Lower limb immobilization is associated with increased corticospinal excitability

Experimental Brain Research

Volumn 181, Issue 2, 2007, Pages 213-220

  Roberts, Donna R ^a   Ricci, Raffaella ^a,b   Funke, Frederick W ^a   Ramsey, Patricia ^a   Kelley, Wayne ^a   Carroll, Jerry Scott ^a   Ramsey, Dave ^a,c   Borckardt, Jeffrey J ^a   Johnson, Kevin ^a   George, Mark S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c South Carolina Research Authority   (United States)

Author keywords

Human; Limb disuse; Motor cortex; Plasticity; TMS

Indexed keywords

ADAPTATION; ADULT; ARTICLE; BED REST; BRAIN DEPTH STIMULATION; CAST APPLICATION; CAST REMOVAL; CONTROLLED STUDY; HUMAN; IMMOBILIZATION; LEG; MALE; MOTOR CORTEX; NERVE CELL PLASTICITY; NORMAL HUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; AFFERENT PATHWAYS; ALGORITHMS; CASTS, SURGICAL; HUMANS; IMMOBILIZATION; LINEAR MODELS; LOWER EXTREMITY; MALE; MOTOR CORTEX; NEURONAL PLASTICITY; PYRAMIDAL TRACTS; RECRUITMENT, NEUROPHYSIOLOGICAL; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 34447343087     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-007-0920-5     Document Type: Article

References (39)

