메뉴 건너뛰기




Volumn 22, Issue 3, 2007, Pages 309-321

Patient-specific vaccines derived from autologous tumor cell lines as active specific immunotherapy: Results of exploratory phase I/II trials in patients with metastatic melanoma

Author keywords

Active specific immunotherapy; Autologous tumor cell lines; Melanoma; Tumor stem cells; Vaccines

Indexed keywords

BCG VACCINE; CANCER VACCINE; GAMMA INTERFERON; GAMMIMMUNE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; SARGAMOSTATIN; UNCLASSIFIED DRUG;

EID: 34447519095     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2007.345     Document Type: Article
Times cited : (32)

References (46)
  • 1
    • 1842582038 scopus 로고    scopus 로고
    • Mature results of a phase III randomized trial of bacillus Calmette-Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I-III melanoma (E1673): A trial of the Eastern Oncology Group
    • Agarwala SS, Neuberg D, Park Y, et al. Mature results of a phase III randomized trial of bacillus Calmette-Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I-III melanoma (E1673): A trial of the Eastern Oncology Group. Cancer 2004;100:1692.
    • (2004) Cancer , vol.100 , pp. 1692
    • Agarwala, S.S.1    Neuberg, D.2    Park, Y.3
  • 2
    • 1842533233 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group: A pooled analysis of Eastern Cooperative Oncology Group and intergroup trials of adjuvant high-dose interferon for melanoma
    • Kirkwood JM, Manola J, Ibrahim J, et al. Eastern Cooperative Oncology Group: A pooled analysis of Eastern Cooperative Oncology Group and intergroup trials of adjuvant high-dose interferon for melanoma. Clin Cancer Res 2004;10:1670.
    • (2004) Clin Cancer Res , vol.10 , pp. 1670
    • Kirkwood, J.M.1    Manola, J.2    Ibrahim, J.3
  • 3
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MA, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin-2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999;17:2105.
    • (1999) J Clin Oncol , vol.17 , pp. 2105
    • Atkins, M.A.1    Lotze, M.T.2    Dutcher, J.P.3
  • 4
    • 7444252305 scopus 로고    scopus 로고
    • On the road to a tumor cell vaccine: 20 years of cellular immunotherapy
    • Yanelli JR, Wroblewski JM. On the road to a tumor cell vaccine: 20 years of cellular immunotherapy. Vaccine 2004;23:97.
    • (2004) Vaccine , vol.23 , pp. 97
    • Yanelli, J.R.1    Wroblewski, J.M.2
  • 5
    • 33746006527 scopus 로고    scopus 로고
    • Clinical results of vaccine therapy for cancer: Learning from history for improving the future
    • Choudhury A, Mosolits S, Kokhaei P, et al. Clinical results of vaccine therapy for cancer: Learning from history for improving the future. Adv Cancer Res 2006;95:147.
    • (2006) Adv Cancer Res , vol.95 , pp. 147
    • Choudhury, A.1    Mosolits, S.2    Kokhaei, P.3
  • 6
    • 0026058517 scopus 로고
    • Improved long-term survival after lymphadenectomy of melanoma metastatic to regional nodes
    • Morton DL, Wanek L, Nizze JA, et al. Improved long-term survival after lymphadenectomy of melanoma metastatic to regional nodes. Ann Surg 1991;214:491.
    • (1991) Ann Surg , vol.214 , pp. 491
    • Morton, D.L.1    Wanek, L.2    Nizze, J.A.3
  • 7
    • 0028205790 scopus 로고
    • Improved survival in stage III melanoma patients with GM2 antibodies: A randomized trial of adjuvant vaccination with GM2 ganglioside
    • Livingston PO, Wong GYC, Adluri S, et al. Improved survival in stage III melanoma patients with GM2 antibodies: A randomized trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994;12: 1036.
    • (1994) J Clin Oncol , vol.12 , pp. 1036
    • Livingston, P.O.1    Wong, G.Y.C.2    Adluri, S.3
  • 8
    • 0030986643 scopus 로고    scopus 로고
    • Autologous hapten-modified melanoma vaccine as postsurgical adjuvant treatment after resection of nodal metastases
    • Berd D, Maguire HC, Jr, Schuchter LM, et al. Autologous hapten-modified melanoma vaccine as postsurgical adjuvant treatment after resection of nodal metastases. J Clin Oncol 1997,15:2359.
