Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction

Circulation

Volumn 94, Issue 12, 1996, Pages 3318-3326

  Kim, Raymond J ^a,b   Chen, Enn Ling ^c   Lima, João A C ^a   Judd, Robert M ^b  

^a Cardiology Division   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

contrast media; magnetic resonance imaging; myocardial infarction; reperfusion

Indexed keywords

CARDIOPLEGIC AGENT; GADOLINIUM PENTETATE; RADIOACTIVE MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; HEART INFARCTION; HEART MUSCLE INJURY; HEART MUSCLE REPERFUSION; KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RABBIT;

EID: 0030454154     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.12.3318     Document Type: Article

References (37)

1. Lima JAC, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA. Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI: potential mechanisms. Circulation. 1995;92:1117-1125.
2. Judd RM, Lugo-Olivieri CH, Arai M, Kondo T, Croisille P, Lima JAC, Mohun V, Becker LC, Zerhouni EA. Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation. 1995;92: 1902-1910.
3. Wolfe CL, Moseley ME, Wikstrom MG, Sievers RE, Wendland MR, Dupon JW, Finkbeiner WE, Lipton MJ, Parmley WW, Brasch RC. Assessment of myocardial salvage after ischemia and reperfusion using magnetic resonance imaging and spectroscopy. Circulation. 1989;80:969-982.
4. Saeed M, Wendland MF, Masui T, Higgins CB. Reperfused myocardial infarctions on T1- and susceptibility-enhanced MRI: evidence for loss of compartmentalization of contrast media. Magn Reson Med. 1994;31:31-39.
5. Peshock RM, Malloy CR, Buja LM, Nunnally RL, Parkey RW, Willerson JT. Magnetic resonance imaging of acute myocardial infarction: gadolinium diethylenetriamine pentaucetic acid as a marker of reperfusion. Circulation. 1986;74:1434-1440.
6. Schaefer S, Malloy CR, Katz J, Parkey RW, Buja M, Willerson JT, Peshock RM. Gadolinium-DTPA-enhanced nuclear magnetic resonance imaging of reperfused myocardium: identification of the myocardial bed at risk. J Am Coll Cardiol. 1988;12:1064-1072.
7. Goldman MR, Brady TJ, Pykett IL, Burt CT, Buonanno FS, Kistler P, Newhouse JH, Hinshaw WS, Pohost GM. Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts. Circulation. 1982;66:1012-1016.
8. Lima JAC, Judd RM, Lugo-Olivieri CH, Schulman SP, Atalar E, Gerstenblith G, Zerhouni EA. Myocardial perfusion pattern by contrast enhanced MRI in the acute post-infarct period can predict myocardial necrosis and eventual extent of scar formation. Circulation. 1994:90(pt 2):I-410. Abstract.
9. Wood ML, Hardy PA. Proton relaxation enhancement. J Magn Reson Imaging. 1993;3:149-156.
10. Diesbourg LD, Prato FS, Wisenberg G, Drost DJ, Marshall TP, Carroll SE, O'Neill B. Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd-DTPA: Kinetic modeling in canine ischemic disease. Magn Reson Med. 1992;23: 239-253.
11. Wesbey GE, Higgins CB, McNamara MT, Engelstad BL, Lipton MJ, Sievers R, Ehman RL, Lovin J, Brasch RC. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984;153:165-169.
12. 19F imaging of perfluorochemical emulsions to measure myocardial vascular volume. Magn Reson Med. 1992;28:129-136.
13. May-Newman K, Judd RM, Zerhouni EA. Myocardial T1 following step changes in perfusate contrast concentration. Proc Soc Magn Reson Imaging. 1994;1:1017. Abstract.
14. Judd RM, Atalay MK, Rottman JR, Zerhouni EA. Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn Reson Med. 1995;33:215-223.
15. Resar JR, Livingston JZ, Yin FCP. In-plane myocardial wall stress is not the primary determinant of coronary systolic flow impediment. Circ Res. 1992;70:583-592.
16. Resar JR, Judd RM, Halperin HR, Chacko VP, Weiss RG, Yin FCP. Direct evidence that coronary perfusion affects diastolic myocardial mechanical properties. Cardiavasc Res. 1993;27:403-410.
