Session 7: Early nutrition and later health Early developmental pathways of obesity and diabetes risk - Symposium on 'Nutrition in early life: New horizons in a new century'

Proceedings of the Nutrition Society

Volumn 66, Issue 3, 2007, Pages 451-457

  Dunger, D B ^a   Salgin, B ^a   Ong, K K ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Catch up growth; Childhood obesity; Insulin resistance; Insulin like growth factor I

Indexed keywords

GHRELIN; GLUCOSE; LEPTIN; SOMATOMEDIN C;

BIRTH WEIGHT; BODY HEIGHT; BODY WEIGHT; CATCH UP GROWTH; CHILD GROWTH; CONFERENCE PAPER; DIETARY INTAKE; DISEASE COURSE; FETUS GROWTH; GESTATIONAL AGE; GLUCOSE TOLERANCE; HUMAN; INFANT NUTRITION; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MATERNAL NUTRITION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITIONAL ASSESSMENT; NUTRITIONAL HEALTH; NUTRITIONAL STATUS; OBESITY; PANCREAS ISLET BETA CELL; PERINATAL PERIOD; PRENATAL EXPOSURE; RISK FACTOR; UMBILICAL CORD BLOOD; WEIGHT GAIN;

BIRTH WEIGHT; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; PREGNANCY; RISK FACTORS; WEIGHT GAIN;

EID: 34447498829     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665107005721     Document Type: Conference Paper

References (58)

