Gestational Ethanol Exposure Disrupts the Expression of FGF8 and Sonic hedgehog during Limb Patterning

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 70, Issue 4, 2004, Pages 163-171

  Chrisman, Kimberly ^a   Kenney, Robert ^a   Comin, Jeremy ^a   Thal, Tanya ^a   Suchocki, Lawrence ^a   Yueh, Y Gloria ^a   Gardner, David P ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

galactosidase; AER; Ectrodactyly; Ethanol; Fetal alcohol syndrome; FGF; Limb; Sonic hedgehog; ZPA

Indexed keywords

ALCOHOL; BETA GALACTOSIDASE; FIBROBLAST GROWTH FACTOR 8; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL ECTODERMAL RIDGE; ARTICLE; BONE MALFORMATION; CONTROLLED STUDY; ECTODERM; ECTRODACTYLY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; EVALUATION; FEEDBACK SYSTEM; FEMALE; FETAL ALCOHOL SYNDROME; FREQUENCY MODULATION; GESTATIONAL AGE; IN SITU HYBRIDIZATION; LIMB DEFECT; LIMB DEVELOPMENT; LIMB MALFORMATION; MESENCHYME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ALCOHOL DRINKING; ANIMALS; BETA-GALACTOSIDASE; FEMALE; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; HEDGEHOG PROTEINS; LIMB BUD; LIMB DEFORMITIES, CONGENITAL; MATERNAL-FETAL EXCHANGE; MICE; PREGNANCY; TRANS-ACTIVATORS;

ERINACEIDAE;

EID: 2342633176     PISSN: 15420752     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdra.20019     Document Type: Article

References (35)

1. Ahlgren SC, Thakur V, Bronner-Fraser M. 2002. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc Natl Acad Sci USA 99:10476-10481.
2. Chernoff GF. 1977. The fetal alcohol syndrome in mice: an animal model. Teratology 15:223-229.
3. Chiang C, Litingtung Y, Lee E, et al. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413.
4. Chiang C, Litingtung Y, Harris MP, et al. 2001. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol 236:421-435.
5. Climent E, Pascual M, Renau-Piqueras J, Guerri C. 2002. Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain-derived neurotrophic factor and its signaling pathways. J Neurosci Res 68:213-225.
6. Croen LA, Shaw GM, Lammer EJ. 2000. Risk factors for cytogenetically normal holoprosencephaly in California: a population-based case-control study. Am J Med Genet 90:320-325.
7. Crossley PH, Martin GR. 1995. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121:439-451.
8. Gardner DP, Byrne GW, Ruddle FH, Kappen C. 1996. Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system. Transgenic Res 5:37-48.
9. Gardner DP, Kappen C. 2000. Developmental characterization and chromosomal mapping of a LacZ transgene expressed in the mouse apical ectodermal ridge. J Exp Zool 287:106-111.
10. Goodlett CR, Horn KH. 2001. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health 25:175-184.
11. Gressens P, Lammens M, Picard JJ, Evrard P. 1992. Ethanol-induced disturbances of gliogenesis and neuronogenesis in the developing murine brain: an in vitro and in vivo immunohistochemical and ultrastructural study. Alcohol Alcohol 27:219-226.
12. Guerri C, Pascual M, Renau-Piqueras J. 2001. Glia and fetal alcohol syndrome. Neurotoxicology 22:593-599.
13. Hanson JW, Jones KL, Smith DW. 1976. Fetal alcohol syndrome. Experience with 41 patients. JAMA 235:1458-1460.
14. Heikinheimo M, Lawshe A, Shackleford GM, et al. 1994. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev 48:129-138.
15. Ikonomidou C, Bittigau P, Ishimaru MJ, et al. 2000. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287:1056-1060.
16. Inouye M. 1976. Differential staining of cartilage and bone in fetal mouse skeleton by alcian blue and alizarin red S. Congenit Anom Kyoto 16:171-173.
17. Jones KL, Smith DW. 1973. Recognition of the fetal alcohol syndrome in early infancy. Lancet 2:999-1001.
18. Kotch LE, Dehart DB, Alles AJ, et al. 1992. Pathogenesis of ethanol-induced limb reduction defects in mice. Teratology 46:323-332.
19. Laufer E, Nelson CE, Johnson RL, et al. 1994. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79:993-1003.
20. Lewandoski M, Sun X, Martin GR. 2000. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26:460-463.
21. Lewis PM, Dunn MP, McMahon JA, et al. 2001. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptcl. Cell 105:599-612.
22. Mitchell JJ, Paiva M, Heaton MB. 1999. Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. Neurosci Lett 263:189-192.
23. Moon AM, Capecchi MR. 2000. Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 26:455-459.
24. Nanni L, Ming JE, Bocian M, et al. 1999. The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly. Hum Mol Genet 8:2479-2488.
25. Ohuchi H, Yoshioka H, Tanaka A, et al. 1994. Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem Biophys Res Commun 204:882-888.
26. Palmer RH, Oullette EM, Warner L, Leichtman SR. 1974. Congenital malformations in offspring of a chronic alcoholic mother. Pediatrics 53:490-494.
27. Ramanathan R, Wilkemeyer MF, Mittal B, et al. 1996. Alcohol inhibits cell-cell adhesion mediated by human L1. J Cell Biol 133:381-390.
28. Ronen GM, Andrews WL. 1991. Holoprosencephaly as a possible embryonic alcohol effect. Am J Med Genet 40:151-154.
29. Saunders J, Cairns JM, Gasseling MT. 1957. The role of the apical ectodermal ridge of ectoderm in the differentiation of the morphological structure and inductive specificity of limb parts of the chick. J Morphol 101:57-88.
30. Spector DL, Goldman RD, Leinwand LA. 1998. Whole Mount In Situ: Detection of RNAs in Vertebrate Embryos and Isolated Organs. In: Janssen K. editor. Cells: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press. p 117.1-117.15.
31. Tickle C, Eichele G. 1994. Vertebrate limb development. Annu Rev Cell Biol 10:121-152.
32. Webster WS, Walsh DA, McEwen SE, Lipson AH. 1983. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome. Teratology 27:231-243.
33. Wilkemeyer MF, Chen SY, Menkari CE, et al. 2003. Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPV-SIPQ prevention of ethanol-induced developmental toxicity. Proc Natl Acad Sci USA 100:8543-8548.
34. Zimmerman EF, Scott WJ Jr, Collins MD. 1990. Ethanol-induced limb defects in mice: effect of strain and Ro15-4513. Teratology 41:453-462.
35. Zwilling E. 1955. Ectoderm-mesoderm relationship in the development of the chick embryo limb bud. J Exp Zool 128:423-441.