1. Birbaumer N, Lutzenberger W, Montoya P, Larbig W, Unertl K, Topfner S, Grodd W, Taub E, Flor H (1997) Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization. J Neurosci 17:5503-5508
2. Bohning DE, He L, George MS, Epstein CM (2001) Deconvolution of transcranial magnetic stimulation (TMS) maps. J Neural Transm 108:35-52
3. Brasil-Neto JP, Cohen LG, Pascual-Leone A, Jabir FK, Wall RT, Hallett M (1992) Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation. Neurology 42:1302-1306
4. Brown JA, Lutsep H, Cramer SC, Weinand M (2003) Motor cortex stimulation for enhancement of recovery after stroke: case report. Neurol Res 25:815-818
5. Bryk AS, Raudenbush SW (1987) Application of hierarchical linear models to assessing change. Psychol Bull 101:147-158
6. Bryk AS, Raudenbush SW (1992) Hierarchical linear models: applications and data analysis methods. Sage Publications, Newbury Park
7. Chen R, Corwell B, Yaseen Z, Hallett M, Cohen LG (1998) Mechanisms of cortical reorganization in lower-limb amputees. J Neurosci 18:3443-3450
8. Classen J, Cohen GL (2003) Practice-induced plasticity in the human motor cortex. In: Boniface SaZU (ed) Plasticity in the human nervous system. Cambridge University Press, Cambridge
9. Classen J, Liepert J, Wise SP, Hallett M, Cohen LG (1998) Rapid plasticity of human cortical movement representation induced by practice. J Neurophysiol 79:1117-1123
10. Cohen LG, Bandinelli S, Findley TW, Hallett M (1991a) Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation Brain 114(Pt 1B):615-627
11. Cohen LG, Bandinelli S, Topka HR, Fuhr P, Roth BJ, Hallett M (1991b) Topographic maps of human motor cortex in normal and pathological conditions: mirror movements, amputations and spinal cord injuries. Electroencephalogr Clin Neurophysiol Suppl 43:36-50
12. Conforto AB, Kaelin-Lang A, Cohen LG (2002) Increase in hand muscle strength of stroke patients after somatosensory stimulation. Ann Neurol 51:122-125
13. Devanne H, Lavoie BA, Capaday C (1997) Input-output properties and gain changes in the human corticospinal pathway. Exp Brain Res 114:329-338
14. Di Lazzaro V, Dileone M, Profice P, Pilato F, Cioni B, Meglio M, Capone F, Tonali PA, Rothwell JC (2006) Direct demonstration that repetitive transcranial magnetic stimulation can enhance corticospinal excitability in stroke. Stroke
15. Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Larbig W, Taub E (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375:482-484
16. Hamdy S, Rothwell JC, Aziz Q, Singh KD, Thompson DG (1998) Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nat Neurosci 1:64-68
17. Hummel F, Celnik P, Giraux P, Floel A, Wu WH, Gerloff C, Cohen LG (2005) Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain 128:490-499
18. Khedr EM, Ahmed MA, Fathy N, Rothwell JC (2005) Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke. Neurology 65:466-468
19. Kim YH, You SH, Ko MH, Park JW, Lee KH, Jang SH, Yoo WK, Hallett M (2006) Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke. Stroke 37:1471-1476
20. Levy WJ Jr, Amassian VE, Traad M, Cadwell J (1990) Focal magnetic coil stimulation reveals motor cortical system reorganized in humans after traumatic quadriplegia. Brain Res 510:130-134
21. Liepert J, Tegenthoff M, Malin JP (1995) Changes of cortical motor area size during immobilization. Electroencephalogr Clin Neurophysiol 97:382-386
22. Lotze M, Braun C, Birbaumer N, Anders S, Cohen LG (2003a) Motor learning elicited by voluntary drive. Brain 126:866-872
23. Lotze M, Scheler G, Tan HR, Braun C, Birbaumer N (2003b) The musician's brain: functional imaging of amateurs and professionals during performance and imagery. Neuroimage 20:1817-1829
24. Mansur CG, Fregni F, Boggio PS, Riberto M, Gallucci-Neto J, Santos CM, Wagner T, Rigonatti SP, Marcolin MA, Pascual-Leone A (2005) A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients. Neurology 64:1802-1804
25. Nudo RJ, Plautz EJ, Frost SB (2001) Role of adaptive plasticity in recovery of function after damage to motor cortex. Muscle Nerve 24:1000-1019
26. Pascual-Leone A, Nguyet D, Cohen LG, Brasil-Neto JP, Cammarota A, Hallett M (1995) Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J Neurophysiol 74:1037-1045
27. Perez MA, Lungholt BK, Nyborg K, Nielsen JB (2004) Motor skill training induces changes in the excitability of the leg cortical area in healthy humans. Exp Brain Res 159:197-205
28. Ridding MC, Rothwell JC (1999) Afferent input and cortical organisation: a study with magnetic stimulation. Exp Brain Res 126:536-544
29. Sadato N, Pascual-Leone A, Grafman J, Ibanez V, Deiber MP, Dold G, Hallett M (1996) Activation of the primary visual cortex by Braille reading in blind subjects. Nature 380:526-528
30. Singer JD (1998) Using SAS PROC MIXED to fit multilevel models, hierarchical models and individual growth curves
31. Stong C (2006) Cortical stimulation for hemiparetic stroke patients-safety and efficacy data. Neurology Reviews 13:8-11
32. Takeuchi N, Chuma T, Matsuo Y, Watanabe I, Ikoma K (2005) Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke. Stroke 36:2681-2686
33. Uy J, Ridding MC, Hillier S, Thompson PD, Miles TS (2003) Does induction of plastic change in motor cortex improve leg function after stroke? Neurology 61:982-984
34. Ward NS (2005) Mechanisms underlying recovery of motor function after stroke. Postgrad Med J 81:510-514
35. Werhahn KJ, Mortensen J, Kaelin-Lang A, Boroojerdi B, Cohen LG (2002a) Cortical excitability changes induced by deafferentation of the contralateral hemisphere. Brain 125:1402-1413
36. Werhahn KJ, Mortensen J, Van Boven RW, Zeuner KE, Cohen LG (2002b) Enhanced tactile spatial acuity and cortical processing during acute hand deafferentation. Nat Neurosci 5:936-938
37. Zanette G, Manganotti P, Fiaschi A, Tamburin S (2004) Modulation of motor cortex excitability after upper limb immobilization. Clin Neurophysiol 115:1264-1275
38. Zanette G, Tinazzi M, Bonato C, di Summa A, Manganotti P, Polo A, Fiaschi A (1997) Reversible changes of motor cortical outputs following immobilization of the upper limb. Electroencephalogr Clin Neurophysiol 105:269-279
39. Ziemann U, Hallett M, Cohen LG (1998) Mechanisms of deafferentation- induced plasticity in human motor cortex. J Neurosci 18:7000-7007