1. Bonner-Weir S, Deery D, Leahy JL & Weir GC (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38, 49-53.
2. Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D & Kahn CR (1997) Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561-572.
3. Bundred P, Kitchiner D & Buchan I (2001) Prevalence of overweight and obese children between 1989 and 1998: population based series of cross sectional studies. British Medical Journal 322, 326-328.
4. Casteels K, Ong K, Phillips D, Bendall H & Pembrey M (1999) Mitochondrial 16189 variant, thinness at birth, and type-2 diabetes. ALSPAC study team. Avon Longitudinal Study of Pregnancy and Childhood. Lancet 353, 1499-1500.
5. Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, Roumain J, Bennett PH & Knowler WC (2000) Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 49, 2208-2211.
6. dos Santos Silva I, De Stavola BL, Mann V, Kuh D, Hardy R & Wadsworth ME (2002) Prenatal factors, childhood growth trajectories and age at menarche. International Journal of Epidemiology 31, 405-412.
7. Dunger DB, Ong KK & Sandhu MS (2003) Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes. Hormone Research 60, Suppl. 3, 131-135.
8. Engel N, West AG, Felsenfeld G & Bartolomei MS (2004) Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Nature Genetics 36, 883-888.
9. Eriksson JG, Forsen TJ, Osmond C & Barker DJ (2003) Pathways of infant and childhood growth that lead to type 2 diabetes. Diabetes Care 26, 3006-3010.
10. Fowden AL (1989) The role of insulin in prenatal growth. Journal of Developmental Physiology 12, 173-182.
11. Franks PW, Looker HC, Kobes S, Touger L, Tataranni PA, Hanson RL & Knowler WC (2006) Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes 55, 460-465.
12. Garnett SP, Cowell CT, Baur LA, Fay RA, Lee J, Coakley J, Peat JK & Boulton TJ (2001) Abdominal fat and birth size in healthy prepubertal children. International Journal of Obesity and Related Metabolic Disorders 25, 1667-1673.
13. Godfrey KM, Barker DJ, Robinson S & Osmond C (1997) Maternal birthweight and diet in pregnancy in relation to the infant's thinness at birth. British Journal of Obstetrics and Gynaecology 104, 663-667.
14. Gohlke BC, Huber A, Hecher K, Fimmers R, Bartmann P & Roth CL (2005) Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth. Journal of Clinical Endocrinology and Metabolism 90, 2270-2274.
15. Haig D (1996) Altercation of generations: genetic conflicts of pregnancy. American Journal of Reproductive Immunology 35, 226-232.
16. Hales CN & Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601.
17. Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C & Winter PD (1991) Fetal and infant growth and impaired glucose tolerance at age 64. British Medical Journal 303, 1019-1022.
18. Hattersley AT, Beards F, Ballantyne E, Appleton M, Harvey R & Ellard S (1998) Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nature Genetics 19, 268-270.
19. Hesse V, Voigt M, Salzler A, Steinberg S, Friese K, Keller E, Gausche R & Eisele R (2003) Alterations in height, weight, and body mass index of newborns, children, and young adults in eastern Germany after German reunification. Journal of Pediatrics 142, 259-262.
20. Holly JM, Smith CP, Dunger DB, Howell RJ, Chard T, Perry LA, Savage MO, Cianfarani S, Rees LH & Wass JA (1989) Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-I. A synchronized approach to pubertal development? Clinical Endocrinology 31, 277-284.
21. Ibanez L, Ong K, Dunger DB & de Zegher F (2006) Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. Journal of Clinical Endocrinology and Metabolism 91, 2153-2158.
22. Iniguez G, Ong K, Bazaes R, Avila A, Salazar T, Dunger D & Mericq V (2006) Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for- gestational-age children. Journal of Clinical Endocrinology and Metabolism 91, 4645-4649.
23. Jensen RB, Chellakooty M, Vielwerth S, Vaag A, Larsen T, Greisen G, Skakkebaek NE, Scheike T & Juul A (2003) Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role? Hormone Research 60, Suppl. 3, 136-148.
24. Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA & Kahn CR (2002) beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nature Genetics 31, 111-115.
25. Low LC, Tam SY, Kwan EY, Tsang AM & Karlberg J (2001) Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life. Pediatric Research 50, 737-742.
26. McKeigue PM, Shah B & Marmot MG (1991) Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337, 382-386.
27. Mathews F, Yudkin P & Neil A (1999) Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. British Medical Journal 319, 339-343.
28. Neel JV (1962) Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? American Journal of Human Genetics 14, 353-362.
29. Ness AR (2004) The Avon Longitudinal Study of Parents and Children (ALSPAC) - a resource for the study of the environmental determinants of childhood obesity. European Journal of Endocrinology 151, Suppl. 3, U141-U149.
30. Ong KK, Ahmed ML, Emmett PM, Preece MA & Dunger DB (2000) Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. British Medical Journal 320, 967-971.
31. Ong KK, Ahmed ML, Sherriff A, Woods KA, Watts A, Golding J & Dunger DB (1999) Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Journal of Clinical Endocrinology and Metabolism 84, 1145-1148.
32. Ong KK & Dunger DB (2004) Birth weight, infant growth and insulin resistance. European Journal of Endocrinology 151, Suppl. 3, U131-U139.
33. Ong KK, Emmett PM, Noble S, Ness A & Dunger DB (2006) Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics 117, e503-e508.
34. Ong KK, Petry CJ, Emmett PM, Sandhu MS, Kiess W, Hales CN, Ness AR & Dunger DB (2004) Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels. Diabetologia 47, 1064-1070.
35. Ong KK, Preece MA, Emmett PM, Ahmed ML & Dunger DB (2002) Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatric Research 52, 863-867.
36. Ounsted M, Scott A & Moar VA (1988) Constrained and unconstrained fetal growth: associations with some biological and pathological factors. Annals of Human Biology 15, 119-129.
37. Ounsted M, Scott A & Ounsted C (1986) Transmission through the female line of a mechanism constraining human fetal growth. Annals of Human Biology 13, 143-151.
38. Ounsted M & Sleigh G (1975) The infant's self-regulation of food intake and weight gain. Difference in metabolic balance after growth constraint or acceleration in utero. Lancet i, 1393-1397.
39. Petry CJ, Ong KK, Barratt BJ, Wingate D, Cordell HJ, Ring SM, Pembrey ME, Reik W, Todd JA & Dunger DB (2005) Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genetics 6, 22.
40. Pettitt DJ, Knowler WC, Bennett PH, Aleck KA & Baird HR (1987) Obesity in offspring of diabetic Pima Indian women despite normal birth weight. Diabetes Care 10, 76-80.
41. Reilly JJ, Dorosty AR & Emmett PM (1999) Prevalence of overweight and obesity in British children: cohort study. British Medical Journal 319, 1039.
42. Reusens B & Remacle C (2006) Programming of the endocrine pancreas by the early nutritional environment. International Journal of Biochemistry and Cell Biology 38, 913-922.
43. Rogers I, Emmett P, Baker D & Golding J (1998) Financial difficulties, smoking habits, composition of the diet and birthweight in a population of pregnant women in the South West of England. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. European Journal of Clinical Nutrition 52, 251-260.
44. Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB & Wareham NJ (2002) Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 359, 1740-1745.
45. Seghieri G, Anichini R, De Bellis A, Alviggi L, Franconi F & Breschi MC (2002) Relationship between gestational diabetes mellitus and low maternal birth weight. Diabetes Care 25, 1761-1765.
46. Silbergeld A, Lazar L, Erster B, Keret R, Tepper R & Laron Z (1989) Serum growth hormone binding protein activity in healthy neonates, children and young adults: correlation with age, height and weight. Clinical Endocrinology 31, 295-303.
47. Silverman BL, Rizzo T, Green OC, Cho NH, Winter RJ, Ogata ES, Richards GE & Metzger BE (1991) Long-term prospective evaluation of offspring of diabetic mothers. Diabetes 40, Suppl. 2, 121-125.
48. Sobngwi E, Boudou P, Mauvais-Jarvis F, Leblanc H, Velho G, Vexiau P et al. (2003) Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet 361, 1861-1865.
49. Stumvoll M, Tataranni PA & Bogardus C (2005) The hyperbolic law - a 25-year perspective. Diabetologia 48, 207-209.
50. Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM et al. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nature Genetics 38, 583-588.
51. Van Assche FA, Aerts L & De Prins F (1978) A morphological study of the endocrine pancreas in human pregnancy. British Journal of Obstetrics and Gynaecology 85, 818-820.
52. van Haeften TW & Twickler TB (2004) Insulin-like growth factors and pancreas beta cells. European Journal of Clinical Investigation 34, 249-255.
53. Widdowson EM & McCance RA (1975) A review: new thoughts on growth. Pediatric Research 9, 154-156.
54. Williams DR, Wareham NJ, Brown DC, Byrne CD, Clark PM, Cox BD et al. (1995) Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project. Diabetic Medicine 12, 30-35.
55. World Health Organization Expert Consultation (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363, 157-163.
56. Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE et al. (2002) Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. Journal of Clinical Investigation 110, 1011-1019.
57. Yuen K, Wareham N, Frystyk J, Hennings S, Mitchell J, Fryklund L & Dunger D (2004) Short-term low-dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on beta-cell function and post-load glucose tolerance. European Journal of Endocrinology 151, 39-45.
58. Yuen KC, Frystyk J, White DK, Twickler TB, Koppeschaar HP, Harris PE, Fryklund L, Murgatroyd PR & Dunger DB (2005) Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency. Clinical Endocrinology 63, 428-436.