    • (1997) J Clin Oncol , vol.15 , pp. 2359
    • Berd, D.1    Maguire Jr, H.C.2    Schuchter, L.M.3
  • 9
    • 0033562786 scopus 로고    scopus 로고
    • Active specific immunotherapy with polyvalent melanoma cell vaccine for patients with in-transit melanoma metastases
    • Hsueh EC, Nathanson L, Foshag LJ, et al. Active specific immunotherapy with polyvalent melanoma cell vaccine for patients with in-transit melanoma metastases. Cancer 1999;85:2160.
    • (1999) Cancer , vol.85 , pp. 2160
    • Hsueh, E.C.1    Nathanson, L.2    Foshag, L.J.3
  • 10
    • 0025262476 scopus 로고
    • Active-specific immunotherapy for melanoma
    • Mitchell MS, Harel W, Kempf RA, et al. Active-specific immunotherapy for melanoma. J Clin Oncol 1990;8:856.
    • (1990) J Clin Oncol , vol.8 , pp. 856
    • Mitchell, M.S.1    Harel, W.2    Kempf, R.A.3
  • 11
    • 0025147441 scopus 로고
    • Treatment of metastatic melanoma with an autologous tumor-cell vaccine: Clinical and immunologic results in 64 patients
    • Berd D, Maguire HC, Jr, McCue P, et al. Treatment of metastatic melanoma with an autologous tumor-cell vaccine: Clinical and immunologic results in 64 patients. J Clin Oncol 1990;8:1858.
    • (1990) J Clin Oncol , vol.8 , pp. 1858
    • Berd, D.1    Maguire Jr, H.C.2    McCue, P.3
  • 12
    • 0026802163 scopus 로고
    • Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine
    • Morton DL, Foshag LJ, Hoon DSB, et al. Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine. Ann Surg 1992;216:463.
    • (1992) Ann Surg , vol.216 , pp. 463
    • Morton, D.L.1    Foshag, L.J.2    Hoon, D.S.B.3
  • 13
    • 0034772102 scopus 로고    scopus 로고
    • Double-blind trial of a polyvalent, shed-antigen, melanoma vaccine
    • Bystryn J-C, Zeleniuch-Jacquotte A, Oratz R, et al. Double-blind trial of a polyvalent, shed-antigen, melanoma vaccine. Clin Cancer Res 2001;7:1882.
    • (2001) Clin Cancer Res , vol.7 , pp. 1882
    • Bystryn, J.-C.1    Zeleniuch-Jacquotte, A.2    Oratz, R.3
  • 14
    • 0037108861 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of patients with high-risk melanoma using vaccinia viral lysates of melanoma: Results of a randomized trial
    • Hersey P, Coates AS, McCarthy WH, et al. Adjuvant immunotherapy of patients with high-risk melanoma using vaccinia viral lysates of melanoma: Results of a randomized trial. J Clin Oncol 2002;20:4181.
    • (2002) J Clin Oncol , vol.20 , pp. 4181
    • Hersey, P.1    Coates, A.S.2    McCarthy, W.H.3
  • 15
    • 0742287072 scopus 로고    scopus 로고
    • Antigen-based immunotherapy of melanoma: Canvaxin therapeutic polyvalent cancer vaccine
    • Hsueh EC, Morton DL. Antigen-based immunotherapy of melanoma: Canvaxin therapeutic polyvalent cancer vaccine. Semin Cancer Biol 2003;13:401.
    • (2003) Semin Cancer Biol , vol.13 , pp. 401
    • Hsueh, E.C.1    Morton, D.L.2
  • 16
    • 34447534154 scopus 로고    scopus 로고
    • Richards J, Testori A, Whitman E, et al. Autologous tumor-derived HSPPC-96 versus physician's choice in a randomized phase II trial in stage IV melanoma. [abstract] J Clin Oncol 2006;24(18S):453.
    • Richards J, Testori A, Whitman E, et al. Autologous tumor-derived HSPPC-96 versus physician's choice in a randomized phase II trial in stage IV melanoma. [abstract] J Clin Oncol 2006;24(18S):453.
  • 17
    • 0037089687 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Overall results of a randomized trial of the Southwest Oncology Group
    • Sondak VK, Liu PY, Tuthill RJ, et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Overall results of a randomized trial of the Southwest Oncology Group. J Clin Oncol 2002;20:2058.
    • (2002) J Clin Oncol , vol.20 , pp. 2058
    • Sondak, V.K.1    Liu, P.Y.2    Tuthill, R.J.3
  • 18
    • 13144275236 scopus 로고    scopus 로고
    • Surgical adjuvant active specific immunotherapy for patients with stage III melanoma: The final analysis of data from a phase III, randomized, double-blind multicenter vaccinia melanoma oncolysate trial
    • Wallack MK, Muthukumaran S, Balch CM, et al. Surgical adjuvant active specific immunotherapy for patients with stage III melanoma: The final analysis of data from a phase III, randomized, double-blind multicenter vaccinia melanoma oncolysate trial. J Am Coll Surg 1998;187:69.
