Mechanisms of cortical reorganization in lower-limb amputees

Journal of Neuroscience

Volumn 18, Issue 9, 1998, Pages 3443-3450

  Chern, Robert ^a   Corwell, Brian ^a   Yaseen, Zaneb ^a   Hallett, Mark ^a   Cohen, Leonardo G ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Amputation; Human; Mechanisms of plasticity; Motor cortex; Motor reorganization; Transcranial magnetic stimulation

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; EVOKED MUSCLE RESPONSE; FACILITATION; FEMALE; HUMAN; LEG AMPUTATION; MALE; MOTOR CORTEX; NERVE CELL PLASTICITY; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 0032079847     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-09-03443.1998     Document Type: Article

References (71)

1. Amassian VE, Quirk GJ, Stewart M (1990) A comparison of corticospinal activation by magnetic coil and electrical stimulation of monkey motor cortex. Electroencephalogr Clin Neurophysiol 77:390-401.
2. Anwyl R (1991) The role of metabotropic receptor in synaptic plasticity. Trends Pharmacol Sci 12:324-326.
3. Benecke R, Meyer B-U, Freund H-J (1991) Reorganization of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation. Exp Brain Res 83:419-426.
4. Brasil-Neto JP, Cohen LG, Pascual-Leone A, Jabir FK, Wall RT, Hallett M (1992) Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation. Neurology 42:1302-1306.
5. Brasil-Neto JP, Valls-Solé J, Pascual-Leone A, Cammarota A, Amassian VE, Cracco R, Maccabee P, Cracco J, Hallett M, Cohen LG (1993) Rapid modulation of human cortical motor outputs following ischemic nerve block. Brain 116:511-525.
6. Carp JS, Wolpaw JR (1994) Motoneuron plasticity underlying operantly conditioned decrease in primate H-reflex. J Neurophysiol 72:431-442.
7. Chen R, Samii A, Caños M, Wassermann E, Hallett M (1997) Effects of phenytoin on cortical excitability in humans. Neurology 49:881-883.
8. Cohen LG, Roth BJ, Nilsson J, Dang N, Panizza M, Bandinelli S, Friauf W, Hallett M (1990) Effect of coil design on delivery of focal magnetic stimulation. Technical considerations. Electroencephalogr Clin Neurophysiol 75:350-357.
9. Cohen LG, Bandinelli S, Findley TW, Hallett M (1991a) Motor reorganization after upper limb amputation in man. Brain 114:615-627.
10. Cohen LG, Zeffiro T, Bookheimer S, Wassermann EM, Fuhr P, Matsumoto J, Toro C, Hallett M (1991b) Reorganization in motor pathways following a large congenital hemispheric lesion in man: different motor representation areas for ipsi- and contralateral muscles. J Physiol (Lond) 438:33P.
11. Conti F, Minelli A, Pons TP (1996) Changes in immunoreactivity in the somatic sensory cortex of adult monkeys induced by nerve cuts. J Comp Neurol 368:503-515.
12. Darian-Smith C, Gilbert CD (1994) Axonal sprouting accompanies functional reogranization in adult cat striate cortex. Nature 68:737-740.
13. Darian-Smith C, Gilbert CD (1995) Topographic reorganization in the striate cortex of the adult cat and monkey is cortically mediated. J Neurosci 15:1631-1647.
14. Davis KD, Kiss ZHT, Luo L, Tasker RR, Lozano AM, Dostrovsky JO (1998) Phantom sensations generated by thalamic microstimulation. Nature 391:385-387.
15. Day BL, Thompson PD, Dick JP, Nakashima K, Marsden CD (1987) Different sites of action of electrical and magnetic stimulation of the human brain. Neurosci Lett 75:101-106.
16. Day BL, Dressler D, Maertens de Noordhout A, Marsden CD, Nakashima K, Rothwell JC, Thompson PD (1989) Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses. J Physiol (Lond) 412:449-473.
17. Donoghue JP, Sanes JN (1988) Organization of adult motor cortex representation patterns following neonatal forelimb nerve injury in rats. J Neurosci 8:3221-3232.
18. Donoghue JP, Suner S, Sanes JN (1990) Dynamic organization of primary motor cortex output to target muscles in adult rat. II. Rapid reorganization following motor nerve lesions. Exp Brain Res 79:492-503.
19. Dykes RW (1997) Mechanisms controlling neuronal plasticity in somatosensory cortex. Can J Physiol Pharmacol 75:535-545.
20. Edgley SA, Eyre JA, Lemon RN, Miller S (1997) Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial magnetic stimulation in the lumbosacral cord of the anaesthetized monkey. Brain 120:839-853.
21. Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Larbig W, Taub E (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375:482-484.
