Cyclic oxonitriles: Stereodivergent Grignard addition-alkylations

Journal of Organic Chemistry

Volumn 72, Issue 14, 2007, Pages 5270-5275

  Fleming, Fraser F ^a   Wei, Guoqing ^a   Zhang, Zhiyu ^a   Steward, Omar W ^a  

^a DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRIGNARD REAGENTS; NITRILES; STEREOCENTERS; STEREOELECTRONIC EFFECTS;

ADDITION REACTIONS; ALKYLATION; CARBON; MAGNESIA; NITROGEN COMPOUNDS; STEREOCHEMISTRY;

ORGANOMETALLICS;

CARBON; CYCLIC OXONITRILE DERIVATIVE; MAGNESIUM; NITRILE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CYCLIZATION; DIASTEREOISOMER; GRIGNARD REACTION; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

ALKYLATION; BROMINE; CYCLIZATION; METALS; MOLECULAR STRUCTURE; NITRILES; OXYGEN; STEREOISOMERISM;

EID: 34447326159     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo070678y     Document Type: Article

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32. Repetitive alkylations consistently proceed with the same yield, accompanied by the hydroxyalkenenitrile 12 (OMgMe = OH) resulting from carbonyl addition.
33. 12
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40. 9
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