    • (1998) J Am Coll Surg , vol.187 , pp. 69
    • Wallack, M.K.1    Muthukumaran, S.2    Balch, C.M.3
  • 19
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002;298:850.
    • (2002) Science , vol.298 , pp. 850
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 20
    • 20044395957 scopus 로고    scopus 로고
    • Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
    • Sanderson K, Scotland R, Lee P, et al. Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol 2005;23:741.
    • (2005) J Clin Oncol , vol.23 , pp. 741
    • Sanderson, K.1    Scotland, R.2    Lee, P.3
  • 21
    • 32644454916 scopus 로고    scopus 로고
    • Prognostic significance of autoimmunity during treatment of melanoma with interferon
    • Gogas H, Ioannovich J, Dafni U, et al. Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 2006;354:709.
    • (2006) N Engl J Med , vol.354 , pp. 709
    • Gogas, H.1    Ioannovich, J.2    Dafni, U.3
  • 22
    • 0027220719 scopus 로고
    • Establishing in vitro cultures of autologous tumor cells for use in active specific immunotherapy
    • Dillman RO, Nayak SK, Beutel L. Establishing in vitro cultures of autologous tumor cells for use in active specific immunotherapy. J Immunother 1993;14:65.
    • (1993) J Immunother , vol.14 , pp. 65
    • Dillman, R.O.1    Nayak, S.K.2    Beutel, L.3
  • 23
    • 0036191898 scopus 로고    scopus 로고
    • Irradiated cells from autologous tumor cell lines as patient-specific vaccine therapy in 125 patients with metastatic cancer: Induction of delayed-type hypersensitivity to autologous tumor is associated with improved survival
    • Dillman RO, Beutel LD, Barth NM, et al. Irradiated cells from autologous tumor cell lines as patient-specific vaccine therapy in 125 patients with metastatic cancer: Induction of delayed-type hypersensitivity to autologous tumor is associated with improved survival. Cancer Biother Radiopharm 2002;17:51.
    • (2002) Cancer Biother Radiopharm , vol.17 , pp. 51
    • Dillman, R.O.1    Beutel, L.D.2    Barth, N.M.3
  • 24
    • 0000374096 scopus 로고
    • Establishment of multiple tumor cell lines from a patient with melanoma: A simple method to control fibroblast growth
    • Nayak SK, Dillman RO. Establishment of multiple tumor cell lines from a patient with melanoma: A simple method to control fibroblast growth. Clin Biotechnol 1991;3:237.
    • (1991) Clin Biotechnol , vol.3 , pp. 237
    • Nayak, S.K.1    Dillman, R.O.2
  • 25
    • 0031824962 scopus 로고    scopus 로고
    • Clinical experience with autologous tumor cell lines for patient-specific vaccine therapy in metastatic melanoma
    • Dillman RO, Nayak SK, Barth NM, et al. Clinical experience with autologous tumor cell lines for patient-specific vaccine therapy in metastatic melanoma. Cancer Biother Radiopharm 1998;13:165.
    • (1998) Cancer Biother Radiopharm , vol.13 , pp. 165
    • Dillman, R.O.1    Nayak, S.K.2    Barth, N.M.3
  • 26
    • 0034980266 scopus 로고    scopus 로고
    • Short-term autologous tumor cell lines for the active specific immunotherapy of patients with metastatic melanoma
    • Dillman RO, DeLeon C, Beutel LD, et al. Short-term autologous tumor cell lines for the active specific immunotherapy of patients with metastatic melanoma. Crit Rev Oncol Hematol 2001;39:115
    • (2001) Crit Rev Oncol Hematol , vol.39 , pp. 115
    • Dillman, R.O.1    DeLeon, C.2    Beutel, L.D.3
  • 27
    • 0030140235 scopus 로고    scopus 로고
    • Transduction of human renal carcinoma cells with human γ-interferon gene via retroviral vector
    • Nayak SK, McCallister T, Han LJ, et al. Transduction of human renal carcinoma cells with human γ-interferon gene via retroviral vector. Cancer Gene Ther 1996;3:143.