22. Florence SL, Kaas JH (1995) Large-scale reorganization at multiple levels of the somatoscnsory pathway follows therapeutic amputation of the hand in monkeys. J Neurosci 15:8083-8095.
23. Fuhr P, Cohen LG, Dang N, Findley TW, Haghighi S, Oro J, Hallett M (1992) Physiological analysis of motor reorganization following lower limb amputation. Electroencephalogr Clin Neurophysiol 85:53-60.
24. Garraghty PE, Kass JH (1991) Functional reorganization in adult monkey thalamus after peripheral nerve injury. Neuro Report 2:747-750.
25. Garraghty PE, Muja N (1996) NMDA receptor and plasticity in adult primate somatosensory cortex. J Comp Neurol 367:319-326.
26. Garraghty PE, LaChica EA, Kaas JH (1991) Injury-induced reorganization of somatosensory cortex is accompanied by reductions in GABA staining. Somatosens Mot Res 8:347-354.
27. Garraghty PE, Muja N, Hoard R (1993) NMDA receptor blockade prevents most cortical reorganization after peripheral nerve injury in adult monkeys. Soc Neurosci Abstr 19:1569.
28. Hall EJ, Flament D, Fraser C, Lemon RN (1990) Noninvasive brain stimulation reveals reorganised cortical outputs in amputees. Neurosci Lett 116:379-386.
29. Halter JA, Carp JS, Wolpaw JR (1995) Operantly conditioned motoneuron plasticity: possible role of sodium channels. J Neurophysiol 73:867-871.
30. Hendry SHC, Jones EG (1986) Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17. Nature 320:750-753.
31. Hess G, Donoghue JP (1994) Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical maps. J Neurophysiol 71:2543-2547.
32. Huntley GW (1997) Correlation between patterns of horizontal connectivity and the extent of short-term representational plasticity in rat motor cortex. Cereb Cortex 7:143-156.
33. Jacobs K, Donoghue J (1991) Reshaping the cortical map by unmasking latent intracortical connections. Science 251:944-947.
34. Jenkins WM, Merzenich MM (1987) Reorganization of ncocortical representations after brain injury: a neurophysiological model of bases of recovery from stroke. Prog Brain Res 71:249-266.
35. Jones EG (1993) GABAergic neurons and their role in cortical plasticity in primates. Cereb Cortex 3:361-372.
36. Juliano SL, Ma W, Eslin D (1991) Cholinergic depletion prevents expansion of topographic maps in somatosensory cortex. Proc Natl Acad Sci USA 88:780-784.
37. Kaas JH (1991) Plasticity of sensory and motor maps in adult mammals, Annu Rev Neurosci 14:137-167.
38. Kaneko K, Kawai S, Fuchigami Y, Morita H, Ofuji A (1996) The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain. Electroencephalogr Clin Neurophysiol 101:478-482.
39. Keller A, Arissian K, Asanuma H (1992) Synaptic proliferation in the motor cortex of adult cats after long-term thalamic stimulation. J Neurophysiol 68:295-308.
40. Kenko T, Caria MA, Asanuma H (1994a) Information processing within the motor cortex. I. Responses of morphologically identified motor cortical cells to stimulation of the somatosensory cortex. J Comp Neurol 345:161-171.
41. Kenko T, Caria MA, Asanuma H (1994b) Information processing within the motor cortex. II. Intracortical connections between neurons receiving somatosensory cortical input and motor output neurons of the cortex. J Comp Neurol 345:172-184.
42. Kew JJM, Ridding MC, Rothwell JC, Passingham RE, Leigh PN, Sooriakumaran S, Frackowiak RSJ, Brooks DJ (1994) Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J Neurophysiol 72:2517-2524.
43. Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD (1993) Corticocortical inhibition in human motor cortex. J Physiol (Lond) 471:501-519.
44. Levy WJ, Amassian VE,Traad M, Cadwell J (1990) Focal magnetic coil stimulation reveals motor cortical system reorganized in humans after traumatic quadriplegia. Brain Res 510:130-134.
45. Meinck H-M (1980) Facilitation and inhibition of the human H-reflex as a function of the amplitude of the control reflex. Electroencephalogr Clin Neurophysiol 48:203-211.
46. Merzenich MM, Jenkins WM (1993) Reorganization of cortical representations of the hand following alterations of skin inputs induced by nerve injury, skin island transfers, and experience. J Hand Ther 6:89-104.
47. Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H (1996) Direct and indirect activation of human corticospinal neurons by transcranial magnetic and electrical stimulation. Neurosci Lett 210:45-48.
