Effect of oral supplementation with iron (III)-hydroxide polymaltose complex on the immunological profile of adolescents with varying iron status

Arzneimittel-Forschung/Drug Research

Volumn 57, Issue 6 A, 2007, Pages 417-425

  Devaki, Pallaki Baby ^a   Chandra, Ranjeet K ^b   Geisser, Peter ^c  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b Asthma and Immunology Centre   (India)

^c Vifor (International) Inc   (Switzerland)

Author keywords

Anemia; Antianemic drugs; Iron deficiency, immunology; Iron(III) hydroxide polymaltose complex; Maltofer

Indexed keywords

IRON POLYMALTOSE; MALTOFER; PLACEBO; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BLOOD EXAMINATION; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL PARAMETERS; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE;

EID: 34447342833     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296690     Document Type: Article

References (37)

1. Chandra RK. Iron and immuno-competence. Nutr Rev. 1976;34:129-132.
2. Chandra RK. Nutrition and the immune system; an introduction. Am J Clin Nutr. 1997;66:4605-4635.
3. Walter T, Arredondo S, Arevalo M, Stekel A. Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants. Am J Clin Nutr. 1986;44:877-882.
4. Baggs RB, Miller SA. Nutritional deficiency as a determinant of host resistance in the rat. J Nutr. 1973;103:1554-1560.
5. Bolin TD, Davis AE, Cummins AG, Duncombe VM, Kelly JD. Effect of iron and protein deficiency on the expulsion of Nippostrongylus brasiliensis from the small intestine of the rat. Gut 1977;18:182-186.
6. Kochanowski BA, Sherman AR. Decreased antibody formation in iron deficient rat pups. Effect of iron repletion. Am J Clin Nutr. 1985;41:278-284.
7. Kochanowski BA, Sherman AR. Cellular growth in iron-deficient rats: Effects of pre:post weaning iron repletion. J Nutr. 1985;115:279-287.
8. Kochanowski BA, Sherman AR. Cellular growth in iron-deficient rat pups. Growth. 1982;46:126-134.
9. Rosch LM, Sherman AR, Layman DK. Iron deficiency impairs protein synthesis in immune tissues of rat pups. J Nutr. 1987;117:1475-1481.
10. Rothenbacher H, Sherman AR. Target organ pathology in iron-deficient suckling rats. J Nutr. 1980;110:1648-1654.
11. 125I-labelled polyvinyl pyrrolidone in iron-deficient and iron replete mice. J Nutr. 1987;117:170-176.
12. Knight S, Ling NR, Sell S, Oxnard CE. The transformation in vitro of peripheral lymphocytes of some laboratory animals. Immunology. 1965;9: 565-574.
13. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet. 1992;340:1124-1127.
14. Seth V, Chandra RK. Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition. Arch Dis Child. 1972;47:282-284.
15. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res. 1995;65:117-121.
16. Ratnam S, Gadag V, West R, Burris J, Oates E, Stead F. Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody. J Clin Microbiol. 1995;33:811-815
17. Cherian T, Varkki S, Raghupathy P, Ratnam S, Chandra RK. Effect of vitamin A supplementation on the immune response to measles vaccination. Vaccine. 2003;21:2418-2420.
18. Santos M, de Sousa M. In vitro modulation of T-cell surface molecules by iron. Cell Immunol. 1994;154:498-506.
19. Feng XY, Yang XQ, Shen J. Influence of iron deficiency on serum IgG subclass and pneumococcal polysaccharides specific IgG subclass antibodies. Chin Med J. 1994;107:813-816.
20. Arbeter A, Echevarri L, Faco D, Munson D, Velex H, Vital JJ. Nutrition and infection. Fed Proc. 1971;30:1421-1428.
21. Thibault H, Galan P, Selz F, Preziosi P, Olivier C, Badoual J et al. The immune response in iron deficient young children: Effect on iron supplementation on cell mediated immunity. Eur J Pediatr. 1993;152:120-124.
22. Zanni G, Ghini M, Mastrantoni M, Bonati ME. An evaluation of the effect of iron treatment on some immune parameters in sideropenic patients. Curr Ther Res. 1989;45:48-52.
23. Djeha A, Brock JH. Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes. Br J Hematol. 1992; 80:235-241.
24. 8-Ick complex in resting peripheral blood T-lymphocytes. Cell Immunol. 1995;161:138-142.
25. Santos PC, Falcao RP. Decreased lymphocyte subsets and K-cell activity in iron deficiency anaemia. Acta Haematol. 1990;84:118-121.
26. Rudd MJ, Good MF, Chapman DE, Powell LW, Halliday JW. Clonal analysis of the effect of iron on human cytotoxic and proliferating T-lymphocytes. Immunol Cell Biol. 1990;68:317-324.
27. De Susa M. T-Lymphocytes and iron over load: Novel correlation of possible significance to the biology of the immunological system. Mem Inst Oswaldo Cruz 1992;87:23-29.
28. Bagchi K, Mohanram M, Reddy V. Humoral immune response in children with iron-deficiency anemia. Br Med J. 1980;2:1251-1253.
29. Gross RL, Reid JVU, Newberne PM, Bugers B, Marston R, Hift W. Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. Am J Dis Child. 1975;28:225-232.
30. Chandra RK. Reduced bactericidal capacity of polymorphs in iron deficiency. Arch Dis Child. 1973;48:863-866.
31. Leberman HM, Cohen A, Lee JWW, Freedman MH, Gelfand EW. Deferoxamine: a reversible S-phase inhibitor of lymphocyte proliferation. Blood. 1994;64:748-753.
32. Brock JH. Iron and immunity. J Nutr Immunol. 1993;2:47-106.
33. Ahluwalia N, Sun J, Krause D, Mastro A, Handte G. Immune function is impaired in iron deficient, home bound older women. Am J Clin Nutr. 2004;79:516-521.
34. Chandra RK. Iron status, Immune Response and Susceptibility to Infection. In: Iron Metabolism. Ciba Foundation Symposium 51. Amsterdam: Elsevier; 1976. p. 249-262.
35. Bhaskaram C, Reddy V. Cell-mediated immunity in iron-and vitamin-deficient children. Br Med J. 1975;3:522-522.
36. Jagadeesan V, Reddy V. Serum complement levels in malnourished children. Ind J Med Res. 1979;70:745-749.
37. Xue-bin F, Xi-quang, Jin G. Influence of iron deficiency or serum IgG sub-class and pneumococcal polysaccharides specific IgG sub-class antibodies. Chin Med J. 1994;107:813-816.