    • (1996) Cancer Gene Ther , vol.3 , pp. 143
    • Nayak, S.K.1    McCallister, T.2    Han, L.J.3
  • 28
    • 0032932657 scopus 로고    scopus 로고
    • Modulation of renal carcinoma cells in vitro: Comparison after transduction with retroviral vector containing a human γ-interferon gene versus incubation with soluble γ-interferon
    • Nayak SK, Schiltz PM, Dillman RO. Modulation of renal carcinoma cells in vitro: comparison after transduction with retroviral vector containing a human γ-interferon gene versus incubation with soluble γ-interferon. J Interfer Cyto Res 1999;19:49.
    • (1999) J Interfer Cyto Res , vol.19 , pp. 49
    • Nayak, S.K.1    Schiltz, P.M.2    Dillman, R.O.3
  • 29
    • 0031472548 scopus 로고    scopus 로고
    • The Cancer Biotherapy Research Group (CBRG), (formerly the National Biotherapy Study Group [NBSG]): A 10-year perspective
    • Dillman RO, Crispin R, Oldham RK. The Cancer Biotherapy Research Group (CBRG), (formerly the National Biotherapy Study Group [NBSG]): A 10-year perspective. Cancer Biother Radiopharm 1997;12:229.
    • (1997) Cancer Biother Radiopharm , vol.12 , pp. 229
    • Dillman, R.O.1    Crispin, R.2    Oldham, R.K.3
  • 30
    • 0038167081 scopus 로고    scopus 로고
    • Interferon-gamma or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated autologous tumor cells from short-term cell line cultures: A randomized phase II trial of the Cancer Biotherapy Research Group
    • Dillman RO, Wiemann M, Nayak SK, et al. Interferon-gamma or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated autologous tumor cells from short-term cell line cultures: A randomized phase II trial of the Cancer Biotherapy Research Group. J Immunother 2003;26:367.
    • (2003) J Immunother , vol.26 , pp. 367
    • Dillman, R.O.1    Wiemann, M.2    Nayak, S.K.3
  • 31
    • 0345368069 scopus 로고    scopus 로고
    • Characterization of tumor-infiltrating lymphocytes derived from human tumors for use as adoptive immunotherapy of cancer
    • Schiltz PM, Beutel LD, Nayak SK, et al. Characterization of tumor-infiltrating lymphocytes derived from human tumors for use as adoptive immunotherapy of cancer. J Immunother 1997;20:377.
    • (1997) J Immunother , vol.20 , pp. 377
    • Schiltz, P.M.1    Beutel, L.D.2    Nayak, S.K.3
  • 32
    • 0348199327 scopus 로고    scopus 로고
    • Serum cytokines in metastatic melanoma patients treated with an autologous tumor vaccine
    • Schiltz PM, Dillman RO. Serum cytokines in metastatic melanoma patients treated with an autologous tumor vaccine. Cancer Biother Radiopharm 2004;18:879.
    • (2004) Cancer Biother Radiopharm , vol.18 , pp. 879
    • Schiltz, P.M.1    Dillman, R.O.2
  • 33
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan G, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457
    • Kaplan, G.1    Meier, P.2
  • 34
    • 0002550742 scopus 로고
    • Statistical analysis of survival data
    • Bailar JC III, Mosteller JC, eds, 2nd ed. Boston: NEJM Books
    • Lagakos SD. Statistical analysis of survival data. In: Bailar JC III, Mosteller JC, eds. Medical Uses of Statistics, 2nd ed. Boston: NEJM Books, 1992.
    • (1992) Medical Uses of Statistics
    • Lagakos, S.D.1
  • 35
    • 0027517610 scopus 로고
    • Regulation of somatic-cell therapy and gene therapy by the Food and Drug Administration
    • Kessler DA, Siegel JP, Hoguchi PD, et al. Regulation of somatic-cell therapy and gene therapy by the Food and Drug Administration. N Engl J Med 1993;329:1169.
    • (1993) N Engl J Med , vol.329 , pp. 1169
    • Kessler, D.A.1    Siegel, J.P.2    Hoguchi, P.D.3
  • 36
    • 0036199280 scopus 로고    scopus 로고
    • Immunologic monitoring of cancer vaccine therapy: Results of a workshop sponsored by the Society for Biological Therapy
    • Keilholz U, Weber J, Finke JH, et al. Immunologic monitoring of cancer vaccine therapy: Results of a workshop sponsored by the Society for Biological Therapy. J Immunother 2002;25:97.
    • (2002) J Immunother , vol.25 , pp. 97
    • Keilholz, U.1    Weber, J.2    Finke, J.H.3
  • 37
    • 0037314635 scopus 로고    scopus 로고
    • Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell response to a dendritic cell-based multipeptide vaccine inpatients with melanoma
    • Whiteside TL, Zhao Y, Tsukishiro T, et al. Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell response to a dendritic cell-based multipeptide vaccine inpatients with melanoma. Clin Cancer Res 2003;9:641.