17. Fishbein MC, Meerbaum S, Rit J, Lando U, Kanmatsuse K, Mercier JC, Corday E, Ganz W. Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J. 1981;101:593-600.
18. Domenech RJ, Hoffman JIE, Noble MIM, Saunders KB, Henson JR, Subijanto S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res. 1969;25:581-596.
19. Ambrosio G, Weisman HF, Mannisi JA, Becker LC. Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation. 1989;80:1846-1861.
20. Winer BJ. Statistical Principles in Experimental Design. New York, NY: McGraw Hill; 1971:351-359.
21. Lotan CS, Miller SK, Cranney GB, Pohost GM, Elgavish GA. The effect of postinfarction intramyocardial hemorrhage on transverse relaxation time. Magn Reson Med. 1992;23:346-355.
22. Koenig SH, Spiller M, Brown RD, Wolf GL. Relaxation of water protons in the intra-and extracellular regions of blood containing Gd(DTPA). Magn Reson Med. 1986;3:791-795.
23. Weinmann HJ, Brasch RC, Press WR, Wesbey GE. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Am J Roentgenol. 1984;142:619-624.
24. Wendland MF, Saeed M, Lauerma K, Derugin N, Cavagna F, Higgins CB. Alterations in T1 in normal and reperfused infarcted myocardium following GdBOPTA or GdDTPA on inversion recovery EPI. Proc Soc Magn Reson Imaging. 1993;2:788. Abstract.
25. Fishbein MC, Y-Rit J, Lando U, Kanmatsuse K, Mercier JC, Ganz W. The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion. Circulation. 1980;62:1274-1279.
26. Weinmann HJ, Laniado M, Mutzel W. Pharmacokinetics of Gd-DTPA-dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys. 1984;16:167-172.
27. Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Resan Med. 1994;32:66-76.
28. Wedeking P, Sotak CH, Telser J, Kumar K, Chang CA, Tweedle MF. Quantitative dependence of MR signal intensity on tissue concentration of Gd(HP-DO3A) in the nephrectomized rat. Magn Reson Imaging. 1992;10:97-108.
29. Saeed M, Wendland MF, Masui T, Yu KK, Li J, Derugin N, Higgins CB. Dual mechanisms for change in inyocardial signal intensity by means of a single MR contrast medium: dependence on concentration and pulse sequence. Radiology. 1993;186:175-182.
30. Tong CY, Prato FS, Wisenberg G, Sandler D, Wills JM. Measurement of the extraction efficiency and distribution volume for Gd-DTPA in canine reperfused myocardium. Proc Soc Magn Reson Imaging. 1992;1:1114. Abstract.
31. Matheijssen NAA, de Roos A, van der Wall EE, Doornbos J, van Dijkman PRM, Bruschke AVG, van Voorthuisen AE. Acute myocardial infarction: comparison of T2-weighted and T1-weighted gadolinium-DTPA enhanced MR imaging. Magn Reson Med. 1991;17: 460-469.
32. Burstein D, Taratuta E, Manning WJ. Factors in myocardial 'perfusion' imaging with ultrafast MRI and Gd-DTPA administration. Magn Reson Med. 1991;20:299-305.
33. Johnston DL, Liu P, Laufler RB, Newell JB, Wedeen VJ, Rosen BR, Brady TJ, Okada RD. Use of gadolinium-DTPA as a myocardial perfusion agent: potential applications and limitations for magnetic resonance imaging. J Nucl Med. 1987;28:871-877.
34. Jeremy RW, Links JM, Becker LC. Progressive failure of coronary flow during reperfusion of myocardial infarction: documentation of the no reflow phenomenon with positron emission tomography. J Am Coll Cardiol. 1990;16:695-704.
35. Engler RL, Dahlgren MD, Peterson MA, Dobbs A, Schmid-Schoenbein G. Accumulation of polymorphonuclear leukocytes during 3 hour experimental myocardial ischemia. Am J Physiol. 1986;251: H93-H100.
36. Bassingthwaighte JB, Goresky CA. Modeling in the analysis of solute and water exchange in the microvasculature. In: Renkin EM, Michel CC, Geiger SR, eds. Handbook of Physiology. Bethesda, Md: American Physiological Society; 1984:549-626.
37. Holman ER, van Jonbergen HPW, van Dijkman PRM, van der Laarse A, de Roos A, van der Wall EE. Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct size. Am J Cardiol. 1993;71: 1036-1040.