

^a Center for Excellence in Eye Care Florida   (United States)

Author keywords

Cornea; Epi laser in situ keratomileusis; Haze; Ketorolac; Nepafenac; Surface ablation

Indexed keywords

KETOROLAC TROMETAMOL; NEPAFENAC;

ADULT; ADVERSE OUTCOME; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EYE; FEMALE; FOLLOW UP; HEALING; HUMAN; KERATOMILEUSIS; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PATIENT SAFETY; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZENEACETAMIDES; CORNEA; CORNEAL OPACITY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPEROPIA; KERATOMILEUSIS, LASER IN SITU; KETOROLAC TROMETHAMINE; MALE; MYOPIA; OPHTHALMIC SOLUTIONS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PHENYLACETATES; PROSPECTIVE STUDIES; VISUAL ACUITY; WOUND HEALING;

EID: 34447532292     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e31805290ce     Document Type: Article

References (18)

1. Albietz JM, McLennan SG, Lenton LM. Ocular surface management of photorefractive keratectomy and laser in situ keratomileusis. J Refract Surg. 2003;19:636-644.
2. Abad JC, An B, Power WJ, et al. A prospective evaluation of alcoholassisted versus mechanical epithelial removal before photorefractive keratectomy. Ophthalmology. 1997;104:1566-1574.
3. Abad JC, Talamo JH, Vidaurri-Leal J, et al. Dilute ethanol versus mechanical debridement before photorefractive keratectomy. J Cataract Refract Surg. 1996;22:1427-1433.
4. Lui MM, Silas MA, Fugishima H. Complications of photorefractive keratectomy and laser in situ keratomileusis. J Refract Surg. 2003;19(2 suppl):S247-S249.
5. Donnenfeld ED, Perry HD, Wittpenn J, et al. Dose-response curve of a topical NSAID as a surgical tool before cataract surgery. J Cataract Refract Surg. 2006;32:1474-1482.
6. Solomon KD, Donnenfeld ED, Raizman M, et al, and the Ketorolac Reformulation Study Groups 1 and 2. Safety and efficacy of ketorolac tromethamine 0.4% ophthalmic solution in post-photorefractive keratectomy patients. J Cataract Refract Surg. 2004;30:1653-1660.
7. Price MO, Price FW. Efficacy of topical ketorolac tromethamine 0.4% for control of pain or discomfort associated with cataract surgery. Curr Med Res Opin. 2004;20:2015-2019.
8. West ES, Behrens A, McDonnell PJ, et al. The incidence of endophthalmitis after cataract surgery among the U.S. Medicare population increased between 1994 and 2001. Ophthalmology. 2005;112:1388-1394.
9. McDonnell PJ, Taban M, Sarayba M, et al. Dynamic morphology of clear corneal cataract incisions. Ophthalmology. 2003;110:2342-2348.
10. Beuerman RW, Thompson HW. Molecular and cellular responses of the corneal epithelium to wound healing. Nordic Congress of Ophthalmology, Helsinki, Finland. August 25-28, 1991. Acta Ophthalmol (Copenh). 1992;70(Suppl 202):7-12.
11. Taban M, Rao B, Reznik J, et al. Dynamic morphology of sutureless cataract wounds - effect of incision angle and location. Surv Ophthalmol. 2004;49:S62-S72.
12. Fagerholm P.Wound healing after photorefractive keratectomy. J Cataract Refract Surg. 2000;26:432-447.
13. Goyal R, Shankar J, Fone DL, et al. Randomised controlled trial of ketorolac in the management of corneal abrasions. Acta Ophthalmol Scand. 2001;79:177-179.
14. Barba KR, Samy A, Lai C, et al. Effect of topical anti-inflammatory drugs on corneal and limbal wound healing. J Cataract Refract Surg. 2000;26:893-897.
15. Waterbury L, Kunysz EA, Beuerman R. Effects of steroidal and nonsteroidal anti-inflammatory agents on corneal wound healing. J Ocul Pharmacol. 1987;3:43-54.
16. Reviglio VE, Rana TS, Li QJ, et al. Effects of topical nonsteroidal antiinflammatory drugs on the expression of matrix metalloproteinases in the cornea. J Cataract Refract Surg. 2003;29:989-997.
17. Donnenfeld ED, Dume DS, Holland EJ, et al. A double-masked study of nepafenac 0.1 and ketorolac 0.4 for pain and epithelial healing following PRK. Presented at the annual meeting of the American Academy of Opthalmology, November 11-14, 2006, Las Vegas, NV.
18. Reilly C, Caldwell M. Double-masked study of nepafenac 0.1 and placebo on pain relief and epithelial healing following PRK. Presented at the annual meeting of the American Academy of Opthalmology, November 11-14, 2006, Las Vegas, NV.