Efficacy of topical ketorolac tromethamine 0.4% for control of pain or discomfort associated with cataract surgery

Current Medical Research and Opinion

Volumn 20, Issue 12, 2004, Pages 2015-2019

  Price, Marianne O ^a   Price, Francis W ^a,b  

^a Lautert)   (United States)

^b PRICE VISION GROUP   (United States)

Author keywords

Cataract extraction; Controlled clinical trial; Ketorolac tromethamine; Ophthalmic solutions; Pain

Indexed keywords

ACULAR LS; CYCLATE; CYCLOPENTOLATE; FENTANYL CITRATE; GATIFLOXACIN; KETOROLAC TROMETAMOL; MIDAZOLAM; MYDRAL; NEOFRIN; ONDANSETRON; PHENYLEPHRINE; PLACEBO; PREDNISOLONE ACETATE; PREDNISONE ACETATE; PROXYMETACAINE; TIMOLOL MALEATE; TROPICAMIDE;

ADULT; AGED; ARTICLE; CATARACT EXTRACTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EYE PAIN; HUMAN; LENS IMPLANT; LENS IMPLANTATION; PAIN; PHACOEMULSIFICATION; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATARACT EXTRACTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KETOROLAC TROMETHAMINE; MALE; MIDDLE AGED; PAIN; PLACEBOS; TREATMENT OUTCOME;

EID: 13144305056     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079904X16759     Document Type: Article

References (26)

1. Jett MF, Ramesha CS, Brown CD, et al. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 1999;288:1288-97
2. Seitz B, Sorken K, LaBree LD, Garbus JJ, McDonnell PJ. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. Arch Ophthalmol 1996;114:921-4
3. Sun R, Gimbel HV. Effects of topical ketorolac and diclofenac on normal corneal sensation. J Refract Surg 1997;13:158-61
4. Narvaez J, Kroll P, Guzek JP. Effect of topical diclofenac and ketorolac on patient discomfort and corneal sensitivity. J Refract Surg 2002;18:145-8
5. Heier J, Cheetham JK, Degryse R, et al. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: a randomized, vehicle-controlled clinical trial. Am J Ophthalmol 1999;127:253-9
6. Solomon KD, Cheetham JK, DeGryse R, Brint SF, Rosenthal A. Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology 2001;108:331-7
7. el-Harazi SM, Ruiz RS, Feldman RM, Villanueva G, Chuang AZ. A randomized double-masked trial comparing ketorolac tromethamine 0.5%, diclofenac sodium 0.1%, and prednisolone acetate 1% in reducing post-phacoemulsification flare and cells. Ophthalmic Surg Lasers 1998;29:539-44
8. Flach AJ, Lavelle CJ, Olander Kw, Retzlaff JA, Sorenson LW. The effect of ketorolac tromethamine solution 0.5% in reducing postoperative inflammation after cataract extraction and intraocular lens implantation. Ophthalmology 1988;95:1279-84
9. Holzer MP, Solomon KD, Sandoval HP, Vroman DT. Comparison of ketorolac tromethamine 0.5% and loteprednol etabonate 0.5% for inflammation after phacoemulsification: prospective randomized double-masked study. J Cataract Refract Surg 2002;28:93-9
10. Ostrov CS, Sirkin SR, Deutsch WE, Masi RJ, Chandler JW, Lindquist TD. Ketorolac, prednisolone, and dexamethasone for postoperative inflammation. Clin Ther 1997;19:259-72
11. Simone JN, Pendelton RA, Jenkins JE. Comparison of the efficacy and safety of ketorolac tromethamine 0.5% and prednisolone acetate 1% after cataract surgery. J Cataract Refract Surg 1999;25:699-704
12. Solomon KD, Vroman DT, Barker D, Gehlken J. Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction. Prospective randomized double-masked study. J Cataract Refract Surg 2001;27:1232-7
13. Brint SF, Cheetham JK, DeGryse R, Abel ML, Thompson VM, Rosenthal A. Efficacy and safety of nonpreserved ketorolac ophthalmic solution in postoperative ocular pain following radial keratotomy. J Cataract Refract Surg 1999;25:41-9
14. McDonald MB, Brint SF, Caplan DI, Bourque LB, Shoaf K. Comparison of ketorolac tromethamine, diclofenac sodium, and moist drops for ocular pain after radial keratotomy. J Cataract Refract Surg 1999;25:1097-108
15. Birt CM. The use of topical ketorolac 0.5% for pain relief following cyclophotocoagulation. Ophthalmic Surg Lasers Imaging 2003;34:381-5
16. Price Jr FW, Price MO, Zeh W, Dobbins K. Pain reduction after laser in situ keratomileusis with ketorolac tromethamine ophthalmic solution 0.5%: a randomized, double-masked, placebo-controlled trial. J Refract Surg 2002;18:140-4
17. Goyal R, Shankar J, Fone DL, Hughes DS. Randomised controlled trial of ketorolac in the management of corneal abrasions. Acta Ophthalmol Scand 2001;79:177-9
18. Kaiser PK, Pineda R 2nd. A study of topical nonsteroidal antiinflammatory drops and no pressure patching in the treatment of corneal abrasions [Corneal Abrasion Patching Study Group]. Ophthalmology 1997;104:1353-9
19. Kitazawa Y. Increased intraocular pressure induced by corticosteroids. Am J Ophthalmol 1976;82:492-5
20. Kolker AE, Stewart RM, Alton E, LeMon L. Dexamethasone testing in prison inmates. Invest Ophthalmol 1971;10:198-202
21. Halpern MT, Palmer CS, Foster S, Pal A, Battista C. A pharmacoeconomic analysis of rimexolone for the treatment of ophthalmic inflammatory conditions. Am J Manag Care 1998;4:854-62
22. Nagy ZZ, Szabo A, Krueger RR, Suveges I. Treatment of intraocular pressure elevation after photorefractive keratectomy. J Cataract Refract Surg 2001;27:1018-24
23. Barba KR, Samy A, Lai C, Perlman JI, Bouchard CS. Effect of topical anti-inflammatory drugs on corneal and limbal wound healing. J Cataract Refract Surg 2000;26:893-7
24. McCarey BE, Napalkov JA, Pippen PA, Koester JM, Reaves T. Corneal wound healing strength with topical antiinflammatory drugs. Cornea 1995;14:290-4
25. Fraser-Smith EB, Matthews TR. Effect of ketorolac on Pseudomonas aeruginosa ocular infection in rabbits. J Ocul Pharmacol 1988;4:101-9
26. Solomon KD, Donnenfeld ED, Raizman MD, et al.; Ketorolac Reformulation Study Groups 1 and 2. Safety and efficacy of ketorolac tromethamine 0.4% ophthalmic solution in postphotorefractive keratectomy patients. J Cataract Refract Surg 2004;30:1653-560