Characterization of the rat urokinase plasminogen activator receptor promoter in PC12 cells

Journal of Neuroscience Research

Volumn 85, Issue 9, 2007, Pages 1952-1958

  Su, Feng ^a   Kozak, Katherine R ^a,c   Herschman, Harvey ^a,b   Reddy, Srinivasa T ^a,b   Farias Eisner, Robin ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

AP 1 transcription factors; Nerve growth factor; Neuronal differentiation; UPAR

Indexed keywords

EPIDERMAL GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; PLASMINOGEN ACTIVATOR; PROTEIN FOS; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; NEURITE; NONHUMAN; NORTHERN BLOTTING; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RAT; RNA ISOLATION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; UPAR GENE;

ANIMALS; BINDING SITES; BLOTTING, NORTHERN; CLONING, MOLECULAR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENES, FOS; GENES, IMMEDIATE-EARLY; MUTAGENESIS, SITE-DIRECTED; NERVE GROWTH FACTORS; PC12 CELLS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RECEPTORS, CELL SURFACE; RNA; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34447321617     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21296     Document Type: Article

References (30)

1. Blasi F, Carmeliet P. 2002. uPAR: a versatile signaling orchestrator. Nat Rev Mol Cell Biol 3:932-943.
2. Bonni A, Greenberg ME. 1997. Neurotrophin regulation of gene expression. Can J Neurol Sci 24:272-283.
3. Chao MV. 1992. Neurotrophin receptors: a window into neuronal differentiation. Neuron 9:583-593.
4. Chaurasia P, Aquirre-Ghiso JA, Liang OD, Gardsvoll H, Ploug M, Ossowski L. 2006. A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth. J Biol Chem 281:14852-14863.
5. Dang J, Boyd D, Wang H, Allgayer H, Doe W, Wang Y. 1999. A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. Eur J Biochem 264:92-99.
6. Deininger MH, Trautmann K, Magdolen V, Luther T, Schluesener HJ, Meyermann R. 2002. Cortical neurons of Creutzfeldt-Jakob disease patients express the urokinase-type plasminogen acticator receptor. Neurosci Lett 324:80-82.
7. Farias-Eisner R, Vician L, Silver A, Reddy S, Rabbani SA, Herschman H. 2000. The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF- driven differentiation. J Neurosci 20:230-239.
8. Farias-Eisner R, Vician L, Reddy S, Basconcillo R, Rabbani SA, Wu YY, Bradshaw RA, Herschman HR. 2001. Expression of the urokinase plasminogen activator receptor, UPAR, is transiently required during "priming" of PC12 cells in NGF-directed cellular differentiation. J Neurosci Res 63:341-346.
9. Figliomeni B, Grasso A. 1985. Tetanus toxin affects the K+-stimulated release of catecholamines from nerve growth factor-treated PC12 cells. Biochem Biophys Res Commun 128:249-256.
10. Greene LA, Tischler AS. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 73:2424-2428.
11. Hayden SM, Seeds NW. 1996. Modulated expression of plasminogen activator system components in cultured cells from dissociated mouse dorsal root ganglia. J Neurosci 16:2307-2317.
12. Herschman HR. 1991. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281-319.
13. Herschman HR. 2000. Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation. Neurochem Res 25:591-602.
14. Huff K, End D, Guroff G. 1981. Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor. J Cell Biol 88:189-198.
15. Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL. 2005. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 280:17449-17457.
16. Kim MH, Cho HS, Jung M, Hong MH, Lee SK, Shin BA, Ahn BW, Jung YD. 2005. Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase plasminogen activator receptor expression in human gastric cancer cells. Int J Oncol 26:1669-1674.
17. Marek L, Levresse V, Amura C, Zentrich E, Van Putten V, Nemenoff RA, Heasley LE. 2004. Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells. J Cell Physiol 201:459-469.
18. Marshall CJ. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
19. Nguyen TT, Scimeca JC, Filloux C, Peraldi P, Carpentier JL, Van Obberghen E. 1993. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. J Biol Chem 268:9803-9810.
20. Okan E, Drewett V, Shaw PE, Jones P. 2001. The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (uPAR) gene via an AP1-dependent mechanism. Oncogene 20:1816-1824.
21. Pang L, Sawada T, Decker SJ, Saltiel AR. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585-13588.
22. Ploug M, Ronne E, Behrendt N, Jensen AL, Blasi F, Dano K. 1991. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem 266:1926-1933.
23. Powell EM, Campbell DB, Stanwood GD, Davis C, Noebels JL, Levitt P. 2003. Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci 23:622-631.
24. Resnati M, Guttinger M, Valcamonica S, Sidenius N, Blasi F, Fazioli F. 1996. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J 15:1572-1582.
25. Siconolfi LB, Seeds NW. 2001. Induction of the plasminogen activator system accompanies peripheral nerve regeneration after sciatic nerve crush. J Neurosci 21:4336-4347.
26. Torocsik B, Angelastro JM, Greene LA. 2002. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. J Neurosci. 22:8971-8980.
27. Vician L, Basconcillo R, Herschman HR. 1997. Identification of genes preferentially induced by nerve growth factor versus epidermal growth factor in PC12 pheochromocytoma cells by means of representational difference analysis. J Neurosci Res 50:32-43.
28. Wang Y, Dang J, Johnson LK, Selhamer JJ, Doe WF. 1995. Structure of the human urokinase receptor gene and its similarity to CD59 and the Ly-6 family. Eur J Biochem 227:116-122.
29. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. 1996. Regulation of integrin function by the urokinase receptor. Science 273:1551-1555.
30. Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA. 1999. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol 144:1285-1294.