    • (2003) Clin Cancer Res , vol.9 , pp. 641
    • Whiteside, T.L.1    Zhao, Y.2    Tsukishiro, T.3
  • 38
    • 0035880957 scopus 로고    scopus 로고
    • Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system
    • Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001;19: 3622.
    • (2001) J Clin Oncol , vol.19 , pp. 3622
    • Balch, C.M.1    Soong, S.J.2    Gershenwald, J.E.3
  • 39
    • 33644835249 scopus 로고    scopus 로고
    • Survival analysis after resection of metastatic disease followed by peptide vaccines in patients with stage IV melanoma
    • Tagawa ST, Cheung E, Banta W, et al. Survival analysis after resection of metastatic disease followed by peptide vaccines in patients with stage IV melanoma. Cancer 2006;106:1353.
    • (2006) Cancer , vol.106 , pp. 1353
    • Tagawa, S.T.1    Cheung, E.2    Banta, W.3
  • 40
    • 9144264534 scopus 로고    scopus 로고
    • Phase I/II trial of melanoma patient-specific vaccine of proliferating autologous tumor cells, dendritic cells, and GM-CSF: Planned interim analysis
    • Dillman RO, Selvan SR, Schiltz PM, et al. Phase I/II trial of melanoma patient-specific vaccine of proliferating autologous tumor cells, dendritic cells, and GM-CSF: Planned interim analysis. Cancer Biother Radiopharm 2004;19:658.
    • (2004) Cancer Biother Radiopharm , vol.19 , pp. 658
    • Dillman, R.O.1    Selvan, S.R.2    Schiltz, P.M.3
  • 41
    • 33748684598 scopus 로고    scopus 로고
    • Long-term progression-free survival in metastatic melanoma following treatment with patient-specific dendritic cell vaccines
    • Dillman RO, Selvan SR, Schiltz PM. Long-term progression-free survival in metastatic melanoma following treatment with patient-specific dendritic cell vaccines. N Engl J Med 2006;355:1179.
    • (2006) N Engl J Med , vol.355 , pp. 1179
    • Dillman, R.O.1    Selvan, S.R.2    Schiltz, P.M.3
  • 42
    • 0036734775 scopus 로고    scopus 로고
    • The treatment of patients with disseminated malignant melanoma by vaccination with autologous cell hybrids of tumor cells and dendritic cells
    • Krause SW, Neumann C, Soruri A, et al. The treatment of patients with disseminated malignant melanoma by vaccination with autologous cell hybrids of tumor cells and dendritic cells. J Immunother 2002;25:421.
    • (2002) J Immunother , vol.25 , pp. 421
    • Krause, S.W.1    Neumann, C.2    Soruri, A.3
  • 43
    • 0037943937 scopus 로고    scopus 로고
    • Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine
    • O'Rourke MG, Johnson M, Lanagan C, et al. Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine. Cancer Immunol Immunother 2003;52:387.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 387
    • O'Rourke, M.G.1    Johnson, M.2    Lanagan, C.3
  • 44
    • 0742269426 scopus 로고    scopus 로고
    • Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma
    • Heresy P, Menzies SW, Halliday GM, et al. Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma. Cancer Immunol Immunother 2004;53:125.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 125
    • Heresy, P.1    Menzies, S.W.2    Halliday, G.M.3
  • 45
    • 3042728750 scopus 로고    scopus 로고
    • Pilot study of treatment of biochemotherapy-refractory stage IV melanoma patients with autologous dendritic cells pulsed with a heterologous melanoma cell line lysate
    • Vilella R, Benitez D, Mila J, et al. Pilot study of treatment of biochemotherapy-refractory stage IV melanoma patients with autologous dendritic cells pulsed with a heterologous melanoma cell line lysate. Cancer Immunol Immunother 2004;53:651.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 651
    • Vilella, R.1    Benitez, D.2    Mila, J.3
  • 46
    • 14844337815 scopus 로고    scopus 로고
    • Tumour-dendritic hybrid cell vaccination for the treatment of patients with malignant melanoma: Immunological effects and clinical results
    • Trefzer U, Herberth G, Wohlan K, et al. Tumour-dendritic hybrid cell vaccination for the treatment of patients with malignant melanoma: Immunological effects and clinical results. Vaccine 2005;23:2367.
    • (2005) Vaccine , vol.23 , pp. 2367
    • Trefzer, U.1    Herberth, G.2    Wohlan, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.