High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 6, 2007, Pages

  Nahrendorf, Matthias ^a   Badea, Cristian ^b   Hedlund, Laurence W ^b   Figueiredo, Jose Luiz ^a   Sosnovik, David E ^a   Johnson, G Allan ^b   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Computed tomography; Remodeling

Indexed keywords

CONTRAST MEDIUM; FENESTRA VC; IOPAMIDOL; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANATOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC VALUE; EX VIVO STUDY; EXPERIMENTAL MOUSE; FEASIBILITY STUDY; FEMALE; HEART DILATATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE; HEART VENTRICLE REMODELING; IMAGE PROCESSING; IMAGE QUALITY; LEFT CORONARY ARTERY; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR WEIGHT; MORPHOLOGY; MOUSE; NONHUMAN; OPTICAL RESOLUTION; PHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; SINGLE DRUG DOSE; STAINING; THREE DIMENSIONAL IMAGING;

ANIMALS; CINERADIOGRAPHY; CONTRAST MEDIA; CORONARY VESSELS; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; FEMALE; IOPAMIDOL; LIGATION; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 34447530429     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01307.2006     Document Type: Article

References (31)

1. Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodelling. Nature 415: 240-243, 2002.
2. Arora SK, Kannan R. Learning mixtures of arbitrary gaussians. In: Proceedings of the 33rd Annual ACM Symposium on Theory of Computing, Hersonissos, Greece. New York: ACM Press, 2001, p. 247-257.
3. Badea C, Hedlund LW, Johnson GA. Micro-CT with respiratory and cardiac gating. Med Phys 31: 3324-3329, 2004.
4. Badea C, Hedlund LW, Wheeler C, Mai W, Johnson GA. Volumetric micro-CT system for in vivo microscopy. In: IEEE International Symposium on Biomedical Imaging: Macro to Nano, Arlington, VA: IEEE, 2004, vol. 2, p. 1377-1380.
5. Badea CT, Fubara B, Hedlund LW, Johnson GA. 4-D micro-CT of the mouse heart. Mol Imaging 4: 110-116, 2005.
6. Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 113: 1005-1014, 2006.
7. Chien KR. Stem cells: lost in translation. Nature 428: 607-608, 2004.
8. Cleutjens JP, Blankesteijn WM, Daemen MJ, Smits JF. The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions. Cardiovasc Res 44: 232-241, 1999.
9. Fayad ZA, Sirol M, Nikolaou K, Choudhury RP, Fuster V. Magnetic resonance imaging and computed tomography in assessment of atherosclerotic plaque. Curr Atheroscler Rep 6: 232-242, 2004.
10. Feldkamp LA, Davis LC, Kress JW. Practical cone-beam algorithm. J Opt Soc Am A 1: 612-619, 1984.
11. Ford NL, Thornton MM, Holdsworth DW. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 30: 2869-2877, 2003.
12. Gaudron P, Eilles C, Kugler I, Ertl G. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation 87: 755-763, 1993.
13. Gerber BL, Belge B, Legros GJ, Lim P, Poncelet A, Pasquet A, Gisellu G, Coche E, Vanoverschelde JL. Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance. Circulation 113: 823-833, 2006.
14. Grothues F, Smith GC, Moon JC, Bellenger NG, Collins P, Klein HU, Pennell DJ. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol 90: 29-34, 2002.
15. Kim RJ, Chen EL, Lima JA, Judd RM. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation 94: 3318-3326, 1996.
16. Kumar D, Hacker TA, Buck J, Whitesell LF, Kaji EH, Douglas PS, Kamp TJ. Distinct mouse coronary anatomy and myocardial infarction consequent to ligation. Coron Artery Dis 16: 41-44, 2005.
17. Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, Schuleri KH, Fernandes VR, Zviman M, Nazarian S, Halperin HR, Wu KC, Hare JM, Lima JA. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation 113: 394-404, 2006.
18. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation 113: 1196-1202, 2006.
19. Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR. Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol 290: H2516-H2521, 2006.
20. Nahrendorf M, Wiesmann F, Hiller KH, Hu K, Waller C, Ruff J, Lanz TE, Neubauer S, Haase A, Ertl G, Bauer WR. Serial cine-magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats. J Magn Reson Imaging 14: 547-555, 2001.
21. Narayan SM, Drinan DD, Lackey RP, Edman CF. Acute volume overload elevates T-wave alternans magnitude. J Appl Physiol. In press.
22. Nieman K, Cury RC, Ferencik M, Nomura CH, Abbara S, Hoffmann U, Gold HK, Jang IK, Brady TJ. Differentiation of recent and chronic myocardial infarction by cardiac computed tomography. Am J Cardiol 98: 303-308, 2006.
23. Paulus MJ, Gleason SS, Easterly ME, Foltz CJ. A review of highresolution X-ray computed tomography and other imaging modalities for small animal research. Lab Anim (NY) 30: 36-45, 2001.
24. Pfeffer JM, Pfeffer MA, Braunwald E. Hemodynamic benefits and prolonged survival with long-term captopril therapy in rats with myocardial infarction and heart failure. Circulation 75: I149-I155, 1987.
25. Ravenel JG, Savino G, Schoepf UJ. Novel developments in cardiac computed tomography. Am Heart Hosp J 3: 167-174, 2005.
26. Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, Finn JP, Judd RM. An improved MR imaging technique for the visualization of myocardial infarction. Radiology 218: 215-223, 2001.
27. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med 54: 718-724, 2005.
28. Su H, Spinale FG, Dobrucki LW, Song J, Hua J, Sweterlitsch S, Dione DP, Cavaliere P, Chow C, Bourke BN, Hu XY, Azure M, Yalamanchili P, Liu R, Cheesman EH, Robinson S, Edwards DS, Sinusas AJ. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112: 3157-3167, 2005.
29. Vogel-Claussen J, Rochitte CE, Wu KC, Kamel IR, Foo TK, Lima JA, Bluemke DA. Delayed enhancement MR imaging: utility in myocardial assessment. Radiographics 26: 795-810, 2006.
30. 2 kinin receptor gene knockout mice. Circ Res 88: 1072-1079, 2001.
31. Yang Z, Berr SS, Gilson WD, Toufektsian MC, French BA. Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarction. Circulation 109: 1161-1167, 2004.