A real-time view of the TAR:Tat:P-TEFb complex at HIV-1 transcription sites

Retrovirology

Volumn 4, Issue , 2007, Pages

  Molle, Dorothée ^a   Maiuri, Paolo ^b   Boireau, Stéphanie ^a   Bertrand, Edouard ^a   Knezevich, Anna ^b   Marcello, Alessandro ^b   Basyuk, Eugenia ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 9; CYCLIN T1; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; TRANSACTIVATOR PROTEIN; VIRUS RNA; CDK9 PROTEIN, HUMAN; ELONGATION FACTOR; FACTOR EF P; FACTOR EF-P; UNCLASSIFIED DRUG;

ARTICLE; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE LOCUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; VIRUS TRANSCRIPTION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; KINETICS; LONG TERMINAL REPEAT; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 9; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; KINETICS; PEPTIDE ELONGATION FACTORS; PROTEIN BINDING; RNA, VIRAL; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 34447330705     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-4-36     Document Type: Article

References (16)

1. Marcello A Zoppe M Giacca M Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator IUBMB Life 2001 51 175-181 11547919
2. Jeang KT Xiao H Rich HA Multifaceted activities of the HIV-1 transactivator of transcription, Tat J Biol Chem 1999 274 28837-28840 10.1074/jbc.274.41.28837 10506122
3. Weinberger LS Burnett JC Toettcher JE Arkin AP Schaffer DV Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity Cell 2005 122 169-182 10.1016/ j.cell.2005.06.006 16051143
4. Wei P Garber ME Fang SM Fischer WH Jones KA A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA Cell 1998 92 451-462 10.1016/S0092-8674(00)80939-3 9491887
5. Peterlin PM Price DH Controlling the elongation phase of transcription with P-TEFb Mol Cell 2006 23 297-305 10.1016/j.molcel.2006.06.014 16885020
6. Ott M Schnolzer M Garnica J Fischle W Emiliani S Rackwitz HR Verdin E Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity Curr Biol 1999 9 1489-1492 10.1016/ S0960-9822(00)80120-7 10607594
7. Kiernan ER Vanhulle C Schiltz L Adam L Xiao H Maudoux F Calomme C Burny A Nakatani Y Jeang KT HIV-1 tat transcriptional activity is regulated by acetylation Embo J 1999 18 6106-6118 1171675 10545121 10.1093/emboj/ 18.21.6106
8. Kaehlcke K Dorr A Hetzer-Egger C Kiermer V Henklein P Schnoelzer M Loret E Cole PA Verdin E Ott M Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation Mol Cell 2003 12 167-176 10.1016/S1097-2765(03)00245-4 12887902
9. Bres V Tagami H Peloponese JM Loret E Jeang KT Nakatani Y Emiliani S Benkirane S Kiernan RE Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF Embo J 2002 21 6811-6819 139090 12486002 10.1093/emboj/cdf669
10. Bres V Gomes N Pickle L Jones K A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat Genes Dev 2005 19 1211-26 1132007 15905409 10.1101/gad.1291705
11. Fusco D Accornero N Lavoie B Shenoy S Blanchard J Singer R Bertrand E Single mRNA molecules demonstrate probabilistic movement in living mammalian cells Curr Biol 2003 13 161-7 10.1016/S0960-9822(02)01436-7 12546792
12. Chene I Du Basyuk E Lin Y Triboulet R Knezevich R Chable-Bessia C Mettling C Baillat V Reynes J Corbeau P Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency EMBO J 2007 26 424-35 10.1038/sj.emboj.7601517 17245432
13. Michels AA Nguyen VT Fraldi A Labas V Edwards M Bonnet F Lania L Bensaude O MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner Mol Cell Biol 2003 23 162212 12832472
14. Sprague BL Pego RL Stavreva DA McNally JG Analysis of binding reactions by fluorescence recovery after photobleaching Biophys J 2004 86 3473-3495 1304253 15189848 10.1529/biophysj.103.026765
15. Yao J Munson K Webb W Lis J Dynamics of heat shock factor association with native gene loci in living cells Nature 2006 442 1050-3 10.1038/ nature05025 16929308
16. Tennyson CN Klamut HJ Worton RG The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced Nat Genet 1995 9 184-190 10.1038/ng0295-184 7719347