48. Nakamura H, Kitagawa H, Kawaguchi Y, Gejo R, Tsuji H (1997a) Direct and indirect activation of corticospinal neurons of hand and leg motor area by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 103:152.
49. Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H (1997b) Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. J Physiol (Lond) 498:817-823.
50. Nicolelis MAL, Lin RCS, Woodward DJ, Chapin JK (1993) Induction of immediate spatiotemporal changes in thalamic networks by peripheral block of ascending cutaneous information. Nature 361:533-536.
51. Nudo RJ, Wise BM, SiFuentes F, Milliken GW (1996) Neural substrates for the effects of rehabilitative training on motor recovery after ische mic infarct. Science 272:1791-1794.
52. Pavlides C, Miyashita E, Asanuma H (1993) Projection from the sensory to the motor cortex is important in learning motor skills in the monkey. J Neurophysiol 70:733-741.
53. Pons T, Garraghty PE, Mishkin M (1988) Lesion-induced plasticity in the second somatosensory cortex of adult macaques, Proe Natl Acad Sci USA 85:5279-5281.
54. Pons T, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M (1991) Massive cortical reorganization after sensory deafferentation in adult macaques. Science 252:1857-1860.
55. Ralston HJ, Ohara PT, Meng XW, Wells J, Ralston DD (1996) Transneuronal changes of the inhibitory circuitry in the macaque somatosensory thalamus following lesions of the dorsal column nuclei. J Comp Neurol 371:325-335.
56. Recanzone GKH, Merzenich MM. Dinse HR (1992) Expansion of the cortical representation of a specific skin field in primary somatosensory cortex by intracortical microstimulation. Cereb Cortex 2:181-196.
57. Ridding MC, Rothwell JC (1995) Reorganization in human motor cortex. Can J Physiol Pharmacol 73:218-222.
58. Ridding MC, Rothwell JC (1997) Stimulus/response curves as a method of measuring motor cortical excitability in man. Electroencephalogr Clin Neurophysiol 105:340-344.
59. Rothwell JC, Thompson PD, Day BL. Boyd S, Marsden CD (1991) Stimulation of the human motor cortex through the scalp. Exp Physiol 76:159-200.
60. Sakamoto T, Porter LL, Asanuma H (1987) Long-lasting potentiation of synaptic potentials in the motor cortex produced by stimulation of the sensory cortex in the cat: a basis of motor learning. Brain Res 413:360-364.
61. Sanes JN, Suner S, Lando JF, Donoghue JP (1988) Rapid reorganization of adult rat motor cortex somatic representation after motor nerve injury. Proc Natl Acad Sci USA 85:2003-2007.
62. Sanes JN, Suner S, Donoghue JP (1990) Dynamic organization of primary motor cortex output to target muscle in adult rats. I. Long-term patterns of reorganization following motor or mixed peripheral nerve lesion. Exp Brain Res 79:479-491.
63. Thompson PD, Day BL, Crockard HA, Calder I, Murray NMF, Rothwell JC, Marsden CD (1991) Intra-operative recording of motor tract potentials at the cervico-medullary junction following scalp electrical and magnetic stimulation of the motor cortex. J Neurol Neurosurg Psychiatry 54:618-623.
64. Topka H, Cohen LG, Cole RA, Hallett M (1991) Reorganization of corticospinal pathways following spinal cord injury. Neurology 41:1276-1283.
65. Weiller C, Chollet F, Friston KJ, Wise RJS, Frackowiak RSJ (1992) Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol 31:463-472.
66. Welker E, Soriano E, Van der Loos H (1989) Plasticity in the barrel cortex of the adult mouse; effects of peripheral deprivation on GAD-immunoreactivity. Exp Brain Res 74:441-452.
67. Werhahn KJ, Fong JKY, Meyer B-U, Priori A, Rothwell JC, Day BL, Thompson PD (1994) The effect of magnetic coil orientation on the latency of surface EMG and single motor unit responses in the first dorsal interosseous muscle. Electroencephalogr Clin Neurophysiol 93:138-146.
68. Ziemann U, Lönnecker S, Steinhoff BJ, Paulus W (1996a) The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 109:127-135.
69. Ziemann U, Lönnecker S, Steinhoff BJ, Paulus W (1996b) Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 40:367-378.
70. Ziemann U, Rothwell JC, Ridding MC (1996c) Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol (Lond) 496:873-881.
71. Ziemann U, Corwell B, Hallett M, Cohen LG (1998) Modulation of plasticity in human motor cortex after forearm ischemic nerve block, J Neurosci 18:1115-1123.